Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

for Bronchopulmonary Dysplasia (BPD)

Sites in Chapel Hill, Greenville +3 more locations

Sponsor: Duke University

Sex: All·Age: 7 Days - 28 Days

Code: NCT07101640·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

for Solid Tumor Malignancies

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06896162·Recruiting·Listed Mar 2025

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Study of the Effect of Innate on the Inflammatory Response to Endotoxin

for Asthma

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT01143480·Recruiting·Listed Jun 2010

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Coping Skills Training for Symptom Management and Daily Steps (Step Up)

for Hematopoietic Stem Cell Transplant

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 99

Code: NCT06575712·Recruiting·Listed Aug 2024

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Abductor Reattachment Methods in Proximal Femur Replacements: What is the Best Method?

for Sarcoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 16 - 75

Code: NCT03261544·Recruiting·Listed Aug 2017

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Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care

for Hiv

Sites in Chapel Hill +2 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05241990·Recruiting·Listed Feb 2022

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Intestinal Microbiome Transplant in ALS

for Amyotrophic Lateral Sclerosis ALS

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07017946·Phase 1, Phase 2·Recruiting·Listed Jun 2025

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TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II

for Lymphoblastic Leukemia

Sites in Charlotte +16 more locations

Sponsor: Tanja Andrea Gruber

Sex: All·Age: Up to 1

Code: NCT05848687·Phase 1, Phase 2·Recruiting·Listed May 2023

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Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

for Sickle Cell Disease (SCD)

Sites in Chapel Hill, Charlotte +29 more locations

Sponsor: University of Rochester

Sex: All·Age: 3 - 20

Code: NCT06941389·Recruiting·Listed Apr 2025

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Restoration of Normative Postural Control

for Lower Limb Amputation Below Knee (Injury)

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 99

Code: NCT06452186·Recruiting·Listed Jun 2024

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Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

for Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation

Sites in Winston-Salem +10 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT05691465·Phase 2·Recruiting·Listed Jan 2023

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Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

for Glaucoma

Sites in Chapel Hill +6 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05924477·Recruiting·Listed Jun 2023

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The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

for Extubation Failure

Sites in Winston-Salem, Charlotte +14 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 0 Days - 9 Weeks

Code: NCT05446272·Recruiting·Listed Jul 2022

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Testing a Device for Automatically TRacking Urine and STool in an Inpatient HCT Setting (Project TRUST)

for Fluid Output

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 80

Code: NCT05520346·Recruiting·Listed Aug 2022

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CHAAMP (CHArlotte Advocate MGUS Project) Internal Pilot Study

for Multiple Myeloma

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06644625·Recruiting·Listed Oct 2024

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Evaluation of the Pathobiology of CALR-mutated MPN Cells

for Myeloproliferative Neoplasm

Sites in Winston-Salem & Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06480591·Recruiting·Listed Jun 2024

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Cognitive Behavioral Theory-assisted Virtual Reality for Chronic CANcer Pain (VR-CAN)

for Cancer

Sites in Durham +1 more location

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT07318519·Recruiting·Listed Jan 2026

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Implementation of an Oral Chemotherapy Adherence Intervention

for Solid Tumor

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 21+

Code: NCT06989489·Recruiting·Listed May 2025

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CommunityRx-Kidney Health

for Chronic Kidney Disease (Stages 1-4)

1 location in Beulaville

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07237295·Recruiting·Listed Nov 2025

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Preoperative Fasting vs. Not Fasting in Critically Ill Patients

for Critical Illness

Sites in Winston-Salem +17 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06751043·Recruiting·Listed Dec 2024

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Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

Sites in Winston-Salem, Charlotte +462 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting·Listed May 2024

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Implementing a Mobile Health Application for Women Veterans With Urinary Incontinence (MyHealtheBladder): Function QUERI 3.0

for Urinary Incontinence

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: Female·Age: All ages

Code: NCT07219433·Recruiting·Listed Oct 2025

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The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

for Traumatic Brain Injury

Sites in Durham +6 more locations

Sponsor: University of Michigan

Sex: All·Age: 16 - 65

Code: NCT04855396·Recruiting·Listed Apr 2021

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Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Chapel Hill, Winston-Salem +5 more locations

Sponsor: Joshua Zeidner

Sex: All·Age: 18+

Code: NCT05442216·Phase 2·Recruiting·Listed Jul 2022

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Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

for Chronic Kidney Disease(CKD)

Sites in Durham +6 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06906640·Recruiting·Listed Apr 2025

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Bump the Lump - Intervention for the Treatment of Globus Pharyngeus

for Globus Pharyngeus

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06762444·Recruiting·Listed Jan 2025

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Observation of Environment and Reproductive-Endocrine Effects

for Hypogonadism

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 8 - 99

Code: NCT06280807·Recruiting·Listed Feb 2024

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Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

for Colorectal Cancer Stage II

Sites in Greensboro, Hendersonville +373 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07018869·Phase 3·Recruiting·Listed Jun 2025

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Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)

for Adult Growth Hormone Deficiency

Sites in Salisbury +14 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 21 - 55

Code: NCT04867317·Phase 3·Recruiting·Listed Apr 2021

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Neuroscience of Psychotherapy for Depression

for Depression

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 30

Code: NCT06696001·Recruiting·Listed Nov 2024

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Duke APOL1 Research Biorepository

for End Stage Kidney Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04160507·Recruiting·Listed Nov 2019

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Eating Disorders Genetics Initiative 2

for Anorexia Nervosa

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 12 - 99·Accepts healthy volunteers

Code: NCT06594913·Recruiting·Listed Sep 2024

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Risk Stratification in Children With Concussion

for Concussion, Brain

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 11 - 17

Code: NCT05825027·Recruiting·Listed Apr 2023

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Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings

for Suicide, Attempted

Sites in Chapel Hill +5 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 12 - 24

Code: NCT06151158·Recruiting·Listed Nov 2023

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Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

for Heart Failure

Sites in Durham +4 more locations

Sponsor: Stanford University

Sex: All·Age: 0 - 16

Code: NCT06080074·Phase 2·Recruiting·Listed Oct 2023

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A New Intervention to Improve Function in Veterans With Anxiety and Depression

for Anxiety and Depression

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65

Code: NCT06188923·Phase 2·Recruiting·Listed Jan 2024

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Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma

for Multiple Myeloma, Newly Diagnosed

Sites in Chapel Hill +9 more locations

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 19+

Code: NCT06974786·Phase 2·Recruiting·Listed May 2025

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A Decisional Intervention for Older Adults With Acute Myeloid Leukemia and Their Caregivers

for Oncology

Sites in Chapel Hill, Winston-Salem +2 more locations

Sponsor: University of Rochester

Sex: All·Age: 60+

Code: NCT06697600·Recruiting·Listed Nov 2024

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Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 60+

Code: NCT05525663·Recruiting·Listed Sep 2022

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Quick Start Durvalumab Following Chemoradiation for Stage III Nonsmall Cell Lung Cancer

for Nonsmall Cell Lung Cancer Stage III

Drug: Durvalumab

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05696782·Phase 2·Recruiting·Listed Jan 2023

Apply to this trial