Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

for Esophageal Adenocarcinoma

Sites in Philadelphia +1 more location

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06340711·Phase 2·Recruiting·Listed Apr 2024

Apply to this trial

International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery

for Congenital Disorders

Sites in Philadelphia +3 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 60 Weeks

Code: NCT05673499·Recruiting·Listed Jan 2023

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Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green (ICG) Kinetic Modeling

for Necrotizing Fascitis

Sites in Philadelphia, Pittsburgh +6 more locations

Sponsor: Eric R. Henderson

Sex: All·Age: 18+

Code: NCT06877793·Recruiting·Listed Mar 2025

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Testicular Tissue Cryopreservation for Fertility Preservation

for Cancer

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: Male·Age: All ages

Code: NCT02972801·Recruiting·Listed Nov 2016

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Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

for Infertility, Male

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: Male·Age: All ages

Code: NCT04452305·Recruiting·Listed Jun 2020

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iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH

for Pulmonary Hypertension

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 8 - 18

Code: NCT05442671·Recruiting·Listed Jul 2022

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Predictors of Improvements in Irritability and Aggression in Children With ADHD Treated With CNS Stimulants

for ADHD - Attention Deficit Disorder With Hyperactivity

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 7 - 12

Code: NCT06871488·Phase 4·Recruiting·Listed Mar 2025

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MetfOrmin BenefIts Lower Extremities With Intermittent Claudication

for Intermittent Claudication

1 location in Pittsburgh

Sponsor: VA Office of Research and Development

Sex: All·Age: 35 - 89

Code: NCT05132439·Phase 3·Recruiting·Listed Nov 2021

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Home Apnea Testing in CHildren Trial

for Sleep Apnea, Obstructive

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 - 12

Code: NCT05382754·Recruiting·Listed May 2022

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Randomized Assessment of TcMS for VT Storm

for Ventricular Tachycardia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05599022·Recruiting·Listed Oct 2022

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Feasibility of Semaglutide in Advanced Lung Disease

for Obesity

Drug: Semaglutide

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT05746039·Phase 1, Phase 2·Recruiting·Listed Feb 2023

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Empagliflozin Treatment in Kidney Transplant Recipients

for Kidney Transplant

Drug: Empagliflozin

Sites in Pittsburgh +4 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 19+

Code: NCT06013865·Phase 4·Recruiting·Listed Aug 2023

Apply to this trial

Enriched Holistic Care to Eradicate Disparities in Maternal Morbidity

for Morbidity

Sites in Philadelphia & Phialdelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 16 - 55·Accepts healthy volunteers

Code: NCT06245057·Recruiting·Listed Feb 2024

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Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma

for Locally Advanced Melanoma

Drug: Cemiplimab

1 location in Pittsburgh

Sponsor: John Kirkwood

Sex: All·Age: 18+

Code: NCT07223411·Recruiting·Listed Oct 2025

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Monitoring Eating Across Locations (MEAL) - Timing, Intake, and Mealtime Evaluation (TIME)

for Pediatric Obesity

1 location in State College

Sponsor: Penn State University

Sex: All·Age: 6 - 9·Accepts healthy volunteers

Code: NCT07095166·Recruiting·Listed Jul 2025

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A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

for Acral Lentiginous Melanoma

Drug: Ipilimumab

Sites in Pittsburgh +302 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04511013·Phase 2·Recruiting·Listed Aug 2020

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Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

for Chronic Kidney Disease

Sites in Philadelphia +1 more location

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 6 Months - 22

Code: NCT00327860·Recruiting·Listed May 2006

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Pittsburgh, Erie +338 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

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Massage Impact on Sleep in Pediatric Oncology

for Cancer

Sites in Philadelphia +1 more location

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 12 - 21

Code: NCT06892158·Recruiting·Listed Mar 2025

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SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05138575·Phase 2·Recruiting·Listed Dec 2021

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Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Philadelphia

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05842174·Phase 1, Phase 2·Recruiting·Listed May 2023

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Nerve Transfer to Improve Function in High Level Tetraplegia

for Cervical Spinal Cord Injury

Sites in Philadelphia +8 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 80

Code: NCT06288763·Recruiting·Listed Mar 2024

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Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT

for Leukemia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 25

Code: NCT06839456·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

Sites in Philadelphia, Erie +71 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting·Listed Apr 2024

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

Sites in Philadelphia, Pittsburgh +66 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting·Listed May 2020

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Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments

for Depression

1 location in Malvern

Sponsor: Neuronetics

Sex: All·Age: 5 - 100

Code: NCT06997549·Recruiting·Listed May 2025

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How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses

for Cardiometabolic Health

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07121010·Recruiting·Listed Aug 2025

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Fontan Fitness Trial

for Single-ventricle

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10 - 17

Code: NCT06918795·Recruiting·Listed Apr 2025

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Family Foundations for Special Education Trial

for Mental Health

1 location in Philadelphia

Sponsor: Penn State University

Sex: All·Age: 18+

Code: NCT07400497·Recruiting·Listed Feb 2026

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ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

for Beta-Thalassemia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 18 - 40

Code: NCT06364774·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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Intraoperative Contrast-Enhanced Ultrasound Evaluation of Blood Flow at the Time of Surgical Hip Reduction for DDH

for Developmental Dysplasia of the Hip

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 4 Months - 24 Months

Code: NCT03107520·EARLY_Phase 1·Recruiting·Listed Apr 2017

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Pencil Beam Scanning in Patients With Renal Tumors

for Renal Tumor

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 30

Code: NCT03810651·EARLY_Phase 1·Recruiting·Listed Jan 2019

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Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

for Preeclampsia

Sites in Pittsburgh +2 more locations

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07041281·Phase 2·Recruiting·Listed Jun 2025

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

Sites in Philadelphia +13 more locations

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting·Listed Apr 2025

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Genetic and Epigenetic Basis of Chronic Wounds

for Chronic Wounds

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 100

Code: NCT03793062·Recruiting·Listed Jan 2019

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Comparing Direct vs Indirect Methods for Cascade Screening

for Long QT Syndrome

1 location in Lancaster

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT05348564·Recruiting·Listed Apr 2022

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Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation

for Metastatic Prostate Carcinoma

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: Male·Age: 18+

Code: NCT05487846·Recruiting·Listed Aug 2022

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Virtual Peer Coaching in Manual Wheelchair Skills

for Wheelchair

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06295146·Recruiting·Listed Mar 2024

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Green Light for Post-Operative Wellness

for Surgery

1 location in Pittsburgh

Sponsor: Rebecca E Kotcher, MD

Sex: All·Age: 18+

Code: NCT07218289·Recruiting·Listed Oct 2025

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Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Philadelphia, Pittsburgh +52 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

Apply to this trial