Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

for Metastatic Breast Cancer

Drug: Palazestrant

Sites in Charlotte +13 more locations

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05508906·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

Study of SGR-3515 In Participants With Advanced Solid Tumors.

for Advanced Solid Tumor

Sites in Charlotte +12 more locations

Sponsor: Schrödinger, Inc.

Sex: All·Age: 18+

Code: NCT06463340·Phase 1·Recruiting·Listed Jun 2024

Apply to this trial

CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma

for Relapsed/Refractory Multiple Myeloma

Sites in Durham, Charlotte +14 more locations

Sponsor: Caribou Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05722418·Phase 1·Recruiting·Listed Feb 2023

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Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

for Melanoma Stage IIIB

Sites in Durham +12 more locations

Sponsor: Philogen S.p.A.

Sex: All·Age: 18+

Code: NCT03567889·Phase 3·Recruiting·Listed Jun 2018

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A Single Dose of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD)

for Lumbar Disc Disease

Sites in Winston-Salem +13 more locations

Sponsor: BioRestorative Therapies

Sex: All·Age: 18+

Code: NCT04042844·Phase 2·Recruiting·Listed Aug 2019

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Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)

for Von Willebrand Diseases

Sites in Morrisville +9 more locations

Sponsor: Vega Therapeutics, Inc

Sex: All·Age: 12 - 60·Accepts healthy volunteers

Code: NCT05776069·Phase 1, Phase 2·Recruiting·Listed Mar 2023

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Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

for Head and Neck Squamous Cell Carcinoma

Sites in Charlotte +14 more locations

Sponsor: Bicara Therapeutics

Sex: All·Age: 18+

Code: NCT04429542·Phase 1·Recruiting·Listed Jun 2020

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AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

for B-cell Malignancy

Sites in Durham +12 more locations

Sponsor: Carna Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05602363·Phase 1·Recruiting·Listed Nov 2022

Apply to this trial

CERAMENT™| Bone Void Filler Device Registry

for Orthopedic Disorder

Sites in Charlotte +10 more locations

Sponsor: BONESUPPORT AB

Sex: All·Age: 18+

Code: NCT04244942·Recruiting·Listed Jan 2020

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A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for Locally Advanced Solid Tumor

Sites in Charlotte +18 more locations

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05118789·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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A Study of RSLV-132 in Females With Sjögren's Disease

for Primary Sjögren Syndrome

Sites in Charlotte, Salisbury +22 more locations

Sponsor: Resolve Therapeutics

Sex: Female·Age: 18 - 75

Code: NCT06440525·Phase 2·Recruiting·Listed Jun 2024

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First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.

for Solid Tumor

Sites in Durham +19 more locations

Sponsor: Corbus Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06603844·Phase 1, Phase 2·Recruiting·Listed Sep 2024

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Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

for Leukemia, Myeloid, Acute

Drug: Tuspetinib

Sites in Durham +9 more locations

Sponsor: Aptose Biosciences Inc.

Sex: All·Age: 18+

Code: NCT03850574·Phase 1, Phase 2·Recruiting·Listed Feb 2019

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A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart

Sites in Durham, Winston-Salem +19 more locations

Sponsor: Vasa Therapeutics

Sex: All·Age: 50+

Code: NCT07219511·Phase 1·Recruiting·Listed Oct 2025

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MB-105 in Patients With CD5 Positive T-cell Lymphoma

for Lymphoma, T-Cell

Sites in Chapel Hill +11 more locations

Sponsor: March Biosciences Inc

Sex: All·Age: 18+

Code: NCT06534060·Phase 2·Recruiting·Listed Aug 2024

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An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene

for Stargardt

Sites in Durham +13 more locations

Sponsor: Splice Bio

Sex: All·Age: 12 - 65

Code: NCT06435000·Recruiting·Listed May 2024

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US National OCS Liver Perfusion (OLP) Registry

for Liver Transplant

Sites in Durham, Charlotte +20 more locations

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05940857·Recruiting·Listed Jul 2023

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Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

for Seizures

Drug: Carisbamate

Sites in Durham +6 more locations

Sponsor: SK Life Science, Inc.

Sex: All·Age: 4 - 55

Code: NCT05219617·Phase 3·Recruiting·Listed Feb 2022

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A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for Low-grade Glioma

