Clinical Trials at Children's Hospital of Philadelphia

As of July 2026, 273 paid clinical trials are recruiting at Children's Hospital of Philadelphia, located at 3550 MARKET ST, 5TH FLOOR, PHILADELPHIA, PA 19104-3329, phone (215) 590-4862 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

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274 clinical trials at Children's Hospital of Philadelphia

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TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

for Hematopoietic Stem Cell Transplant (HSCT)

Sites in Philadelphia +8 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: Up to 24

Code: NCT04098445·Recruiting·Listed Sep 2019

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NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

for Neuroblastoma

Drug: Irinotecan

Sites in Philadelphia +12 more locations

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 1 - 31

Code: NCT06450041·Phase 2·Recruiting·Listed Jun 2024

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PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

for Refractory Solid Tumors

Sites in Philadelphia +6 more locations

Sponsor: Theodore Laetsch

Sex: All·Age: 1 - 30

Code: NCT06721689·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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ARPKD Database Study

for Hepato/Renal Fibrocystic Disease

Sites in Philadelphia +5 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 18

Code: NCT01401998·Recruiting·Listed Jul 2011

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Autosomal Dominant Polycystic Kidney Disease (ADPKD) Study

for ADPKD

Sites in Philadelphia +3 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 18

Code: NCT04338048·Recruiting·Listed Apr 2020

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Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)

for Depressive Symptoms

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 13 - 17

Code: NCT07020572·Recruiting·Listed Jun 2025

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Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies

for Deep Venous Thrombosis

Sites in Philadelphia, Hershey +18 more locations

Sponsor: Yale University

Sex: All·Age: Up to 17

Code: NCT04924322·Phase 2, Phase 3·Recruiting·Listed Jun 2021

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A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

for B Acute Lymphoblastic Leukemia Associated With Down Syndrome

Sites in Philadelphia, Pittsburgh +67 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 6 - 39

Code: NCT05702645·Recruiting·Listed Jan 2023

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Anti-CD7 CAR-T Cells in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia or Lymphoma

for T-Cell Acute Lymphoblastic Leukemia/Lymphoma

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: 0 - 29

Code: NCT06934382·Phase 1·Recruiting·Listed Apr 2025

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Get ActivE Study for At-risk Youth

for Anhedonia

Sites in Philadelphia & Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 12 - 18

Code: NCT06829953·Recruiting·Listed Feb 2025

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Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention

for Sepsis

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 17

Code: NCT07084129·Phase 1·Recruiting·Listed Jul 2025

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Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

for Hematologic Malignancy

Drug: Venetoclax

Sites in Philadelphia +4 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 0 - 38

Code: NCT06131801·Recruiting·Listed Nov 2023

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Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

Sites in Philadelphia, Pittsburgh +74 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting·Listed Oct 2024

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Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma

for Childhood Astrocytoma

Sites in Philadelphia, Pittsburgh +18 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 22

Code: NCT06894979·Phase 1·Recruiting·Listed Mar 2025

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VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

for Solid Tumor

Drug: Atezolizumab

Sites in Philadelphia +6 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 6 Months - 30

Code: NCT04796012·Phase 1, Phase 2·Recruiting·Listed Mar 2021

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Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)

for Neurofibromatosis 1

Sites in Philadelphia +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT02544022·Recruiting·Listed Sep 2015

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Health-E You Efficacy Trial for Male Adolescents

for Sexually Transmitted Diseases

Sites in Philadelphia, Hershey +6 more locations

Sponsor: Johns Hopkins University

Sex: Male·Age: 13 - 21·Accepts healthy volunteers

Code: NCT06525064·Recruiting·Listed Jul 2024

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Fiber Food Introduction in Pediatric Short Bowel Syndrome

for Short Gut Syndrome

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 4 Months - 18·Accepts healthy volunteers

