Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,657 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 10, 2026.

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3,657 clinical trials

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A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

for Non-small Cell Lung Cancer

Drug: Intismeran autogene

68 locations incl. Anchorage

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06077760·Phase 3·Recruiting

Apply to this trial

Transforming Hemodialysis-Related Vascular Access Education

for Chronic Kidney Disease

3 locations incl. Baltimore

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05997875·Recruiting

Apply to this trial

AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma

for Multiple Myeloma

9 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06106945·Phase 1, Phase 2·Recruiting

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Middle Meningeal Artery Embolization (MMAE) Outcomes for Chronic Subdural Hematoma (cSDH)

for Chronic Subdural Hematoma

15 locations incl. Coral Gables

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06181994·Recruiting

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Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia

for Bronchopulmonary Dysplasia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 1

Code: NCT06475976·Recruiting

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Development of 3D Multi-Parametric Ultrasound (MPUS) as a Decision Support Tool for Patients

for Liver Cancer, Adult

3 locations incl. Palo Alto

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT05705219·Recruiting

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Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the Ileostomy

for Colorectal Surgery

3 locations incl. Buffalo

Sponsor: JSR Medical Co., Ltd.

Sex: All·Age: 19 - 80·Accepts healthy volunteers

Code: NCT05826743·Recruiting

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Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

for Delirium

7 locations incl. Orange

Sponsor: University of Michigan

Sex: All·Age: 70+

Code: NCT05929703·Recruiting

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LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

for Advanced Colorectal Carcinoma

225 locations incl. Fort Smith

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT06073431·Recruiting

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus

for Esophageal Stricture

34 locations incl. Birmingham

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561114·Phase 3·Recruiting

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Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2)

for Airway Management

1 location in Philadelphia

Sponsor: Thomas Riva

Sex: All·Age: Up to 52 Weeks

Code: NCT05967507·Recruiting

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Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine

for Schizophrenia

1 location in Pittsburgh

Sponsor: Deepak K. Sarpal, M.D.

Sex: All·Age: 18 - 50

Code: NCT06003036·Recruiting

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A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

for NASH With Fibrosis

Drug: Efruxifermin

205 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06215716·Phase 3·Recruiting

Apply to this trial

PEACE for ImPACT Study

for Autism Spectrum Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 12 Months+·Accepts healthy volunteers

Code: NCT06374381·Enrolling By Invitation

Platelet Transfusion and Repeat TEG-PM in Patients With Severe TBI on Antiplatelet Therapy (Repeat TEG-PM)

for Traumatic Intracranial Hemorrhage

1 location in Lancaster

Sponsor: Lancaster General Hospital

Sex: All·Age: 18+

Code: NCT06433622·Enrolling By Invitation

Personalized Postoperative Pain Management Following Thoracic Surgery in Adults

for Thoracic Surgery

4 locations incl. Pittsburgh

Sponsor: OpalGenix, Inc

Sex: All·Age: 18 - 99

Code: NCT05525923·Recruiting

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A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

for B Acute Lymphoblastic Leukemia Associated With Down Syndrome

69 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 6 - 39

Code: NCT05702645·Recruiting

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The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

51 locations incl. Birmingham

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting

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Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)

for Soft Tissue Sarcoma

26 locations incl. Phoenix

Sponsor: Polaris Group

Sex: All·Age: 18 - 99

Code: NCT05712694·Phase 3·Recruiting

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PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

for Heart Failure NYHA Class II

47 locations incl. Phoenix

Sponsor: Endotronix, Inc.

Sex: All·Age: 18+

Code: NCT05934487·Recruiting

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Evaluation of the GORE® Ascending Stent Graft

for Aortic Aneurysm, Thoracic

41 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT05800743·Enrolling By Invitation

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

for Lung Cancer Diagnosis

36 locations incl. Los Angeles

Sponsor: Freenome Holdings Inc.

Sex: All·Age: 50+

Code: NCT06122077·Recruiting

Apply to this trial

Prehospital Analgesia INtervention Trial (PAIN)

for Traumatic Injury

11 locations incl. San Diego

Sponsor: Jason Sperry

Sex: All·Age: 18+

Code: NCT05437575·Phase 3·Recruiting

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Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia

for Aphasia

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT05653440·Phase 2·Recruiting

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Healthy Mom Zone Gestational Weight Gain Management Intervention 2.0

for Gestational Weight Gain

1 location in University Park

Sponsor: Penn State University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05807594·Recruiting

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Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy

for Spinal Muscular Atrophy

15 locations incl. Phoenix

Sponsor: Alcyone Therapeutics, Inc

Sex: All·Age: 3+

Code: NCT05866419·Recruiting

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A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

for Locally Advanced Solid Tumors

Drug: Atezolizumab

6 locations incl. Birmingham

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06031441·Phase 1·Recruiting

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Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

for Anatomic Stage II Breast Cancer AJCC v8

Drug: Durvalumab

535 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06058377·Phase 3·Recruiting

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A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer

for Carcinoma, Non-small-Cell Lung

7 locations incl. Newnan

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18+

Code: NCT06116786·Phase 1·Recruiting

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Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

for Lymphatic Malformations

16 locations incl. Oakland

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 0 - 100

Code: NCT05948943·Phase 2, Phase 3·Recruiting

Apply to this trial

Comparison of Apixaban Versus Enoxaparin

for Bladder Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06243510·Enrolling By Invitation

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

for Breast Cancer

Drug: Durvalumab

64 locations incl. Daphne

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06103864·Phase 3·Recruiting

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ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

for Aortic Valve Insufficiency

32 locations incl. Newport Beach

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT05172973·Recruiting

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A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts

for Influenza

28 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 3 Weeks - 11

Code: NCT06094010·Phase 3·Recruiting

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A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies

for Hematologic Malignancy

17 locations incl. Duarte

Sponsor: CRISPR Therapeutics AG

Sex: All·Age: 18+

Code: NCT06208878·Enrolling By Invitation

Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

for Radiation Retinopathy

23 locations incl. Palo Alto

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT05844982·Phase 3·Recruiting

Apply to this trial

Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents

for Psychological Distress

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 12 - 17

Code: NCT06002191·Recruiting

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Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis

for Sinus Infection

7 locations incl. Los Angeles

Sponsor: Daniel Merenstein

Sex: All·Age: 18 - 75

Code: NCT06076304·Phase 4·Recruiting

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Risk and Resilience to Suicide Following Late-Life Spousal Bereavement

for Suicide

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 65+

Code: NCT06191484·Recruiting

Apply to this trial

The PEERLESS II Study

for Pulmonary Embolism

50 locations incl. Birmingham

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT06055920·Recruiting

Apply to this trial