Sites in Durham +11 more locations

Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All·Age: 6 Months - 25

Code: NCT04775485·Phase 2·Recruiting·Listed Mar 2021

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Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma

for Relapsed Multiple Myeloma

Sites in Chapel Hill +11 more locations

Sponsor: Opna Bio LLC

Sex: All·Age: 18+

Code: NCT06433947·Phase 1·Recruiting·Listed May 2024

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Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera

for Polycythemia Vera

Drug: Givinostat

Sites in Chapel Hill +13 more locations

Sponsor: Italfarmaco

Sex: All·Age: 18+

Code: NCT06093672·Phase 3·Recruiting·Listed Oct 2023

Apply to this trial

Phase 1 Study of ACR-2316 in Specific Advanced Solid Tumors

for Specific Advanced Solid Tumors

Sites in Huntersville +14 more locations

Sponsor: Acrivon Therapeutics

Sex: All·Age: 18+

Code: NCT06667141·Phase 1·Recruiting·Listed Oct 2024

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A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

for Narcolepsy Type 1

Drug: ORX750

Sites in Huntersville, Denver +17 more locations

Sponsor: Centessa Pharmaceuticals (UK) Limited

Sex: All·Age: 18 - 65

Code: NCT07096674·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare

for Acute Gouty Arthritis

Sites in Morehead City +13 more locations

Sponsor: Atom Therapeutics Co., Ltd

Sex: All·Age: 18 - 70

Code: NCT07145229·Phase 2·Recruiting·Listed Aug 2025

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XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

for Heart Transplant

Sites in Durham +13 more locations

Sponsor: XVIVO Perfusion

Sex: All·Age: 18+

Code: NCT06895070·Recruiting·Listed Mar 2025

Apply to this trial

Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS

for Interstitial Cystitis

Sites in Winston-Salem +10 more locations

Sponsor: Vaneltix Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05737121·Phase 2·Recruiting·Listed Feb 2023

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A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)

for Urinary Tract Infections

Sites in Raleigh +11 more locations

Sponsor: Locus Biosciences

Sex: Female·Age: 18 - 75

Code: NCT05488340·Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

Matrion Decellularized Placental Membrane Versus Conventional Wound Management in Subjects With Diabetic Foot Ulcers

for Diabetic Foot Ulcer (DFU)

Sites in Raleigh, Rocky Mount +16 more locations

Sponsor: LifeNet Health

Sex: All·Age: 21 - 80

Code: NCT07116876·Recruiting·Listed Aug 2025

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Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated or Spliceosome Mutated Relapsed or Refractory Acute Myeloid Leukemia

for AML With Gene Mutations

Sites in Chapel Hill +11 more locations

Sponsor: Lomond Therapeutics Holdings, Inc.

Sex: All·Age: 18+

Code: NCT06366789·Phase 1·Recruiting·Listed Apr 2024

Apply to this trial

Clinical Study of a Vaginal Cooling Device for the Treatment of Vulvovaginal Candidiasis (VVC)

for Vulvovaginal Candidiasis (VVC)

Sites in Winston-Salem, Raleigh +6 more locations

Sponsor: Coologics, Inc

Sex: Female·Age: 22 - 49

Code: NCT06983041·Recruiting·Listed May 2025

Apply to this trial

A Study of NX-1607 in Adults With Advanced Malignancies

for Ovarian Cancer, Epithelial

Sites in Chapel Hill +8 more locations

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05107674·Phase 1·Recruiting·Listed Nov 2021

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Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT

for Thrombosis, Deep Vein

Sites in Raleigh +12 more locations

Sponsor: Mercator MedSystems, Inc.

Sex: All·Age: 18 - 89

Code: NCT04862468·Phase 2·Recruiting·Listed Apr 2021

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Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis

for Idiopathic Pulmonary Fibrosis (IPF)

Sites in Winston-Salem +11 more locations

Sponsor: InSilico Medicine Hong Kong Limited

Sex: All·Age: 40+

Code: NCT05975983·Phase 2·Recruiting·Listed Aug 2023

Apply to this trial

Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer

for Endometrial Cancer

Sites in Pinehurst +18 more locations

Sponsor: Kartos Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT05797831·Phase 2, Phase 3·Recruiting·Listed Apr 2023

Apply to this trial

uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

Sites in Chapel Hill +21 more locations

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting·Listed May 2023

Apply to this trial

A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes

for Higher-risk Myelodysplastic Syndromes

Sites in Chapel Hill +13 more locations

Sponsor: Akeso

Sex: All·Age: 18+

Code: NCT06196203·Phase 2·Recruiting·Listed Jan 2024

Apply to this trial

A Study of NST-6179 in Subjects With Intestinal Failure-Associated Liver Disease (IFALD).

for Intestinal Failure Associated Liver Disease

Sites in Durham +12 more locations

Sponsor: NorthSea Therapeutics B.V.

Sex: All·Age: 16+

Code: NCT05919680·Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

for Pulmonary Nodule, Solitary

Sites in Greensboro +21 more locations

Sponsor: Veracyte, Inc.

Sex: All·Age: 29 - 85

Code: NCT06426628·Recruiting·Listed May 2024

Apply to this trial

Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD

for Age-Related Macular Degeneration

Sites in Asheville +9 more locations

Sponsor: VisionCare, Inc.

Sex: All·Age: 65+

Code: NCT05438732·Recruiting·Listed Jun 2022

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IDP-023 as a Single Agent and in Combination With Antibody Therapies in Patients With Advanced Hematologic Cancers

for NHL

Sites in Winston-Salem +8 more locations

Sponsor: Indapta Therapeutics, INC.

Sex: All·Age: 18+

Code: NCT06119685·Phase 1, Phase 2·Recruiting·Listed Nov 2023

Apply to this trial