Paid Clinical Trials in North Carolina

North Carolina has 2,812 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,435 clinical trials

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

for Aortic Stenosis

Sites in Winston-Salem +70 more locations

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18 - 105

Code: NCT06777368·Recruiting·Listed Jan 2025

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Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

for Cutaneous Squamous Cell Carcinoma (CSCC)

Drug: Cemiplimab

Sites in Chapel Hill +43 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06585410·Phase 3·Recruiting·Listed Sep 2024

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Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

for Metastatic Non Small Cell Lung Cancer

Sites in Chapel Hill +20 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT04614103·Phase 2·Recruiting·Listed Nov 2020

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Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)

for Liver Neoplasms

Sites in Winston-Salem +26 more locations

Sponsor: HistoSonics, Inc.

Sex: All·Age: 22+

Code: NCT06486454·Recruiting·Listed Jul 2024

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JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

for Carcinoma, Squamous Cell

Sites in Chapel Hill, Charlotte +20 more locations

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 60+

Code: NCT04892173·Phase 3·Recruiting·Listed May 2021

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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

for Psychosis Associated With Alzheimer's Disease

Drug: KarXT

Sites in Greensboro, Morehead City +84 more locations

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 55 - 90

Code: NCT05980949·Phase 3·Recruiting·Listed Aug 2023

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Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

for Metastatic Breast Cancer

Sites in Durham +30 more locations

Sponsor: LeonaBio

Sex: All·Age: 18+

Code: NCT05696626·Phase 3·Recruiting·Listed Jan 2023

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A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

for Lupus Erythematosus, Systemic

Drug: BMS-986353

Sites in Charlotte +39 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 16+

Code: NCT07015983·Phase 2·Recruiting·Listed Jun 2025

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A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

for Dravet Syndrome

Sites in Durham, Winston-Salem +17 more locations

Sponsor: Epygenix

Sex: All·Age: 2+

Code: NCT04462770·Phase 3·Recruiting·Listed Jul 2020

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ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

for Aortic Valve Insufficiency

Sites in Charlotte +31 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT05172973·Recruiting·Listed Dec 2021

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ELEVATE-HFpEF Clinical Study

for Heart Failure With Preserved Ejection Fraction (HFpEF)

Sites in Durham +25 more locations

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Sex: All·Age: 40+

Code: NCT06678841·Recruiting·Listed Nov 2024

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The THOR IDE Study

for Peripheral Artery Disease

Sites in Cary +28 more locations

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT05916950·Recruiting·Listed Jun 2023

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Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

for Relapsing Multiple Sclerosis

Drug: Remibrutinib

Sites in Raleigh +39 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 40 - 70

Code: NCT06846281·Phase 3·Recruiting·Listed Feb 2025

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Tracking Results of Ablations to Combat AF Registry Generation 2

for Atrial Fibrillation

Sites in Winston-Salem +25 more locations

Sponsor: AtriCure, Inc.

Sex: All·Age: 18+

Code: NCT05111015·Recruiting·Listed Nov 2021

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PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

for Heart Failure NYHA Class II

Sites in Durham +44 more locations

Sponsor: Endotronix, Inc.

Sex: All·Age: 18+

Code: NCT05934487·Recruiting·Listed Jul 2023

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SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

for Melanoma, Cutaneous Malignant

Sites in Chapel Hill +36 more locations

Sponsor: Immatics US, Inc.

Sex: All·Age: 18+

Code: NCT06743126·Phase 3·Recruiting·Listed Dec 2024

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LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

for Metastatic Non-small Cell Lung Cancer

Sites in Cary +36 more locations

Sponsor: NovoCure GmbH

Sex: All·Age: 18+

Code: NCT06216301·Phase 3·Recruiting·Listed Jan 2024

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Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

for Platinum-resistant Ovarian Cancer

Drug: Bevacizumab

Sites in Charlotte, Greenville +30 more locations

Sponsor: Genelux Corporation

Sex: Female·Age: 18+

Code: NCT05281471·Phase 3·Recruiting·Listed Mar 2022

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Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System

for Pulmonary Embolism

Sites in Raleigh +54 more locations

Sponsor: Penumbra Inc.

