18F-FTHA IMAGING OF THE INTESTINAL AND CENTRAL LYMPHATIC SYSTEM

Conditions

• Lymphatic Obstruction

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• [18F]FTHA PET/CT scan — DIAGNOSTIC_TEST
  Positron Emission Tomography/Computed Tomography (PET/CT) scans

Study Details

The project will be performed over a period of approximately two years. In the first year the \[18F\]FTHA tracer will be developed, optimized, and tested on normal volunteers. During the second year, the tracer will be investigated on patients with suspected obstruction of the thoracic duct (TD).

Key Dates

Start date

Oct 10, 2025

Status verified

Jun 2026

Primary completion

Jun 30, 2028

Completion

Jun 30, 2029

Study Design

Enrollment

25 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Healthy Volunteer
  Healthy volunteers will undergo a single injection of \[18F\]-FTHA (a long-chain fatty acid positron emitting radiotracer) followed by up to 4 PET/CT scans.
• Experimental: TD-Venous Obstruction patients
  Patients with known or suspected obstruction of the thoracic duct (TD)-venous junction will undergo a single injection of \[18F\]-FTHA (a long-chain fatty acid positron emitting radiotracer) followed by up to 4 PET/CT scans. If the patient undergoes a clinical surgical procedure then they will be asked to undergo a second \[18F\]FTHA PET/Ct scan following the same procedure as the baseline scan.

Primary Outcome Measure

FTHA transit time [ Time Frame: 4 weeks ]

Central Contacts

• Erin K Schubert, BA
  2155736569
  [email protected]
• Mary Hansbury, BS
  215-746-8192
  [email protected]

Locations (1)

Find similar trials in Philadelphia, PA

Related Studies

• Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease
  Recruiting · MMI (Medical Microinstruments, Inc.) · Palo Alto, California