Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Automated Robotic TCD in Traumatic Brain Injury

for Brain Injuries, Traumatic

Sites in Winston-Salem +2 more locations

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18+

Code: NCT05848297·Recruiting·Listed May 2023

Apply to this trial

Sugary Drink Labeling Study

for Health Behavior

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07294053·Recruiting·Listed Dec 2025

Apply to this trial

Integrated Cancer Repository for Cancer Research

for Pancreatic Cancer

Sites in Fayetteville +41 more locations

Sponsor: University of Nebraska

Sex: All·Age: 19 - 110·Accepts healthy volunteers

Code: NCT02012699·Recruiting·Listed Dec 2013

Apply to this trial

Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

for Extensive Stage Lung Small Cell Carcinoma

Sites in Pinehurst +145 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06769126·Phase 2·Recruiting·Listed Jan 2025

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Longitudinal Study of the Porphyrias

for Acute Porphyrias

Sites in Winston-Salem +14 more locations

Sponsor: The American Porphyrias Expert Collaborative

Sex: All·Age: 1 Minute+

Code: NCT01561157·Recruiting·Listed Mar 2012

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Registry Study for Radiation Therapy Outcomes

for Neoplasms

Sites in Charlotte +28 more locations

Sponsor: Proton Collaborative Group

Sex: All·Age: All ages

Code: NCT01255748·Recruiting·Listed Dec 2010

Apply to this trial

Implementing a Group Physical Therapy Program for Veterans (GroupPT): Function QUERI 3.0

for Knee Osteoarthritis

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07215572·Recruiting·Listed Oct 2025

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Pre- and Post-neuromusculoskeletal Injury Risk Evaluation for Return-to-Duty Enhancement

for Musculoskeletal Injuries

Sites in Fort Liberty +1 more location

Sponsor: Womack Army Medical Center

Sex: All·Age: 18 - 44·Accepts healthy volunteers

Code: NCT05111925·Recruiting·Listed Nov 2021

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Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Sites in Durham, Chapel Hill +3 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05145400·Phase 2·Recruiting·Listed Dec 2021

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Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users

for Cannabis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05401929·Recruiting·Listed Jun 2022

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Olfactory Biopsies

for Alzheimer Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07021040·Recruiting·Listed Jun 2025

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Effects of Systematic Cervical Exam Training on Labor and Delivery Care

for Delivery Problem

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04421768·Recruiting·Listed Jun 2020

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Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

for Salt

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 22 - 33·Accepts healthy volunteers

Code: NCT04026776·EARLY_Phase 1·Recruiting·Listed Jul 2019

Apply to this trial

Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures

for Pain, Postoperative

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 80

Code: NCT05415384·Recruiting·Listed Jun 2022

Apply to this trial

Horizon Two: HR NDMM (MMRC-100)

for High Risk Newly Diagnosed Multiple Myeloma

Sites in Chapel Hill +6 more locations

Sponsor: Multiple Myeloma Research Consortium

Sex: All·Age: 18+

Code: NCT07053436·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Hyaluronic Acid-based Gel Spacers in Gynecologic Malignancies

for Cervix Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07292818·Phase 1·Recruiting·Listed Dec 2025

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Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy

for Malignant Solid Neoplasm

Sites in Greensboro, Gastonia +31 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05642611·Phase 3·Recruiting·Listed Dec 2022

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Intramedullary Calcium Sulfate Antibiotic Depot

for Open tíbia Fracture

Sites in Winston-Salem, Charlotte +8 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05766670·Phase 3·Recruiting·Listed Mar 2023

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Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses

for Dentofacial Abnormalities

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 15 - 40

Code: NCT04117360·Recruiting·Listed Oct 2019

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Animal Assisted Therapy in Pediatric Dentistry

for Anxiety

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 4 - 8·Accepts healthy volunteers

Code: NCT05464888·Recruiting·Listed Jul 2022

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COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)

for Ulcerative Colitis, Pediatric

Sites in Durham, Chapel Hill +2 more locations

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 - 18

Code: NCT07198113·Recruiting·Listed Sep 2025

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Study of Individuals Affected With Hypoplasminogenemia

for Plasminogen Deficiency

Sites in Winston-Salem, Raleigh +9 more locations

Sponsor: Indiana Hemophilia &Thrombosis Center, Inc.

