Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,650 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 9, 2026.

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3,654 clinical trials

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Comparative Study of Three Collagen Membranes: 1 Non-cross-linked and 2 Cross-linked

for Bone Regeneration

1 location in Pittsburgh

Sponsor: Andrea Ravida

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06944639·Enrolling By Invitation

T1D Pregnancy & Me

for Diabetes Mellitus, Type 1

10 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+

Code: NCT06959316·Recruiting

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A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

for Carcinoma, Non-Small-Cell Lung

Drug: Adagrasib

54 locations incl. Birmingham

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06875310·Phase 3·Recruiting

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Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis

for Severe Hypertriglyceridemia

Drug: Plozasiran

16 locations incl. Los Angeles

Sponsor: Arrowhead Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06880770·Phase 3·Recruiting

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MMA Embolization for Refractory Chronic Migraine

for Migraine Disorders

9 locations incl. Phoenix

Sponsor: Cerenovus, Part of DePuy Synthes Products, Inc.

Sex: All·Age: 18 - 65

Code: NCT06735833·Recruiting

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Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery

for Oropharyngeal Squamous Cell Carcinoma (OPSCCA)

1 location in Philadelphia

Sponsor: Ryan Carey

Sex: All·Age: 18+

Code: NCT06747390·Phase 1·Recruiting

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Pivotal Study for the Cardiac Performance System (CPS)

for Cardiovascular Diseases

10 locations incl. Huntsville

Sponsor: Sensydia Corporation

Sex: All·Age: 18+

Code: NCT06870591·Recruiting

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Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders

for Placenta Accreta Spectrum

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18+

Code: NCT06512181·Recruiting

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Use of tAN® in Alcohol Withdrawal Management

for Alcohol Withdrawal

1 location in Wernersville

Sponsor: Erin Deneke

Sex: All·Age: 18 - 65

Code: NCT06771037·Recruiting

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Healthy Volunteers Study

for Ovarian Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 30 - 50·Accepts healthy volunteers

Code: NCT06962059·Recruiting

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Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer

for Prostate Cancer

3 locations incl. Burlington

Sponsor: Albany Medical College

Sex: Male·Age: 18+

Code: NCT06517901·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

for Metastatic Microsatellite Stable Colorectal Carcinoma

8 locations incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06654037·Phase 1·Recruiting

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Cigarillo Public Education Messaging for Black Young Adults

for Cigarillo Smoking

2 locations incl. Philadelphia

Sponsor: Drexel University

Sex: All·Age: 18 - 30

Code: NCT06863168·Recruiting

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An Extension Study of Subjects Who Received an Avalyn Inhaled Antifibrotic Agent (SAIL)

for Progressive Pulmonary Fibrosis

23 locations incl. Birmingham

Sponsor: Avalyn Pharma Inc.

Sex: All·Age: 18+

Code: NCT06951217·Phase 2·Recruiting

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Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

40 locations incl. Huntsville

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06966401·Phase 3·Recruiting

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A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

146 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting

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Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for Advanced Solid Tumors

11 locations incl. San Diego

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT06795412·Phase 1, Phase 2·Recruiting

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Informing Low-acuity Emergency Department Patients of Non-emergent Resources (2)

for Emergency Service, Hospital

1 location in Danville

Sponsor: Geisinger Clinic

Sex: All·Age: 18+

Code: NCT07185828·Recruiting

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ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

for Beta-Thalassemia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 18 - 40

Code: NCT06364774·Phase 1, Phase 2·Recruiting

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Philly CEAL- DECIDE+ Adaptation

for Disparities

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 35 - 75·Accepts healthy volunteers

Code: NCT06732102·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)

for Hepatocellular Cancer

10 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06858813·Phase 1·Recruiting

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Registry on NeVa VS for CerebraL VAsospasm ManagemenT in Post SAH PatiEnts

for Cerebral Vasospasm

16 locations incl. Burbank

Sponsor: Vesalio

Sex: All·Age: 22+

Code: NCT06893588·Recruiting

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Mental Health Clinician / Chaplain Collaboration

for Moral Injury

2 locations incl. Little Rock

Sponsor: Central Arkansas Veterans Healthcare System

Sex: All·Age: 18 - 80

Code: NCT07579143·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis

for Psoriatic Arthritis

16 locations incl. Huntington Beach

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06865105·Phase 2·Recruiting

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A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

for Lymphoma, Large B-Cell, Diffuse

Drug: Polatuzumab Vedotin

70 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06890884·Phase 2·Recruiting

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Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers

for Ovarian Cancer

16 locations incl. Birmingham

Sponsor: Corcept Therapeutics

Sex: Female·Age: 18+

Code: NCT06906341·Phase 2·Recruiting

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Real-world Study of Treatment Outcomes in Chronic Inflammatory Demyelinating Polyneuropathy/Polyradiculoneuropathy (CIDP)

for Polyneuropathy, Inflammatory Demyelinating, Chronic

1 location in Swiftwater

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06968975·Recruiting

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A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

for CLL

21 locations incl. Jonesboro

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06846671·Phase 3·Recruiting

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

for Carcinoma, Non-Small Cell Lung

Drug: Rilvegostomig

37 locations incl. La Mesa

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06868277·Phase 3·Recruiting

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NIBS Therapy in Subacute Spinal Cord Injury

for Traumatic Spinal Cord Injury

1 location in Elkins Park

Sponsor: Albert Einstein Healthcare Network

Sex: All·Age: 18 - 80

Code: NCT06247904·Enrolling By Invitation

Impact of Brief Daily Functional Resistance Training on Lower Extremity Physical Performance

for Mobility Limitation

2 locations incl. Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 65+

Code: NCT06396247·Phase 2, Phase 3·Recruiting

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Tissue Reinforcement for Breast Reconstruction (TRBR) Pivotal Clinical Study (REDEFINE)

for Breast Reconstruction Surgery

20 locations incl. Scottsdale

Sponsor: W.L.Gore & Associates

Sex: Female·Age: 22+

Code: NCT06556654·Recruiting

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Neuromodulation of Brain and Emotional Responses to Psychological Stress

for Healthy

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 30 - 50·Accepts healthy volunteers

Code: NCT06603064·Recruiting

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A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

for Breast Cancer

51 locations incl. Phoenix

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06790693·Phase 3·Recruiting

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Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

for Hypertriglyceridemia

Drug: Plozasiran

76 locations incl. Bakersfield

Sponsor: Arrowhead Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06822790·Phase 3·Recruiting

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Evaluation of Hypoxia in Primary Melanoma

for Melanoma

1 location in Pittsburgh

Sponsor: Yana Najjar

Sex: All·Age: 18+

Code: NCT06831071·Recruiting

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A Phase 2 Study of the Safety and Efficacy of Brepocitinib in Adults With Cutaneous Sarcoidosis (BEACON)

for Cutaneous Sarcoidosis

4 locations incl. San Francisco

Sponsor: Priovant Therapeutics, Inc.

Sex: All·Age: 18 - 75

Code: NCT06978725·Phase 2·Recruiting

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Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

43 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06287775·Phase 1, Phase 2·Recruiting

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CGM for Management of Type 2 Diabetes in Pregnancy

for Type 2 Diabetes Mellitus (T2DM)

7 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18 - 50

Code: NCT06628453·Recruiting

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Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85

Code: NCT06968663·Phase 2·Recruiting

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