As of August 2026, 507 paid clinical trials are recruiting in Orange, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Orange offers studies at sites including Children's Hospital of Orange County for conditions such as Breast Cancer, Ovarian Cancer, Acute Myeloid Leukemia, Major Depressive Disorder. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Researchers run research studies in Orange, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Children's Hospital of Orange County | Recurrent Malignant Solid Neoplasm, B Acute Lymphoblastic Leukemia, Neuroblastoma | 72 |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Metastatic Malignant Solid Neoplasm, Stage IV Colorectal Cancer AJCC v8, Stage III Laryngeal Cancer AJCC v8 | 58 |
| University of California Irvine | Amyotrophic Lateral Sclerosis, Anticoagulants, Carcinoma, Non-Small-Cell Lung | 24 |
| University of California Irvine Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 19 |
| Chao Family Comprehensive Cancer Center, University of California, Irvine | Hepatocellular Carcinoma, Pancreatic Cancer, Peritoneal Carcinomatosis | 17 |
| University of California, Irvine | Myasthenia Gravis, Parkinson Disease, Acute Myeloid Leukemia (AML) | 17 |
| UC Irvine Health | Multiple Myeloma, B-cell Malignancy, Cachexia | 12 |
| UC Irvine Medical Center | Advanced Metastatic Castration Resistant Prostate Cancer, Atrial Fibrillation, Autosomal Dominant Polycystic Kidney Disease | 12 |
| NRC Research Institute | Bipolar Disorder, Bipolar I Disorder, Bipolar Depression | 9 |
| Chao Family Comprehensive Cancer Center University of California, Irvine | Melanoma (Skin), Cervical Cancer, Chronic Myeloid Leukemia | 8 |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center | Neoplasm Metastasis, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung | 8 |
| University of California, Irvine Medical Center | Cancer, Lung, Cardiovascular Diseases, Colorectal Cancer; Lung Cancer | 8 |
| ATP Clinical Research | Bipolar Disorder, Bipolar Depression, Bipolar I Disorder | 8 |
| Children's Hospital Orange County | ALL, AML, Acute Undifferentiated Leukemia | 7 |
| Saint Joseph Hospital - Orange | Advanced Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | 7 |
| Knowledge Research Center | Ankylosing Spondylitis, Autoimmune Diseases, Birdshot Chorioretinitis | 5 |
| UC Irvine Health - Chao Family Comprehensive Cancer Center | Gastric Cancer, Acute Myeloid Leukemia, Breast Cancer, Metastatic | 5 |
| UCI Health | Cancer, Crohn's Disease, Fatigue Related to Cancer Treatment | 5 |
| Chao Family Comprehensive Cancer Center, University of California Irvine | Allogeneic Stem Cell Transplantation, Breast Cancer, Colorectal Cancer | 4 |
| Children's Hospital of Orange County (CHOC) | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Anti-myostatin | 4 |
| Neurocrine Clinical Site | Major Depressive Disorder, Bipolar Disorder, Schizoaffective Disorder | 4 |
| UC Irvine | Autoimmune Encephalitis, Encephalitis, Overactive Bladder (OAB) | 4 |
| UCI Medical Center | Deep Venous Thrombosis, Locally Advanced Solid Tumor, Metastatic Solid Tumor | 4 |
| Center for Inherited Blood Disorders | Hemophilia A, Hemophilia B | 3 |
| Chao Family Comprehensive Cancer Center | Advanced Clear Cell Renal Cell Carcinoma, Chronic Lymphocytic Leukemia, Endometrial Cancer | 3 |
Recruiting trials in Orange grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 507 recruiting clinical trials in Orange, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Orange compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Orange include Breast Cancer (10), Ovarian Cancer (9), Acute Myeloid Leukemia (8), Major Depressive Disorder (8), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orange on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Orange include Children's Hospital of Orange County, UC Irvine Health/Chao Family Comprehensive Cancer Center, University of California Irvine, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Orange are Cancer & tumors (208), Mental health & behavior (19), Cardiovascular (19). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.