Paid Clinical Trials in Newport Beach, CA

As of September 2026, 183 paid clinical trials are recruiting in Newport Beach, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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170 clinical trials

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Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers

for Metastatic Pancreatic Adenocarcinoma

Sites in Newport Beach, Irvine +20 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06524973·Recruiting·Listed Jul 2024

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Decolonization to Reduce After-Surgery Events of Surgical Site Infection

for Surgical Site Infection

Sites in Newport Beach, Orange +2 more locations

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT05586776·Phase 4·Recruiting·Listed Oct 2022

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Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for Anatomic Stage III Breast Cancer AJCC v8

Sites in Newport Beach, Los Angeles +5 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05372640·Phase 1·Recruiting·Listed May 2022

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Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

for Lung Non-Small Cell Carcinoma

Sites in Newport Beach, Irvine +11 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07288034·Phase 2·Recruiting·Listed Dec 2025

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Pancreatic Cancer Detection Consortium

for Pancreatic Cancer

Sites in Newport Beach, Monrovia +7 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06388967·Recruiting·Listed Apr 2024

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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

Sites in Newport Beach, Duarte +31 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Newport Beach, Irvine +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

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Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for Metastatic Malignant Neoplasm in the Liver

Sites in Newport Beach, Irvine +378 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05040360·Phase 2·Recruiting·Listed Sep 2021

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Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

for Recurrent Plasma Cell Myeloma

Sites in Newport Beach, Huntington Beach +6 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04508790·Phase 2·Recruiting·Listed Aug 2020

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Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

for Stage III Ovarian Cancer

Drug: Niraparib

Sites in Newport Beach, Duarte +57 more locations

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05659381·Phase 3·Recruiting·Listed Dec 2022

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S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

for Cardiotoxicity

Sites in Newport Beach, Torrance +142 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03418961·Phase 3·Recruiting·Listed Feb 2018

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A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients

for Multiple Myeloma

Sites in Newport Beach, Irvine +9 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07225738·Recruiting·Listed Nov 2025

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Newport Beach, Huntington Beach +338 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

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Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

for Grade 3b Follicular Lymphoma

Sites in Newport Beach, Huntington Beach +97 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05890352·Phase 2·Recruiting·Listed Jun 2023

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Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

for Aortic Aneurysm

Sites in Newport Beach, Sacramento +12 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04005976·Recruiting·Listed Jul 2019

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A Novel Multiplex ELISA Assay for Evaluating Patients With Microscopic Hematuria for Bladder Cancer

for Bladder Cancer

Sites in Newport Beach, Long Beach +4 more locations

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18 - 90

Code: NCT03193541·Recruiting·Listed Jun 2017

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A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis

for Breast Carcinoma

Sites in Newport Beach & Los Angeles

Sponsor: University of Southern California

Sex: Female·Age: 18+

Code: NCT06336928·Recruiting·Listed Mar 2024

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EndoPAT Device for Endothelial Dysfunction in ED

for Erectile Dysfunction

1 location in Newport Beach

Sponsor: University of California, Irvine

Sex: Male·Age: 18+

Code: NCT06720597·Recruiting·Listed Dec 2024

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Perioperative Mindfulness Proposal

for Breast Cancer

1 location in Newport Beach

Sponsor: Hoag Memorial Hospital Presbyterian

Sex: Female·Age: 18+

Code: NCT04049214·Recruiting·Listed Aug 2019

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A Study to Assess the Safety and Efficacy of AGN-151586 Injections for the Treatment of Moderate to Severe Forehead Lines (FHL) in Adult Participants

for Forehead Lines

Sites in Newport Beach +4 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07730554·Phase 2·Recruiting·Listed Jul 2026

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Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

for Lung Cancer Screening

Sites in Newport Beach, Costa Mesa +55 more locations

Sponsor: University of California, Irvine

Sex: All·Age: 50 - 80

Code: NCT07711691·Recruiting·Listed Jul 2026

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SLR-108 PET Imaging in Subjects With Metastatic Solid Tumors

for Metastatic Solid Tumors

1 location in Newport Beach

Sponsor: Solve Therapeutics

Sex: All·Age: 18+

Code: NCT07728942·Phase 1·Recruiting·Listed Jul 2026

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A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.

for Idiopathic Pulmonary Fibrosis (IPF)

Sites in Newport Beach, Los Angeles +33 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT07652658·Phase 2·Recruiting·Listed Jun 2026

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Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation

for Atrial Fibrillation (AF)

Sites in Newport Beach, Pasadena +30 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07626411·Phase 3·Recruiting·Listed Jun 2026

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AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

for Metastatic Castration-resistant Prostate Cancer

Sites in Newport Beach, Irvine +23 more locations

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT07611110·Phase 3·Recruiting·Listed May 2026

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FIBRONEER-ACT: A Study to Test Whether Nerandomilast Helps People With Fibrosing Interstitial Lung Disease at Risk for Disease Progression

for Interstitial Lung Diseases

Drug: Nerandomilast

Sites in Newport Beach, Los Angeles +29 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07540988·Phase 3·Recruiting·Listed Apr 2026

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A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma

for Asthma

Drug: Depemokimab

Sites in Newport Beach +15 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 12+

Code: NCT07456033·Phase 3·Recruiting·Listed Mar 2026

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IS-001 Injection in Patients Undergoing Robotic-Assisted Colorectal Surgery

for Ureter Injury

Sites in Newport Beach +8 more locations

Sponsor: Intuitive Surgical

Sex: All·Age: 16 - 75

Code: NCT07346066·Phase 3·Recruiting·Listed Jan 2026

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A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

for Sepsis

Sites in Newport Beach +13 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 80

Code: NCT07215702·Phase 2·Recruiting·Listed Oct 2025

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OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity

for Vision Loss Night

Sites in Newport Beach, Torrance +18 more locations

Sponsor: Ocuphire Pharma, Inc.

Sex: All·Age: 18+

Code: NCT07140783·Phase 3·Recruiting·Listed Aug 2025

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A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Newport Beach, Norco +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT07082738·Phase 2·Recruiting·Listed Jul 2025

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eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation

for Pulmonary Disease, Chronic Obstructive

Drug: Depemokimab

Sites in Newport Beach +41 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 40 - 75

Code: NCT07177339·Phase 3·Recruiting·Listed Sep 2025

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Newport Beach, Garden Grove +66 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting·Listed Mar 2025

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Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

for Advanced Breast Cancer

Drug: Camizestrant

Sites in Newport Beach, Fountain Valley +38 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06380751·Phase 3·Recruiting·Listed Apr 2024

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A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

for Cardiovascular Disease

Sites in Newport Beach, Fountain Valley +308 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07000357·Phase 3·Recruiting·Listed Jun 2025

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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for Non-small Cell Lung Cancer

Sites in Newport Beach, Duarte +17 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05877599·Phase 1·Recruiting·Listed May 2023

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Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

for Viral Lung Infection and Acute Respiratory Failure

Sites in Newport Beach, Torrance +34 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05624450·Phase 3·Recruiting·Listed Nov 2022

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A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

for COPD (Chronic Obstructive Pulmonary Disease)

Sites in Newport Beach, Garden Grove +132 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06283966·Phase 3·Recruiting·Listed Feb 2024

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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

Sites in Newport Beach, Duarte +16 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting·Listed Jan 2024

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Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

for Asthma

Sites in Newport Beach, Bakersfield +28 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT06932263·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial