Clinical Trials at Children's Hospital of Philadelphia

As of June 2026, 300 paid clinical trials are recruiting at Children's Hospital of Philadelphia in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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300 clinical trials at Children's Hospital of Philadelphia

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Diet and Motility in IBS

for Irritable Bowel Syndrome (IBS)

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 8 - 18·Accepts healthy volunteers

Code: NCT07283341·Recruiting

Apply to this trial

Lurbinectedin in FET-Fused Tumors

for Ewing Sarcoma

Drug: Lurbinectedin

6 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10+

Code: NCT05918640·Phase 1, Phase 2·Recruiting

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Virtual Patient Navigation During a Pandemic

for Post-partum Depression

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06208852·Recruiting

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Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study

for Friedreich Ataxia

9 locations incl. Los Angeles

Sponsor: Friedreich's Ataxia Research Alliance

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06016946·Recruiting

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A Retrospective Study to Characterize Participants With Propionic Acidemia

for Propionic Acidemia

6 locations incl. Stanford

Sponsor: ModernaTX, Inc.

Sex: All·Age: 2+

Code: NCT05769621·Recruiting

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A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome

for Rett Syndrome

13 locations incl. Birmingham

Sponsor: Neurogene Inc.

Sex: Female·Age: 3+

Code: NCT05898620·Phase 3·Recruiting

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Synovial Sarcoma Registry / Biospecimen Repository

for Synovial Sarcoma

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT05910307·Recruiting

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Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

for Crohn Disease

22 locations incl. Phoenix

Sponsor: Connecticut Children's Medical Center

Sex: All·Age: 6 - 17

Code: NCT05781152·Phase 4·Recruiting

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GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma

for Refractory Neuroblastoma

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: 1+

Code: NCT05650749·Phase 1·Recruiting

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Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma

for Refractory Ewing Sarcoma

Drug: Lurbinectedin

14 locations incl. Los Angeles

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 2 - 30

Code: NCT05734066·Phase 1, Phase 2·Recruiting

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Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma

for T-cell Acute Lymphoblastic Leukemia

16 locations incl. Phoeniz

Sponsor: New York Medical College

Sex: All·Age: Up to 39

Code: NCT04972942·Phase 1·Recruiting

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A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Drug: Nivolumab

390 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 60

Code: NCT05675410·Phase 3·Recruiting

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VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

for Solid Tumor

Drug: Atezolizumab

7 locations incl. Chicago

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 6 Months - 30

Code: NCT04796012·Phase 1, Phase 2·Recruiting

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Distal Radius Interventions for Fracture Treatment

for Fracture Distal Radius

25 locations incl. Phoenix

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4 - 10

Code: NCT05131685·Recruiting

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Applying pGz in Mitochondrial Disease

for Mitochondrial Myopathies

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10 - 60·Accepts healthy volunteers

Code: NCT05569122·Phase 1·Recruiting

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A Prospective Natural History Study of Lymphatic Anomalies

for Lymphatic Diseases

2 locations incl. Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 1 Day - 100·Accepts healthy volunteers

Code: NCT05731141·Recruiting

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A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition

for Primary Immune Regulatory Disorder

13 locations incl. San Francisco

Sponsor: Joseph Oved

Sex: All·Age: All ages

Code: NCT05787574·Phase 2·Recruiting

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An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease

for Vanishing White Matter Disease

3 locations incl. Boston

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 6 Months+

Code: NCT05757141·Phase 1, Phase 2·Recruiting

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A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

for High Grade Osteosarcoma

Drug: Cabozantinib

174 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 40

Code: NCT05691478·Phase 2, Phase 3·Recruiting

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Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC

for Thyroid Cancer

6 locations incl. Washington D.C.

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12+

Code: NCT05668962·Phase 2·Recruiting

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Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors

for Lymphoblastic Leukemia

3 locations incl. Duarte

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10 - 30

Code: NCT05194397·Phase 2·Recruiting

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An Extension Study of JR-141 to Evaluate the Long-term Safety and Efficacy in MPS II (Hunter Syndrome) Subjects

for Mucopolysaccharidosis II

2 locations incl. Oakland

Sponsor: JCR Pharmaceuticals Co., Ltd.

Sex: All·Age: All ages

Code: NCT05594992·Phase 3·Enrolling By Invitation

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

for Ductus Arteriosus, Patent

24 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 7 Days - 32 Days

Code: NCT05547165·Recruiting

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

101 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting

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Co-administration of CART22-65s and huCART19 for B-ALL

for B-cell Acute Lymphoblastic Leukemia

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: Up to 29

Code: NCT05674175·Phase 1, Phase 2·Recruiting

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taVNS for FRNS in Children

for Nephrotic Syndrome in Children

2 locations incl. New Hyde Park

Sponsor: Northwell Health

Sex: All·Age: 3 - 17

Code: NCT05588063·Recruiting

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Beta-blocker Administration for Cardiomyocyte Division

for Tetralogy of Fallot

3 locations incl. New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 30 Days - 60 Days

Code: NCT04713657·Phase 1·Recruiting

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Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

for High Grade Glioma

4 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 4 - 39

Code: NCT05278208·Phase 1, Phase 2·Recruiting

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EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study

for Heart Failure

15 locations incl. Los Angeles

Sponsor: Berlin Heart, Inc

Sex: All·Age: Up to 21

Code: NCT05610787·Enrolling By Invitation

A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

22 locations incl. South Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting

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Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

for Hematologic Malignancy

29 locations incl. Los Angeles

Sponsor: Therapeutic Advances in Childhood Leukemia Consortium

Sex: All·Age: 1 - 21

Code: NCT05476770·Phase 1·Recruiting

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Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

45 locations incl. Phoenix

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting

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Autologous HuCART19 T Cells Manufactured Using the CliniMACS Prodigy Platform for Pediatric B-ALL (huCART19 Prodigy)

for B Cell Acute Lymphoblastic Leukemia (B-ALL)

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: 0 - 29

Code: NCT05480449·Phase 1, Phase 2·Recruiting

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A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)

for Nephrotic Syndrome in Children

2 locations incl. New Hyde Park

Sponsor: Northwell Health

Sex: All·Age: 3 - 17

Code: NCT05583942·Recruiting

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Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

for Craniopharyngioma, Child

15 locations incl. Birmingham

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 1 - 39

Code: NCT05465174·Phase 2·Recruiting

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Follow-up Automatically vs. As-Needed Comparison (FAAN-C) Trial

for Pneumonia

14 locations incl. Phoenix

Sponsor: University of Utah

Sex: All·Age: Up to 18

Code: NCT05471908·Recruiting

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A Long-Term Safety Follow-Up Study for Patients Treat With WU-CART-007

for T-cell Acute Lymphoblastic Leukemia

4 locations incl. Duarte

Sponsor: Wugen, Inc.

Sex: All·Age: 12+

Code: NCT05509855·Enrolling By Invitation

International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery

for Congenital Disorders

4 locations incl. New York

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 60 Weeks

Code: NCT05673499·Recruiting

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Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

for Cardiac Arrest, Out-Of-Hospital

50 locations incl. Birmingham

Sponsor: University of Michigan

Sex: All·Age: 2 Days - 17

Code: NCT05376267·Recruiting

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

165 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting

Apply to this trial