Paid Clinical Trials in North Carolina

North Carolina has 2,811 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,435 clinical trials

Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Etentamig

Sites in Hillsborough +6 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06896916·Phase 1·Recruiting·Listed Mar 2025

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Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Pinehurst +3 more locations

Sponsor: Teligene US

Sex: All·Age: 18+

Code: NCT05168566·Phase 2·Recruiting·Listed Dec 2021

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Safety and Efficacy Study of PF-06835375 in Primary Immune Thrombocytopenia

for Primary Immune Thrombocytopenia

1 location in Greenville

Sponsor: Pfizer

Sex: All·Age: 18 - 70

Code: NCT05070845·Phase 2·Recruiting·Listed Oct 2021

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Clinical Study To Further Evaluate The Efficacy Of Dabrafenib Plus Trametinib In Patients With Rare BRAF V600E Mutation-Positive Unresectable or Metastatic Solid Tumors

for Rare Unresectable or Metastatic BRAF V600E Mutation-positive Solid Tumors

Drug: Dabrafenib

Sites in Durham +7 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 1 - 100

Code: NCT05868629·Recruiting·Listed May 2023

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GI-101/GI-101A as a Single Agent or in Combination With Pembrolizumab or Lenvatinib in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Huntersville +1 more location

Sponsor: GI Innovation, Inc.

Sex: All·Age: 18+

Code: NCT04977453·Phase 1, Phase 2·Recruiting·Listed Jul 2021

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Royal Ancient Oats™ Study

for Healthy Participants

1 location in Kannapolis

Sponsor: Standard Process Inc.

Sex: All·Age: 35 - 65·Accepts healthy volunteers

Code: NCT07371598·Recruiting·Listed Jan 2026

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Observational Study to Assess Maternal, Fetal and Infant Outcomes Following Exposure to Rimegepant

for Migraine

Drug: Rimegepant

1 location in Wilmington

Sponsor: Pfizer

Sex: Female·Age: 0+

Code: NCT05046613·Recruiting·Listed Sep 2021

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A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)

for PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)

Sites in Durham +1 more location

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05885412·Phase 1·Recruiting·Listed Jun 2023

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A Multi-center, Early Feasibility Study of Using the Mechanical Tissue Resuscitation™ (MTR®) Therapy System for Removal of Excess Fluid in Subjects Who Have Had a Portion of Their Skull Removed to Expose the Dura/Brain and Require Drainage for Fluid Removal.

for Clinical Need for Craniotomy or Craniectomy

Sites in Winston-Salem +2 more locations

Sponsor: Renovo Concepts, Inc.

Sex: All·Age: 22 - 65

Code: NCT06201429·Recruiting·Listed Jan 2024

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A Study of Migalastat in Pediatric Subjects (2 to <12 Yrs) With Fabry Disease and Amenable GLA Variants

for Fabry Disease

Sites in Charlotte +5 more locations

Sponsor: Amicus Therapeutics

Sex: All·Age: 2 - 11

Code: NCT06904261·Phase 3·Recruiting·Listed Apr 2025

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Identifying Patterns in the Breath of Individuals With Breast Cancer

for Breast Cancer

Sites in Durham +3 more locations

Sponsor: Breathe BioMedical Inc

Sex: Female·Age: 40 - 74·Accepts healthy volunteers

Code: NCT06512350·Recruiting·Listed Jul 2024

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A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

for Thrombocythemia, Essential

Sites in Durham +3 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06351631·Phase 3·Recruiting·Listed Apr 2024

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Study of CTO1681 for the Prevention and Treatment of CRS in DLBCL Patients Receiving CAR T-Cell Therapy

for Cytokine Release Syndrome

Sites in Durham +5 more locations

Sponsor: CytoAgents, Inc.

Sex: All·Age: 18+

Code: NCT05905328·Phase 1, Phase 2·Recruiting·Listed Jun 2023

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Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial (NEXT Trial)

for Cerebral Aneurysms

Sites in Raleigh +8 more locations

Sponsor: Cerus Endovascular, Inc.

Sex: All·Age: 18 - 75

Code: NCT06693011·Recruiting·Listed Nov 2024

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Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

for B-cell Acute Lymphoblastic Leukemia

Sites in Chapel Hill +8 more locations

Sponsor: Vironexis Biotherapeutics Inc.

Sex: All·Age: 13 - 90

Code: NCT06533579·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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Detrusor Nerve Radiofrequency Ablation for Overactive Bladder in Women

for Overactive Bladder

Sites in Winston-Salem +8 more locations

Sponsor: InMode MD Ltd.

Sex: Female·Age: 22 - 80

Code: NCT07209397·Recruiting·Listed Oct 2025

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A Global, Multicenter Study to Assess Maternal, Fetal and Infant Outcomes of Exposure to Palynziq® (Pegvaliase) During Pregnancy and Breastfeeding

for Phenylketonuria, Maternal

Drug: Pegvaliase

1 location in Wilmington

Sponsor: BioMarin Pharmaceutical

Sex: Female·Age: All ages

Code: NCT05579548·Recruiting·Listed Oct 2022

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Enhancing Heart Allograft Function With the OCS Heart System Trial

for Heart Transplant

Sites in Durham +7 more locations

Sponsor: TransMedics

Sex: All·Age: 18+

Code: NCT07145515·Recruiting·Listed Aug 2025

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease

for Tremor Associated With Tremor Dominant Parkinson's Disease

Sites in Huntsville +6 more locations

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT04991831·Recruiting·Listed Aug 2021

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MiREA-AC for Reducing Problematic Alcohol and Marijuana Use in College Students

for Alcohol Misuse

Sites in Charlotte +1 more location

Sponsor: mHealth Systems Inc.

