Oncology Clinical Trials in Orange, CA

As of July 2026, 126 paid clinical trials are recruiting for Oncology in Orange, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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127 clinical trials for Oncology

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Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

for Non-Small Cell Lung Cancer (NSCLC)

Drug: daraxonrasib

Sites in Orange, Stanford +16 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06128551·Phase 1, Phase 2·Recruiting·Listed Nov 2023

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A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment

for Multiple Myeloma

Drug: Linvoseltamab

Sites in Orange, Los Angeles +11 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05828511·Phase 1, Phase 2·Recruiting·Listed Apr 2023

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A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sites in Orange, Los Angeles +16 more locations

Sponsor: Tvardi Therapeutics, Incorporated

Sex: All·Age: 18+

Code: NCT05440708·Phase 1, Phase 2·Recruiting·Listed Jul 2022

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A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

for Myelodysplastic Syndromes

Drug: Venetoclax

Sites in Orange, Los Angeles +20 more locations

Sponsor: Taiho Oncology, Inc.

Sex: All·Age: 18+

Code: NCT04256317·Phase 2, Phase 3·Recruiting·Listed Feb 2020

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Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

for Solid Tumor

Drug: Givastomig

Sites in Orange +5 more locations

Sponsor: I-Mab Biopharma US Limited

Sex: All·Age: 18+

Code: NCT04900818·Phase 1·Recruiting·Listed May 2021

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Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

Sites in Orange, Irvine +22 more locations

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting·Listed Aug 2023

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A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

for Hepatocellular Carcinoma

Drug: Livmoniplimab

Sites in Orange, Irvine +10 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06109272·Phase 2, Phase 3·Recruiting·Listed Oct 2023

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AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

for B-cell Malignancy

Sites in Orange +12 more locations

Sponsor: Carna Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05602363·Phase 1·Recruiting·Listed Nov 2022

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A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for Locally Advanced Solid Tumor

Sites in Orange, Palo Alto +17 more locations

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05118789·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

for Ovarian Cancer

Drug: Cemiplimab

Sites in Orange, Irvine +10 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT04590326·Phase 1, Phase 2·Recruiting·Listed Oct 2020

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Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

for AML (Acute Myeloid Leukemia)

Sites in Orange +1 more location

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07486713·Phase 4·Recruiting·Listed Mar 2026

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A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer (NSCLC)

Sites in Orange, Fullerton +7 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07140016·Phase 1·Recruiting·Listed Aug 2025

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A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

for Breast Cancer

Sites in Orange, Los Angeles +2 more locations

Sponsor: Hoffmann-La Roche

Sex: Female·Age: 18+

Code: NCT07054190·Phase 2·Recruiting·Listed Jul 2025

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A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma

for Multiple Myeloma

Sites in Orange +6 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06980480·Phase 3·Recruiting·Listed May 2025

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ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

for Hepatoblastoma

Sites in Orange, Los Angeles +2 more locations

Sponsor: Eureka Therapeutics Inc.

Sex: All·Age: 1 - 21

Code: NCT04634357·Phase 1, Phase 2·Recruiting·Listed Nov 2020

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Combination of TATE and PD-1 Inhibitor in Liver Cancer

for Hepatocellular Carcinoma

Sites in Orange +2 more locations

Sponsor: Teclison Ltd.

Sex: All·Age: 18 - 80

Code: NCT03259867·Phase 2·Recruiting·Listed Aug 2017

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A Study of VET3-TGI in Patients With Solid Tumors

for Solid Tumor, Adult

Sites in Orange, Los Angeles +5 more locations

Sponsor: KaliVir Immunotherapeutics

Sex: All·Age: 18+

Code: NCT06444815·Phase 1·Recruiting·Listed Jun 2024

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A Phase 1 Dose Escalation Study of ZG006 in Patients With Small Cell Lung Cancer

for Small Cell Lung Cancer

Sites in Orange +5 more locations

Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Sex: All·Age: 18 - 75

Code: NCT06592638·Phase 1·Recruiting·Listed Sep 2024

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64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

for Metastatic Sarcoma

Sites in Orange, Duarte +3 more locations

Sponsor: Lantheus Medical Imaging

Sex: All·Age: 15+

Code: NCT06298916·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study

for Cancer

Sites in Orange & Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07581080·Recruiting·Listed May 2026