Code: NCT05432648·Recruiting·Listed Jun 2022

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A Prospective Natural History Study of Lymphatic Anomalies

for Lymphatic Diseases

Sites in Philadelphia +1 more location

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 1 Day - 100·Accepts healthy volunteers

Code: NCT05731141·Recruiting·Listed Feb 2023

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CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT

for Acute Leukemia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 25

Code: NCT03810196·Recruiting·Listed Jan 2019

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Sleep Promotion and Pediatric Hypertension

for Insufficient Sleep

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 13 - 18

Code: NCT06642246·Recruiting·Listed Oct 2024

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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

for Infusion Reactions

Sites in Philadelphia, Hershey +58 more locations

Sponsor: New York Blood Center

Sex: All·Age: All ages

Code: NCT01656603·Phase 2·Recruiting·Listed Aug 2012

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

Sites in Philadelphia, Allentown +161 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022

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Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

for Seizures

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 18

Code: NCT03419260·Recruiting·Listed Feb 2018

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Sleep and Glycemic Control in Type 2 Diabetes Adolescents

for Type 2 Diabetes

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 12 - 20

Code: NCT04213547·Recruiting·Listed Dec 2019

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CEUS Evaluation of Hydrocephalus in Neonates and Infants

for Hydrocephalus in Infants

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Minute - 18 Months

Code: NCT06693752·Phase 2·Recruiting·Listed Nov 2024

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Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria

for Idiopathic Infantile Hypercalcaemia - Severe Form

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 6 Months - 65

Code: NCT03301038·Phase 2·Recruiting·Listed Oct 2017

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CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus

for SLE

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 12 - 29

Code: NCT06839976·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

for B-ALL

Sites in Philadelphia +5 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 30

Code: NCT06579469·Recruiting·Listed Aug 2024

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Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma

for T-cell Acute Lymphoblastic Leukemia

Sites in Philadelphia +15 more locations

Sponsor: New York Medical College

Sex: All·Age: Up to 39

Code: NCT04972942·Phase 1·Recruiting·Listed Jul 2021

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Quantifying New Heart Muscle Cells

for Tetralogy of Fallot With Pulmonary Stenosis

Sites in Philadelphia, Pittsburgh +2 more locations

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 30 Days - 1

Code: NCT06587165·Recruiting·Listed Sep 2024

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ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

for Diffuse Midline Glioma (DMG)

Sites in Philadelphia +4 more locations

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 2 - 21

Code: NCT04732065·Phase 1·Recruiting·Listed Feb 2021

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Synovial Sarcoma Registry / Biospecimen Repository

for Synovial Sarcoma

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT05910307·Recruiting·Listed Jun 2023

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Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

for Refractory Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Philadelphia +9 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 1 - 30

Code: NCT06177067·Phase 1·Recruiting·Listed Dec 2023

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Treatment of BK Virus Infection With CTL Cells in Immunocompromised Transplant Patients

for BK Polyomavirus

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 Weeks - 25

Code: NCT04293042·EARLY_Phase 1·Recruiting·Listed Mar 2020

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Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

Sites in Philadelphia +29 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting·Listed Sep 2025

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Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

for Craniopharyngioma, Child

Sites in Philadelphia +14 more locations

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 1 - 39

Code: NCT05465174·Phase 2·Recruiting·Listed Jul 2022

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A Socio-ecological Approach for Improving Self-management in Adolescents With SCD

for Anemia, Sickle Cell

Sites in Philadelphia +3 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 13 - 21

Code: NCT06290401·Recruiting·Listed Mar 2024

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A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition

for Primary Immune Regulatory Disorder

Sites in Philadelphia +5 more locations

Sponsor: Joseph Oved

Sex: All·Age: All ages

Code: NCT05787574·Phase 2·Recruiting·Listed Mar 2023

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PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for High Grade Glioma

Sites in Philadelphia +12 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 3 - 39

Code: NCT05096481·Phase 2·Recruiting·Listed Oct 2021

Apply to this trial