Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,654 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 9, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

3,654 clinical trials

↓ Download CSV

A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

for Acute HIV Infection

32 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT05719441·Phase 2·Recruiting

Apply to this trial

Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)

for Necrotizing Enterocolitis

8 locations incl. Little Rock

Sponsor: Noveome Biotherapeutics, formerly Stemnion

Sex: All·Age: 2 Weeks - 8 Weeks

Code: NCT06315738·Phase 1, Phase 2·Recruiting

Apply to this trial

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

for Antiphospholipid Syndrome (APS)

11 locations incl. Orange

Sponsor: Chugai Pharmaceutical

Sex: All·Age: 18 - 85

Code: NCT06371417·Phase 1·Recruiting

Apply to this trial

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

for B-cell Acute Lymphoblastic Leukemia

17 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 25

Code: NCT06395103·Phase 1, Phase 2·Recruiting

Apply to this trial

Bone in CKD Alkali Response (BICARb Pilot Trial)

for Chronic Kidney Diseases

2 locations incl. The Bronx

Sponsor: Albert Einstein College of Medicine

Sex: All·Age: 5 - 100

Code: NCT05918029·Phase 2, Phase 3·Recruiting

Apply to this trial

Nafamostat Efficacy in Phase 3 Registrational CRRT Study

for Acute Kidney Injury

10 locations incl. Los Angeles

Sponsor: Talphera, Inc

Sex: All·Age: 18 - 80

Code: NCT06150742·Recruiting

Apply to this trial

Evaluating a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)

for Hip Fractures

6 locations incl. Gainesville

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT06438640·Recruiting

Apply to this trial

The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial

for Endometriosis

1 location in Wynnewood

Sponsor: Main Line Health

Sex: Female·Age: 18+

Code: NCT06439524·Phase 3·Recruiting

Apply to this trial

TumorGlow Intraoperative Molecular Imaging (IMI)

for Tumor, Solid

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04723810·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy

for Muscular Atrophy, Spinal

10 locations incl. Little Rock

Sponsor: Hoffmann-La Roche

Sex: All·Age: 3 Months - 24 Months

Code: NCT05861999·Phase 4·Recruiting

Apply to this trial

Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

for Heart Failure

4 locations incl. Detroit

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06291922·Recruiting

Apply to this trial

A Study to Evaluate Solrikitug in Participants With COPD (ZION)

for COPD

101 locations incl. Birmingham

Sponsor: Uniquity One (UNI)

Sex: All·Age: 40 - 75

Code: NCT06496620·Phase 2·Recruiting

Apply to this trial

Evaluating the Relationship Between Skin Color and Pulse Oximeter Accuracy in Children

for Pediatric ALL

3 locations incl. New York

Sponsor: University of Pennsylvania

Sex: All·Age: 4 Weeks - 18

Code: NCT06529575·Recruiting

Apply to this trial

MSC EVs in Dystrophic Epidermolysis Bullosa

for Dystrophic Epidermolysis Bullosa

3 locations incl. Phoenix

Sponsor: Aegle Therapeutics

Sex: All·Age: 6 Months+

Code: NCT04173650·Phase 1, Phase 2·Recruiting

Apply to this trial

EFS of the DUO System for Tricuspid Regurgitation

for Tricuspid Regurgitation

12 locations incl. Phoenix

Sponsor: CroiValve Limited

Sex: All·Age: 18+

Code: NCT05913908·Recruiting

Apply to this trial

Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE)

for Urothelial Carcinoma

2 locations incl. Omaha

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT06396533·Recruiting

Apply to this trial

A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

for Metastatic HER2-positive Breast Cancer

48 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06435429·Phase 3·Recruiting

Apply to this trial

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

48 locations incl. Scottsdale

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting

Apply to this trial

Melodi Matrix™ in Breast Reconstruction

for Breast Reconstruction

10 locations incl. Palo Alto

Sponsor: Melodi Health, Inc.

Sex: Female·Age: 22+

Code: NCT06027996·Recruiting

Apply to this trial

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

266 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting

Apply to this trial

A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

13 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06313593·Phase 1·Recruiting

Apply to this trial

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Upadacitinib

12 locations incl. Oakland

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT06332534·Phase 3·Recruiting

Apply to this trial

Driver Education Research Study

for Risk Reduction Behavior

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 16 - 17·Accepts healthy volunteers

Code: NCT06413927·Recruiting

Apply to this trial

18F-Fluciclovine PET-MRI in High-grade Glioma

for Glioma

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 - 21

Code: NCT05553041·EARLY_Phase 1·Recruiting

Apply to this trial

Contrast Enhanced Ultrasound to Evaluate Response to Chemoembolization in Patients With Liver Tumors

for Liver Neoplasms

1 location in Philadelphia

Sponsor: john eisenbrey

Sex: All·Age: 18+

Code: NCT06261814·Phase 2·Recruiting

Apply to this trial

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

for Gastroesophageal Junction

8 locations incl. Tucson

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06445972·Phase 1, Phase 2·Recruiting

Apply to this trial

Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib

for Alopecia Areata

Drug: Ritlecitinib

25 locations incl. Montgomery

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06531109·Recruiting

Apply to this trial

A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

for Untreated Follicular Lymphoma

Drug: Rituximab

51 locations incl. Huntsville

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06549595·Phase 3·Recruiting

Apply to this trial

A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for Epithelial Ovarian Cancer

5 locations incl. Boston

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06469281·Phase 1·Recruiting

Apply to this trial

CARE Study: Cancer, Asian Americans, and Relationship Enrichment

for Neoplasm

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 21 - 80·Accepts healthy volunteers

Code: NCT06782581·Recruiting

Apply to this trial

Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS)

for Tricuspid Regurgitation

9 locations incl. Thousand Oaks

Sponsor: Innoventric LTD

Sex: All·Age: 18 - 85

Code: NCT06212193·Recruiting

Apply to this trial

Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder

for Generalized Anxiety Disorder

34 locations incl. Chandler

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18+

Code: NCT06480383·Phase 2·Recruiting

Apply to this trial

Targeted Pediatric High-Grade Glioma Therapy

for High Grade Glioma

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05839379·Recruiting

Apply to this trial

Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

7 locations incl. Gilbert

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT06544798·Phase 2·Enrolling By Invitation

A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)

for Epidermolysis Bullosa Dystrophica

1 location in Pittsburgh

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 6 Months+

Code: NCT06563414·Recruiting

Apply to this trial

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

for Hepatocellular Carcinoma

12 locations incl. Beverly Hills

Sponsor: Replimune, Inc.

Sex: All·Age: 18+

Code: NCT05733598·Phase 2·Recruiting

Apply to this trial

Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

for Traumatic Brain Injury

18 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18 - 65

Code: NCT05826912·Phase 2·Enrolling By Invitation

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

29 locations incl. Duarte

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06163534·Recruiting

Apply to this trial

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

for Advanced Breast Cancer

Drug: Camizestrant

54 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06380751·Phase 3·Recruiting

Apply to this trial

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

21 locations incl. Tuscaloosa

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting

Apply to this trial