Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,659 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 4, 2026.

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3,659 clinical trials

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Thiotepa-based Conditioning Regimen With De-escalated Post-graft Cyclophosphamide for Allogeneic Stem Cell Transplantation in Hematologic Malignancies

for Acute Lymphocytic Leukemia (ALL)

1 location in Pittsburgh

Sponsor: Sawa Ito, MD

Sex: All·Age: 18+

Code: NCT07565220·Phase 1·Not Yet Recruiting

Combined Functional Electrical and Transcranial Direct Current Stimulation for Foot Drop

for Falls

1 location in Philadelphia

Sponsor: Saint Joseph's University, Philadelphia

Sex: All·Age: 18+

Code: NCT07592221·Recruiting

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Imaging CRF X NOP Interactions in Alcohol Use Disorder

for Alcohol Use Disorder

1 location in Pittsburgh

Sponsor: Rajesh Narendran

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07612631·EARLY_Phase 1·Recruiting

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nVNS, CBD, and SoC for Persistent Post-Traumatic Headache

for Persistent Post Traumatic Headache

8 locations incl. Scottsdale

Sponsor: American Society of Pain and Neuroscience, Inc.

Sex: All·Age: 18 - 75

Code: NCT07624279·Phase 2·Not Yet Recruiting

Retreatment With CTL019/CTL119

for Lymphoma, B-Cell

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04419909·Phase 1·Not Yet Recruiting

Precision Analgesia for Cardiac Surgery

for Analgesia

1 location in Pittsburgh

Sponsor: Kathirvel Subramaniam

Sex: All·Age: 60 - 110

Code: NCT05612399·Not Yet Recruiting

Prediction and Prevention of Postoperative Mortality and Morbidity

for Dementia

5 locations incl. Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 65+

Code: NCT06042413·Not Yet Recruiting

Ultrasound (US) Guided External Ventricular Catheter Placement

for Hydrocephalus

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18+

Code: NCT06253858·Recruiting

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Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves

for Lumbar Spondylosis

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18+

Code: NCT06283628·Not Yet Recruiting

An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)

for REM Sleep Behavior Disorder

19 locations incl. Los Angeles

Sponsor: Yale University

Sex: All·Age: 50 - 80

Code: NCT06996652·Phase 2·Not Yet Recruiting

Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease

for Degenerative Disc Disease

5 locations incl. Baton Rouge

Sponsor: CGBio Inc.

Sex: All·Age: 21 - 80

Code: NCT07017634·Phase 3·Recruiting

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Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis

for Axial Spondylarthritis (axSpA)

Drug: Upadacitinib

1 location in Philadelphia

Sponsor: CARE ARTHRITIS LTD.

Sex: All·Age: 18+

Code: NCT07018206·Phase 4·Not Yet Recruiting

Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area

for Anastomotic Leaks

8 locations incl. Orlando

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07035431·Recruiting

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A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

for Amyotrophic Lateral Sclerosis (ALS)

3 locations incl. Hershey

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07071935·Phase 2·Not Yet Recruiting

Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration Technology

for Urolithiasis

3 locations incl. Birmingham

Sponsor: Calyxo, Inc.

Sex: All·Age: 18+

Code: NCT07101809·Recruiting

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IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

for Relapsed/Refractory Primary Central Nervous System Lymphoma

Drug: Rituximab

10 locations incl. Scottsdale

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT07104032·Phase 3·Recruiting

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Ketones for Opioid Craving

for Opioid Use Disorder

1 location in Wernersville

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 75

Code: NCT07128524·Phase 2·Not Yet Recruiting

Smoothie Program for Achieving and Resilient Kids

for Executive Functions (EF)

