Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

for Refractory Cancer

Drug: Nivolumab

Sites in Philadelphia, Pittsburgh +11 more locations

Sponsor: Immatics US, Inc.

Sex: All·Age: 18+

Code: NCT03686124·Phase 1, Phase 2·Recruiting·Listed Sep 2018

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OssDsign® Spine Registry Study ("Propel")

for Degenerative Disc Disease

Sites in State College +7 more locations

Sponsor: OssDsign

Sex: All·Age: 21+

Code: NCT05329129·Recruiting·Listed Apr 2022

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Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

for Advanced Solid Tumor Cancer

Drug: ABBV-CLS-484

Sites in Philadelphia, Pittsburgh +11 more locations

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18+

Code: NCT04777994·Phase 1·Recruiting·Listed Mar 2021

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A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

for Melanoma

Drug: Cemiplimab

Sites in Pittsburgh +10 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06413680·Phase 1, Phase 2·Recruiting·Listed May 2024

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A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

for Solid Tumor

Sites in Philadelphia +14 more locations

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06586957·Phase 1·Recruiting·Listed Sep 2024

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An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

for Advanced Solid Tumors

Sites in Pittsburgh +9 more locations

Sponsor: Teva Branded Pharmaceutical Products R&D LLC

Sex: All·Age: 18+

Code: NCT06480552·Phase 1·Recruiting·Listed Jun 2024

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A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

for Pancreatic Ductal Adenocarcinoma

Sites in Philadelphia +12 more locations

Sponsor: Verastem, Inc.

Sex: All·Age: 18+

Code: NCT07020221·Phase 1, Phase 2·Recruiting·Listed Jun 2025

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A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815

for Advanced Cancer

Sites in Philadelphia +14 more locations

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05557045·Phase 1·Recruiting·Listed Sep 2022

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A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

for Crohn's Disease (CD)

Sites in Pittsburgh +14 more locations

Sponsor: Takeda

Sex: All·Age: 2 - 17

Code: NCT04779320·Phase 3·Recruiting·Listed Mar 2021

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ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

for Transthyretin-Mediated Amyloidosis

Sites in Philadelphia +11 more locations

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: All ages

Code: NCT04561518·Recruiting·Listed Sep 2020

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Acellular Dermal Matrix Investigation in Breast Reconstruction

for Breast Reconstruction

Sites in Philadelphia +12 more locations

Sponsor: RTI Surgical

Sex: Female·Age: 22+·Accepts healthy volunteers

Code: NCT06456554·Recruiting·Listed Jun 2024

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Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively

for Hemophilia A

Sites in Philadelphia +12 more locations

Sponsor: Pfizer

Sex: Male·Age: 18+

Code: NCT05568719·Phase 3·Recruiting·Listed Oct 2022

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Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma

for Advanced Or Metastatic Merkel Cell Carcinoma

Sites in Pittsburgh +17 more locations

Sponsor: TuHURA Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT06947928·Phase 2, Phase 3·Recruiting·Listed Apr 2025

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A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

for Oncology

Sites in Pittsburgh +12 more locations

Sponsor: Nested Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06326411·Phase 1·Recruiting·Listed Mar 2024

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Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

for COPD

Sites in Philadelphia, Pittsburgh +8 more locations

Sponsor: Nuvaira, Inc.

Sex: All·Age: 40 - 80

Code: NCT07051707·Recruiting·Listed Jul 2025

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A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata.

for Severe Alopecia Areata

Drug: Ritlecitinib

Sites in Hershey +17 more locations

Sponsor: Pfizer

Sex: All·Age: 6 - 14

Code: NCT07029828·Phase 3·Recruiting·Listed Jun 2025

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A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Sites in Philadelphia +12 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06798012·Phase 2·Recruiting·Listed Jan 2025

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AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

for ALS

Sites in Philadelphia +9 more locations

Sponsor: Amylyx Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06665165·Phase 1·Recruiting·Listed Oct 2024

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A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

for KRAS G12C Mutation

Sites in Philadelphia +10 more locations

Sponsor: Kumquat Biosciences Inc.

Sex: All·Age: 18+

Code: NCT06720987·Phase 1·Recruiting·Listed Dec 2024

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A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

Sites in Philadelphia +12 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT05125016·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)

for Pulmonary Arterial Hypertension

Sites in Philadelphia +8 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 - 17

Code: NCT05587712·Phase 2·Recruiting·Listed Oct 2022

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Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities

for Actinic Keratosis

Sites in Plymouth Meeting +19 more locations

Sponsor: Sun Pharmaceutical Industries, Inc.

