Cardiovascular Effects of Very Low Nicotine Content Cigarettes

Part of paid clinical trials in Winston-Salem, North Carolina.

Sponsor
Wake Forest University Health Sciences
Study ID
NCT05707871
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Tobacco Use

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • SPECTRUM cigarettes — DRUG
    SPECTRUM cigarettes have varying amount of nicotine content
  • usual brand of Cigarettes — OTHER
    Usual Brand of Cigarettes

Study Details

The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers

Key Dates

First listed
Feb 1, 2023
Start date
Apr 4, 2023
Status verified
Sep 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
49 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Usual Brand of Cigarettes
    Participants will smoke 2-3 cigarettes of their usual brand
  • Experimental: Research Cigarettes (SPECTRUM)
    Participants will smoke 1-2 SPECTRUM cigarettes

Primary Outcome Measure

Change in Heart rate - Very Low Nicotine Content Cigarettes (VLNCC)s - NRC102/103(0.5mg nicotine) [ Time Frame: Hour 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wake Forest University Health SciencesWinston-SalemNorth Carolina27157
Maria Anwar, MS
[email protected]
802-922-3343

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Wake Forest University Health Sciences· Winston-Salem, NC

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