Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Study of Trilaciclib and Lurbinectidin

for Lung Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05578326·Phase 2·Recruiting·Listed Oct 2022

Apply to this trial

Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

for Sarcoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05743426·Recruiting·Listed Feb 2023

Apply to this trial

American Lung Association (ALA) Lung Health Cohort

for Lung Diseases

Sites in Durham, Winston-Salem +28 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT04543461·Recruiting·Listed Sep 2020

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Wake Forest Alzheimer's Disease Clinical Core

for Alzheimer's Disease

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT03140865·Recruiting·Listed May 2017

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Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

for Neuroblastoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 Months+

Code: NCT03721068·Phase 1·Recruiting·Listed Oct 2018

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Muscle Fiber Fragments for Improved Function of Rotator Cuff Musculature Following Rotator Cuff Repair

for Rotator Cuff

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 40 - 80

Code: NCT03752034·Recruiting·Listed Nov 2018

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Predictors of Pain in Sickle Cell Disease

for Sickle Cell Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 15 - 40

Code: NCT06139510·Recruiting·Listed Nov 2023

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Advancing Pediatric Retinal Imaging With Auto-aligned OCT

for Eye Diseases

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 1 Month+·Accepts healthy volunteers

Code: NCT06841575·Recruiting·Listed Feb 2025

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Transforming Hemodialysis-Related Vascular Access Education

for Chronic Kidney Disease

Sites in Chapel Hill +2 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05997875·Recruiting·Listed Aug 2023

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A Pragmatic Rehabilitation Intervention: The Active Rehab Study

for Concussion, Brain

2 locations in Fort Liberty

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT05320822·Recruiting·Listed Apr 2022

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Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

for Pancreatic Ductal Adenocarcinoma

Sites in Chapel Hill +4 more locations

Sponsor: Gulam Manji

Sex: All·Age: 18+

Code: NCT06048484·Phase 2·Recruiting·Listed Sep 2023

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Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

for Tourniquet Hypertension

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT04454203·Phase 4·Recruiting·Listed Jul 2020

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Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation

for Kidney Transplant

Sites in Durham +14 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT05917522·Phase 2·Recruiting·Listed Jun 2023

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

Sites in Durham, Greenville +33 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting·Listed Aug 2019

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Repurposing Tilmanocept for Cardiac Sarcoidosis

for Cardiac Sarcoidosis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07159074·Phase 2·Recruiting·Listed Sep 2025

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Intra-abdominal Pressure (IAP) During PFA Treatment of A-fib/ A-Flutter

for Intra-Abdominal Hypertension

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06876896·Recruiting·Listed Mar 2025

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Immersive Physical Therapy in the Neonatal Intensive Care Unit (NICU)

for Physical Therapy

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 0 - 99

Code: NCT06927037·Recruiting·Listed Apr 2025

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Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement

for Posttraumatic Stress Disorder

Sites in Durham +2 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05267665·Recruiting·Listed Mar 2022

Apply to this trial

Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis

for Rheumatoid Arthritis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06841562·Recruiting·Listed Feb 2025

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Timing of Physician Rounds for Antepartum Patients

for Physician Rounds

2 locations in Durham

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT07215507·Recruiting·Listed Oct 2025

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Collection and Storage of Tissue Samples From Patients Undergoing Surgery For Suspected Solid Tumors

for Unspecified Adult Solid Tumor, Protocol Specific

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 120

Code: NCT00900471·Recruiting·Listed May 2009

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Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study

for Preoperative Care

Sites in Winston-Salem +4 more locations

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 45+

Code: NCT04973397·Recruiting·Listed Jul 2021

Apply to this trial

Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

for Lung Neoplasm

Sites in Durham +13 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT02984761·Recruiting·Listed Dec 2016

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STRW-T Intervention for Autistic Adolescents in 11th and 12th Grade

for Autism Spectrum Disorder

Sites in Carrboro +1 more location

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 15 - 21

Code: NCT06552286·Recruiting·Listed Aug 2024

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Optimizing Timing of Cesarean Delivery Consent on Labor and Delivery

for Pregnancy

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT07117708·Recruiting·Listed Aug 2025

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Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery

for Adult Spinal Deformity

Sites in Durham +10 more locations

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04885244·Recruiting·Listed May 2021

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Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients

for Adult Spinal Deformity

Sites in Durham +7 more locations

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04888104·Recruiting·Listed May 2021

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Optimal Ventilation for Cardiac Arrest

for Cardiac Arrest (CA)

Sites in Chapel Hill +19 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 37 Weeks - 18

Code: NCT07114510·Recruiting·Listed Aug 2025

Apply to this trial

Engage Psychosocial Intervention for Cancer Symptoms

for Advanced Breast Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06555588·Recruiting·Listed Aug 2024

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Post-Operative Cesarean Section Cosmesis

for Cesarean Delivery

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18 - 44·Accepts healthy volunteers

Code: NCT06412978·Recruiting·Listed May 2024

Apply to this trial

Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation

for Cardiac Rehabilitation

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07214350·Recruiting·Listed Oct 2025

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Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

for Sickle Cell Disease

Sites in Durham +5 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 15 - 40

Code: NCT06260891·Phase 2·Recruiting·Listed Feb 2024

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Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children

for Respiratory Syncytial Virus Infections

Sites in Chapel Hill +14 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 3 Days - 2

Code: NCT05026749·Phase 3·Recruiting·Listed Aug 2021

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Use of an Integrated Orthotic and Rehabilitation Initiative for Treatment of Lower Extremity Musculoskeletal Disorders

for Musculoskeletal Injury

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05780502·Recruiting·Listed Mar 2023

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Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures

for Depression in Old Age

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65+

Code: NCT05851898·Phase 4·Recruiting·Listed May 2023

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Biomarker Directed Trial of Temozolomide and Stenoparib in Relapsed SCLC

for Relapsed Small Cell Lung Cancer

Sites in Salisbury +10 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06681220·Phase 1, Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

for Gram-negative Bacteremia

Sites in Durham +10 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06080698·Recruiting·Listed Oct 2023

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Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease

for Sickle Cell Disease

Sites in Charlotte +4 more locations

Sponsor: Robert Nickel

Sex: All·Age: 2 - 25

Code: NCT03587272·Phase 2·Recruiting·Listed Jul 2018

Apply to this trial

Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

for Estrogen Receptor Negative

Sites in Charlotte +5 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 30+

Code: NCT02945579·Recruiting·Listed Oct 2016

Apply to this trial

Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit

for Depression

Sites in Winston-Salem & Greenville

Sponsor: East Carolina University

Sex: All·Age: 15 - 39

Code: NCT07173205·Recruiting·Listed Sep 2025

Apply to this trial