Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Immune Cell Response to Stimuli

for Inflammation

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT00397280·Recruiting·Listed Nov 2006

Apply to this trial

Reducing Risk for Infective Endocarditis

for Bacteremia

Sites in Charlotte +3 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05721781·Recruiting·Listed Feb 2023

Apply to this trial

Using PrEP, Doing It for Ourselves

for HIV Prevention

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06638892·Recruiting·Listed Oct 2024

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Enhancing Slow Wave Sleep in Depression

for Depression - Major Depressive Disorder

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 40 - 80

Code: NCT07143838·Recruiting·Listed Aug 2025

Apply to this trial

Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

for Depression

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06538246·Recruiting·Listed Aug 2024

Apply to this trial

The Osteoarthritis Prevention Study

for Osteoarthritis, Knee

Sites in Winston-Salem +1 more location

Sponsor: Wake Forest University

Sex: Female·Age: 50+·Accepts healthy volunteers

Code: NCT05946044·Recruiting·Listed Jul 2023

Apply to this trial

NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

for Asthma

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 60

Code: NCT02327897·Recruiting·Listed Dec 2014

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Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

for Interstitial Lung Disease

Sites in Durham +5 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 4+

Code: NCT04925375·Phase 2·Recruiting·Listed Jun 2021

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LCI-PED-NOS-EXER-001: Exercise in Pediatric Oncology Patients

for Pediatric Cancer

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 2 - 25

Code: NCT05058508·Recruiting·Listed Sep 2021

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Coconut Oil to Prevent Mouth Sores in Pediatric Patients Receiving High Dose Chemotherapy

for Oral Mucositis

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 7 - 26

Code: NCT05441813·Phase 2·Recruiting·Listed Jul 2022

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BOTOX® vs. XEOMIN® for Chronic Migraine

for Chronic Migraine

Drug: Xeomin

1 location in Jacksonville

Sponsor: Naval Medical Center Camp Lejeune

Sex: All·Age: 18 - 89

Code: NCT05598723·Phase 3·Recruiting·Listed Oct 2022

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Prescription of Letrozole for Uterine Myoma

for Leiomyoma, Uterine

Sites in Durham +4 more locations

Sponsor: University of California, San Francisco

Sex: Female·Age: 21 - 53·Accepts healthy volunteers

Code: NCT06143631·Phase 4·Recruiting·Listed Nov 2023

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Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

for Ankle Sprains

Sites in Charlotte +1 more location

Sponsor: Danielle Torp

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06868316·Recruiting·Listed Mar 2025

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Inherited Reproductive Disorders

for Genetic Disorder

Sites in Research Triangle Park +1 more location

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 6 Weeks - 120

Code: NCT01500447·Recruiting·Listed Dec 2011

Apply to this trial

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

for Barrett Esophagus

Sites in Chapel Hill +4 more locations

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06687603·Recruiting·Listed Nov 2024

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Belimumab With Rituximab for Primary Membranous Nephropathy

for Membranous Nephropathy

Drug: Rituximab

Sites in Chapel Hill +19 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT03949855·Phase 2·Recruiting·Listed May 2019

Apply to this trial

CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study

for Cardiac Amyloidosis

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06096675·Recruiting·Listed Oct 2023

Apply to this trial

Functional Incremental Stepping in Place Test (F-IST) Validation

for Intensive Care Medicine

Sites in Durham +1 more location

Sponsor: Kirby Mayer

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06853236·Recruiting·Listed Feb 2025

Apply to this trial

Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

for Chronic Subdural Hematoma

Sites in Winston-Salem +28 more locations

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 40 - 90

Code: NCT06347796·Recruiting·Listed Apr 2024

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Improving Parental Support in Hypospadias Care

for Hypospadias

Sites in Chapel Hill +1 more location

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: All ages

Code: NCT06832280·Recruiting·Listed Feb 2025

Apply to this trial

Cereset Research Exploratory Study

for Neurological Diseases or Conditions

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 11+

Code: NCT03777267·Recruiting·Listed Dec 2018

Apply to this trial

Lerapolturev (PVSRIPO) in GBM

for Recurrent Supratentorial Glioblastoma

1 location in Durham

Sponsor: Darell Bigner

Sex: All·Age: 18+

Code: NCT06177964·Phase 2·Recruiting·Listed Dec 2023

Apply to this trial

CTSN Embolic Protection Trial

for Delirium

Sites in Durham +18 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting·Listed Sep 2023

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Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

for Chronic Kidney Disease(CKD)

Sites in Durham, Houston +5 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06906627·Recruiting·Listed Apr 2025

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Nephrotic Syndrome Study Network

for Minimal Change Disease (MCD)

Sites in Chapel Hill, Charlotte +32 more locations

Sponsor: University of Michigan

Sex: All·Age: Up to 80

Code: NCT01209000·Recruiting·Listed Sep 2010

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Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM

for Epiretinal Membrane

Sites in Chapel Hill +46 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 50+

Code: NCT05145491·Recruiting·Listed Dec 2021

Apply to this trial

IL-17 Blockade to Decrease irAEs (REPLAY)

for Metastatic Melanoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07237594·Phase 1·Recruiting·Listed Nov 2025

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Allopregnanolone (Zuranolone) in Post-stroke Depression

for Post Stroke Depression

Drug: Zuranolone

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21 - 65

Code: NCT06759558·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

CGM for Management of Type 2 Diabetes in Pregnancy

for Type 2 Diabetes Mellitus (T2DM)

Sites in Chapel Hill +6 more locations

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18 - 50

Code: NCT06628453·Recruiting·Listed Oct 2024

Apply to this trial

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

Sites in Durham +9 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting·Listed Mar 2024

Apply to this trial

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

for HER2-negative Breast Cancer

Sites in Chapel Hill +4 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 99

Code: NCT05029999·Phase 1·Recruiting·Listed Sep 2021

Apply to this trial

Gastroschisis Outcomes of Delivery (GOOD) Study

for Gastroschisis

Sites in Chapel Hill +35 more locations

Sponsor: Medical College of Wisconsin

Sex: Female·Age: 18+

Code: NCT02774746·Recruiting·Listed May 2016

Apply to this trial

Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer

for Head and Neck Squamous Cell Carcinoma

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT04375384·Phase 2·Recruiting·Listed May 2020

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Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

for Brain Metastases

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05692635·Phase 2·Recruiting·Listed Jan 2023

Apply to this trial

Physician Engagement in EMS Transport Refusal Rates

for Refusal of Transport

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07107737·Recruiting·Listed Aug 2025

Apply to this trial

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

Sites in Durham, Chapel Hill +140 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

Apply to this trial

Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma

for Acute Lymphoblastic Leukemia

Sites in Charlotte +2 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 1 - 18

Code: NCT06533748·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

Evaluating Treatments for Suicidal Veterans With PTSD

for Self-directed Violence

Sites in Durham +3 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05974631·Recruiting·Listed Aug 2023

Apply to this trial

Improving Thoracic Surgical Care Using Electronic Patient-Reported Outcomes (ePROS)

for Thoracic

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT06075316·Recruiting·Listed Oct 2023

Apply to this trial

Clinical Procedures to Support Research in ALS

for Amyotrophic Lateral Sclerosis

Sites in Durham, Winston-Salem +8 more locations

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT03489278·Recruiting·Listed Apr 2018

Apply to this trial