Paid Clinical Trials in North Carolina

North Carolina has 2,811 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,435 clinical trials

AI-CARE: Artificial Intelligence for Cardiovascular Analysis and Risk Evaluation

for Aortic Aneurysm

Sites in Chapel Hill +1 more location

Sponsor: Aiatella Oy

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07438327·Recruiting·Listed Feb 2026

Apply to this trial

CATALINA-4: A Study to Investigate the Safety and Efficacy of TORL-1-23 With Chemotherapy Given Before Initial Surgery in Women With Advanced Stage Ovarian Cancer

for FIGO Stage III and IV Ovarian Cancer

Sites in Durham +6 more locations

Sponsor: TORL Biotherapeutics, LLC

Sex: Female·Age: 18 - 75

Code: NCT07322094·Phase 1, Phase 2·Recruiting·Listed Jan 2026

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An Efficacy and Safety Study of DFL24498 in the Treatment of AKC

for Atopic Keratoconjunctivitis

Sites in Durham +7 more locations

Sponsor: Dompé Farmaceutici S.p.A

Sex: All·Age: 18 - 65

Code: NCT07395232·Phase 3·Recruiting·Listed Feb 2026

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Descartes-08 in Autoantibody Myositis

for Antisynthetase Syndrome

Sites in Chapel Hill +1 more location

Sponsor: Cartesian Therapeutics

Sex: All·Age: 18+

Code: NCT07391605·Phase 2·Recruiting·Listed Feb 2026

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A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late-Onset Pompe Disease (PROGRESS-GT LOPD)

for Pompe Disease (Late-onset)

Sites in Durham +8 more locations

Sponsor: AskBio Inc

Sex: All·Age: 18 - 65

Code: NCT07282847·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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A U.S. Pilot Human Investigation of RadiofrEquency Vapor Ablation System to Evaluate Safety, TOleRability, and Effectiveness for Proximal Intestinal Mucosal Ablation in Patients With Type 2 Diabetes Mellitus (RESTORE-1 Study)

for Type-2 Diabetes Mellitus

Sites in Chapel Hill +3 more locations

Sponsor: Aqua Medical, Inc.

Sex: All·Age: 22 - 65

Code: NCT07355270·Recruiting·Listed Jan 2026

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Confirmatory Clinical Study in Active Ulcerative Colitis

for Colitis, Ulcerative

Sites in Fayetteville, High Point +4 more locations

Sponsor: MRM Health NV

Sex: All·Age: 16+

Code: NCT07296315·Phase 2·Recruiting·Listed Dec 2025

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DOC1021 Dendritic Cell Immunotherapy for Refractory Melanoma

for Refractory Melanoma

Sites in Chapel Hill +6 more locations

Sponsor: Diakonos Oncology Corporation

Sex: All·Age: 18+

Code: NCT07288112·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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Evaluation of Efficacy and Safety of THRV-1268 in Long QT Syndrome Type 2 (LQTS 2)

for Long QT Syndrome (LQTS) 2

Sites in Wilmington +8 more locations

Sponsor: Thryv Therapeutics, Inc.

Sex: All·Age: 15+

Code: NCT07277582·Phase 2, Phase 3·Recruiting·Listed Dec 2025

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A Study to Train a Machine Learning Algorithm for an Evaluation of the Use of Biometric Data Captured at the Wrist for the Identification of Acute Opioid Use Events and the Quantification of Opioid Withdrawal in Opioid Dependent Individuals

for Treatment for Opioid Use Disorder

Sites in Wilmington +3 more locations

Sponsor: OpiAID

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07405398·Recruiting·Listed Feb 2026

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CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

for Aortic Valve Stenosis

Sites in Asheville +2 more locations

Sponsor: EmStop Inc

Sex: All·Age: 22+

Code: NCT07276711·Recruiting·Listed Dec 2025

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A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

for Renal Cell Carcinoma

Sites in Charlotte +8 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07227402·Phase 3·Recruiting·Listed Nov 2025

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Trial Investigating Visugromab and Nivolumab With or Without Docetaxel in 2L Treatment of Participants With Metastatic NSCLC

for Metastatic Non-Squamous Non-Small Cell Lung Cancer

Drug: Nivolumab

Sites in Durham +4 more locations

Sponsor: CatalYm GmbH

Sex: All·Age: 18+

Code: NCT07246863·Phase 2·Recruiting·Listed Nov 2025

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A Study to Describe the Real-world Effectiveness, Safety and Patterns of Use of Dupilumab in Patients With Chronic Spontaneous Urticaria

for Chronic Spontaneous Urticaria

Drug: Dupilumab

1 location in Wilmington

Sponsor: Sanofi

Sex: All·Age: 12+

Code: NCT07316114·Recruiting·Listed Jan 2026

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A Study of DB-1324 in Advanced/Metastatic Gastrointestinal Tumors

for Gastrointestinal Cancer

Sites in Huntersville +3 more locations

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT07263594·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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Nalmefene Implant in Healthy Subjects

for Opioid Abuse and Addiction

1 location in Morrisville

Sponsor: ReacX Pharmaceuticals, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07325279·Phase 1·Recruiting·Listed Jan 2026

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A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions.

