Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

Part of paid clinical trials in Aurora, Colorado.

Sponsor
St. Jude Children's Research Hospital
Study ID
NCT06579469
Status
Recruiting
Apply to this trial

Conditions

  • B-ALL
  • Hematologic Malignancy
  • Solid Tumor

Eligibility Criteria

Sex
ALL
Age
N/A - 30 Years
Healthy Volunteers
Not accepted

Study Details

This study is being done to learn more about the short-term and long-term side effects of CAR-T cell therapy. Specifically, researchers want to know how often patients get infections, have delays in recovering blood cell counts and/or have damage to the nervous system.

Key Dates

First listed
Aug 30, 2024
Start date
Jan 20, 2026
Status verified
Jun 2026
Primary completion
Mar 31, 2027
Completion
Mar 31, 2029

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: B cell acute lymphoblastic leukemia (B cell acute lymphoblastic leukemia (B-ALL) ) cohort
    B-ALL participants who have received initial CAR T cell therapy within the last 1-3 months.
  • Arm: Other hematologic malignancy
    Other hematologic malignancy participants who have received initial CAR T cell therapy within the last 1-3 months.
  • Arm: Solid tumor (ST)
    ST participants who have received initial CAR T cell therapy within the last 1-3 months.

Primary Outcome Measure

Presence of bone marrow dysfunction (BMD) [ Time Frame: Within 6 months post CAR T-cell therapy ]

Central Contacts

Locations (6)

FacilityCityStateZIPSite coordinators
Childrens Hospital of ColoradoAuroraColorado80045
Hesham Eissa, MD, MSc
[email protected]
720-777-4151
Hesham Eissa, MD, MSc (PRINCIPAL_INVESTIGATOR)
Children's Hospital of PhiladelphiaPhiladelphiaPennsylvania19104
Regina Myers, MD
[email protected]
215-590-1000
Regina Myers, MD (PRINCIPAL_INVESTIGATOR)
St. Jude Children's Research HospitalMemphisTennessee38105
Rebecca Epperly, MD
[email protected]
888-226-4343
Rebecca Epperly, MD (PRINCIPAL_INVESTIGATOR)
Primary Children's HospitalSalt Lake CityUtah84113
Joseph G. Dolan, MD
[email protected]
801-662-4700
Joseph G Dolan, MD (PRINCIPAL_INVESTIGATOR)
Seattle Childrens HospitalSeattleWashington98105
Mallory Taylor, MD
[email protected]
206-884-1582
Mallory Taylor, MD (PRINCIPAL_INVESTIGATOR)
Children's Hospital of Wisconsin.MilwaukeeWisconsin53226
Amy Moskop, MD
[email protected]
414-955-4142
Amy Moskop, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Aurora, CO

By research site
Childrens Hospital of Colorado· Aurora, COChildren's Hospital of Philadelphia· Philadelphia, PASt. Jude Children's Research Hospital· Memphis, TNPrimary Children's Hospital· Salt Lake City, UTSeattle Childrens Hospital· Seattle, WAChildren's Hospital of Wisconsin.· Milwaukee, WI

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