Sex: All·Age: 18 - 85

Code: NCT07144852·Phase 3·Recruiting·Listed Aug 2025

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Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

for COPD

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: Apreo Health, Inc.

Sex: All·Age: 40 - 84

Code: NCT06891755·Recruiting·Listed Mar 2025

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Study to Evaluate Subcutaneous (SC) VGA039 in Patients With Von Willebrand Disease (VWD)

for Von Willebrand Disease (VWD)

Sites in Pittsburgh +10 more locations

Sponsor: Vega Therapeutics, Inc

Sex: All·Age: 12 - 75

Code: NCT07115004·Phase 3·Recruiting·Listed Aug 2025

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Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

for HR+/HER2-negative Breast Cancer

Sites in Hershey +9 more locations

Sponsor: SynDevRx, Inc.

Sex: All·Age: 18+

Code: NCT05455619·Phase 1, Phase 2·Recruiting·Listed Jul 2022

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A Study of Bleeding and Treatment in Participants With Von Willebrand Disease

for Von Willebrand Disease (VWD)

Sites in Pittsburgh +12 more locations

Sponsor: Hemab ApS

Sex: All·Age: 16+

Code: NCT06610201·Recruiting·Listed Sep 2024

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

Sites in Philadelphia +11 more locations

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)

for Phenylketonuria (PKU)

Sites in Pittsburgh +11 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: All ages

Code: NCT05813678·Recruiting·Listed Apr 2023

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Device Global Registry for the IlluminOss Bone Stabilization System

for Traumatic Fracture

Sites in Philadelphia, Pittsburgh +8 more locations

Sponsor: IlluminOss Medical, Inc.

Sex: All·Age: 50+

Code: NCT05206981·Recruiting·Listed Jan 2022

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A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

for Cancer

Sites in Philadelphia +10 more locations

Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05948865·Phase 1·Recruiting·Listed Jul 2023

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A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia

Drug: Revumenib

Sites in Philadelphia +9 more locations

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 30 Days+

Code: NCT04065399·Phase 1, Phase 2·Recruiting·Listed Aug 2019

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Medtronic Cardiac Surgery PMCF Registry

for Valve Disease, Heart

Sites in Pittsburgh +9 more locations

Sponsor: Medtronic Cardiac Surgery

Sex: All·Age: All ages

Code: NCT04073420·Recruiting·Listed Aug 2019

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An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

for Emphysema, Pulmonary

Sites in Philadelphia, Pittsburgh +14 more locations

Sponsor: Pulmonx Corporation

Sex: All·Age: 40 - 80

Code: NCT06035120·Recruiting·Listed Sep 2023

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Artificial Intelligence Mapping and Ablation of Non-Pulmonary Vein Electrical Drivers of AF Study

for Atrial Fibrillation (AF)

Sites in Philadelphia +11 more locations

Sponsor: Vektor Medical

Sex: All·Age: 22+

Code: NCT06935591·Recruiting·Listed Apr 2025

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A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

for Advanced or Metastatic Solid Tumors

Sites in Philadelphia +13 more locations

Sponsor: 858 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06395519·Phase 1, Phase 2·Recruiting·Listed May 2024

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A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis

for Ulcerative Colitis

Sites in Harrisburg +20 more locations

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06975722·Phase 2·Recruiting·Listed May 2025

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A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)

for Hepatocellular Cancer

Sites in Philadelphia +9 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06858813·Phase 1·Recruiting·Listed Mar 2025

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A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)

for Phenylketonuria (PKU)

Sites in Pittsburgh +10 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: All ages

Code: NCT06305234·Recruiting·Listed Mar 2024

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A Global Prospective Observational Registry of Patients With Pompe Disease

for Pompe Disease

Sites in Philadelphia, Pittsburgh +13 more locations

Sponsor: Amicus Therapeutics

Sex: All·Age: All ages

Code: NCT06121011·Recruiting·Listed Nov 2023

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NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)

for Duchenne Muscular Dystrophy

Sites in Philadelphia, Pittsburgh +8 more locations

Sponsor: NS Pharma, Inc.

Sex: Male·Age: 4 - 14

Code: NCT05996003·Phase 2·Recruiting·Listed Aug 2023

Apply to this trial