1 location in State College

Sponsor: Penn State University

Sex: All·Age: 7 - 9·Accepts healthy volunteers

Code: NCT07195474·Not Yet Recruiting

Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease

for Sickle Cell Disease

Drug: Ruxolitinib

4 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 12 - 45

Code: NCT07252050·Phase 1, Phase 2·Recruiting

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Fluorometholone Study

for Keratitis Bacterial

1 location in Pittsburgh

Sponsor: Vishal Jhanji

Sex: All·Age: 18+

Code: NCT07308938·Phase 2·Not Yet Recruiting

Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways

for Stroke

1 location in Pittsburgh

Sponsor: Peter C. Gerszten, MD

Sex: All·Age: 21 - 75·Accepts healthy volunteers

Code: NCT07401186·Recruiting

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A Prospective Study of Pediatric Participants up to 16 Years of Age With Methylmalonic Acidemia (MMA) Due to Mutations in the MMUT Gene

for Methylmalonic Acidemia (MMA)

2 locations incl. Philadelphia

Sponsor: Genespire Srl

Sex: All·Age: Up to 16

Code: NCT07432880·Not Yet Recruiting

NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty

for Total Knee Arthroplasty Postoperative Pain

3 locations incl. Pittsburgh

Sponsor: Jacques E. Chelly

Sex: All·Age: 18+

Code: NCT07439666·Not Yet Recruiting

Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors

for Malignant Pleural Effusion

1 location in Pittsburgh

Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: All·Age: 18 - 79

Code: NCT07443020·Phase 1·Recruiting

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"Vasectomy: Right for Me?" Decision Support Tool

for Vasectomy

2 locations incl. San Francisco

Sponsor: University of Pittsburgh

Sex: Male·Age: 21 - 55

Code: NCT07451067·Not Yet Recruiting

A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia

for Insomnia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT07542756·Phase 4·Not Yet Recruiting

Creation of a Decision Aid for Coronary Anomalies

for AAOCA

5 locations incl. Boston

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 10 - 35

Code: NCT07544979·Not Yet Recruiting

Evaluating an Artificial Intelligence-Based Diagnostic Support Tool for Older Adults in Primary Care

for Diagnostic Support

1 location in Philadephia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT07553559·Not Yet Recruiting

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

for Cognitive Dysfunction

Drug: Donanemab

42 locations incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 55 - 85

Code: NCT07589595·Phase 2·Not Yet Recruiting

Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage

for Gingival Recession

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 65

Code: NCT07590960·Not Yet Recruiting

Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot

for Spine Surgery

1 location in Philadelphia

Sponsor: Medasense Biometrics Ltd

Sex: All·Age: 18+

Code: NCT07608276·Not Yet Recruiting

A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

for Atherosclerosis

Drug: Lepodisiran

17 locations incl. La Jolla

Sponsor: Eli Lilly and Company

Sex: All·Age: 45 - 80

Code: NCT07613294·Phase 3·Not Yet Recruiting

Testing the Combination of Anti-cancer Drugs, Tovorafenib Plus Rituximab, in Patients With Hairy Cell Leukemia

for Hairy Cell Leukemia

Drug: Rituximab

4 locations incl. Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06965114·Phase 1, Phase 2·Recruiting

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A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis

for Systemic Sclerosis

Drug: BMS-986353

16 locations incl. Scottsdale

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 16+

Code: NCT07335562·Phase 3·Recruiting

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A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis

for Atopic Dermatitis

33 locations incl. Birmingham

Sponsor: Apollo Therapeutics Ltd

Sex: All·Age: 18 - 65

Code: NCT07599813·Phase 2·Recruiting

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Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

Drug: Cemiplimab

6 locations incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06980038·Phase 2·Recruiting

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Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

7 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting

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Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder

for Opioid Withdrawal

1 location in Pittsburgh

Sponsor: Payel Roy

Sex: All·Age: 18+

Code: NCT07079826·Recruiting

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Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas

for Large B Cell Lymphoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07478848·Phase 1·Not Yet Recruiting

Cardiometabolic Effects of Pecan Snacking in Prediabetes

for Prediabetes

1 location in University Park

Sponsor: Penn State University

Sex: All·Age: 25 - 65

Code: NCT07235358·Recruiting

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