Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

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2,944 clinical trials

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Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

for Agitation

53 locations incl. Homewood

Sponsor: Celgene

Sex: All·Age: 55 - 90

Code: NCT06808984·Phase 2·Recruiting

Apply to this trial

The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis

for Bronchiectasis

80 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT06872892·Phase 3·Recruiting

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ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

for Autosomal Dominant Polycystic Kidney Disease

35 locations incl. Garden Grove

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18 - 55

Code: NCT06902558·Phase 2·Recruiting

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HLA Demographics Study in Adults With Type 1 Diabetes

for Diabetes Mellitus, Type I

5 locations incl. San Francisco

Sponsor: GentiBio, Inc

Sex: All·Age: 18 - 55

Code: NCT06860516·Recruiting

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DBT-P Treatment Study

for Emotion Dysregulation

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 45

Code: NCT06963801·Recruiting

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Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

for Acute Leukemia of Ambiguous Lineage

Drug: Venetoclax

112 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 365 Days

Code: NCT06317662·Phase 2·Recruiting

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Virtuos Bone Graft in Lumbar Fusion

for Degenerative Disc Disease

9 locations incl. South Bend

Sponsor: Orthofix Inc.

Sex: All·Age: 18+

Code: NCT06686017·Enrolling By Invitation

A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema

for Macular Edema

23 locations incl. Arcadia

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06962839·Phase 2·Recruiting

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A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

for Leukemia, Myeloid, Acute

Drug: Venetoclax

50 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06852222·Phase 3·Recruiting

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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

for Dravet Syndrome

Drug: zorevunersen

31 locations incl. Phoenix

Sponsor: Stoke Therapeutics, Inc

Sex: All·Age: 2 - 17

Code: NCT06872125·Phase 3·Recruiting

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Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery

for Cleft Palate

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 6 Months - 4

Code: NCT06962306·Phase 4·Recruiting

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A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

for Cardiovascular Disease

315 locations incl. Athens

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07000357·Phase 3·Recruiting

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Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

for Non-Muscle Invasive Bladder Urothelial Carcinoma

132 locations incl. Fayetteville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06770582·Phase 2·Recruiting

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Combating Cancer-Related Fatigue: A Personalized Supportive Care Program

for Indolent Lymphomas

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06860880·Recruiting

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XL092 and Cemiplimab in BRAF WT Thyroid Cancer

for Anaplastic Thyroid Cancer

Drug: Cemiplimab

2 locations incl. Boston

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06902376·Phase 1·Recruiting

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A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease

for Crohn's Disease

20 locations incl. Tucson

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06958536·Phase 2·Recruiting

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A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

for Triple Negative Breast Cancer

10 locations incl. Denver

Sponsor: Dren Bio

Sex: All·Age: 18+

Code: NCT06999187·Phase 1·Recruiting

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Concentration of n-3 PUFA Monohydroxylated Derivatives in Adults With Obesity After n-3 PUFA Supplementation.

for Obesity

1 location in Kannapolis

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 45 - 60

Code: NCT06991296·Recruiting

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TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

for Cystic Fibrosis (CF)

13 locations incl. Orange

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18 Months - 11

Code: NCT07048574·Recruiting

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Ultrasound for Quantifying Muscle Activation Elicited by Spinal Cord Stimulation and Functional Electrical Stimulation

for Neuromodulatory Effects of TSCS and FES in Lower Limbs

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07206797·Recruiting

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Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

for PDAC

18 locations incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06922591·Phase 1, Phase 2·Recruiting

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Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplant

for Hematopoietic Stem Cell Transplantation

3 locations incl. Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18 - 80

Code: NCT06953648·Not Yet Recruiting

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

for B Acute Lymphoblastic Leukemia

138 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 366 Days - 46

Code: NCT06124157·Phase 2·Recruiting

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Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

for B-cell Acute Lymphoblastic Leukemia

9 locations incl. Duarte

Sponsor: Vironexis Biotherapeutics Inc.

Sex: All·Age: 13 - 90

Code: NCT06533579·Phase 1, Phase 2·Recruiting

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Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

for Somatostatin Receptor Positive (SSTR+)

19 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 100

Code: NCT06784752·Phase 3·Recruiting

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Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

for Aortoiliac Occlusive Disease

19 locations incl. Fresno

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 100

Code: NCT06872905·Recruiting

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A Study to Evaluate ARV-806 in Adults With Advanced Cancer That Has the KRAS G12D Mutation

for KRAS G12D Mutation

14 locations incl. Phoenix

Sponsor: Arvinas Inc.

Sex: All·Age: 18+

Code: NCT07023731·Phase 1, Phase 2·Recruiting

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A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

for Obesity

Drug: Retatrutide

25 locations incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07035093·Phase 3·Recruiting

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Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

for Prostate Cancer (Adenocarcinoma)

350 locations incl. Anchorage

Sponsor: Canadian Cancer Trials Group

Sex: Male·Age: 18+

Code: NCT06592924·Phase 3·Recruiting

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Advancing Identification of Circadian Delay in ADHD Youth: Associations With Clinical Heterogeneity and Cognition

for ADHD - Attention Deficit Disorder With Hyperactivity

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 6 - 9

Code: NCT06971640·Recruiting

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Implementation of an Oral Chemotherapy Adherence Intervention

for Solid Tumor

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 21+

Code: NCT06989489·Recruiting

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Evaluating the Safety and Tolerability of Orally Administered DF-003 in ROSAH Syndrome Patients

for ROSAH

3 locations incl. Bethesda

Sponsor: Shanghai Yao Yuan Biotechnology Ltd. (also known as Drug Farm)

Sex: All·Age: 18 - 65

Code: NCT06395285·Phase 1·Recruiting

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Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

for Ankle Sprains

2 locations incl. Lexington

Sponsor: University of Kentucky

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06868316·Recruiting

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A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

for Ulcerative Colitis

25 locations incl. Canoga Park

Sponsor: Spyre Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07012395·Phase 2·Recruiting

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Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: IMVT-1402

47 locations incl. Huntsville

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 80

Code: NCT07039916·Phase 3·Recruiting

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Small Cell Lung Cancer Community Engagement to Eliminate Research Discepancies

for Small-cell Lung Cancer

52 locations incl. Multiple Locations

Sponsor: Addario Lung Cancer Medical Institute

Sex: All·Age: 18+

Code: NCT06486428·Recruiting

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Oral Ketorolac for IUD Pain Reduction

for IUD Insertion Pain

1 location in Hillsborough

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06853327·Phase 2·Enrolling By Invitation

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

386 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting

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A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia

for Idiopathic Hypersomnia

Drug: ALKS 2680

32 locations incl. Cullman

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT06843590·Phase 2·Recruiting

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Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE Peds)

for Muscular Dystrophy, Facioscapulohumeral

6 locations incl. Palo Alto

Sponsor: University of Kansas Medical Center

Sex: All·Age: 5 - 17

Code: NCT06847282·Recruiting

Apply to this trial