Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,657 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 10, 2026.

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3,657 clinical trials

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MASA Valve Early Feasibility Study

for Tetrology of Fallot

5 locations incl. Peoria

Sponsor: PECA Labs

Sex: All·Age: 0 - 22

Code: NCT05452720·Recruiting

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A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

for Esophageal Squamous Cell Carcinoma

5 locations incl. Tucson

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT05319730·Phase 1, Phase 2·Recruiting

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A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

for Ulcerative Colitis

22 locations incl. Mobile

Sponsor: Takeda

Sex: All·Age: 2+

Code: NCT05442567·Phase 3·Recruiting

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Comparing Direct vs Indirect Methods for Cascade Screening

for Long QT Syndrome

1 location in Lancaster

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT05348564·Recruiting

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Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

for Osteomyelitis Tibia

14 locations incl. Gainesville

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05421741·Phase 4·Recruiting

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Vismodegib Combined With Atezolizumab in Platinum Resistant Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

for Platinum-Resistant Fallopian Tube Carcinoma

Drug: Atezolizumab

1 location in Pittsburgh

Sponsor: Ronald Buckanovich

Sex: Female·Age: 18+

Code: NCT05538091·Phase 2·Recruiting

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Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

for Inherited Retinal Degeneration

19 locations incl. Little Rock

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4+

Code: NCT05589714·Recruiting

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A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Drug: Nivolumab

390 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 60

Code: NCT05675410·Phase 3·Recruiting

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XTX301 in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

11 locations incl. Sacramento

Sponsor: Xilio Development, Inc.

Sex: All·Age: 18+

Code: NCT05684965·Phase 1, Phase 2·Recruiting

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Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma

for Relapsed Non-Hodgkin Lymphoma

32 locations incl. Irvine

Sponsor: Lyell Immunopharma, Inc.

Sex: All·Age: 18+

Code: NCT05826535·Phase 1, Phase 2·Recruiting

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A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

for Heart Failure

Drug: Ziltivekimab

184 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05636176·Phase 3·Recruiting

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A Non-interventional, International, Multicentre Clinical Research Study to Build the Largest Collection of Multimodal Data (Including Clinical Data, Imaging Data and Omics Data) in Oncology

for Diffuse Large B Cell Lymphoma

1 location in Pittsburgh

Sponsor: OWKIN

Sex: All·Age: 18+

Code: NCT06625203·Recruiting

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Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

454 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05642572·Phase 2·Recruiting

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Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma

for Renal Cell Carcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05733715·EARLY_Phase 1·Recruiting

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Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

for Major Depressive Disorder

24 locations incl. Huntsville

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18 - 65

Code: NCT05850689·Phase 3·Recruiting

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A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

for Episodic Migraine

Drug: Atogepant

42 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 6 - 17

Code: NCT05711394·Phase 3·Recruiting

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The Ailliance Post-Market Clinical Study

for Spinal Deformity

22 locations incl. Tucson

Sponsor: Medtronic Spinal and Biologics

Sex: All·Age: 18+

Code: NCT05856370·Recruiting

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Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

26 locations incl. Tucson

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting

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Comparison of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2, 3 and 4 Pressure Injuries

for Pressure Ulcers Stage II

14 locations incl. San Diego

Sponsor: ULURU Inc.

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05496296·Recruiting

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Empathic Communication Skills (ECS) Training

for Lung Cancer

12 locations incl. Irvine

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05456841·Recruiting

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A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer

for Metastatic Castration-resistant Prostate Neoplasms

Drug: Pasritamig

7 locations incl. Sarasota

Sponsor: Janssen Research & Development, LLC

Sex: Male·Age: 18+

Code: NCT05818683·Phase 1·Recruiting

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Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

for Recurrent Endometrial Carcinoma

Drug: Selumetinib

293 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05554328·Phase 2·Recruiting

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An Open-label Study of XEN1101 in Epilepsy

for Focal Epilepsy

53 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05718817·Phase 3·Enrolling By Invitation

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

59 locations incl. Birmingham

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting

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ZEN003694 Combined With Talazoparib in Patients With Recurrent Ovarian Cancer

for Ovarian Cancer

1 location in Pittsburgh

Sponsor: Alexander B Olawaiye, MD

Sex: Female·Age: 18+

Code: NCT05071937·Phase 2·Recruiting

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Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)

for Tachycardia, Ventricular

11 locations incl. Los Angeles

Sponsor: Varian, a Siemens Healthineers Company

Sex: All·Age: 18+

Code: NCT05765175·Recruiting

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Prophylaxis With Direct-acting Antivirals for Kidney Transplantation From HCV-Infected Donors to Uninfected Recipients

for HCV

9 locations incl. La Jolla

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT05653232·Recruiting

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VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

for Solid Tumor

Drug: Atezolizumab

7 locations incl. Chicago

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 6 Months - 30

Code: NCT04796012·Phase 1, Phase 2·Recruiting

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A Study to Investigate the Safety, Tolerability, and Efficacy of BxC-I17e Single and Multiple Dose SC Injection in Patients With Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis

3 locations incl. North Little Rock

Sponsor: Brexogen Inc.

Sex: All·Age: 18+

Code: NCT06055361·Phase 1·Recruiting

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

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Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury

for Acute Kidney Injury

38 locations incl. Birmingham

Sponsor: SeaStar Medical

Sex: All·Age: 18+

Code: NCT05758077·Recruiting

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SEEG-Guided DBS for OCD

for Obsessive-Compulsive Disorder

2 locations incl. Stanford

Sponsor: Casey H. Halpern, M.D.

Sex: All·Age: 22 - 75

Code: NCT05623306·Recruiting

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Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)

for Induction of Labor Affected Fetus / Newborn

6 locations incl. Newark

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 60·Accepts healthy volunteers

Code: NCT05759988·Recruiting

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Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

for Prostate Cancer

5 locations incl. Duarte

Sponsor: Varian, a Siemens Healthineers Company

Sex: Male·Age: 18+

Code: NCT05804318·Recruiting

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Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes

for Gestational Diabetes

1 location in Pittsburgh

Sponsor: Maisa N. Feghali, MD

Sex: Female·Age: 18 - 50

Code: NCT05482789·Phase 4·Recruiting

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Task Switching Between Target Templates During Visual Search in Healthy Adults

for Healthy

1 location in Bethlehem

Sponsor: Lehigh University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05709743·Enrolling By Invitation

Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

for Neurotrophic Keratopathy

29 locations incl. Laguna Hills

Sponsor: ReGenTree, LLC

Sex: All·Age: 18+

Code: NCT05555589·Phase 3·Recruiting

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

20 locations incl. Phoenix

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting

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Distal Radius Interventions for Fracture Treatment

for Fracture Distal Radius

25 locations incl. Phoenix

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4 - 10

Code: NCT05131685·Recruiting

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for Advanced Malignant Solid Neoplasm

475 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT05564377·Phase 2·Recruiting

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