Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

for Beta-Thalassemia

Sites in Charlotte +2 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 12 - 35

Code: NCT05477563·Phase 3·Recruiting·Listed Jul 2022

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A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.

for Solid Tumor, Adult

1 location in Huntersville

Sponsor: BioCytics, Inc.

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT00571389·Recruiting·Listed Dec 2007

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Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Sites in Chapel Hill +2 more locations

Sponsor: argenx

Sex: All·Age: 2 - 18

Code: NCT04833894·Phase 2, Phase 3·Recruiting·Listed Apr 2021

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Detrusor Nerve Radiofrequency Ablation for Overactive Bladder in Women

for Overactive Bladder

Sites in Winston-Salem +8 more locations

Sponsor: InMode MD Ltd.

Sex: Female·Age: 22 - 80

Code: NCT07209397·Recruiting·Listed Oct 2025

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PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients

for Breast Cancer

Sites in Chapel Hill +1 more location

Sponsor: Endomagnetics Ltd.

Sex: All·Age: 18+

Code: NCT06610539·Recruiting·Listed Sep 2024

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A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

for Myelofibrosis

Drug: Selinexor

Sites in Durham +6 more locations

Sponsor: Karyopharm Therapeutics Inc

Sex: All·Age: 18+

Code: NCT05980806·Phase 2·Recruiting·Listed Aug 2023

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X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

for Advanced Solid Tumor Cancer

Sites in Durham, Charlotte +2 more locations

Sponsor: Immunolight, LLC

Sex: All·Age: 18+

Code: NCT04389281·Phase 1·Recruiting·Listed May 2020

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A Study to Evaluate the Safety, Efficacy, PK, PD and Immunogenicity of Cipaglucosidase Alfa/Miglustat in IOPD Subjects Aged 0 to <18

for Glycogen Storage Disease Type II Infantile Onset

Sites in Durham +5 more locations

Sponsor: Amicus Therapeutics

Sex: All·Age: Up to 17

Code: NCT04808505·Phase 3·Recruiting·Listed Mar 2021

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Clinical Study of ARD103 CAR-T Therapy for Patients With R/R AML or MDS

for Acute Myeloid Leukemia, in Relapse

Sites in Winston-Salem, Charlotte +1 more location

Sponsor: ARCE Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06680752·Phase 1, Phase 2·Recruiting·Listed Nov 2024

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Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer

for Endometrial Cancer

Sites in Charlotte +8 more locations

Sponsor: Aadi Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT05997017·Phase 2·Recruiting·Listed Aug 2023

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Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

for CLL/SLL

Sites in Durham +3 more locations

Sponsor: Newave Pharmaceutical Inc

Sex: All·Age: 18+

Code: NCT04775745·Phase 1·Recruiting·Listed Mar 2021

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Royal Ancient Oats™ Study

for Healthy Participants

1 location in Kannapolis

Sponsor: Standard Process Inc.

Sex: All·Age: 35 - 65·Accepts healthy volunteers

Code: NCT07371598·Recruiting·Listed Jan 2026

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A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

for Advanced Solid Tumor

Sites in Huntersville +3 more locations

Sponsor: FBD Biologics Limited

Sex: All·Age: 18+

Code: NCT05892718·Phase 1·Recruiting·Listed Jun 2023

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An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis Exposed to Ruxolitinib Cream Versus Topical Corticosteroids During Pregnancy: A US Claims Database Analysis

for Pregnancy Related

Drug: Ruxolitinib

1 location in Morrisville

Sponsor: Incyte Corporation

Sex: Female·Age: 14+

Code: NCT06627335·Recruiting·Listed Oct 2024

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Study to Compare Maternal, Fetal, and Infant Outcomes of Women With Mild to Moderate Atopic Dermatitis Exposed to Ruxolitinib Cream During Pregnancy With an Unexposed Control Population

for Pregnancy Related

Drug: Ruxolitinib

1 location in Morrisville

Sponsor: Incyte Corporation

Sex: Female·Age: 15 - 50

Code: NCT06259669·Recruiting·Listed Feb 2024

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Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

for Postoperative Pain

Sites in Durham +4 more locations

Sponsor: Pacira Pharmaceuticals, Inc

Sex: All·Age: 0 - 6

Code: NCT06271265·Phase 1·Recruiting·Listed Feb 2024

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BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL

for Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma

Sites in Charlotte +5 more locations

Sponsor: PeproMene Bio, Inc.

Sex: All·Age: 18+

Code: NCT05370430·Phase 1·Recruiting·Listed May 2022

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The Safety and Tolerability of LBS-007 in Patients With Relapsed or Resistant Acute Leukaemias

for Relapsed or Resistant Acute Leukaemias

Sites in Chapel Hill +4 more locations

Sponsor: Lin BioScience, Inc

Sex: All·Age: 18 - 120

Code: NCT05756322·Phase 1, Phase 2·Recruiting·Listed Mar 2023

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Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes

for Renal Impairment After Cardiac Surgery

Sites in Chapel Hill +3 more locations

Sponsor: 3ive Labs

Sex: All·Age: 22 - 85

Code: NCT07017933·Recruiting·Listed Jun 2025

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Observational Study to Describe Health-Related Quality of Life and Measure Disease Burden Among Patients With Long QT Syndrome Types (LQTS) 2 and 3

for Long QT Syndrome Type 3

1 location in Greenville

Sponsor: Thryv Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07075445·Recruiting·Listed Jul 2025

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Observational Study to Assess Adverse Events When Adult Female Participants Are Treated With Ubrelvy (Ubrogepant) or Qulipta (Atogepant) During Pregnancy

for Migraine

Drug: Ubrogepant

1 location in Durham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT05158894·Recruiting·Listed Dec 2021

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Knee Biofeedback Rehabilitation Through Game Therapy

for Knee Osteoarthritis

1 location in Chapel Hill

Sponsor: Barron Associates, Inc.

