Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,657 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 10, 2026.

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3,657 clinical trials

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mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

785 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05677490·Phase 3·Recruiting

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The Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)

for Lower Respiratory Tract Infection

8 locations incl. Jacksonville

Sponsor: MeMed Diagnostics Ltd.

Sex: All·Age: 18 - 99

Code: NCT05762302·Recruiting

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Surgical Treatment of Peri-implantitis Using a Bone Substitute With or Without a Resorbable Collagen Membrane

for Peri-Implantitis

1 location in Pittsburgh

Sponsor: Andrea Ravida

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05699343·Enrolling By Invitation

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

for Mood Disorders

3 locations incl. Monroeville

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 100

Code: NCT05658796·Recruiting

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Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention

for Suicide and Depression

13 locations incl. Gibbsboro

Sponsor: University of Pittsburgh

Sex: All·Age: 12 - 18

Code: NCT05748730·Recruiting

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Co-administration of CART22-65s and huCART19 for B-ALL

for B-cell Acute Lymphoblastic Leukemia

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: Up to 29

Code: NCT05674175·Phase 1, Phase 2·Recruiting

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The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)

for Pregnancy Related

1 location in Philadelphia

Sponsor: Temple University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05499507·Recruiting

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Penn Family Screening for Familial Hypercholesterolemia

for Familial Hypercholesterolemia

1 location in Philadelphia

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05750667·Enrolling By Invitation

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

23 locations incl. Los Angeles

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting

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A Study to See Iftolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old withAutosomal Recessive Polycystic Kidney Disease (ARPKD)

for Autosomal Recessive Polycystic Kidney (ARPKD)

12 locations incl. Washington D.C.

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 28 Days - 18

Code: NCT04782258·Phase 3·Recruiting

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Descemet Endothelial Thickness Comparison Trial II

for Fuchs

8 locations incl. Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT05275972·Phase 3·Recruiting

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

for Movement Disorders

4 locations incl. Baltimore

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT05539196·Recruiting

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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

for H3 K27M

67 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: All ages

Code: NCT05580562·Phase 3·Recruiting

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PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial

for Lung Carcinoma

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05775939·Recruiting

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Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)

for Pulmonary Arterial Hypertension

10 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 - 17

Code: NCT05587712·Phase 2·Recruiting

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Posterior Cingulate Cortex and Executive Control of Episodic Memory

for Episodic Memory

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 50

Code: NCT06540976·Recruiting

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Validation of Oxygen Nanosensor in Mitochondrial Myopathy

for Mitochondrial Myopathies

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04086329·Phase 1·Recruiting

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Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

for Gastric Cancer

11 locations incl. Los Angeles

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05702229·Phase 2·Recruiting

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WBSI Guided Personalized Delivery of TTFields

for GBM

2 locations incl. Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 22+

Code: NCT05086497·Recruiting

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Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

for Multiple Sclerosis

12 locations incl. New Haven

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55

Code: NCT05285891·Phase 4·Recruiting

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FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

for Urinary Bladder Neoplasms

41 locations incl. Tucson

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05614739·Phase 1·Recruiting

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Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)

for Mesotheliomas Pleural

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT03760575·Phase 1·Recruiting

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Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

Treatment for Problematic Sexual Behavior of Preteen Children

for Problematic Sexual Behavior Among Preteen Children

1 location in Harrisburg

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 4 - 12

Code: NCT05514730·Recruiting

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Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

for Acute Gout Flare

25 locations incl. Birmingham

Sponsor: Olatec Therapeutics LLC

Sex: All·Age: 18+

Code: NCT05658575·Phase 2, Phase 3·Recruiting

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DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis

for Venous Thromboembolism

48 locations incl. Scottsdale

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT05701917·Recruiting

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Endurant Stent Graft System vs Excluder Endoprothesis: ADVANCE Trial

for Abdominal Aortic Aneurysm

32 locations incl. Loma Linda

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 20+

Code: NCT05378347·Recruiting

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taVNS for FRNS in Children

for Nephrotic Syndrome in Children

2 locations incl. New Hyde Park

Sponsor: Northwell Health

Sex: All·Age: 3 - 17

Code: NCT05588063·Recruiting

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The Effects of Medicaid Policy Interventions on Racial Equity in Severe Maternal Morbidity

for Severe Maternal Morbidity

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05678699·Recruiting

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A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

for Autoimmune Diseases

12 locations incl. Orange

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06587828·Recruiting

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Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study

for Pain, Chronic

5 locations incl. Phoenix

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT05612750·Recruiting

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A Long-Term Follow-Up Study in Severe Hemophilia A Subjects Who Received BMN 270 in a Prior BioMarin Clinical Trial (270-401)

for Hemophilia A

13 locations incl. Los Angeles

Sponsor: BioMarin Pharmaceutical

Sex: Male·Age: 18+

Code: NCT05768386·Enrolling By Invitation

Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema

for Hereditary Angioedema

13 locations incl. Birmingham

Sponsor: Pharvaris Netherlands B.V.

Sex: All·Age: 12+

Code: NCT05396105·Phase 2, Phase 3·Enrolling By Invitation

Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively

for Hemophilia A

14 locations incl. Rancho Cordova

Sponsor: Pfizer

Sex: Male·Age: 18+

Code: NCT05568719·Phase 3·Recruiting

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Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA Study

for Breast Cancer

17 locations incl. Greenbrae

Sponsor: Tolmar Inc.

Sex: All·Age: 18 - 51

Code: NCT05645536·Phase 3·Enrolling By Invitation

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

for Atrial Fibrillation (AF)

Drug: Abelacimab

150 locations incl. Birmingham

Sponsor: Anthos Therapeutics, Inc.

Sex: All·Age: 65+

Code: NCT05712200·Phase 3·Recruiting

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PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

for Critical Limb Ischemia

30 locations incl. La Jolla

Sponsor: LimFlow, Inc.

Sex: All·Age: 18 - 95

Code: NCT05313165·Recruiting

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A Study of Photobiomodulation (PBM) Therapy in People With Oral Graft-Versus-Host Disease (GVHD) After Stem Cell Transplant

for Graft-Versus-Host Disease

9 locations incl. Bethesda

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 4+

Code: NCT05675930·Phase 2·Recruiting

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First in Human Study of AZD9592 in Solid Tumors

for Advanced Solid Tumours

17 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05647122·Phase 1·Recruiting

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EXploring Inflammation and Social deTerminants Study in Breast Cancer Patients

for Breast Cancer

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: Female·Age: 18+

Code: NCT07478016·Recruiting

Apply to this trial