Non-small cell lung cancer (NSCLC) Clinical Trials in Orange, CA
As of August 2026, 22 paid clinical trials are recruiting for Non-small cell lung cancer (NSCLC) in Orange, California. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Related specialties in Orange
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22 clinical trials for Non-small cell lung cancer (NSCLC)
·Clear filters·A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)
A Study of VET3-TGI in Patients With Solid Tumors
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies
Assess Diversity of Gut Microbiome in Met NSCLC in Correlation to Tx & Adverse Effects
Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer
Top Research Study Locations in Orange
Researchers run research studies in Orange, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Children's Hospital of Orange County | B Acute Lymphoblastic Leukemia, Neuroblastoma, Acute Lymphoblastic Leukemia | 68 |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Metastatic Malignant Solid Neoplasm, Stage IV Colorectal Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 61 |
| University of California Irvine | Amyotrophic Lateral Sclerosis, Anticoagulants, Carcinoma, Non-Small-Cell Lung | 26 |
| University of California Irvine Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 20 |
| Chao Family Comprehensive Cancer Center, University of California, Irvine | Hepatocellular Carcinoma, Pancreatic Cancer, Peritoneal Carcinomatosis | 18 |
| University of California, Irvine | Myasthenia Gravis, Parkinson Disease, Acute Myeloid Leukemia (AML) | 17 |
| UC Irvine Health | Multiple Myeloma, B-cell Malignancy, Cachexia | 13 |
| UC Irvine Medical Center | Advanced Metastatic Castration Resistant Prostate Cancer, Atrial Fibrillation, Autosomal Dominant Polycystic Kidney Disease | 12 |
| NRC Research Institute | Bipolar Disorder, Bipolar I Disorder, Bipolar Depression | 10 |
| Chao Family Comprehensive Cancer Center University of California, Irvine | Melanoma (Skin), Cervical Cancer, Chronic Myeloid Leukemia | 8 |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center | Neoplasm Metastasis, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung | 8 |
| University of California, Irvine Medical Center | Cancer, Lung, Cardiovascular Diseases, Colorectal Cancer; Lung Cancer | 8 |
| ATP Clinical Research | Bipolar Disorder, Bipolar Depression, Bipolar I Disorder | 8 |
| Children's Hospital Orange County | ALL, AML, Acute Undifferentiated Leukemia | 7 |
| Saint Joseph Hospital - Orange | Advanced Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | 7 |
| UC Irvine Health - Chao Family Comprehensive Cancer Center | Gastric Cancer, Hepatocellular Carcinoma, Acute Myeloid Leukemia | 6 |
| Knowledge Research Center | Ankylosing Spondylitis, Autoimmune Diseases, Birdshot Chorioretinitis | 5 |
| UCI Health | Cancer, Crohn's Disease, Fatigue Related to Cancer Treatment | 5 |
| Chao Family Comprehensive Cancer Center | Chronic Lymphocytic Leukemia, Advanced Clear Cell Renal Cell Carcinoma, Endometrial Cancer | 4 |
| Chao Family Comprehensive Cancer Center, University of California Irvine | Allogeneic Stem Cell Transplantation, Breast Cancer, Colorectal Cancer | 4 |
| Children's Hospital of Orange County (CHOC) | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Anti-myostatin | 4 |
| Neurocrine Clinical Site | Major Depressive Disorder, Bipolar Disorder, Schizoaffective Disorder | 4 |
| UC Irvine | Autoimmune Encephalitis, Encephalitis, Overactive Bladder (OAB) | 4 |
| UCI Medical Center | Deep Venous Thrombosis, Locally Advanced Solid Tumor, Metastatic Solid Tumor | 4 |
| Center for Inherited Blood Disorders | Hemophilia A, Hemophilia B | 3 |
Active & Upcoming Studies in Orange (2026)
Recruiting trials in Orange grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (216 active studies)
- Testing the Effect of Teclistamab on Recurrent Plasmablastic Lymphoma · Phase 1 · National Cancer Institute (NCI)
- Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma · Phase 2 · National Cancer Institute (NCI)
Neurology & pain (19 active studies)
- A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE) · Phase 4 · Alpha Cognition, Inc
- Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study · University of California, Irvine
Cardiovascular (19 active studies)
- Optimal Ventilation for Cardiac Arrest · Children's Hospital of Philadelphia
- EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease · Phase 3 · Boehringer Ingelheim
Mental health & behavior (18 active studies)
- Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia · Phase 3 · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+) · University of California, Irvine
Diabetes & metabolic (13 active studies)
- EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease · Phase 3 · Boehringer Ingelheim
- Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity · Phase 3 · Amgen
Pediatric (7 active studies)
- Pediatric Down Syndrome Post-Approval Study · Inspire Medical Systems, Inc.
- Epilepsy Journey-An Executive Functioning Intervention for Teens With Epilepsy · Children's Hospital Medical Center, Cincinnati
Vaccines (2 active studies)
- Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS) · Children's Hospital of Orange County
- SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry · Massive Bio, Inc.
Eye & vision (2 active studies)
- A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy · Astellas Pharma Global Development, Inc.
- The Myelin Disorders Biorepository Project · Children's Hospital of Philadelphia
Common conditions studied in Orange
- Breast Cancer (10 active studies)
- Ovarian Cancer (9 active studies)
- Acute Myeloid Leukemia (8 active studies)
- Hepatocellular Carcinoma (8 active studies)
- Major Depressive Disorder (8 active studies)
- Endometrial Cancer (7 active studies)
Leading research sponsors in Orange
- University of California, Irvine
- National Cancer Institute (NCI)
- Children's Oncology Group
- NRG Oncology
- Alliance for Clinical Trials in Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Orange?
There are approximately 511 recruiting clinical trials in Orange, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Orange pay participants?
Most recruiting trials in Orange compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Orange?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Orange?
The most common conditions under active study in Orange include Breast Cancer (10), Ovarian Cancer (9), Acute Myeloid Leukemia (8), Hepatocellular Carcinoma (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Orange?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orange on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Orange?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Orange?
Recruiting research sites in Orange include Children's Hospital of Orange County, UC Irvine Health/Chao Family Comprehensive Cancer Center, University of California Irvine, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Orange right now?
The largest active categories in Orange are Cancer & tumors (216), Neurology & pain (19), Cardiovascular (19). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.