Sex: All·Age: 30 - 75

Code: NCT06090097·Recruiting·Listed Oct 2023

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Registry to Collect Information on Pregnancy, Neonatal, and Infant Outcomes in Pregnant Women Exposed to QUVIVIQ®

for Insomnia

1 location in Durham

Sponsor: Idorsia Pharmaceuticals Ltd.

Sex: Female·Age: 15 - 50

Code: NCT06498128·Recruiting·Listed Jul 2024

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MiREA-AC for Reducing Problematic Alcohol and Marijuana Use in College Students

for Alcohol Misuse

Sites in Charlotte +1 more location

Sponsor: mHealth Systems Inc.

Sex: All·Age: 18 - 26·Accepts healthy volunteers

Code: NCT07339150·Recruiting·Listed Jan 2026

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A Study for Participants Previously Treated With Century Therapeutics Cellular Therapy Product

for Hematological Malignancy

Sites in Charlotte +6 more locations

Sponsor: Century Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05768269·Recruiting·Listed Mar 2023

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Safety and Effectiveness of the Yaari Extractor for Management of Shoulder Dystocia

for Shoulder Dystocia

Sites in Winston-Salem +3 more locations

Sponsor: FetalEase Ltd.

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05913609·Recruiting·Listed Jun 2023

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A Study of HyQvia in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) in Routine Clinical Care

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Sites in Winston-Salem +8 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06538064·Recruiting·Listed Aug 2024

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Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

for Peripheral Arterial Diseases

Sites in Chapel Hill +8 more locations

Sponsor: Angiodynamics, Inc.

Sex: All·Age: All ages

Code: NCT06777901·Phase 4·Recruiting·Listed Jan 2025

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Mavacamten Pregnancy Surveillance Program

for Breastfeeding

Drug: Mavacamten

1 location in Wilmington

Sponsor: Bristol-Myers Squibb

Sex: Female·Age: 15+

Code: NCT05939700·Recruiting·Listed Jul 2023

Apply to this trial

Aimovig Pregnancy Exposure Registry

for Migraine

1 location in Durham

Sponsor: Amgen

Sex: Female·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06150781·Recruiting·Listed Nov 2023

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Reducing Fluid Overload in Heart Failure Patients Using a Non-invasive, Renal Independent System

for Chronic Heart Failure

Sites in Greensboro, Asheville +6 more locations

Sponsor: AquaPass Medical Ltd.

Sex: All·Age: 21 - 79

Code: NCT06360380·Recruiting·Listed Apr 2024

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CERAMENT G Device Registry

for Chronic Osteomyelitis

Sites in Charlotte +2 more locations

Sponsor: BONESUPPORT AB

Sex: All·Age: 18+

Code: NCT06010433·Recruiting·Listed Aug 2023

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ViTAA Registry Pre- and Post-Operative Monitoring for Endovascular Aortic Aneurysm Repair and Serial Monitoring for AAA

for Abdominal Aortic Aneurysms

Sites in Chapel Hill +3 more locations

Sponsor: ViTAA Medical Solutions

Sex: All·Age: 18+

Code: NCT05004051·Recruiting·Listed Aug 2021

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Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Extended-release Tablets in Pediatric Subjects Aged 5 to 17 Years With Active, Mild to Moderate Ulcerative Colitis

for Ulcerative Colitis

Sites in Greenville +3 more locations

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 5 - 17

Code: NCT04314375·Phase 4·Recruiting·Listed Mar 2020

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Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness

for Hearing Loss, Unilateral

Sites in Chapel Hill +5 more locations

Sponsor: Cochlear

Sex: All·Age: 5+

Code: NCT05318417·Recruiting·Listed Apr 2022

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Relugolix Pregnancy Registry: An Observational Study of the Safety of Relugolix-Containing Therapy Exposure in Pregnant Women and Their Offspring

for Pregnancy Related

Drug: Relugolix

1 location in Wilmington

Sponsor: Sumitomo Pharma Switzerland GmbH

Sex: Female·Age: 0+

Code: NCT05739123·Recruiting·Listed Feb 2023

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US National TOP Registry

for Lung Transplant

Sites in Durham +6 more locations

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT06513091·Recruiting·Listed Jul 2024

Apply to this trial

Continuous Glucose Monitoring, Diabetes Education, and Peer Support for Management of Uncontrolled Type 2 Diabetes

for Type 2 Diabetes Mellitus - Poor Control

1 location in Asheville

Sponsor: Whole Endo

Sex: All·Age: 18+

Code: NCT07054125·Recruiting·Listed Jul 2025

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CAP-100 for Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia

for Lymphocytic Leukemia, Chronic

Sites in Durham +1 more location

Sponsor: Catapult Therapeutics

Sex: All·Age: 18+

Code: NCT04704323·Phase 1·Recruiting·Listed Jan 2021

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Study to Evaluate Pregnancy Outcomes in Risankizumab Exposed Pregnancies Relative to Those Non-risankizumab Exposed Pregnancies in Women With FDA Approved Indications

for Plaque Psoriasis, Psoriatic Arthritis, Crohn's Disease, or Other Conditions for Which Risankizumab is an FDA-approved Treatment

Drug: Risankizumab

1 location in Morrisville

Sponsor: AbbVie

Sex: Female·Age: All ages

Code: NCT04846959·Recruiting·Listed Apr 2021

Apply to this trial