Neurology Clinical Trials in Philadelphia, PA

As of July 2026, 81 paid clinical trials are recruiting for Neurology in Philadelphia, Pennsylvania. Neurology trials investigate disease-modifying therapies for Alzheimer's, Parkinson's, multiple sclerosis, ALS, and stroke recovery alongside symptomatic treatments for epilepsy, migraine, and cognitive decline. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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82 clinical trials for Neurology

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CTSN Embolic Protection Trial

for Delirium

Sites in Philadelphia +18 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting·Listed Sep 2023

Apply to this trial

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

for Multiple Sclerosis

Sites in Philadelphia +12 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55

Code: NCT05285891·Phase 4·Recruiting·Listed Mar 2022

Apply to this trial

BLOCK-SAH - PPF-Block for Post-SAH Headache

for Subarachnoid Hemorrhage, Aneurysmal

Sites in Philadelphia +12 more locations

Sponsor: University of Florida

Sex: All·Age: 18 - 85

Code: NCT06008795·Phase 2·Recruiting·Listed Aug 2023

Apply to this trial

Sense4Safety Intervention

for Mild Cognitive Impairment

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT07220668·Phase 1, Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85

Code: NCT06968663·Phase 2·Recruiting·Listed May 2025

Apply to this trial

Tele-Exercise to Promote Empowered Movement in Individuals With Spinal Cord Injury

for Spinal Cord Injury

1 location in Philadelphia

Sponsor: Drexel University

Sex: All·Age: 18 - 75

Code: NCT07022808·Recruiting·Listed Jun 2025

Apply to this trial

ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Philadelphia, Hershey +29 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

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Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders

for Movement Disorders

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06848530·Recruiting·Listed Feb 2025

Apply to this trial

Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

for Seizures

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 18

Code: NCT03419260·Recruiting·Listed Feb 2018

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Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury

for Spinal Cord Injuries

1 location in Philadelphia

Sponsor: Temple University

Sex: All·Age: 18 - 75

Code: NCT05317832·Phase 2·Recruiting·Listed Apr 2022

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PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

Sites in Philadelphia, Pittsburgh +28 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting·Listed Jul 2020

Apply to this trial

Facilitating Access to Specialty Treatment

for Mild Traumatic Brain Injury

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 13 - 18

Code: NCT05741411·Recruiting·Listed Feb 2023

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Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

for Delirium

Sites in Philadelphia, Pittsburgh +5 more locations

Sponsor: University of Michigan

Sex: All·Age: 70+

Code: NCT05929703·Recruiting·Listed Jul 2023

Apply to this trial

Longitudinal Assessment of Traumatic Microvascular Injury-2

for Traumatic Brain Injury

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05725993·Recruiting·Listed Feb 2023

Apply to this trial

Promoting Recovery After STroke With Amantadine

for Stroke, Ischemic

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85

Code: NCT05140148·Phase 2·Recruiting·Listed Dec 2021

Apply to this trial

Responding With Evidence and Access for Childhood Headaches

for Headache

Sites in Philadelphia +14 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 10 - 17

Code: NCT05889624·Recruiting·Listed Jun 2023

Apply to this trial

Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Philadelphia, York +52 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

Apply to this trial

Optimizing the Prehospital Use of Stroke Systems of Care-Reacting to Changing Paradigms-Implementation (OPUS-i)

for Stroke

Sites in Philadelphia +1 more location

Sponsor: Temple University

Sex: All·Age: 18+

Code: NCT06530693·Recruiting·Listed Jul 2024

Apply to this trial

Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

for Aphasia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85

Code: NCT06842745·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Localizing Epileptic Networks Using MRI and iEEG

for Epilepsy

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04649008·EARLY_Phase 1·Recruiting·Listed Dec 2020

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Philadelphia, Pittsburgh +39 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

Sites in Philadelphia +27 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

Apply to this trial

Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke

for Ischemic Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 90

Code: NCT04897334·Recruiting·Listed May 2021

Apply to this trial

Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

for Stroke

Sites in Philadelphia, Hershey +39 more locations

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05338697·Recruiting·Listed Apr 2022

Apply to this trial

Surviving Daily Life

for Stress

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: Female·Age: 40+

Code: NCT07054723·Recruiting·Listed Jul 2025

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Sildenafil for Microvasculopathy in Chronic TBI

for Traumatic Brain Injury

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 70

Code: NCT05782244·Phase 2·Recruiting·Listed Mar 2023

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PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620

for Frontotemporal Lobar Degeneration

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05456503·Phase 3·Recruiting·Listed Jul 2022

Apply to this trial

Parkinson's Disease and Movement Disorders Clinical Database

for Parkinson Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04997642·Recruiting·Listed Aug 2021

Apply to this trial

Using the EHR to Advance Genomic Medicine Across a Diverse Health System

for Genetic Predisposition

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06377033·Recruiting·Listed Apr 2024

Apply to this trial

Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

for Alzheimer's Disease

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 120

Code: NCT05658913·Recruiting·Listed Dec 2022

Apply to this trial

tACS to Enhance Language Abilities

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06092814·Recruiting·Listed Oct 2023

Apply to this trial

Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

Sites in Philadelphia +13 more locations

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting·Listed Apr 2018

Apply to this trial

Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes

for Craniocerebral Trauma

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06632587·Recruiting·Listed Oct 2024

Apply to this trial

Epilepsy Learning Healthcare System (ELHS)

for Epilepsy

Sites in Philadelphia, Hershey +11 more locations

Sponsor: Epilepsy Foundation of America

Sex: All·Age: All ages

Code: NCT06265103·Recruiting·Listed Feb 2024

Apply to this trial

Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

Sites in Philadelphia +52 more locations

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting·Listed Aug 2021

Apply to this trial

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Philadelphia +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

Apply to this trial

The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis

for Myasthenia Gravis

Sites in Philadelphia +9 more locations

Sponsor: Ad scientiam

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05564936·Recruiting·Listed Oct 2022

Apply to this trial

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)

for Parkinson's Disease

Sites in Philadelphia +1 more location

Sponsor: University of Nebraska

Sex: All·Age: 18 - 80

Code: NCT05070013·Recruiting·Listed Oct 2021

Apply to this trial

Spinal Cord Injury Registry - North American Clinical Trials Network

for Spinal Cord Injury

Sites in Philadelphia +9 more locations

Sponsor: Robert G. Grossman, MD

Sex: All·Age: 18+

Code: NCT00178724·Recruiting·Listed Sep 2005

Apply to this trial

Environmental and Sensory Intervention for Nursing Home Residents With Dementia Who Exhibit Persistent Vocalizations

for Dementia

1 location in Philadelphia

Sponsor: Drexel University

Sex: All·Age: 50+

Code: NCT06568107·Recruiting·Listed Aug 2024

Apply to this trial

Conditions in Neurology (Philadelphia, PA)

Stroke· 22 Parkinson's disease· 11 Alzheimer's disease· 8 ALS (amyotrophic lateral sclerosis)· 8 Traumatic brain injury (TBI)· 8 Epilepsy· 7 Myasthenia gravis· 7 Mild cognitive impairment (MCI)· 6 Migraine· 6 Spinal cord injury· 6 Dementia· 5 Multiple sclerosis· 5 Aphasia· 3 Cognitive impairment / decline· 3 Headache· 2 Huntington disease· 2 Movement disorders· 2 Essential tremor· 1