Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

for Cardiovascular Disease

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT06263452·Phase 4·Recruiting

Apply to this trial

Precision Nudging for Hypertension Management: Observational Study

for Hypertension

1 location in Greensboro

Sponsor: Lirio

Sex: All·Age: 18+

Code: NCT06354192·Recruiting

Apply to this trial

Screening for AL Amyloidosis in Smoldering Multiple Myeloma

for Smoldering Multiple Myeloma

13 locations incl. Birmingham

Sponsor: Tufts Medical Center

Sex: All·Age: 40+

Code: NCT06365060·Recruiting

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A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

for Heterozygous Familial Hypercholesterolemia

8 locations incl. Dothan

Sponsor: Verve Therapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06164730·Phase 1·Recruiting

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Ultrasound for Evaluation of Percutaneous G-tube Position

for Gastrostomy

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: Up to 18

Code: NCT06361498·Recruiting

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A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)

for Homocystinuria

13 locations incl. Phoenix

Sponsor: Travere Therapeutics, Inc.

Sex: All·Age: 5 - 65

Code: NCT06431893·Phase 3·Enrolling By Invitation

A Study for Participants Previously Treated With Century Therapeutics Cellular Therapy Product

for Hematological Malignancy

7 locations incl. Gilbert

Sponsor: Century Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05768269·Recruiting

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A Study of Lebrikizumab in Adult Participants With Perennial Allergic Rhinitis (PREPARED-1)

for Perennial Allergic Rhinitis (PAR)

27 locations incl. Huntington Beach

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06339008·Phase 3·Recruiting

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A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

for Hypothyroidism

134 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06345339·Phase 2, Phase 3·Recruiting

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Elucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using Solriamfetol

for Binge-Eating Disorder

Drug: Solriamfetol

45 locations incl. Encino

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 55

Code: NCT06413433·Phase 3·Recruiting

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Multi-Center Study of Clinical and Inflammatory Outcomes in Intensive Cardiac Rehabilitation and Traditional Cardiac Rehabilitation Programs

for Cardiovascular Diseases

3 locations incl. Ypsilanti

Sponsor: Pritikin ICR

Sex: All·Age: 18+

Code: NCT06424119·Recruiting

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ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells

for Hodgkin Lymphoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06090864·Phase 1, Phase 2·Recruiting

Apply to this trial

A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF

for Atrial Fibrillation

35 locations incl. Birmingham

Sponsor: Heart Rhythm Clinical and Research Solutions, LLC

Sex: All·Age: 18+

Code: NCT06335082·Enrolling By Invitation

The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study

for Kidney Transplant

Drug: Finerenone

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT06059664·Phase 2·Recruiting

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The Treatment of Painful Diabetic Neuropathy With Diet

for Painful Diabetic Neuropathy (PDN)

1 location in Hendersonville

Sponsor: AdventHealth

Sex: All·Age: 18+

Code: NCT07509671·Recruiting

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A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

for Myelofibrosis

Drug: Selinexor

7 locations incl. Duarte

Sponsor: Karyopharm Therapeutics Inc

Sex: All·Age: 18+

Code: NCT05980806·Phase 2·Recruiting

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A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

15 locations incl. La Jolla

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06385080·Phase 1, Phase 2·Recruiting

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UNC Metastatic Cancer Radiation Therapy Registry

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06306924·Recruiting

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Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

for Ganglioneuroblastoma, Nodular

156 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 30

Code: NCT06172296·Phase 3·Recruiting

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A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer

for Non-Muscle Invasive Bladder Neoplasms

38 locations incl. Little Rock

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06319820·Phase 3·Recruiting

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The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs).

for Intracranial Aneurysm

22 locations incl. Englewood

Sponsor: Medtronic Neurovascular Clinical Affairs

Sex: All·Age: 18 - 75

Code: NCT02998229·Recruiting

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MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

for In-Stent Restenosis

28 locations incl. Birmingham

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 110

Code: NCT05908331·Recruiting

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Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults

for Obesity

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 65 - 85

Code: NCT06044571·Recruiting

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Pivotal Trial of the Boomerang Catheter for pDVA

for Chronic Limb-Threatening Ischemia

19 locations incl. Sylmar

Sponsor: Aveera Medical, Inc.

Sex: All·Age: 18+

Code: NCT06311773·Enrolling By Invitation

Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

34 locations incl. St Louis

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting

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IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

61 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting

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A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

for Breast Neoplasms

46 locations incl. Chandler

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06312176·Phase 3·Recruiting

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Personalized Nutrition to Improve Recovery in Trauma

for Abdominal Trauma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 15+

Code: NCT06065202·Phase 2·Recruiting

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Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

for Aging

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06239688·Recruiting

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Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

for Heart Failure and Impaired Kidney Function

Drug: Dapagliflozin

166 locations incl. Alexander City

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06307652·Phase 3·Recruiting

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Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

for Glioblastoma, IDH-Wildtype

12 locations incl. Los Angeles

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT06319027·Phase 2·Recruiting

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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

for Non-Small Cell Lung Cancer

Drug: Rilvegostomig

63 locations incl. Anchorage

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06357533·Phase 3·Recruiting

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Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

for Distal Radius Fractures

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06179004·Phase 3·Recruiting

Apply to this trial

Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Drug: Livmoniplimab

19 locations incl. La Jolla

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06236438·Phase 2, Phase 3·Recruiting

Apply to this trial

Intramedullary Calcium Sulfate Antibiotic Depot

for Open tíbia Fracture

10 locations incl. Los Angeles

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05766670·Phase 3·Recruiting

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Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures

for Depression in Old Age

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65+

Code: NCT05851898·Phase 4·Recruiting

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Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC

for Head and Neck Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06096038·Phase 1, Phase 2·Recruiting

Apply to this trial

Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne

for Acne

79 locations incl. Scottsdale

Sponsor: Sanofi Pasteur, a Sanofi Company

Sex: All·Age: 18 - 45

Code: NCT06316297·Phase 1, Phase 2·Recruiting

Apply to this trial

Core Competency Model for Corrections

for Knowledge, Attitudes, Practice

1 location in Raleigh

Sponsor: University of North Carolina, Charlotte

Sex: All·Age: 18 - 99

Code: NCT06359574·Enrolling By Invitation

Project Mountain - Comparing SpO2 and SaO2 for Accuracy

for SpO2

5 locations incl. Phoenix

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06372106·Recruiting

Apply to this trial