Sex: All·Age: 18 - 26·Accepts healthy volunteers

Code: NCT07339150·Recruiting·Listed Jan 2026

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A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

for Propionic Acidemia

Sites in Durham +6 more locations

Sponsor: ModernaTX, Inc.

Sex: All·Age: 1+

Code: NCT05130437·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

for Beta-Thalassemia

Sites in Charlotte +2 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 12 - 35

Code: NCT05477563·Phase 3·Recruiting·Listed Jul 2022

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A Study to Assess Sulbactam-durlobactam in Pediatric Patients With Acinetobacter Baumannii-calcoaceticus Complex Infection

for Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC)

Sites in Greenville +3 more locations

Sponsor: Innoviva Specialty Therapeutics

Sex: All·Age: 1 Day - 18

Code: NCT06801223·Phase 1·Recruiting·Listed Jan 2025

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A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.

for Solid Tumor, Adult

1 location in Huntersville

Sponsor: BioCytics, Inc.

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT00571389·Recruiting·Listed Dec 2007

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PKP2-ACM Natural History Study

for Cardiomyopathies

Sites in Durham +1 more location

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT06644742·Recruiting·Listed Oct 2024

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PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients

for Breast Cancer

Sites in Chapel Hill +1 more location

Sponsor: Endomagnetics Ltd.

Sex: All·Age: 18+

Code: NCT06610539·Recruiting·Listed Sep 2024

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MagDI U.S. Registry

for Anastomosis, Surgical

Sites in Cary +4 more locations

Sponsor: GT Metabolic Solutions, Inc.

Sex: All·Age: 22+

Code: NCT06928545·Recruiting·Listed Apr 2025

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A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Charlotte +6 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06697197·Phase 1, Phase 2·Recruiting·Listed Nov 2024

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Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Sites in Chapel Hill +2 more locations

Sponsor: argenx

Sex: All·Age: 2 - 18

Code: NCT04833894·Phase 2, Phase 3·Recruiting·Listed Apr 2021

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A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

for Myelofibrosis

Drug: Selinexor

Sites in Durham +6 more locations

Sponsor: Karyopharm Therapeutics Inc

Sex: All·Age: 18+

Code: NCT05980806·Phase 2·Recruiting·Listed Aug 2023

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Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Huntersville +6 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06750185·Phase 1·Recruiting·Listed Dec 2024

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Multicenter Symphony IL-6 Monitoring Sepsis ICU Validation Study

for Sepsis, Septic Shock

Sites in Winston-Salem +4 more locations

Sponsor: Bluejay Diagnostics, Inc.

Sex: All·Age: 22+

Code: NCT06654895·Recruiting·Listed Oct 2024

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A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

Sites in Durham +6 more locations

Sponsor: Bristol-Myers Squibb

Sex: Male·Age: 18+

Code: NCT06067841·Phase 1·Recruiting·Listed Oct 2023

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X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

for Advanced Solid Tumor Cancer

Sites in Durham, Charlotte +2 more locations

Sponsor: Immunolight, LLC

Sex: All·Age: 18+

Code: NCT04389281·Phase 1·Recruiting·Listed May 2020

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A Study to Evaluate the Safety, Efficacy, PK, PD and Immunogenicity of Cipaglucosidase Alfa/Miglustat in IOPD Subjects Aged 0 to <18

for Glycogen Storage Disease Type II Infantile Onset

Sites in Durham +5 more locations

Sponsor: Amicus Therapeutics

Sex: All·Age: Up to 17

Code: NCT04808505·Phase 3·Recruiting·Listed Mar 2021

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Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

for CLL/SLL

Sites in Durham +3 more locations

Sponsor: Newave Pharmaceutical Inc

Sex: All·Age: 18+

Code: NCT04775745·Phase 1·Recruiting·Listed Mar 2021

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The Safety and Tolerability of LBS-007 in Patients With Relapsed or Resistant Acute Leukaemias

for Relapsed or Resistant Acute Leukaemias

Sites in Chapel Hill +4 more locations

Sponsor: Lin BioScience, Inc

Sex: All·Age: 18 - 120

Code: NCT05756322·Phase 1, Phase 2·Recruiting·Listed Mar 2023

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Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes

for Renal Impairment After Cardiac Surgery

Sites in Chapel Hill +3 more locations

Sponsor: 3ive Labs

Sex: All·Age: 22 - 85

Code: NCT07017933·Recruiting·Listed Jun 2025

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A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

for Colorectal Cancer

Sites in Durham, Huntersville +5 more locations

Sponsor: Apollo Therapeutics Ltd

Sex: All·Age: 18+

Code: NCT06399757·Phase 1, Phase 2·Recruiting·Listed May 2024

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A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

for Advanced Solid Tumor

Sites in Huntersville +3 more locations

Sponsor: FBD Biologics Limited

Sex: All·Age: 18+

Code: NCT05892718·Phase 1·Recruiting·Listed Jun 2023

Apply to this trial