Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,944 clinical trials

↓ Download CSV

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

for Advanced Solid Tumor

10 locations incl. Denver

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06120283·Phase 1·Recruiting

Apply to this trial

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

for NASH With Fibrosis

Drug: Efruxifermin

205 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06215716·Phase 3·Recruiting

Apply to this trial

GWICTIC: NAC Mechanistic Study in Gulf War Veterans

for Gulf War Syndrome

7 locations incl. Palo Alto

Sponsor: Nova Southeastern University

Sex: All·Age: 47 - 70

Code: NCT04987775·EARLY_Phase 1·Recruiting

Apply to this trial

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

for B Acute Lymphoblastic Leukemia Associated With Down Syndrome

69 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 6 - 39

Code: NCT05702645·Recruiting

Apply to this trial

Hyperpolarized 129Xe MRI Lung Health Cohort

for Healthy

6 locations incl. Chicago

Sponsor: University of Kansas Medical Center

Sex: All·Age: 25 - 35

Code: NCT05766384·Recruiting

Apply to this trial

The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

51 locations incl. Birmingham

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting

Apply to this trial

Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)

for Soft Tissue Sarcoma

26 locations incl. Phoenix

Sponsor: Polaris Group

Sex: All·Age: 18 - 99

Code: NCT05712694·Phase 3·Recruiting

Apply to this trial

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

for Heart Failure NYHA Class II

47 locations incl. Phoenix

Sponsor: Endotronix, Inc.

Sex: All·Age: 18+

Code: NCT05934487·Recruiting

Apply to this trial

Oxygen Toxicity: Mechanisms in Humans

for Oxygen Toxicity

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05761756·Recruiting

Apply to this trial

Evaluation of the GORE® Ascending Stent Graft

for Aortic Aneurysm, Thoracic

41 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT05800743·Enrolling By Invitation

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

for Lung Cancer Diagnosis

36 locations incl. Los Angeles

Sponsor: Freenome Holdings Inc.

Sex: All·Age: 50+

Code: NCT06122077·Recruiting

Apply to this trial

Integrating Biological, Clinical, and Behavioral Factors to Improve Breast Cancer Outcomes - Carolina Breast Cancer Study

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 20 - 74

Code: NCT07214610·Recruiting

Apply to this trial

Prehospital Analgesia INtervention Trial (PAIN)

for Traumatic Injury

11 locations incl. San Diego

Sponsor: Jason Sperry

Sex: All·Age: 18+

Code: NCT05437575·Phase 3·Recruiting

Apply to this trial

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

for Anatomic Stage II Breast Cancer AJCC v8

Drug: Durvalumab

539 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06058377·Phase 3·Recruiting

Apply to this trial

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

for Aortic Valve Insufficiency

32 locations incl. Newport Beach

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT05172973·Recruiting

Apply to this trial

uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

22 locations incl. Santa Monica

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting

Apply to this trial

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

for Obesity

49 locations incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT06143956·Phase 2·Recruiting

Apply to this trial

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

for Non-Small Cell Lung Cancer (NSCLC)

Drug: Sotorasib

21 locations incl. Santa Barbara

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT05920356·Phase 3·Recruiting

Apply to this trial

Safety and Effectiveness of the Yaari Extractor for Management of Shoulder Dystocia

for Shoulder Dystocia

4 locations incl. Miami

Sponsor: FetalEase Ltd.

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05913609·Recruiting

Apply to this trial

Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.

for Sciatica Acute

24 locations incl. Auburn

Sponsor: Primus Pharmaceuticals

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06157177·Phase 4·Recruiting

Apply to this trial

Improving Thoracic Surgical Care Using Electronic Patient-Reported Outcomes (ePROS)

for Thoracic

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT06075316·Recruiting

Apply to this trial

Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

16 locations incl. Birmingham

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting

Apply to this trial

A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis

for Pulmonary Sarcoidosis

17 locations incl. Birmingham

Sponsor: Xentria, Inc.

Sex: All·Age: 18 - 80

Code: NCT05890729·Phase 1, Phase 2·Recruiting

Apply to this trial

LATe Cerclage in High-risk Pregnancies (LATCH)

for Premature Birth

2 locations incl. Charlotte

Sponsor: Thomas Jefferson University

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06036446·Recruiting

Apply to this trial

Mavacamten Pregnancy Surveillance Program

for Breastfeeding

Drug: Mavacamten

1 location in Wilmington

Sponsor: Bristol-Myers Squibb

Sex: Female·Age: 15+

Code: NCT05939700·Recruiting

Apply to this trial

GRID Therapy for Extremity Soft Tissue Sarcoma

for Sarcoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06073067·Recruiting

Apply to this trial

Pulmonary Hypertension SOLAR

for Interstitial Lung Disease

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18+

Code: NCT04778046·Phase 2·Recruiting

Apply to this trial

Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

for Cancer

17 locations incl. San Francisco

Sponsor: MBrace Therapeutics

Sex: All·Age: 18+

Code: NCT06014658·Phase 1, Phase 2·Recruiting

Apply to this trial

JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

for Advanced Solid Tumor

10 locations incl. Encinitas

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06108050·Phase 1·Recruiting

Apply to this trial

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart Failure

31 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 40 - 85

Code: NCT06122779·Phase 2·Recruiting

Apply to this trial

Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)

for Ileal Pouch

8 locations incl. Los Angeles

Sponsor: Exegi Pharma, LLC

Sex: All·Age: 18+

Code: NCT05938465·Phase 1, Phase 2·Recruiting

Apply to this trial

The Care Tracker Study: Using Patient-Reported Data to Address Racial Disparity in Cancer Treatment

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06096623·Recruiting

Apply to this trial

Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

for Carcinoma, Hepatocellular

34 locations incl. Birmingham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 75

Code: NCT05486572·Recruiting

Apply to this trial

Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

for Neuromyelitis Optica

10 locations incl. Los Angeles

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT05566769·Recruiting

Apply to this trial

TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II

for Lymphoblastic Leukemia

17 locations incl. Phoenix

Sponsor: Tanja Andrea Gruber

Sex: All·Age: Up to 1

Code: NCT05848687·Phase 1, Phase 2·Recruiting

Apply to this trial

Community Health Worker Based Intervention to Improve Palliative Care

for Cancer

4 locations incl. Birmingham

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05407844·Enrolling By Invitation

Detection and Risk Stratification in Veterans Presenting With Microscopic Hematuria

for Urothelial Carcinoma

4 locations incl. Murrieta

Sponsor: Pacific Edge Limited

Sex: All·Age: 18 - 89

Code: NCT05889195·Recruiting

Apply to this trial

Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy

for Becker Muscular Dystrophy

24 locations incl. Little Rock

Sponsor: Edgewise Therapeutics, Inc.

Sex: Male·Age: All ages

Code: NCT06066580·Phase 2·Enrolling By Invitation

Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel

for Bowel

33 locations incl. Scottsdale

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561127·Phase 3·Recruiting

Apply to this trial

Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

for Relapsed/Refractory Multiple Myeloma

10 locations incl. Palo Alto

Sponsor: Ichnos Sciences SA

Sex: All·Age: 18+

Code: NCT05862012·Phase 1·Recruiting

Apply to this trial