Sex: All·Age: All ages

Code: NCT03797495·Recruiting·Listed Jan 2019

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Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy

for Pediatric Patients Treated With Radiation Therapy

Sites in Chapel Hill +22 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: Up to 21

Code: NCT01696721·Recruiting·Listed Oct 2012

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NEPTUNE Match Study

for Nephrotic Syndrome in Children

Sites in Chapel Hill +15 more locations

Sponsor: University of Michigan

Sex: All·Age: 1 - 80

Code: NCT04571658·Recruiting·Listed Oct 2020

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Environmental Risk Factors for the Anti-synthetase Syndrome

for Myositis

Sites in Research Triangle Park +1 more location

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 2 - 100·Accepts healthy volunteers

Code: NCT01276470·Recruiting·Listed Jan 2011

Apply to this trial

NIEHS Repository of Stored Biological Samples for Future Use

for Normal Physiology

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05666739·Recruiting·Listed Dec 2022

Apply to this trial

Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence

for Stress Urinary Incontinence

Sites in Durham +6 more locations

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 21+

Code: NCT06480227·Recruiting·Listed Jun 2024

Apply to this trial

ERP to Improve Functioning in Veterans With OCD

for Obsessive Compulsive Disorder (OCD)

Sites in Durham, Asheville +17 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05240924·Recruiting·Listed Feb 2022

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Autologous CAR-T Cells Targeting B7-H3 in PDAC

for Pancreas Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06158139·Phase 1·Recruiting·Listed Dec 2023

Apply to this trial

IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

Sites in Durham +51 more locations

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting·Listed Oct 2023

Apply to this trial

BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia

for Endotracheal Extubation

Sites in Winston-Salem +1 more location

Sponsor: Telethon Kids Institute

Sex: All·Age: 0 - 16

Code: NCT07204990·Recruiting·Listed Oct 2025

Apply to this trial

Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Chapel Hill, Greensboro +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

Apply to this trial

Ultrasound Simulation Case-based Workshop Implementation and Impact Assessment

for Point-of-care Ultrasound

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06960837·Recruiting·Listed May 2025

Apply to this trial

Open Versus Arthroscopic Stabilization of Shoulder Instability With Subcritical Bone Loss: The OASIS Trial

for Shoulder Dislocation

Sites in Durham, Chapel Hill +8 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 17 - 50

Code: NCT04809064·Recruiting·Listed Mar 2021

Apply to this trial

BE WELL With Migraine: Brain Education and WELLness With Migraine

for Migraine

Sites in Winston-Salem +2 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05987592·Recruiting·Listed Aug 2023

Apply to this trial

Sickle Cell Clinical Research and Intervention Program

for Sickle Cell Disease

Sites in Charlotte +4 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages

Code: NCT02098863·Recruiting·Listed Mar 2014

Apply to this trial

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

for Glioma, Malignant

1 location in Durham

Sponsor: Darell Bigner

Sex: All·Age: 18+

Code: NCT04547777·Phase 1·Recruiting·Listed Sep 2020

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Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples

for Infertility, Male

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Male·Age: 18+

Code: NCT04298255·Recruiting·Listed Mar 2020

Apply to this trial

Late Onset Alzheimer's Disease

for Alzheimer Disease

Sites in Raleigh +11 more locations

Sponsor: Columbia University

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT05010603·Recruiting·Listed Aug 2021

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Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

for Trauma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 45+

Code: NCT06521086·Recruiting·Listed Jul 2024

Apply to this trial