Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Comparison of Urinary Flow Study

for Urinary Retention

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT06918067·Recruiting·Listed Apr 2025

Apply to this trial

Cervical Cancer Detection Using Optical Spectroscopy

for Cervical Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT00900575·Recruiting·Listed May 2009

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Pilot Study for Speculum Free Cervical Cancer Screening

for Cervical Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 21 - 65·Accepts healthy volunteers

Code: NCT04107181·Recruiting·Listed Sep 2019

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Natural History Study of Patients With Hypophosphatasia (HPP)

for Hypophosphatasia

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT02237625·Recruiting·Listed Sep 2014

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Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for Advanced Ovarian Carcinoma

Sites in Durham +11 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT04575935·Phase 3·Recruiting·Listed Oct 2020

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Cognitive and Neurological Pathologies in Pompe Disease

for Pompe Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 18

Code: NCT04639336·Recruiting·Listed Nov 2020

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Neurostimulation Versus Therapy for Problems With Emotions

for Emotion Regulation

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 55

Code: NCT05712057·Recruiting·Listed Feb 2023

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Optimizing Tracheal Intubation Outcomes and Neonatal Safety

for Infant

Sites in Raleigh +6 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 1

Code: NCT05838690·Recruiting·Listed May 2023

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The Myelin Disorders Biorepository Project

for Leukodystrophy

Sites in Winston-Salem +22 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT03047369·Recruiting·Listed Feb 2017

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Chapel Hill, Charlotte +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

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Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome

for Down Syndrome (DS)

Sites in Asheville +11 more locations

Sponsor: Woolfson Eye Institute

Sex: All·Age: 8+

Code: NCT07135167·Phase 3·Recruiting·Listed Aug 2025

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Beat Childhood Cancer Specimen Banking and Data Registry

for Pediatric Cancer

Sites in Winston-Salem +16 more locations

Sponsor: Giselle Sholler

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04715178·Recruiting·Listed Jan 2021

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Feasibility of an ADAPTive Intervention to Improve Food Security and Maternal-Child Health

for Food Insecurity

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06942598·Recruiting·Listed Apr 2025

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Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases

for Keratoconus

Sites in Asheville +11 more locations

Sponsor: Woolfson Eye Institute

Sex: All·Age: 8+

Code: NCT07124910·Phase 3·Recruiting·Listed Aug 2025

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TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

for Cystic Fibrosis (CF)

Sites in Chapel Hill +11 more locations

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18 Months - 11

Code: NCT07048574·Recruiting·Listed Jul 2025

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SenseToKnow Autism Screening Device Validation Study

for Autism

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 16 Months - 36 Months·Accepts healthy volunteers

Code: NCT05874466·Recruiting·Listed May 2023

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Trans-Rectal Ultrasound of the Female Pelvis for Real-Time MRI-US Fusion Based Needle Tracking

for Uterine Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 90

Code: NCT05977621·Recruiting·Listed Aug 2023

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Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

for T-Cell Neoplasm

Drug: Pacritinib

Sites in Durham +5 more locations

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 18+

Code: NCT04858256·Phase 2·Recruiting·Listed Apr 2021

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A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

Sites in Chapel Hill, Winston-Salem +66 more locations

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting·Listed Jul 2024

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Maternal Newborn Health Registry

for Pregnancy Outcome Trends in Low-resource Geographic Areas

Sites in Chapel Hill +7 more locations

Sponsor: NICHD Global Network for Women's and Children's Health

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01073475·Recruiting·Listed Feb 2010

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Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL

for PTCL

Sites in Durham +5 more locations

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT04747236·Phase 2·Recruiting·Listed Feb 2021

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Evaluating the Effect of Surgical Drain Securement on Patient Quality of Life and Postoperative Drain-related Complications

for Surgical Drain

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06916286·Recruiting·Listed Apr 2025

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Epidermal Sensors for Wireless and Enhanced Amputee Skin Tracking (E-SWEAT) Part 1

for Transtibial Amputation

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 75

Code: NCT07216183·Phase 1·Recruiting·Listed Oct 2025

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Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial

for Lipid Disorder

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 40 - 75

Code: NCT06488105·Phase 2·Recruiting·Listed Jul 2024

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Optimization of Postoperative Bowel Habits

for Constipation

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT06335797·Recruiting·Listed Mar 2024

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Autologous Muscle Fiber Fragment Injections

for Fecal Incontinence

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05396456·Recruiting·Listed May 2022

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NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks

for Overweight or Obesity

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18 - 39·Accepts healthy volunteers

Code: NCT05674799·Recruiting·Listed Jan 2023

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Concentration of n-3 PUFA Monohydroxylated Derivatives in Adults With Obesity After n-3 PUFA Supplementation.

for Obesity

1 location in Kannapolis

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 45 - 60

Code: NCT06991296·Recruiting·Listed May 2025

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A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

for Metastatic Breast Cancer

Sites in Chapel Hill +11 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06099769·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

SEVENFACT® for Bleeding Events in Hemophilia With Inhibitors

for Hemophilia A With Inhibitor

Sites in Greenville +16 more locations

Sponsor: American Thrombosis and Hemostasis Network

Sex: All·Age: 12 - 100

Code: NCT04647227·Phase 4·Recruiting·Listed Nov 2020

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129 Xenon Imaging in Patients Treated With Sotatercept

for Pulmonary Hypertension

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18 - 75

Code: NCT06351345·Phase 2·Recruiting·Listed Apr 2024

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Pulmonary Hypertension SOLAR

for Interstitial Lung Disease

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18+

Code: NCT04778046·Phase 2·Recruiting·Listed Mar 2021

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129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

for Pulmonary Arterial Hypertension

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18 - 75

Code: NCT06104228·Phase 2·Recruiting·Listed Oct 2023

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Winston-Salem, Charlotte +39 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

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Physical Activity and Community EmPOWERment Project

for Intellectual Disability

Sites in Chapel Hill +1 more location

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06740162·Recruiting·Listed Dec 2024

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Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

for Sickle Cell Trait

Sites in Durham, Chapel Hill +8 more locations

Sponsor: National Alliance for Sickle Cell Centers

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06071377·Recruiting·Listed Oct 2023

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TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

for BRCA1 Gene Mutation

Sites in Durham +10 more locations

Sponsor: University Medical Center Nijmegen

Sex: Female·Age: 25 - 50

Code: NCT04294927·Recruiting·Listed Mar 2020

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A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

for Advanced Pancreatic Carcinoma

Sites in Charlotte, Raleigh +107 more locations

Sponsor: Sameek Roychowdhury

Sex: All·Age: 18+

Code: NCT06906562·Phase 2·Recruiting·Listed Apr 2025

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Integrating Biological, Clinical, and Behavioral Factors to Improve Breast Cancer Outcomes - Carolina Breast Cancer Study

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 20 - 74

Code: NCT07214610·Recruiting·Listed Oct 2025

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A Mobile Intervention to Reduce Pain and Improve Health-III

for Chronic Pain

1 location in Winston-Salem

Sponsor: Wake Forest University

Sex: All·Age: 65+

Code: NCT06623669·Phase 2·Recruiting·Listed Oct 2024

Apply to this trial