Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,657 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 11, 2026.

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3,655 clinical trials

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Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

for Renal Pelvis and Ureter Urothelial Carcinoma

Drug: Durvalumab

258 locations incl. Kingman

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04628767·Phase 2, Phase 3·Recruiting

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Clinical and Radiographic Success of MTA vs Biodentine

for Indirect Pulp Cap

1 location in Danville

Sponsor: Geisinger Clinic

Sex: All·Age: 2 - 12·Accepts healthy volunteers

Code: NCT04863222·Phase 4·Recruiting

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DISE: Phenotyping Obstruction Patterns

for Obstructive Sleep Apnea

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05050383·Recruiting

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Ceribell Delirium Data Collection Study

for Delirium

7 locations incl. Stanford

Sponsor: Ceribell Inc.

Sex: All·Age: 18+

Code: NCT04962815·Recruiting

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Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

for Breast Cancer, NOS

347 locations incl. Fairbanks

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18 - 39

Code: NCT05108298·Recruiting

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Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

for Healthy Children

5 locations incl. Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 6 Months - 8·Accepts healthy volunteers

Code: NCT04639830·Recruiting

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A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

for Propionic Acidemia

7 locations incl. Los Angeles

Sponsor: ModernaTX, Inc.

Sex: All·Age: 1+

Code: NCT05130437·Phase 1, Phase 2·Recruiting

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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

for Colorectal Carcinoma

21 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 30

Code: NCT04851119·Phase 1, Phase 2·Recruiting

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Increasing Gait Automaticity in Older Adults by Exploiting Locomotor Adaptation

for Community Mobility of Older Adults

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT04934956·Recruiting

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Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)

for Acute Stroke

35 locations incl. Fairhope

Sponsor: DiaMedica Therapeutics Inc

Sex: All·Age: 18 - 90

Code: NCT05065216·Phase 2, Phase 3·Recruiting

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A Phase I Safety and Pharmacokinetic Study of Gamitrinib Administered Intravenously to Patients With Advanced Cancer

for Lymphoma

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT04827810·Phase 1·Recruiting

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CAR-T Followed by Bispecific Antibodies

for Large B-cell Lymphoma

2 locations incl. Omaha

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04889716·Phase 2·Recruiting

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Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia

for Schizophrenia

1 location in Pittsburgh

Sponsor: Fabio Ferrarelli

Sex: All·Age: 18 - 40

Code: NCT05102929·Recruiting

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Impact of Tamsulosin on Post-Operative Urinary Retention Following Pelvic Reconstructive Surgery

for Urinary Retention Postoperative

1 location in Pittsburgh

Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT04597372·Phase 2·Recruiting

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SHAPE of Portal Hypertension in Children

for Hypertension, Portal

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 6 - 21

Code: NCT04720456·Phase 2·Recruiting

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ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04523857·Phase 2·Recruiting

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Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

for Disorder

4 locations incl. Portland

Sponsor: Unity Health Toronto

Sex: All·Age: 18 - 65

Code: NCT04754022·Recruiting

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Desara ® One Single Incision Sling 522 Study

for Stress Urinary Incontinence

15 locations incl. Phoenix

Sponsor: Caldera Medical, Inc.

Sex: Female·Age: 18+

Code: NCT04772131·Recruiting

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Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

for Acute Kidney Injury

3 locations incl. Pittsburgh

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT04982419·Phase 2, Phase 3·Recruiting

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Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder

for Alcohol Use Disorder (AUD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT05015881·Phase 2, Phase 3·Enrolling By Invitation

Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy

for Cardiomyopathy

21 locations incl. Little Rock

Sponsor: Tenaya Therapeutics

Sex: All·Age: 0 - 18

Code: NCT05112237·Recruiting

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American Lung Association (ALA) Lung Health Cohort

for Lung Diseases

37 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT04543461·Recruiting

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Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT

for Thrombosis, Deep Vein

15 locations incl. Orange

Sponsor: Mercator MedSystems, Inc.

Sex: All·Age: 18 - 89

Code: NCT04862468·Phase 2·Recruiting

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Customized TULSA-PRO Ablation Registry

for Prostate Cancer

5 locations incl. West Hills

Sponsor: Profound Medical Inc.

Sex: Male·Age: 18+

Code: NCT05001477·Recruiting

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Two Step Haplo With Radiation Conditioning

for Acute Lymphoblastic Leukemia

1 location in Philadephia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05031897·Phase 2·Recruiting

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A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

for Metastatic Colorectal Cancer

35 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT04929223·Phase 1·Recruiting

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A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

for Endometrial Cancer

21 locations incl. Duarte

Sponsor: Alliance Foundation Trials, LLC.

Sex: Female·Age: 18+

Code: NCT04486352·Phase 1, Phase 2·Recruiting

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Combination Therapy for the Treatment of Diffuse Midline Gliomas

for Diffuse Intrinsic Pontine Glioma

19 locations incl. Birmingham

Sponsor: University of California, San Francisco

Sex: All·Age: 2 - 39

Code: NCT05009992·Phase 2·Recruiting

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ConsideRAte Study - Splenic Stimulation for RA

for Rheumatoid Arthritis

12 locations incl. Anniston

Sponsor: Galvani Bioelectronics

Sex: All·Age: 22 - 75

Code: NCT05003310·Recruiting

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A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

for Breast Cancer

14 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05123482·Phase 1, Phase 2·Recruiting

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Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs

for Interstitial Lung Disease

14 locations incl. Phoenix

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04930289·Enrolling By Invitation

US National OCS Liver Perfusion (OLP) Registry

for Liver Transplant

22 locations incl. Birmingham

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05940857·Recruiting

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PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

for Aortic Stenosis, Calcific

65 locations incl. Huntsville

Sponsor: Edwards Lifesciences

Sex: All·Age: 65+

Code: NCT04889872·Recruiting

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Matching Perfusion and Metabolic Activity in HFpEF

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04913805·Phase 2·Recruiting

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STRIVE Post-Market Registry Study

for Emphysema

14 locations incl. Phoenix

Sponsor: Olympus Corporation of the Americas

Sex: All·Age: 18+

Code: NCT04302272·Recruiting

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CapTemY90 for Grade 2/3 NET Liver Metastases

for Neuroendocrine Tumor Grade 2

4 locations incl. La Jolla

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04339036·Phase 2·Recruiting

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Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults

for Influenza, Human

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05108818·Phase 4·Recruiting

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Trial of Vision Therapy for Intermittent Exotropia

for Intermittent Exotropia

6 locations incl. Birmingham

Sponsor: Southern California College of Optometry at Marshall B. Ketchum University

Sex: All·Age: 8 - 16

Code: NCT04487249·Recruiting

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BSGM to Evaluate Patients With GI Symptoms

for Gastrointestinal Motility Disorders in Children

5 locations incl. San Diego

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 8 - 25·Accepts healthy volunteers

Code: NCT05880199·Recruiting

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Early Antenatal Support for Iron Deficiency Anemia

for Pregnancy Related

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: Female·Age: 18 - 65

Code: NCT04278651·Phase 4·Recruiting

Apply to this trial