Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

for Propionic Acidemia

Sites in Philadelphia +6 more locations

Sponsor: ModernaTX, Inc.

Sex: All·Age: 1+

Code: NCT05130437·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

for Movement Disorders

Sites in Philadelphia +3 more locations

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT05539196·Recruiting·Listed Sep 2022

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A Study for CTC Expression and cfDNA/RNA Assessment in Metastatic Breast Cancer Patients

for Metastatic Breast Cancer (MBC)

1 location in Pittsburgh

Sponsor: Menarini Silicon Biosystems, INC

Sex: All·Age: 18+

Code: NCT06833853·Recruiting·Listed Feb 2025

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S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors

for Solid Tumors

Sites in Philadelphia +2 more locations

Sponsor: Shionogi

Sex: All·Age: 18+

Code: NCT05101070·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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RELIVE (Randomized Evaluation of Less Invasive Ventricular Enhancement) Trial

for Left Ventricle Remodeling

Sites in Hershey +5 more locations

Sponsor: BioVentrix

Sex: All·Age: 18+

Code: NCT06813820·Recruiting·Listed Feb 2025

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A Multicenter, Prospective, Clinical Trial Evaluating a Single Layer Amniotic Membrane and Standard of Care Versus Matched Controls in the Management of Nonhealing Pressure Ulcers

for Pressure Ulcer

1 location in Monroeville

Sponsor: Applied Biologics, LLC

Sex: All·Age: 18+

Code: NCT07126886·Phase 4·Recruiting·Listed Aug 2025

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Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

for Degenerative Disc Disease

Sites in Philadelphia +5 more locations

Sponsor: Kuros Biosurgery AG

Sex: All·Age: 18+

Code: NCT04679844·Recruiting·Listed Dec 2020

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The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry)

for Heart Failure

Sites in Hershey +4 more locations

Sponsor: EBR Systems, Inc.

Sex: All·Age: All ages

Code: NCT07098858·Recruiting·Listed Aug 2025

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Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

for Sensorineural Hearing Loss, Bilateral

Sites in Philadelphia +5 more locations

Sponsor: Akouos, Inc.

Sex: All·Age: All ages

Code: NCT05821959·Phase 1, Phase 2·Recruiting·Listed Apr 2023

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Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Pittsburgh +3 more locations

Sponsor: Ankyra Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06171750·Phase 1·Recruiting·Listed Dec 2023

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A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

for Melanoma (Skin Cancer)

Sites in Philadelphia +8 more locations

Sponsor: Linnaeus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06624644·Phase 2, Phase 3·Recruiting·Listed Oct 2024

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ResQ133A-NMIBC: Intravesical Recombinant Mycobacterium (rMBCG) in Participants With NMIBC Eligible to Receive Intravesical Tice BCG

for NMIBC

Sites in Cynwyd +8 more locations

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18 - 85

Code: NCT06800963·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for Epithelial Ovarian Cancer

Sites in Pittsburgh +4 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06469281·Phase 1·Recruiting·Listed Jun 2024

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Modified Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of Hard-to-Heal DFUs

for Diabetic Foot Ulcer (DFU)

Sites in Monroeville, Jefferson Hills +3 more locations

Sponsor: StimLabs

Sex: All·Age: 18+

Code: NCT06449638·Recruiting·Listed Jun 2024

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A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)

for Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia

Sites in Philadelphia +2 more locations

Sponsor: Autolus Limited

Sex: All·Age: 0 - 18

Code: NCT06173518·Phase 1·Recruiting·Listed Dec 2023

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A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.

for Advanced Solid Tumors

Sites in Pittsburgh +1 more location

Sponsor: AskGene Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05867420·Phase 1, Phase 2·Recruiting·Listed May 2023

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A Study to Evaluate the Safety, Efficacy, PK, PD and Immunogenicity of Cipaglucosidase Alfa/Miglustat in IOPD Subjects Aged 0 to <18

for Glycogen Storage Disease Type II Infantile Onset

Sites in Pittsburgh +5 more locations

Sponsor: Amicus Therapeutics

Sex: All·Age: Up to 17

Code: NCT04808505·Phase 3·Recruiting·Listed Mar 2021

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Phase I Study to Assess the Safety and Efficacy of OCU200 for Center-Involved Diabetic Macular Edema (DME)

for Center Involved Diabetic Macular Edema

Sites in Erie +4 more locations

Sponsor: Ocugen

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05802329·Phase 1·Recruiting·Listed Apr 2023

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Mindfulness Training and Respiration Biosignal Feedback - Study 2

for Psychological Distress

1 location in Pittsburgh

Sponsor: Equa Health

Sex: All·Age: 18 - 30

Code: NCT07136948·Recruiting·Listed Aug 2025

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Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer

for Non Small Cell Lung Cancer (NSCLC)

