Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

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2,944 clinical trials

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Global Open-Label Extension Study of Del-desiran for the Treatment of DM1

for Myotonic Dystrophy Type 1

17 locations incl. Los Angeles

Sponsor: Avidity Biosciences, Inc.

Sex: All·Age: 16+

Code: NCT07008469·Phase 3·Enrolling By Invitation

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

for Atherosclerotic Cardiovascular Disease

139 locations incl. Daphne

Sponsor: Amgen

Sex: All·Age: 45 - 99

Code: NCT07037433·Phase 3·Recruiting

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Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder

for Bipolar 1 Disorder

22 locations incl. Little Rock

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 65

Code: NCT07046494·Phase 2·Recruiting

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Safety and Efficacy of VDPHL01 in Females With Androgenetic Alopecia (AGA)

for Androgenetic Alopecia (AGA)

71 locations incl. Birmingham

Sponsor: Veradermics, Inc.

Sex: Female·Age: 18 - 65

Code: NCT07146022·Phase 3·Recruiting

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Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke

for Acute Ischemic Stroke

15 locations incl. Tucson

Sponsor: Pharmazz, Inc.

Sex: All·Age: 18 - 80

Code: NCT05691244·Phase 3·Recruiting

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4D Duke Microscope Integrated Optical Coherence Tomography in a Zeiss Artevo 800

for Corneal Diseases

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07024719·Recruiting

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This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

for Non-Small Cell Lung Cancer

Drug: sigvotatug vedotin

58 locations incl. Fullerton

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06758401·Phase 3·Recruiting

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Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

for Relapsing Multiple Sclerosis

Drug: Remibrutinib

38 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 40 - 70

Code: NCT06846281·Phase 3·Recruiting

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Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

for Percutaneous Coronary Intervention

Drug: Inclisiran

103 locations incl. Alexander City

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06909565·Phase 4·Recruiting

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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

for Pulmonary Hypertension

25 locations incl. Birmingham

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06911632·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

for Multiple Myeloma

10 locations incl. Los Angeles

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06953960·Phase 1, Phase 2·Recruiting

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Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)

for HIV Pre-exposure Prophylaxis

31 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07047716·Phase 3·Recruiting

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EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

for Diabetes Mellitus, Type 2

Drug: Empagliflozin

216 locations incl. Anniston

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07064473·Phase 3·Recruiting

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Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

for Neovascular Age-Related Macular Degeneration (nAMD)

54 locations incl. Scottsdale

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT07064759·Phase 3·Recruiting

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A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

10 locations incl. San Francisco

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting

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A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

for Ovarian Cancer

14 locations incl. Augusta

Sponsor: Compugen Ltd

Sex: Female·Age: 18+

Code: NCT06888921·Phase 1, Phase 2·Recruiting

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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

for Pancreatic Neuroendocrine Tumor (pNET)

39 locations incl. Birmingham

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06943755·Phase 2, Phase 3·Recruiting

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A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

for Breast Neoplasms

33 locations incl. Daphne

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07060807·Phase 3·Recruiting

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Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

for Renal Cell Carcinoma

7 locations incl. San Francisco

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 120

Code: NCT07049926·Phase 1, Phase 2·Recruiting

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Resources for Optimizing Outcomes in Toddlers on the Spectrum

for Autism Spectrum Disorder

1 location in Carrboro

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 - 99

Code: NCT07086781·Recruiting

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Evaluating Microarray Pharmacogenetic Testing in Cancer Patients

for Cancer

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06489041·Recruiting

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A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

for Bipolar Disorder Type I With Mania

Drug: KarXT

52 locations incl. Glendale

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT06929273·Phase 3·Recruiting

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Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

for Non-small Cell Lung Cancer

22 locations incl. Glendale

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06765109·Phase 3·Recruiting

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A Study of Subcutaneous Trastuzumab Deruxtecan in Participants With Metastatic Solid Tumors

for Recurrent or Metastatic Solid Tumors

6 locations incl. Newport Beach

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT07015697·Phase 1·Recruiting

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Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

8 locations incl. San Diego

Sponsor: MOMA Therapeutics

Sex: All·Age: 18+

Code: NCT06974110·Phase 1·Recruiting

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A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE

for Macular Edema Secondary to Inflammation

55 locations incl. Phoenix

Sponsor: Kodiak Sciences Inc

Sex: All·Age: 18+

Code: NCT06996080·Phase 3·Recruiting

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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-2)

for Alzheimer Disease

Drug: KarXT

39 locations incl. Chandler

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 55 - 90

Code: NCT07011745·Phase 3·Recruiting

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Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes

for Renal Impairment After Cardiac Surgery

4 locations incl. Weston

Sponsor: 3ive Labs

Sex: All·Age: 22 - 85

Code: NCT07017933·Recruiting

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A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

for Early Alzheimer's Disease

36 locations incl. Irvine

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 50 - 85

Code: NCT07033494·Phase 2·Recruiting

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ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

for Low Grade Glioma of Brain

Drug: Vorasidenib

1 location in Durham

Sponsor: Katy Peters, MD, PhD

Sex: All·Age: 18+

Code: NCT05609994·Phase 1·Recruiting

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Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke

for Acute Ischemic Stroke

3 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18+

Code: NCT06440707·Phase 2·Recruiting

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A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)

for Chronic Hepatitis B Infection

18 locations incl. Chandler

Sponsor: Aligos Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06963710·Phase 2·Recruiting

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A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy

for Kidney Disease

40 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06963827·Phase 3·Recruiting

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A Study Evaluating BFB759 in Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis (AD)

48 locations incl. Phoenix

Sponsor: Bluefin Biomedicine, Inc.

Sex: All·Age: 18 - 75

Code: NCT07105488·Phase 2·Recruiting

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Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

for Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 39

Code: NCT06371768·Recruiting

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Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis

for Rheumatoid Arthritis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06841562·Recruiting

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Shield Post-Approval Study Protocol

for Colo-rectal Cancer

56 locations incl. Chandler

Sponsor: Guardant Health, Inc.

Sex: All·Age: 45 - 81·Accepts healthy volunteers

Code: NCT06880055·Recruiting

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Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

for Acute Decompensated Heart Failure

37 locations incl. Irvine

Sponsor: Reprieve Cardiovascular, Inc

Sex: All·Age: 22+

Code: NCT06898515·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

for Alzheimer's Disease

Drug: KarXT

28 locations incl. Long Beach

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 60 - 85

Code: NCT06976216·Phase 3·Recruiting

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A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

for COVID-19 Infection

65 locations incl. Canoga Park

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07013474·Phase 3·Recruiting

Apply to this trial