Sex: All·Age: 18+

Code: NCT04798261·Recruiting·Listed Mar 2021

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DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

for Pulmonary Hypertension Due to Lung Diseases and Hypoxia

Sites in Durham, Chapel Hill +64 more locations

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT06388421·Recruiting·Listed Apr 2024

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A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

for Alzheimer Disease

Drug: KarXT

Sites in Morehead City +47 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 55 - 90

Code: NCT06937229·Phase 3·Recruiting·Listed Apr 2025

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Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))

for Mesial Temporal Lobe Epilepsy

Sites in Durham, Winston-Salem +33 more locations

Sponsor: Neurona Therapeutics

Sex: All·Age: 18 - 75

Code: NCT05135091·Phase 3·Recruiting·Listed Nov 2021

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A Phase 1/1b Study of IAM1363 in HER2 Cancers

for HER2 Mutation-Related Tumors

Sites in Durham +28 more locations

Sponsor: Iambic Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06253871·Phase 1·Recruiting·Listed Feb 2024

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ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

for Autosomal Dominant Polycystic Kidney Disease

Sites in Chapel Hill, Winston-Salem +33 more locations

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18 - 55

Code: NCT06902558·Phase 2·Recruiting·Listed Mar 2025

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A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

for Sickle Cell Disease

Drug: Etavopivat

Sites in Durham, Winston-Salem +43 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 12+

Code: NCT06612268·Phase 3·Recruiting·Listed Sep 2024

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Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

for Lewy Body Dementia Psychosis

Sites in Chapel Hill +26 more locations

Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All·Age: 55 - 84

Code: NCT07029581·Phase 2·Recruiting·Listed Jun 2025

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RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

for Adjustment Disorder

Sites in Chapel Hill +29 more locations

Sponsor: Reunion Neuroscience Inc

Sex: All·Age: 18 - 80

Code: NCT07002034·Phase 2·Recruiting·Listed Jun 2025

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Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

for Prostate Cancer

Sites in Durham, Winston-Salem +21 more locations

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT04221542·Phase 1·Recruiting·Listed Jan 2020

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A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction

for Lung Transplant Rejection

Sites in Durham +31 more locations

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06082037·Phase 3·Recruiting·Listed Oct 2023

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TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

for Transthyretin Amyloidosis With Cardiomyopathy

Drug: Nucresiran

Sites in Charlotte +39 more locations

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT07052903·Phase 3·Recruiting·Listed Jul 2025

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Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

for Open Midline Laparotomy

Sites in Wilmington +10 more locations

Sponsor: C. R. Bard

Sex: All·Age: 18+

Code: NCT03911700·Recruiting·Listed Apr 2019

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Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib

for Alopecia Areata

Drug: Ritlecitinib

Sites in Hickory +25 more locations

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06531109·Recruiting·Listed Jul 2024

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Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma

for Relapsed Non-Hodgkin Lymphoma

Sites in Winston-Salem +31 more locations

Sponsor: Lyell Immunopharma, Inc.

Sex: All·Age: 18+

Code: NCT05826535·Phase 1, Phase 2·Recruiting·Listed Apr 2023

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A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

for Sickle Cell Disease

Drug: Etavopivat

Sites in Durham, Winston-Salem +21 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 2+

Code: NCT06609226·Phase 3·Recruiting·Listed Sep 2024

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A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

for Episodic Migraine

Drug: Atogepant

Sites in Greensboro +31 more locations

Sponsor: AbbVie

Sex: All·Age: 6 - 17

Code: NCT05711394·Phase 3·Recruiting·Listed Feb 2023

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A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

for Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)

Drug: Rituximab

Sites in Durham, Charlotte +18 more locations

Sponsor: Pierre Fabre Medicament

Sex: All·Age: All ages

Code: NCT03394365·Phase 3·Recruiting·Listed Jan 2018

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A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

for Lower Extremity Acute Limb Ischemia

Sites in Chapel Hill, Raleigh +29 more locations

Sponsor: Penumbra Inc.

Sex: All·Age: 18+

Code: NCT06747117·Recruiting·Listed Dec 2024

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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

for Pulmonary Hypertension

Sites in Winston-Salem +29 more locations

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06911632·Recruiting·Listed Apr 2025

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A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC

for Adenocarcinoma, Pancreatic Ductal

Drug: Atezolizumab

Sites in Durham +29 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT05968326·Phase 2·Recruiting·Listed Aug 2023

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A Study of Telitacicept for the Treatment of Generalized Myasthenia Gravis (UPSTREAM MG)

for Generalized Myasthenia Gravis

Drug: Telitacicept

Sites in Chapel Hill +25 more locations

Sponsor: Vor Biopharma

Sex: All·Age: 18+

Code: NCT06456580·Phase 3·Recruiting·Listed Jun 2024

Apply to this trial