Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Women s Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH) Equity

for Mental Health

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: Female·Age: 18 - 100·Accepts healthy volunteers

Code: NCT04983251·Recruiting·Listed Jul 2021

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Prospective Multisite Study of Quality of Life in Pediatric Intestinal Failure

for Pediatric Intestinal Failure

Sites in Durham +10 more locations

Sponsor: Boston Children's Hospital

Sex: All·Age: 6 Months - 25

Code: NCT04629014·Recruiting·Listed Nov 2020

Apply to this trial

Prehospital Analgesia INtervention Trial (PAIN)

for Traumatic Injury

Sites in Charlotte +9 more locations

Sponsor: Jason Sperry

Sex: All·Age: 18+

Code: NCT05437575·Phase 3·Recruiting·Listed Jun 2022

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A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

for Acral Lentiginous Melanoma

Drug: Ipilimumab

Sites in Winston-Salem, Statesville +301 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04511013·Phase 2·Recruiting·Listed Aug 2020

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Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide

for Traumatic Brain Injury

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06866691·Phase 4·Recruiting·Listed Mar 2025

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Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

for Pancreatic Adenocarcinoma

Drug: Erlotinib

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06483555·Phase 1, Phase 2·Recruiting·Listed Jul 2024

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Muscle Fiber Fragment Treatment for Urinary Incontinence

for Urinary Incontinence

1 location in Winston-Salem

Sponsor: Wake Forest University

Sex: Female·Age: 18 - 75

Code: NCT01953263·Phase 1, Phase 2·Recruiting·Listed Sep 2013

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Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

for Cerebrovascular Disorders

2 locations in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 80

Code: NCT05871606·Phase 1·Recruiting·Listed May 2023

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Fecal Microbiota Transplant National Registry

for Fecal Microbiota Transplantation

Sites in Chapel Hill +27 more locations

Sponsor: American Gastroenterological Association

Sex: All·Age: All ages

Code: NCT03325855·Recruiting·Listed Oct 2017

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Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

for Glioblastoma Multiforme

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05366179·Phase 1·Recruiting·Listed May 2022

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The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial

for Coronary Artery Disease

Sites in Durham +8 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05618353·Phase 4·Recruiting·Listed Nov 2022

Apply to this trial

ATHNdataset Registry

for Hemophilia

1 location in Hickory

Sponsor: American Thrombosis and Hemostasis Network

Sex: All·Age: All ages

Code: NCT06820515·Recruiting·Listed Feb 2025

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Avocado Consumption, Nutrients in Human Milk, and Infant Cognitive Development

for Breastfeeding, Exclusive

1 location in Kannapolis

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06208085·Recruiting·Listed Jan 2024

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Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Winston-Salem, Raleigh +52 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

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SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

for Breast Cancer

Sites in Durham +10 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06896474·Recruiting·Listed Mar 2025

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Synergistic Activity of Human Milk Nutrients and Infant Cognition

for Breastfeeding, Exclusive

1 location in Kannapolis

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 3 Months - 35·Accepts healthy volunteers

Code: NCT03838536·Recruiting·Listed Feb 2019

Apply to this trial

Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

Sites in Durham, Chapel Hill +71 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting·Listed Apr 2024

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

Sites in Durham, Chapel Hill +66 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting·Listed May 2020

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Nerve Transfer to Improve Function in High Level Tetraplegia

for Cervical Spinal Cord Injury

Sites in Winston-Salem +8 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 80

Code: NCT06288763·Recruiting·Listed Mar 2024

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Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery

for Cleft Palate

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 6 Months - 4

Code: NCT06962306·Phase 4·Recruiting·Listed May 2025

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Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2

for Aging

Sites in Winston-Salem +3 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07166861·Recruiting·Listed Sep 2025

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The Validation Study of Bioelectronics

for Healthy

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT05397951·Recruiting·Listed May 2022

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Accountability for Care Through Undoing Racism & Equity for Moms

for Pregnancy Related

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 12 - 99·Accepts healthy volunteers

Code: NCT05484804·Recruiting·Listed Aug 2022

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Complex Adult Deformity Surgery (CADS)

for Adult Spinal Deformity

Sites in Durham +15 more locations

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04194138·Recruiting·Listed Dec 2019

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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

Sites in Charlotte, Monroe +292 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting·Listed Sep 2018

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Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252

for Recurrent High Grade Glioma

Sites in Durham +1 more location

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06126744·Phase 1·Recruiting·Listed Nov 2023

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Improving PCP Advance Care Planning for People With ADRD

for Alzheimer Disease

1 location in Chapel Hill

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 99

Code: NCT06565169·Recruiting·Listed Aug 2024

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Transformative Research in Diabetic Nephropathy

for Diabetic Nephropathies

Sites in Chapel Hill +12 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100

Code: NCT02986984·Recruiting·Listed Dec 2016

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Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

for Peripheral Arterial Disease

Sites in Durham, Chapel Hill +17 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT04774159·Phase 3·Recruiting·Listed Mar 2021

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Pharmacogenomic Informed Statin Prescribing

for Hypercholesterolemia

Sites in Durham +1 more location

Sponsor: VA Office of Research and Development

Sex: All·Age: 40 - 75

Code: NCT06568601·Recruiting·Listed Aug 2024

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The Prospective Collection, Storage and Reporting of Data on Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing a Standard Preparative Regimen

for Acute Myelogenous Leukemia

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 120

Code: NCT01890486·Recruiting·Listed Jul 2013

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Androgens and NAFLD Longitudinal Cohort Study

for PCOS

Sites in Durham +1 more location

Sponsor: University of California, San Francisco

Sex: Female·Age: 18 - 42

Code: NCT06124261·Recruiting·Listed Nov 2023

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Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

for Aging

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06239688·Recruiting·Listed Feb 2024

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A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

Sites in Durham, Chapel Hill +20 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

DBT-P Treatment Study

for Emotion Dysregulation

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 45

Code: NCT06963801·Recruiting·Listed May 2025

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Microneedling vs Dermabrasion for Early Facial Scar Resurfacing

for Scar

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06171386·Recruiting·Listed Dec 2023

Apply to this trial

Pilot Study of Mindset Moments Among Adolescent and Young Adult Cancer Survivors

for Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 19 - 25·Accepts healthy volunteers

Code: NCT06732375·Recruiting·Listed Dec 2024

Apply to this trial

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

for Substance Abuse

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 12 - 100·Accepts healthy volunteers

Code: NCT06627764·Recruiting·Listed Oct 2024

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Immunomodulation to Optimize Vascularized Composite Allograft Integration for Limb Loss Therapy

for Immunosuppression

1 location in Durham

Sponsor: Linda Cendales

Sex: All·Age: 18 - 65

Code: NCT02310867·Phase 2·Recruiting·Listed Dec 2014

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A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

for AML (Acute Myelogenous Leukemia)

Sites in Chapel Hill +12 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: 18 - 66

Code: NCT06859424·Phase 2·Recruiting·Listed Mar 2025

Apply to this trial