Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder

for Generalized Anxiety Disorder

Sites in Allentown, Media +23 more locations

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: All ages

Code: NCT06480383·Phase 2·Recruiting·Listed Jun 2024

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Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

for Endometrial Carcinoma

Sites in Philadelphia, Allentown +330 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05256225·Phase 3·Recruiting·Listed Feb 2022

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A Study of AZD3470, a PRMT5 Inhibitor, Given as Monotherapy and in Combination in Patients With MTAP Deficient Advanced/Metastatic Solid Tumors

for Advanced Solid Tumors That Are MTAP Deficient

Sites in Pittsburgh +6 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06130553·Phase 1, Phase 2·Recruiting·Listed Nov 2023

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A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

Sites in Media, Butler +115 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06742723·Phase 3·Recruiting·Listed Dec 2024

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A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

for COPD (Chronic Obstructive Pulmonary Disease)

Sites in Philadelphia, Camp Hill +132 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06283966·Phase 3·Recruiting·Listed Feb 2024

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A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

for Graves' Disease

Drug: IMVT-1402

Sites in Pottstown +54 more locations

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 75

Code: NCT06727604·Phase 2·Recruiting·Listed Dec 2024

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Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity

for Primary Sjögren's Syndrome

Drug: IMVT-1402

Sites in Philadelphia +28 more locations

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 74

Code: NCT06979531·Phase 2·Recruiting·Listed May 2025

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Study of Cabozantinib With Selumetinib for Plexiform Neurofibromas

for Neurofibromatosis 1

Drug: Cabozantinib

Sites in Philadelphia +5 more locations

Sponsor: Girish Dhall, MD

Sex: All·Age: 16+

Code: NCT06502171·Phase 1·Recruiting·Listed Jul 2024

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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting·Listed Jan 2024

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Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

for Metastatic Malignant Solid Neoplasm

Sites in Pittsburgh +17 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05372614·Phase 1·Recruiting·Listed May 2022

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Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Pittsburgh +18 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 95

Code: NCT05061550·Phase 2·Recruiting·Listed Sep 2021

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Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

for Arrhythmia

Sites in Philadelphia, Pittsburgh +82 more locations

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT00271180·Recruiting·Listed Dec 2005

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The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)

for Cardiac Arrest (CA)

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07002294·Recruiting·Listed Jun 2025

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Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

for Metastatic Clear Cell Renal Cell Carcinoma

Drug: Cabozantinib

Sites in Monroeville +45 more locations

Sponsor: Arcus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07011719·Phase 3·Recruiting·Listed Jun 2025

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A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

for Untreated Follicular Lymphoma

Drug: Rituximab

Sites in Pittsburgh +56 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06549595·Phase 3·Recruiting·Listed Aug 2024

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Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

for Transthyretin Amyloidosis

Sites in Philadelphia, Danville +31 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06465810·Recruiting·Listed Jun 2024

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in Pittsburgh +30 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting·Listed Jun 2024

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Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

for Coronary Artery Disease

Sites in Pittsburgh, York +31 more locations

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: All ages

Code: NCT02061436·Recruiting·Listed Feb 2014

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AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma

for Multiple Myeloma

Sites in Philadelphia +7 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06106945·Phase 1, Phase 2·Recruiting·Listed Oct 2023

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Optimizing Digital Health Technology Interventions to Increase Skill Acquisition and Utilization

for Bulimia Nervosa

1 location in Philadelphia

Sponsor: Nemours Children's Clinic

Sex: All·Age: 18 - 70

Code: NCT05473013·Recruiting·Listed Jul 2022

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Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

for Endometrial Cancer

Sites in Philadelphia, Pittsburgh +65 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07044336·Phase 3·Recruiting·Listed Jun 2025

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Alleviant ALLAY-HFrEF Study

for Heart Failure

Sites in Harrisburg +38 more locations

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Recruiting·Listed Feb 2025

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A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)

for Staphylococcus Aureus

Sites in Bethlehem +39 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT06749457·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

for Chronic Lymphocytic Leukaemia

Sites in Philadelphia +1 more location

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06651970·Phase 4·Recruiting·Listed Oct 2024

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC

for Non-squamous Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in York +60 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06627647·Phase 3·Recruiting·Listed Oct 2024

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Alleviant ALLAY-HF Study

for Heart Failure

Sites in Harrisburg +42 more locations

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Recruiting·Listed Jan 2023

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An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

for Systemic Lupus Erythematosus

Sites in Philadelphia +19 more locations

Sponsor: AstraZeneca

Sex: All·Age: 5 - 17

Code: NCT05835310·Phase 3·Recruiting·Listed Apr 2023

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Hershey, York +63 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06692738·Phase 3·Recruiting·Listed Nov 2024

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Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

for B-cell Non-Hodgkin Lymphoma

Sites in Philadelphia, Pittsburgh +14 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06526793·Phase 2·Recruiting·Listed Jul 2024

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Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

for Asthma

Sites in Pittsburgh +95 more locations

Sponsor: AstraZeneca

Sex: All·Age: 12 - 17

Code: NCT06307665·Phase 3·Recruiting·Listed Mar 2024

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Observational Study Protocol: LIVER-R

for Hepatobiliary Cancers

Sites in Philadelphia, Pittsburgh +22 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06252753·Recruiting·Listed Feb 2024

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Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

for Arthritis, Psoriatic

Sites in Duncansville +35 more locations

Sponsor: MoonLake Immunotherapeutics AG

Sex: All·Age: 18+

Code: NCT06641089·Phase 3·Recruiting·Listed Oct 2024

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A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

for Chronic Lymphocytic Leukaemia

Sites in Philadelphia, Pittsburgh +10 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06564038·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

for Breast Cancer

Sites in Pittsburgh +9 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05123482·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)

for Sarcoma,Soft Tissue

Sites in Philadelphia +9 more locations

Sponsor: Intensity Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06263231·Phase 3·Recruiting·Listed Feb 2024

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PSMA PET Combined With MRI for the Detection of PCa

for PCA

Sites in Philadelphia +15 more locations

Sponsor: Telix Pharmaceuticals (Innovations) Pty Limited

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT07052214·Phase 3·Recruiting·Listed Jul 2025

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A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

for Clear Cell Renal Cell Carcinoma

Sites in Pittsburgh +19 more locations

Sponsor: Arcus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05536141·Phase 1·Recruiting·Listed Sep 2022

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

for Carcinoma, Non-Small Cell Lung

Drug: Rilvegostomig

Sites in Philadelphia, Fountain Hill +37 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06868277·Phase 3·Recruiting·Listed Mar 2025

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A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease

for Liver Diseases, Alcoholic

Sites in Philadelphia +32 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 70

Code: NCT06613698·Phase 2·Recruiting·Listed Sep 2024

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Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias

for Spinocerebellar Ataxia Type 1

Sites in Philadelphia +13 more locations

Sponsor: Lauren Moore

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT01060371·Recruiting·Listed Feb 2010

Apply to this trial