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PhIbRandomGemcitabine(G)w/or w/Out Pitavastatin(P)MainTx UnresecPancreaticAdenocarcinoma(uPDAC)

for Pancreatic Cancer

1 location in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07549958·Phase 1·Recruiting·Listed Apr 2026

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Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

for Breast Cancer

1 location in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07447050·Phase 2·Recruiting·Listed Mar 2026

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Orange, Anaheim +1103 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

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Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

for Head and Neck Squamous Cell Carcinoma

Sites in Orange, Irvine +464 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

Sites in Orange, Anaheim +306 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020

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Mobile Health for Adherence in Breast Cancer Patients

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Orange, Anaheim +457 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06112613·Recruiting·Listed Nov 2023

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for Advanced Malignant Solid Neoplasm

Sites in Orange, Los Angeles +428 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT05564377·Phase 2·Recruiting·Listed Oct 2022

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E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

Sites in Orange, Anaheim +355 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024

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MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for Acute Myeloid Leukemia

Sites in Orange, Irvine +326 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05564390·Phase 2·Recruiting·Listed Oct 2022

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BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

for Clinical Stage III Cutaneous Melanoma AJCC v8

Drug: Cabozantinib

Sites in Orange, Irvine +204 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05136196·Phase 2·Recruiting·Listed Nov 2021

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Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for Metastatic Renal Cell Carcinoma

Sites in Orange, Irvine +278 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05327686·Phase 2·Recruiting·Listed Apr 2022

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Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

for Myelodysplastic Syndrome

Sites in Orange, Irvine +138 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06577441·Phase 2·Recruiting·Listed Aug 2024

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Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

for Prostate Adenocarcinoma

Sites in Orange, Irvine +397 more locations

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT05946213·Phase 3·Recruiting·Listed Jul 2023

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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Orange, Anaheim +255 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting·Listed Jul 2024

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Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

for B Acute Lymphoblastic Leukemia

Sites in Orange, Long Beach +186 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 25

Code: NCT03959085·Phase 3·Recruiting·Listed May 2019

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Orange, Duarte +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

Sites in Orange, Long Beach +169 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting·Listed Mar 2020

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The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

Sites in Orange, Long Beach +154 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

for Ganglioneuroblastoma, Nodular

Sites in Orange, Long Beach +151 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 30

Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

Sites in Orange, Irvine +101 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting·Listed Jan 2024

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Conditions in Oncology (Orange, CA)

Non-small cell lung cancer (NSCLC)· 22 Solid tumor· 14 Breast cancer· 12 Prostate cancer· 11 Pancreatic cancer· 10 Gastric cancer· 10 Liver cancer· 10 Acute myeloid leukemia (AML)· 9 Melanoma· 9 Ovarian cancer· 8 Head and neck cancer· 8 Cancer (any)· 8 Colorectal cancer· 7 Esophageal cancer· 7 Endometrial cancer· 7 Leukemia (other)· 6 Non-Hodgkin lymphoma· 6 Hematologic malignancy· 6 Biliary tract cancer· 5 Bladder cancer· 5 Myelodysplastic syndromes (MDS)· 5 Lung cancer· 4 Kidney cancer· 4 Chronic lymphocytic leukemia (CLL)· 4 Diffuse large B-cell lymphoma (DLBCL)· 4 Small lymphocytic lymphoma· 4 Metastatic breast cancer· 3 Triple-negative breast cancer· 3 Gastroesophageal junction cancer· 3 Cervical cancer· 3 Fallopian tube cancer· 3 Multiple myeloma· 3 Hodgkin lymphoma· 3 Follicular lymphoma· 3 Mantle cell lymphoma· 3 Sarcoma· 3 Neuroblastoma· 3 Small cell lung cancer· 2 Gynecologic cancer· 2 Glioblastoma· 2 Glioma· 2 Acute lymphoblastic leukemia· 2 Myelofibrosis· 2 Myeloproliferative neoplasm· 2 Marginal zone lymphoma· 2 Skin cancer· 2 Osteosarcoma· 2 Neuroendocrine tumors· 2 HER2-negative breast cancer· 1 Rectal cancer· 1 Gastrointestinal cancer· 1 Metastatic prostate cancer· 1 Brain cancer· 1 Chronic myelomonocytic leukemia· 1 Burkitt lymphoma· 1 Soft tissue sarcoma· 1 Ewing sarcoma· 1 Rhabdomyosarcoma· 1 Mesothelioma· 1