Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,650 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 8, 2026.

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3,650 clinical trials

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Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

386 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting

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Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.

for Advanced Melanoma

11 locations incl. Chandler

Sponsor: Eikon Therapeutics

Sex: All·Age: 18+

Code: NCT06697301·Phase 2, Phase 3·Recruiting

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A Phase Ib Study of VK-2019 in Patients With Relapsed or Refractory EBV+ Diffuse Large B-cell Lymphomas (DLBCL)

for Diffuse Large B Cell Lymphoma Refractory

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT06789159·Phase 1·Recruiting

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A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia

for Idiopathic Hypersomnia

Drug: ALKS 2680

32 locations incl. Cullman

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT06843590·Phase 2·Recruiting

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A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

for Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer

Drug: zolbetuximab

36 locations incl. Birmingham

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT06901531·Phase 3·Recruiting

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Minima Stent System Post- Approval Study (PAS)

for Pulmonary Artery Stenosis

15 locations incl. Los Angeles

Sponsor: Renata Medical

Sex: All·Age: All ages

Code: NCT06828770·Recruiting

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A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

for Endometrial Cancer

44 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT06952504·Phase 3·Recruiting

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Prospective Study of EXErcise Regimens After Treatment for Breast Cancer for Hypertrophy and Conditioning

for Cancer

1 location in Pittsburgh

Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: Female·Age: 20 - 89

Code: NCT07023887·Recruiting

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MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels

for Coronary Artery Disease

24 locations incl. Gilbert

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 80

Code: NCT06271590·Recruiting

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Transtibial Osseointegration

for Amputation

2 locations incl. Bethesda

Sponsor: Walter Reed National Military Medical Center

Sex: All·Age: 22 - 65

Code: NCT06636136·Recruiting

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Assessing Improvements in Mood and Sleep Trial

for Depression

3 locations incl. Los Angeles

Sponsor: University of Pittsburgh

Sex: All·Age: 55+

Code: NCT06639477·Recruiting

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A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

for Chronic Lymphocytic Leukemia

20 locations incl. Jacksonville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06876649·Phase 4·Recruiting

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A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

for Chronic Lymphocytic Leukemia

18 locations incl. Miami

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06876662·Phase 4·Recruiting

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A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

for Heart Failure

Drug: Empagliflozin

105 locations incl. Mobile

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06935370·Phase 3·Recruiting

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A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

for Asthma

Drug: PF-07275315

36 locations incl. Mobile

Sponsor: Pfizer

Sex: All·Age: 18 - 70

Code: NCT06977581·Phase 2·Recruiting

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Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Matched Standard of Care Controls in the Management of Nonhealing Pressure Ulcers

for Pressure Ulcer

1 location in Monroeville

Sponsor: Tiger Biosciences, LLC.

Sex: All·Age: 18+

Code: NCT06999590·Phase 4·Recruiting

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Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.

for ARDS (Acute Respiratory Distress Syndrome)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 90

Code: NCT07125079·Recruiting

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A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition

for X-Linked Myotubular Myopathy

6 locations incl. Chicago

Sponsor: Astellas Gene Therapies

Sex: Male·Age: Up to 17

Code: NCT06581146·Recruiting

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Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

for Delayed Graft Function

32 locations incl. Phoenix

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06830798·Phase 3·Recruiting

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Pelacarsen Roll-over Extension Program

for Atherosclerotic Cardiovascular Disease

Drug: Pelacarsen

91 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06875973·Phase 3·Recruiting

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DB-3Q bmMSC-EVs in Patients With Perianal Fistulizing Crohn's Disease

for Perianal Fistula Due to Crohn's Disease

5 locations incl. Aurora

Sponsor: Direct Biologics, LLC

Sex: All·Age: 18 - 75

Code: NCT06918808·Phase 2·Recruiting

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Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

128 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06672146·Phase 2·Recruiting

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Tibulizumab Skin Healing and Inflammation Evaluation for Lasting Defense

for Hidradenitis Suppurativa (HS)

31 locations incl. Phoenix

Sponsor: Zura Bio Inc

Sex: All·Age: 18 - 70

Code: NCT06993610·Phase 2·Recruiting

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Brief Behavioral Sleep Intervention for Obesity Prevention in Primary Care

for Obesity, Childhood

1 location in Philadelphia

Sponsor: Temple University

Sex: All·Age: 6 - 11

Code: NCT06810557·Recruiting

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Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments

for Depression

1 location in Malvern

Sponsor: Neuronetics

Sex: All·Age: 5 - 100

Code: NCT06997549·Recruiting

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A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

13 locations incl. La Jolla

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06798012·Phase 2·Recruiting

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Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

for Central Line Associated Blood Stream Infections (CLABSI)

17 locations incl. Los Angeles

Sponsor: CorMedix

Sex: All·Age: 18+

Code: NCT06822426·Phase 3·Recruiting

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A proof-of Concept Study to Assess Safety and Tolerability of HM15421/GC1134A in Patients With Fabry Disease

for Fabry Disesase

6 locations incl. Los Angeles

Sponsor: GC Biopharma Corp

Sex: All·Age: 18+

Code: NCT06858397·Phase 1, Phase 2·Recruiting

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Study of GS-0151 in Participants With Rheumatoid Arthritis

for Rheumatoid Arthritis

15 locations incl. Anniston

Sponsor: Gilead Sciences

Sex: All·Age: 18 - 75

Code: NCT06902519·Phase 1·Recruiting

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

14 locations incl. Duarte

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting

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A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

for Atopic Dermatitis

21 locations incl. Fountain Valley

Sponsor: Apogee Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07003425·Phase 2·Recruiting

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Effects of Ketone Supplement and Alcohol on Brain Metabolism

for Ketosis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT06815237·Phase 2, Phase 3·Recruiting

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A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

for Prostate Cancer

50 locations incl. Phoenix

Sponsor: Merck Sharp & Dohme LLC

Sex: Male·Age: 18+

Code: NCT06925737·Phase 3·Recruiting

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Outcomes for VersaWrap in Achilles Tendon Repair

for Achilles Tendon Injury

3 locations incl. Sacramento

Sponsor: Research Source

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT07025252·Enrolling By Invitation

Observation Study in Patients Age 0-5 Years With LAMA2-related Congenital Muscular Dystrophy

for LAMA2-MD \(Merosin Deficient Congenital Muscular Dystrophy, MDC1A\)

14 locations incl. Los Angeles

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 5

Code: NCT06503367·Recruiting

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Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

25 locations incl. Birmingham

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting

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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

for Amyloidosis

Drug: Acoramidis

39 locations incl. La Jolla

Sponsor: Eidos Therapeutics, a BridgeBio company

Sex: All·Age: 18 - 75

Code: NCT06563895·Phase 3·Recruiting

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A Study of ZL-1310 in Participants With Selected Solid Tumors

for Solid Tumors

12 locations incl. San Francisco

Sponsor: Zai Lab (Shanghai) Co., Ltd.

Sex: All·Age: 18+

Code: NCT06885281·Phase 1, Phase 2·Recruiting

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Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID)

for Age-Related Macular Degeneration

7 locations incl. Fargo

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06924021·Recruiting

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Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency (VIP-RACE)

for Depressive Symptoms

1 location in Harrisburg

Sponsor: Penn State University

Sex: All·Age: 10 - 14·Accepts healthy volunteers

Code: NCT07055906·Recruiting

Apply to this trial