Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,657 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 10, 2026.

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3,657 clinical trials

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A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

for Hidradenitis Suppurativa

Drug: Upadacitinib

87 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT05889182·Phase 3·Recruiting

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Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers

for Diabetic Foot Ulcer

30 locations incl. Mesa

Sponsor: Piomic Medical

Sex: All·Age: 22 - 90

Code: NCT05758545·Recruiting

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Characterization of Gastric Evoked Potentials

for Healthy

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 60·Accepts healthy volunteers

Code: NCT05924009·Recruiting

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A Retrospective Study to Characterize Participants With Propionic Acidemia

for Propionic Acidemia

6 locations incl. Stanford

Sponsor: ModernaTX, Inc.

Sex: All·Age: 2+

Code: NCT05769621·Recruiting

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Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD) and Non-interventional Arm With Untreated Patients

for LCA5

2 locations incl. Philadelphia

Sponsor: Opus Genetics, Inc

Sex: All·Age: 4+

Code: NCT05616793·Phase 1, Phase 2·Recruiting

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DFC 004 Biomarkers for Active Diabetic Foot Ulcers

for Diabetic Foot Ulcer

8 locations incl. Tucson

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT06104969·Recruiting

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Neuro-affective Response to Light in Depressed Adolescents and Young Adults

for Depression in Adolescence

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 12 - 30

Code: NCT05712772·Recruiting

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

820 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting

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A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome

for Rett Syndrome

13 locations incl. Birmingham

Sponsor: Neurogene Inc.

Sex: Female·Age: 3+

Code: NCT05898620·Phase 3·Recruiting

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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

18 locations incl. Gilbert

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT05926765·Phase 2·Recruiting

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Reducing Alcohol Involved Sexual Violence in Higher Education

for Sexual Violence

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 24·Accepts healthy volunteers

Code: NCT05185440·Recruiting

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Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

87 locations incl. Tucson

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting

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Synovial Sarcoma Registry / Biospecimen Repository

for Synovial Sarcoma

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT05910307·Recruiting

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Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

for Crohn Disease

22 locations incl. Phoenix

Sponsor: Connecticut Children's Medical Center

Sex: All·Age: 6 - 17

Code: NCT05781152·Phase 4·Recruiting

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Alzheimer's Disease Neuroimaging Initiative 4

for Mild Cognitive Impairment

59 locations incl. Birmingham

Sponsor: University of Southern California

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05617014·Enrolling By Invitation

Effects of the Contraceptive Implant in Women With Sickle Cell Disease

for Sickle Cell Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 45

Code: NCT05730205·Phase 4·Recruiting

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Study of ALTO-300 in MDD

for Major Depressive Disorder

45 locations incl. Phoenix

Sponsor: Alto Neuroscience

Sex: All·Age: 18 - 70

Code: NCT05922878·Phase 2·Recruiting

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Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

for Sickle Cell Disease

9 locations incl. Birmingham

Sponsor: RTI International

Sex: All·Age: 18+

Code: NCT06385886·Recruiting

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A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

for Cancer

11 locations incl. Los Angeles

Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05948865·Phase 1·Recruiting

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Human Learning of New Structured Information Across Time and Sleep

for Learning

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT05910762·Recruiting

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An Augmented Reality Based System for Neglect Detection, Assessment, and Rehabilitation

for Stroke

2 locations incl. Boston

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT04187131·Recruiting

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Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)

for Peripheral Nerve Injuries

7 locations incl. Baltimore

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18 - 80

Code: NCT04789044·Phase 2·Recruiting

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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

for Recurrent Melanoma (Skin)

Drug: Nivolumab

13 locations incl. Orange

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05655312·Phase 1, Phase 2·Recruiting

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Amygdala Neurofeedback for Depression - Large Scale Clinical Trial

for Major Depressive Disorder

1 location in Pittsburgh

Sponsor: Kymberly Young

Sex: All·Age: 18 - 55

Code: NCT05703256·Recruiting

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Study of Effect of Azeliragon in Patients Refractory to Prior Treatment of Metastatic Pancreatic Cancer

for Metastatic Pancreatic Cancer

6 locations incl. Los Angeles

Sponsor: Cantex Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT05766748·Phase 1, Phase 2·Recruiting

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Liposomal Bupivacaine and Transoral Robotic Surgery

for Oropharyngeal Cancer

1 location in Danville

Sponsor: Geisinger Clinic

Sex: All·Age: 18+

Code: NCT05862792·Recruiting

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ML-004 Open-Label Extension Study in Adults and Adolescents With Autism Spectrum Disorders (ASD)

for Autism Spectrum Disorder

18 locations incl. Dothan

Sponsor: MapLight Therapeutics

Sex: All·Age: 12 - 46

Code: NCT05889273·Phase 2·Enrolling By Invitation

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

for Heart Failure

20 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 29 Days - 17

Code: NCT05714085·Phase 2, Phase 3·Recruiting

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PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

for Infections

13 locations incl. Indianapolis

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18+

Code: NCT05699174·Phase 3·Recruiting

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Comparison of EVAR and ESAR for Infrarenal Aortic Aneurysms With a Wide Proximal Neck

for Aortic Aneurysm, Abdominal

16 locations incl. Washington

Sponsor: Rijnstate Hospital

Sex: All·Age: 18+

Code: NCT05484115·Recruiting

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Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury

for Spinal Cord Injuries

1 location in Philadelphia

Sponsor: Temple University

Sex: All·Age: 18 - 75

Code: NCT05317832·Phase 2·Recruiting

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REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study

for Intra Cerebral Hemorrhage

26 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: All ages

Code: NCT05611918·Enrolling By Invitation

GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma

for Refractory Neuroblastoma

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: 1+

Code: NCT05650749·Phase 1·Recruiting

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QOL and Sarcopenia in Patients With Ascites

for Ascites Hepatic

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT05726747·Recruiting

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Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma

for Refractory Ewing Sarcoma

Drug: Lurbinectedin

14 locations incl. Los Angeles

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 2 - 30

Code: NCT05734066·Phase 1, Phase 2·Recruiting

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FOG-001 in Locally Advanced or Metastatic Solid Tumors

for Cancer

31 locations incl. Phoenix

Sponsor: Parabilis Medicines, Inc.

Sex: All·Age: 18+

Code: NCT05919264·Phase 1, Phase 2·Recruiting

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Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma

for T-cell Acute Lymphoblastic Leukemia

16 locations incl. Phoeniz

Sponsor: New York Medical College

Sex: All·Age: Up to 39

Code: NCT04972942·Phase 1·Recruiting

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Phase IB/II of CPX-351 for Relapse Prevention in AML

for Acute Myeloid Leukemia (AML) in Remission

3 locations incl. Washington D.C.

Sponsor: Georgetown University

Sex: All·Age: 18+

Code: NCT04990102·Phase 1, Phase 2·Recruiting

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Randomized Assessment of TcMS for VT Storm

for Ventricular Tachycardia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05599022·Recruiting

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A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

for Myositis

47 locations incl. Glendale

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05895786·Phase 3·Recruiting

Apply to this trial