Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

Filter results

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

2,435 clinical trials

Get a weekly email when new trials open in Durham, NC.

LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy in Sarcoma Patients

for Sarcoma

Sites in Winston-Salem & Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: All ages

Code: NCT06958107·Recruiting·Listed May 2025

Apply to this trial

A Mobile Patient Health Technology Intervention for Improving Lung Cancer Screening Rates in Eligible High Risk Patients

for Lung Cancer

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 50 - 77

Code: NCT07322367·Recruiting·Listed Jan 2026

Apply to this trial

Developing and Testing Drone-Delivered AEDs for Cardiac Arrests In Rural America

for Cardiac Arrest

1 location in Clemmons

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06229418·Recruiting·Listed Jan 2024

Apply to this trial

Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient Patients

for Triple Negative Breast Cancer

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT04677816·Phase 2·Recruiting·Listed Dec 2020

Apply to this trial

Cardiovascular Effects of Very Low Nicotine Content Cigarettes

for Tobacco Use

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT05707871·EARLY_Phase 1·Recruiting·Listed Feb 2023

Apply to this trial

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

for Hematologic Disorder

Sites in Chapel Hill, Winston-Salem +74 more locations

Sponsor: American Thrombosis and Hemostasis Network

Sex: All·Age: All ages

Code: NCT04398628·Recruiting·Listed May 2020

Apply to this trial

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

Sites in Durham, Greenville +41 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting·Listed Jan 2023

Apply to this trial

Personalized Environment and Genes Study

for Diabetes

Sites in Chapel Hill & Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT00341237·Recruiting·Listed Jun 2006

Apply to this trial

Stool Transplants to Treat Refractory Clostridium Difficile Colitis

for Clostridium Difficile Colitis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT02127398·Phase 2·Recruiting·Listed Apr 2014

Apply to this trial

Natural History of the Human Biological Response to Environmental Exposure and Injury

for Inflammation

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04888923·Recruiting·Listed May 2021

Apply to this trial

Kaempferol Absorption and Pharmacokinetics Evaluation

for No Disease

Sites in Chapel Hill +2 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07322406·Recruiting·Listed Jan 2026

Apply to this trial

Prospective Trial Assessing Real World Outcomes Response to Pembro in Black Patients w/ NSCLC

for Non-small Cell Lung Cancer

Sites in Pinehurst +7 more locations

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+

Code: NCT06745882·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Enhancing Physical Function in Older Adults With Chronic Kidney Disease

for Chronic Kidney Diseases

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65 - 100

Code: NCT06738394·Recruiting·Listed Dec 2024

Apply to this trial

Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

for Obesity

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 39

Code: NCT06848491·Recruiting·Listed Feb 2025

Apply to this trial

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

Sites in Durham, Pinehurst +379 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting·Listed Sep 2024

Apply to this trial

The SEQUENCE Trial

for Pulmonary Nodules

Sites in Chapel Hill +4 more locations

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06676956·Recruiting·Listed Nov 2024

Apply to this trial

Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial

for Prostate Adenocarcinoma

Sites in Durham +4 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT06022822·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

Health Education Approach to Lung Screening

for Lung Cancer

Sites in Carrboro +2 more locations

Sponsor: Virginia Commonwealth University

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT06070870·Recruiting·Listed Oct 2023

Apply to this trial

The Impact of Music Intervention on Sleep

for Dementia

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06088810·Recruiting·Listed Oct 2023

Apply to this trial

Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors

for Cancer

Sites in Winston-Salem & Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06634381·Recruiting·Listed Oct 2024

Apply to this trial

Toxicity Genetic Determinants and Response to Azacitidine and Venetoclax in AML

for Leukemia, Myeloid, Acute

Drug: Venetoclax

Sites in Winston-Salem & Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06580106·Recruiting·Listed Aug 2024

Apply to this trial

Expanding Liver Transplant Immunosuppression Minimization Via Everolimus

for Liver Transplant

Sites in Durham +7 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06280950·Phase 2·Recruiting·Listed Feb 2024

Apply to this trial

Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics

for Traumatic Brain Injury

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: Up to 18

Code: NCT06697808·Recruiting·Listed Nov 2024

Apply to this trial

ETHAN - ET for Male BC

for Male Breast Cancer

Sites in Chapel Hill +8 more locations

Sponsor: Jose Pablo Leone

Sex: Male·Age: 18+

Code: NCT05501704·Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

for Low Grade Glioma of Brain

Drug: Vorasidenib

1 location in Durham

Sponsor: Katy Peters, MD, PhD

Sex: All·Age: 18+

Code: NCT05609994·Phase 1·Recruiting·Listed Nov 2022

Apply to this trial

Discharge Medication Use Post-Operatively in GU Cancer Patients

for Genitourinary Cancer

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06795087·Recruiting·Listed Jan 2025

Apply to this trial

The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

for Toxicity

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04700527·Phase 1, Phase 2·Recruiting·Listed Jan 2021

Apply to this trial

Improving Needs Among Older Adults

for Critical Illness

Sites in Durham +3 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06588556·Recruiting·Listed Sep 2024

Apply to this trial

Immune Function and Response to Vaccination After Cancer Therapy in Pediatric Patients

for Pediatric Cancer

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 2 - 21

Code: NCT04948619·Phase 2·Recruiting·Listed Jul 2021

Apply to this trial

Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma

for Pancreas Adenocarcinoma

Sites in Winston-Salem & Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05376592·Recruiting·Listed May 2022

Apply to this trial

A Study to Give Treatment Inside the Eye to Treat Retinoblastoma

for Bilateral Retinoblastoma

Sites in Durham +15 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 18

Code: NCT05504291·Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

for Stroke

Sites in Durham +1 more location

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT07050355·Recruiting·Listed Jul 2025

Apply to this trial

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

for Breast Carcinoma

Sites in Chapel Hill +3 more locations

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05557877·Phase 2·Recruiting·Listed Sep 2022

Apply to this trial

Trial of Ovarian Vein and Pelvic Vein Embolization in Women With Chronic Pelvic Pain and Pelvic Varices

for Chronic Pelvic Pain Syndrome

Sites in Chapel Hill +2 more locations

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06168058·Recruiting·Listed Dec 2023

Apply to this trial

Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab

for Newly Diagnosed Glioblastoma

Drug: Relatlimab

Sites in Durham +1 more location

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06816927·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

RESTORE: Comparing Two Approaches to Repeat TT Surgery Performed by Integrated Eye Care Workers (IECWs)

for Trachoma

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07322302·Recruiting·Listed Jan 2026

Apply to this trial

Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors

for Tumor, Solid

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT03454035·Phase 1·Recruiting·Listed Mar 2018

Apply to this trial

Leveraging Social Innovation and Community-Engagement to Reduce Disparities in Outbreak Control Outcomes

for Outbreak Investigation

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05123729·Recruiting·Listed Nov 2021

Apply to this trial

Optimizing Surgical Decisions in Young Adults With Breast Cancer

for Breast Cancer Stage 0

Sites in Durham +3 more locations

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18 - 44

Code: NCT06275126·Recruiting·Listed Feb 2024

Apply to this trial

Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children

for Hemorrhagic Shock

Sites in Wake Forest +19 more locations

Sponsor: Philip Spinella

Sex: All·Age: Up to 17

Code: NCT06070350·Phase 3·Recruiting·Listed Oct 2023

Apply to this trial