for Ankle Arthrodesis or Arthroplasty

Sites in Charlotte +5 more locations

Sponsor: Kuros Biosurgery AG

Sex: All·Age: 18 - 75

Code: NCT07225751·Recruiting·Listed Nov 2025

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A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors

for Advanced Squamous Tumors

Sites in Huntersville +5 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07241039·Phase 1·Recruiting·Listed Nov 2025

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A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

for Squamous Cell Carcinoma of Head and Neck

Sites in Chapel Hill +8 more locations

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18 - 74

Code: NCT07219212·Phase 1·Recruiting·Listed Oct 2025

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TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy

for Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy

Drug: Nucresiran

Sites in Chapel Hill +8 more locations

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT07223203·Phase 3·Recruiting·Listed Oct 2025

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Real-World Efgartigimod Effectiveness in CIDP: A Prospective Study

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

1 location in Wilmington

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT07264426·Recruiting·Listed Dec 2025

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A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.

for Colorectal Cancer

Drug: Atezolizumab

Sites in Durham +5 more locations

Sponsor: Kahr Bio Australia Pty Ltd

Sex: All·Age: 18+

Code: NCT07235293·Phase 2·Recruiting·Listed Nov 2025

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Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

for Glioblastoma

Sites in Greenville +5 more locations

Sponsor: GT Medical Technologies, Inc.

Sex: All·Age: 18+

Code: NCT07195591·Phase 3·Recruiting·Listed Sep 2025

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A Safety and Efficacy Study of GTX-102 in Subjects With Deletion- or Nondeletion-type Angelman Syndrome (AS)

for Angelman Syndrome

Sites in Hillsborough +7 more locations

Sponsor: Ultragenyx Pharmaceutical Inc

Sex: All·Age: 1 - 64

Code: NCT07157254·Phase 2·Recruiting·Listed Sep 2025

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A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.

for Malocclusion

Sites in Huntersville +3 more locations

Sponsor: Dentsply Sirona Implants and Consumables

Sex: All·Age: 18+

Code: NCT07290790·Recruiting·Listed Dec 2025

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A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

for Sickle Cell Disease

Sites in Durham +7 more locations

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT07187973·Phase 1·Recruiting·Listed Sep 2025

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A Phase 1 Study of JMT108 in Participants With Advanced Solid Tumors

for Cancer

Sites in Huntersville +2 more locations

Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07317505·Phase 1·Recruiting·Listed Jan 2026

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Safety and Effectiveness Evaluation of the High-intensity Focused Ultrasound Device for Lifting Lax Submental and Neck Tissue

for Skin Laxity (Submental and Neck)

Sites in Charlotte, Wilmington +3 more locations

Sponsor: CLASSYS Inc.

Sex: All·Age: 30 - 65·Accepts healthy volunteers

Code: NCT07229430·Recruiting·Listed Nov 2025

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A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

for Heterozygous Familial Hypercholesterolemia

Sites in High Point +7 more locations

Sponsor: Verve Therapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06164730·Phase 1·Recruiting·Listed Dec 2023

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TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

for Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

Drug: Tulmimetostat

Sites in Durham +7 more locations

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT07190300·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

for Pompe Disease

Sites in Durham +8 more locations

Sponsor: Shionogi

Sex: All·Age: 18+

Code: NCT07123155·Phase 2·Recruiting·Listed Aug 2025

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Respiration From Pleth Validation

for Respiratory Rate Monitoring

1 location in Durham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 4+

Code: NCT07449715·Recruiting·Listed Mar 2026

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A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

for Atrial Fibrillation

Sites in Durham +4 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07217067·Phase 2·Recruiting·Listed Oct 2025

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A Study Evaluating the Real-World Experience of Givinostat in Patients With Duchenne Muscular Dystrophy

for Duchene Muscular Dystrophy

Drug: Givinostat

Sites in Durham +8 more locations

Sponsor: ITF Therapeutics LLC

Sex: All·Age: 6+

Code: NCT07127978·Recruiting·Listed Aug 2025

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MOVE: Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib

for Tenosynovial Giant Cell Tumor

1 location in Wilmington

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT07075471·Recruiting·Listed Jul 2025

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Virtue® SAB in the Treatment of Coronary ISR Trial

for Coronary Artery Disease

Sites in Asheville +14 more locations

Sponsor: Orchestra BioMed, Inc

Sex: All·Age: 18+

Code: NCT07045194·Recruiting·Listed Jul 2025

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BIOTRONIK Investigation of the LivIQ Leadless Pacemaker System

for Leadless Pacemaker

Sites in Winston-Salem +6 more locations

Sponsor: Biotronik, Inc.

Sex: All·Age: 18+

Code: NCT07118358·Recruiting·Listed Aug 2025

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Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

for Pain

Sites in Chapel Hill +4 more locations

Sponsor: Synaptrix, Inc.

Sex: All·Age: 21+

Code: NCT07191067·Recruiting·Listed Sep 2025

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First In Human Study of CX-2051 in Advanced Solid Tumors

for Solid Tumor, Adult

Sites in Huntersville +7 more locations

Sponsor: CytomX Therapeutics

Sex: All·Age: 18+

Code: NCT06265688·Phase 1·Recruiting·Listed Feb 2024

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Mobilization and Outcomes After Venous Closure

for Venous Vascular Closure

Sites in Raleigh +2 more locations

Sponsor: Cordis US Corp.

Sex: All·Age: All ages

Code: NCT07246902·Recruiting·Listed Nov 2025

Apply to this trial