Paid Clinical Trials in North Carolina

North Carolina has 2,939 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,939 clinical trials

↓ Download CSV

Efficacy and Safety of Ribupatide (KAI-9531) Administered Once Weekly in Participants Living With Obesity Who Do Not Have Diabetes

for Obesity

35 locations incl. Mesa

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07458269·Phase 2·Enrolling By Invitation

Intra-abdominal Pressure (IAP) During PFA Treatment of A-fib/ A-Flutter

for Intra-Abdominal Hypertension

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06876896·Recruiting

Apply to this trial

A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

for Clinical High Risk for Psychosis (CHR)

15 locations incl. Irvine

Sponsor: Monument Therapeutics Limited

Sex: All·Age: 17 - 30

Code: NCT07226895·Phase 1, Phase 2·Recruiting

Apply to this trial

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

for Pulmonary Hypertension Associated With HFpEF

18 locations incl. Alexander City

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT07288398·Phase 3·Recruiting

Apply to this trial

GORE® TAG® Thoracic Branch Endoprosthesis Zone 0/1 Post-Approval Study

for Aortic Arch Dissection

6 locations incl. Gainesville

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT07166133·Recruiting

Apply to this trial

Automated Applanation Tonometry - Updated

for Glaucoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07298356·Recruiting

Apply to this trial

A Mobile Text Approach to Measurement and Feedback for Wraparound Care Coordination

for Mental Health Services

1 location in Durham

Sponsor: 3-C Institute for Social Development

Sex: All·Age: 8+

Code: NCT07300930·Not Yet Recruiting

Adolescent Mental Health Parenting Program for Child-Adult Relationship Enhancement

for Adolescent Behavior

2 locations incl. Cary

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07303062·Not Yet Recruiting

Tirzepatide in Idiopathic Intracranial Hypertension Trial

for Idiopathic Intracranial Hypertension (IIH)

Drug: Tirzepatide

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 60

Code: NCT07191873·Phase 4·Not Yet Recruiting

A Usability Study of a Multi-channel ECG Monitoring Device

for Healthy Adult Participants

1 location in New London

Sponsor: Wearlinq

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07388355·Not Yet Recruiting

BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline Phase II Aim 4

for Sarcopenia

2 locations incl. Chapel Hill

Sponsor: SynchroHealth LLC

Sex: All·Age: 65+

Code: NCT07421648·Not Yet Recruiting

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

for Gonorrhea

13 locations incl. Los Angeles

Sponsor: Westat

Sex: Female·Age: 13 - 29

Code: NCT06738407·Phase 4·Recruiting

Apply to this trial

A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)

for Liver Cirrhosis

Drug: BI 3802876

26 locations incl. Chandler

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18 - 75

Code: NCT07325526·Phase 2·Recruiting

Apply to this trial

An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

for Stomatitis

20 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07357597·Phase 4·Not Yet Recruiting

PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07069595·Phase 2·Recruiting

Apply to this trial

Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)

for Schizophrenia

Drug: KarXT

45 locations incl. Bryant

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07379827·Recruiting

Apply to this trial

A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations

for Parkinson Disease

25 locations incl. Little Rock

Sponsor: Appello Pharmaceuticals, Inc.

Sex: All·Age: 30 - 80

Code: NCT07432958·Phase 2·Recruiting

Apply to this trial

Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

for COPD

10 locations incl. Birmingham

Sponsor: Nuvaira, Inc.

Sex: All·Age: 40 - 80

Code: NCT07051707·Recruiting

Apply to this trial

Neural Mechanisms of Light Driven Analgesia

for Musculoskeletal Pain

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07245303·Recruiting

Apply to this trial

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

for Obesity

Drug: NNC0487-0111

22 locations incl. Miramar

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07339423·Phase 3·Recruiting

Apply to this trial

A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)

for Obesity

35 locations incl. Anaheim

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07400653·Phase 3·Recruiting

Apply to this trial

Biomarker Directed Trial of Temozolomide and Stenoparib in Relapsed SCLC

for Relapsed Small Cell Lung Cancer

11 locations incl. Palo Alto

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06681220·Phase 1, Phase 2·Recruiting

Apply to this trial

PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

for Bronchopulmonary Dysplasia (BPD)

5 locations incl. Little Rock

Sponsor: Duke University

Sex: All·Age: 7 Days - 28 Days

Code: NCT07101640·Phase 1, Phase 2·Recruiting

Apply to this trial

Nalmefene Implant in Healthy Subjects

for Opioid Abuse and Addiction

1 location in Morrisville

Sponsor: ReacX Pharmaceuticals, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07325279·Phase 1·Recruiting

Apply to this trial

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

for Relapsed Refractory Multiple Myeloma

48 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07391657·Phase 3·Recruiting

Apply to this trial

A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

for Metastatic Castration-Resistant Prostate Cancer

20 locations incl. Goodyear

Sponsor: Kyntra Bio

Sex: Male·Age: 18+

Code: NCT06842498·Phase 2·Recruiting

Apply to this trial

Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer

for Locally Advanced Adrenal Cortical Carcinoma

Drug: Cabozantinib

69 locations incl. La Jolla

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT06900595·Phase 2·Recruiting

Apply to this trial

A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults

for Stargardt Disease

8 locations incl. Phoenix

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 6+

Code: NCT07425574·Recruiting

Apply to this trial

AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction

for Corneal Edema

12 locations incl. Mesa

Sponsor: Aurion Biotech

Sex: All·Age: 18+

Code: NCT07368959·Phase 3·Recruiting

Apply to this trial

Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

for Trauma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 45+

Code: NCT06521086·Recruiting

Apply to this trial

A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)

for Active Rheumatoid Arthritis

22 locations incl. Gilbert

Sponsor: Elevara Medicines Limited

Sex: All·Age: 18 - 75

Code: NCT07409103·Phase 2·Recruiting

Apply to this trial

A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

for Moderate to Severe Glabellar Lines

41 locations incl. Los Angeles

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT07435428·Phase 3·Recruiting

Apply to this trial

Connectomic Guided DBS for Parkinson's Disease

for Parkinson Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06618157·Enrolling By Invitation

A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)

for Focal Segmental Glomerulosclerosis

65 locations incl. Alabaster

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07220083·Phase 3·Recruiting

Apply to this trial

Sugary Drink Labeling Study

for Health Behavior

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07294053·Recruiting

Apply to this trial

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

for Breast Cancer

2 locations incl. Rochester

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07340541·Phase 2·Recruiting

Apply to this trial

Impacts of Sugar Warnings on Weight Bias

for Nutrition

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07346001·Recruiting

Apply to this trial

COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

50 locations incl. Bakersfield

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449936·Phase 3·Recruiting

Apply to this trial

Ultrasound Imaging of the Head, Neck, and Airway

for Healthy

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07406061·Not Yet Recruiting

Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

for Sickle Cell Disease

6 locations incl. Oakland

Sponsor: University of California, San Francisco

Sex: All·Age: 15 - 40

Code: NCT06260891·Phase 2·Recruiting

Apply to this trial