Sites in Philadelphia +1 more location

Sponsor: Integro Theranostics

Sex: All·Age: 18+

Code: NCT07276789·Phase 2·Recruiting·Listed Dec 2025

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Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD) and Non-interventional Arm With Untreated Patients

for LCA5

Sites in Philadelphia +1 more location

Sponsor: Opus Genetics, Inc

Sex: All·Age: 4+

Code: NCT05616793·Phase 1, Phase 2·Recruiting·Listed Nov 2022

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BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

for Advanced Malignancies

Sites in Philadelphia +2 more locations

Sponsor: BioInvent International AB

Sex: All·Age: 18+

Code: NCT04752826·Phase 1, Phase 2·Recruiting·Listed Feb 2021

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Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors

for Malignant Mesothelioma

Sites in Philadelphia +5 more locations

Sponsor: InSilico Medicine Hong Kong Limited

Sex: All·Age: 18+

Code: NCT06566079·Phase 1·Recruiting·Listed Aug 2024

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A Study Evaluating the Safety and Efficacy of the 3M™ V.A.C. Peel and Place Dressing

for Wound

Sites in Bethlehem +2 more locations

Sponsor: Solventum US LLC

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT06625385·Recruiting·Listed Oct 2024

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Otoferlin Gene-mediated Hearing Loss Natural History Study

for Sensorineural Hearing Loss, Bilateral

Sites in Philadelphia +3 more locations

Sponsor: Akouos, Inc.

Sex: All·Age: Up to 44

Code: NCT05572073·Recruiting·Listed Oct 2022

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A Retrospective Study to Characterize Participants With Propionic Acidemia

for Propionic Acidemia

Sites in Philadelphia +3 more locations

Sponsor: ModernaTX, Inc.

Sex: All·Age: 2+

Code: NCT05769621·Recruiting·Listed Mar 2023

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A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT

for Port-wine Birthmarks

Sites in Bethlehem +4 more locations

Sponsor: Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT05171894·Phase 2·Recruiting·Listed Dec 2021

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Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease

for Fabry Disease

Sites in Pittsburgh +7 more locations

Sponsor: UniQure Biopharma B.V.

Sex: Male·Age: 18 - 50

Code: NCT06270316·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumor

Sites in Pittsburgh +4 more locations

Sponsor: ImmVira Pharma Co. Ltd

Sex: All·Age: 18+

Code: NCT04370587·Phase 1, Phase 2·Recruiting·Listed May 2020

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A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer

for Non Small Cell Lung Cancer

Sites in Pittsburgh +7 more locations

Sponsor: Wayshine Biopharm, Inc.

Sex: All·Age: 18+

Code: NCT06868485·Phase 2·Recruiting·Listed Mar 2025

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Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears

for Rotator Cuff Injuries

Sites in Pittsburgh +2 more locations

Sponsor: Smith & Nephew, Inc.

Sex: All·Age: 18+

Code: NCT05444465·Recruiting·Listed Jul 2022

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Safety Study of SMOFlipid to Evaluate the Risk of Developing EFAD and/or PNAC in Pediatric and Adult Patients

for Malnutrition, Child

Sites in Pittsburgh +4 more locations

Sponsor: Fresenius Kabi

Sex: All·Age: 1 Month - 17

Code: NCT06049680·Phase 4·Recruiting·Listed Sep 2023

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Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

for Advanced Solid Tumor

Sites in Pittsburgh +5 more locations

Sponsor: Strand Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06249048·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

for Recurrent Head and Neck Squamous Cell Carcinoma

Sites in Philadelphia +6 more locations

Sponsor: Rakuten Medical, Inc.

Sex: All·Age: 18+

Code: NCT06699212·Phase 3·Recruiting·Listed Nov 2024

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IBS Skin Patch Test Food Allergy Study

for Irritable Bowel Syndrome

Sites in North Wales +1 more location

Sponsor: IBS-80, LLC

Sex: All·Age: 18+

Code: NCT06288672·Recruiting·Listed Mar 2024

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A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)

for Mucopolysaccharidosis II

Sites in Philadelphia +7 more locations

Sponsor: Denali Therapeutics Inc.

Sex: All·Age: 2 - 25

Code: NCT05371613·Phase 2, Phase 3·Recruiting·Listed May 2022

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Observational, Passive Surveillance Program to Collect Information on Women and Their Offspring Exposed to MenQuadfi® During Pregnancy, in United States (US)

for Meningococcal Infection

1 location in Swiftwater

Sponsor: Sanofi Pasteur, a Sanofi Company

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04843111·Recruiting·Listed Apr 2021

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A proof-of Concept Study to Assess Safety and Tolerability of HM15421/GC1134A in Patients With Fabry Disease

for Fabry Disesase

Sites in Pittsburgh +5 more locations

Sponsor: GC Biopharma Corp

Sex: All·Age: 18+

Code: NCT06858397·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas

for Anal Fistula

Sites in Pittsburgh +7 more locations

Sponsor: RedDress Ltd.

Sex: All·Age: 18+

Code: NCT05641844·Recruiting·Listed Dec 2022

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VIZ ACCESS HCM - Multi-Site Registry

for Hypertrophic Cardiomyopathy

Sites in Philadelphia +2 more locations

Sponsor: Viz.ai, Inc.

Sex: All·Age: 18+

Code: NCT07103057·Recruiting·Listed Aug 2025

Apply to this trial