Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology

for Electronic Cigarette Related Lung Damage

Sites in Durham +1 more location

Sponsor: Y. Michael Shim, MD

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT06856525·Phase 2, Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for High Grade Glioma

Sites in Durham +8 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 21

Code: NCT04655404·EARLY_Phase 1·Recruiting·Listed Dec 2020

Apply to this trial

Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

for Pompe Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT01665326·Recruiting·Listed Aug 2012

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Exercise and Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 85

Code: NCT04921917·Recruiting·Listed Jun 2021

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Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)

for Spinal Cord Injuries

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05458947·Recruiting·Listed Jul 2022

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The WISER Study: Web Based Methods for Enhancing Resilience

for Burnout

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05636072·Recruiting·Listed Dec 2022

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Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial

for Lymphoma

Sites in Winston-Salem, Greensboro +42 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05006482·Phase 3·Recruiting·Listed Aug 2021

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LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

for Angina

Sites in Durham +9 more locations

Sponsor: Yale University

Sex: All·Age: 65+

Code: NCT05786417·Phase 4·Recruiting·Listed Mar 2023

Apply to this trial

Telehealth Intervention for Improving Distress and Financial Toxicity in the Caregivers

for Hematopoietic and Lymphatic System Neoplasm

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06709404·Recruiting·Listed Nov 2024

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Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure

for Shoulder Surgery

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07216820·Recruiting·Listed Oct 2025

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CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)

for Chest Pain

Sites in Winston-Salem, Charlotte +1 more location

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 21+

Code: NCT05897632·Recruiting·Listed Jun 2023

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Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

Sites in Durham, Chapel Hill +56 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting·Listed Jul 2024

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Epcoritamab in Previously Treated WM

for Waldenstrom Macroglobulinemia

Drug: Epcoritamab

Sites in Chapel Hill +2 more locations

Sponsor: Gottfried von Keudell, MD PhD

Sex: All·Age: 18+

Code: NCT06510491·Phase 2·Recruiting·Listed Jul 2024

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Evaluating a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)

for Hip Fractures

Sites in Winston-Salem +5 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT06438640·Recruiting·Listed Jun 2024

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Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE Peds)

for Muscular Dystrophy, Facioscapulohumeral

Sites in Durham +5 more locations

Sponsor: University of Kansas Medical Center

Sex: All·Age: 5 - 17

Code: NCT06847282·Recruiting·Listed Feb 2025

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Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

for Adverse Childhood Experiences

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 21·Accepts healthy volunteers

Code: NCT05665465·EARLY_Phase 1·Recruiting·Listed Dec 2022

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Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs

for Failed or Difficult Intubation, Sequela

Sites in Durham, Raleigh +49 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT02493478·Recruiting·Listed Jul 2015

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Personalized Nutrition to Improve Recovery in Trauma

for Abdominal Trauma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 15+

Code: NCT06065202·Phase 2·Recruiting·Listed Oct 2023

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Tafasitamab and Rituximab for Front-Line Treatment of Post-Transplant Lymphoproliferative Disorder

for Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

Drug: Tafasitamab

Sites in Hillsborough +3 more locations

Sponsor: Timothy Voorhees

Sex: All·Age: 18+

Code: NCT05786040·Phase 2·Recruiting·Listed Mar 2023

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The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study

for Kidney Transplant

Drug: Finerenone

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT06059664·Phase 2·Recruiting·Listed Sep 2023

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JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

for Patellar Dislocation, Recurrent

Sites in Wake Forest +15 more locations

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 10 - 35

Code: NCT06883396·Recruiting·Listed Mar 2025

Apply to this trial

Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

Sites in Durham +15 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting·Listed Jan 2024

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Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer

for Prostate Cancer

Sites in Winston-Salem & Salisbury

Sponsor: Wake Forest University Health Sciences

Sex: Male·Age: 18+

Code: NCT04337580·Phase 2·Recruiting·Listed Apr 2020

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The APS Phenotyping Study

for ARDS

Sites in Durham +19 more locations

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT06521502·Recruiting·Listed Jul 2024

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Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

for Anterior Cruciate Ligament Injuries

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 14 - 39

Code: NCT06942754·Recruiting·Listed Apr 2025

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Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

Sites in Durham, Chapel Hill +23 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting·Listed Jul 2024

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Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity: A Multi-Center Study 2.0

for Cervical Deformity

Sites in Durham +12 more locations

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04194996·Recruiting·Listed Dec 2019

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Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms

for Gastroparesis

Sites in Winston-Salem +4 more locations

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT04661215·Recruiting·Listed Dec 2020

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Gastroparesis Registry 4

for Gastroparesis

Sites in Charlotte +5 more locations

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 85

Code: NCT05846802·Recruiting·Listed May 2023

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Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs

for Epilepsy Intractable

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06545643·Recruiting·Listed Aug 2024

Apply to this trial

Vitamin D for Prostate Endocrine Therapy

for Stage I Prostate Cancer AJCC v8

Sites in New Bern, Rocky Mount +49 more locations

Sponsor: University of Rochester

Sex: Male·Age: 50+

Code: NCT05838716·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Enhancing Wellness Through Affirming Services and Education

for HIV

1 location in Charlotte

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05700474·Recruiting·Listed Jan 2023

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Support Through Remote Observation and Nutrition Guidance Program for Individuals With Gastroesophageal Cancer

for GastroEsophageal Cancer

Sites in Chapel Hill +1 more location

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+

Code: NCT06497569·Recruiting·Listed Jul 2024

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Facial Analysis to Classify Difficult Intubation

for Difficult Intubation

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT01612949·Recruiting·Listed Jun 2012

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Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

for Cystic Fibrosis (CF)

Sites in Winston-Salem +17 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 12+

Code: NCT06837181·Recruiting·Listed Feb 2025

Apply to this trial

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study

for Central Centrifugal Cicatricial Alopecia (CCCA)

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18 - 60

Code: NCT04207931·Phase 4·Recruiting·Listed Dec 2019

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Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

for Cannabis

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 25 - 59·Accepts healthy volunteers

Code: NCT04810858·Recruiting·Listed Mar 2021

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Connect-Home: Alzheimer's Disease and Related Dementias

for Alzheimer Disease

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 19+

Code: NCT06840587·Recruiting·Listed Feb 2025

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Evaluation of Flexible Conductive Hearing Aids

for Conductive Hearing Loss

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 6 Months - 80·Accepts healthy volunteers

Code: NCT07222202·Recruiting·Listed Oct 2025

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His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

Sites in Asheville +13 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting·Listed Mar 2022

Apply to this trial