Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )

for Hypertension

1 location in Winston-Salem

Sponsor: Wake Forest University

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06375694·Recruiting

Apply to this trial

Fundus Ablation Registry (Gastric Fundus Mucosal Ablation for Weight Loss)

for Obesity

1 location in Cary

Sponsor: True You Weight Loss

Sex: All·Age: 18 - 65

Code: NCT06428617·Recruiting

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A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

for Multiple Sclerosis

1 location in Wilmington

Sponsor: TG Therapeutics, Inc.

Sex: Female·Age: 15 - 50

Code: NCT06433765·Recruiting

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Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

for Sickle Cell Disease (SCD)

31 locations incl. Birmingham

Sponsor: University of Rochester

Sex: All·Age: 3 - 20

Code: NCT06941389·Recruiting

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A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia

for Leukemia, Lymphocytic, Chronic, B-Cell

Drug: Ibrutinib

32 locations incl. Cerritos

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05963074·Phase 2·Recruiting

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Nutrition and Obesity in Under-Represented Populations: Food Insecurity Research to Advance Science and Improve Health

for Pediatric Obesity

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 12 Months - 24 Months·Accepts healthy volunteers

Code: NCT06116422·Recruiting

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Health Outcomes of Parents With Cystic Fibrosis-Aim 2

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06296394·Recruiting

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Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated or Spliceosome Mutated Relapsed or Refractory Acute Myeloid Leukemia

for AML With Gene Mutations

12 locations incl. Los Angeles

Sponsor: Lomond Therapeutics Holdings, Inc.

Sex: All·Age: 18+

Code: NCT06366789·Phase 1·Recruiting

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A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

for Pediatric

Drug: Aficamten

26 locations incl. Phoenix

Sponsor: Cytokinetics

Sex: All·Age: 12 - 17

Code: NCT06412666·Phase 2, Phase 3·Recruiting

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Impella RP Flex with Smart Assist

for Right Ventricular (RV) Dysfunction

31 locations incl. Birmingham

Sponsor: Abiomed Inc.

Sex: All·Age: All ages

Code: NCT06637644·Recruiting

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A Study of Pitolisant in Patients With Prader-Willi Syndrome

for Prader-Willi Syndrome

21 locations incl. Los Angeles

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 6+

Code: NCT06366464·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

for Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis

135 locations incl. Birmingham

Sponsor: 89bio, Inc.

Sex: All·Age: 18 - 75

Code: NCT06419374·Phase 3·Recruiting

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Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

for Colorectal Cancer

32 locations incl. Chandler

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06445062·Phase 1, Phase 2·Recruiting

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A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

for Thrombocythemia, Essential

4 locations incl. Ann Arbor

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06351631·Phase 3·Recruiting

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Advancing Transplantation Outcomes in Children

for Kidney Transplant

20 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 13 - 20

Code: NCT06055608·Phase 2·Recruiting

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PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC

for Head and Neck Squamous Cell Carcinoma

Drug: Rilvegostomig

7 locations incl. Sacramento

Sponsor: Presage Biosciences

Sex: All·Age: 18+

Code: NCT06366451·EARLY_Phase 1·Recruiting

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A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias

for Acute Myeloid Leukemias

26 locations incl. Burbank

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06226571·Phase 1·Recruiting

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Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

for Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Drug: Polatuzumab Vedotin

8 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06015880·Phase 1·Recruiting

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Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

for Asthma

105 locations incl. Anchorage

Sponsor: AstraZeneca

Sex: All·Age: 12 - 17

Code: NCT06307665·Phase 3·Recruiting

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Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Etentamig

46 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06158841·Phase 3·Recruiting

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A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

for Cerebral Amyloid Angiopathy

34 locations incl. Los Angeles

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 30+

Code: NCT06393712·Phase 2·Recruiting

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Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis

for Myasthenia Gravis

11 locations incl. Carlsbad

Sponsor: NMD Pharma A/S

Sex: All·Age: 18+

Code: NCT06414954·Phase 2·Recruiting

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Vaginal Ecosystem and Network in the United States Study

for Bacterial Vaginosis

20 locations incl. Fullerton

Sponsor: Vaginal Biome Science

Sex: Female·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06472765·Enrolling By Invitation

Inspiring Seniors Towards Exercise Promotion to Protect Cognition

for Alzheimer Disease

2 locations incl. Atlanta

Sponsor: Emory University

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06496425·Recruiting

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ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

for Prostate Cancer

3 locations incl. New York

Sponsor: Duke University

Sex: Male·Age: 18+

Code: NCT06141993·Recruiting

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Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

for Focal Epilepsy

65 locations incl. Birmingham

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18 - 75

Code: NCT06309966·Phase 2, Phase 3·Recruiting

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Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

for Bipolar Depression

52 locations incl. Dothan

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 10 - 17

Code: NCT06372964·Phase 3·Recruiting

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CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

for Traumatic Brain Injury

5 locations incl. Eglin Air Force Base

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT05663034·Recruiting

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Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

for Pancreatic Ductal Adenocarcinoma

5 locations incl. Lake Success

Sponsor: Gulam Manji

Sex: All·Age: 18+

Code: NCT06048484·Phase 2·Recruiting

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A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII Deficiency)

for Healthy Participants

9 locations incl. Glendale

Sponsor: Equilibra Bioscience LLC

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06349473·Phase 1·Recruiting

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Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

for Acute Ischemic Stroke

51 locations incl. Mobile

Sponsor: Mercy Health Ohio

Sex: All·Age: 18 - 79

Code: NCT05611242·Phase 3·Recruiting

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Cervical Plexus Versus Infiltration for Clavicular Operations (CERPICO)

for Clavicle Surgery

1 location in Marine Corps Base Camp Lejeune

Sponsor: Naval Medical Center Camp Lejeune

Sex: All·Age: 18 - 64

Code: NCT06737237·Enrolling By Invitation

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

for Malignant Female Reproductive System Neoplasm

186 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06126276·Phase 2·Recruiting

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Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis

for AAA - Abdominal Aortic Aneurysm

56 locations incl. Little Rock

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06218875·Recruiting

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Preventing Injured Knees From osteoArthritis: Severity Outcomes

for Osteoarthritis, Knee

9 locations incl. Atlanta

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45

Code: NCT06096259·Phase 2·Recruiting

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A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

for Idiopathic Pulmonary Fibrosis

Drug: Nerandomilast

58 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06238622·Phase 3·Recruiting

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Blood and Urine HPVDNA as Minimally Invasive Biomarkers for Cervical Cancer Detection and Surveillance Following Treatment

for Cervical Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT04743674·Recruiting

Apply to this trial

Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

for Acute Myeloid Leukemia

Drug: Venetoclax

7 locations incl. Miami

Sponsor: Joshua Zeidner

Sex: All·Age: 18+

Code: NCT05442216·Phase 2·Recruiting

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Preserving Physical Function in Older Adults With Cancer: Impact of an Optimizing Nutrition Intervention Applied Before and After Surgery

for Cancer

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 55+

Code: NCT05912257·Recruiting

Apply to this trial

Apathy in Parkinson Disease TMS Study

for Parkinson Disease

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 55 - 80

Code: NCT06087926·Recruiting

Apply to this trial