DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
Part of paid clinical trials in Birmingham, Alabama.
- Sponsor
- George Washington University
- Study ID
- NCT06525259
- Status
- Recruiting
Conditions
- Diabetes Mellitus Type 2, Childhood-Onset
Eligibility Criteria
- Sex
- ALL
- Age
- 8 Years - 15 Years
- Healthy Volunteers
- Not accepted
Study Details
The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes.
Key Dates
- First listed
- Jul 29, 2024
- Start date
- Oct 1, 2024
- Status verified
- Apr 2026
- Primary completion
- Jan 31, 2028
- Completion
- Jan 31, 2028
Study Design
- Enrollment
- 3,600 participants (estimated)
Primary Outcome Measure
Type 2 diabetes [ Time Frame: Through study completion, an average of 2.5 years ]
Central Contacts
- Barbara Braffett, PhD3018819260
- Brian Burke, MS3018819260
Locations (20)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | Barbara Gower, PhD (PRINCIPAL_INVESTIGATOR) Ambika Ashraf, MD (PRINCIPAL_INVESTIGATOR) |
| Arizona State University | Phoenix | Arizona | 85004 | Gabriel Shaibi, PhD (PRINCIPAL_INVESTIGATOR) |
| Phoenix Children's | Phoenix | Arizona | 85006 | Melissa Chambers, DO (PRINCIPAL_INVESTIGATOR) |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | Michael Goran, PhD (PRINCIPAL_INVESTIGATOR) |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | Kristen Nadeau, MD (PRINCIPAL_INVESTIGATOR) Megan Kelsey, MD (PRINCIPAL_INVESTIGATOR) |
| Johns Hopkins All Children's Hospital | St. Petersburg | Florida | 33701 | Sheela N Magge, MD, MSCE (PRINCIPAL_INVESTIGATOR) |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | Sheela N Magge, MD, MSCE (PRINCIPAL_INVESTIGATOR) |
| Boston Children's/Joslin Diabetes Center/Massachusetts General Hospital | Boston | Massachusetts | 02215 | Elvira Isganaitis, MD, MPH (PRINCIPAL_INVESTIGATOR) Amy Fleischman, MD (PRINCIPAL_INVESTIGATOR) Takara Stanley, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| Colorado Navajo Nation | Shiprock | New Mexico | 87420 | Dana Dabelea, MD, PhD (PRINCIPAL_INVESTIGATOR) Wei Perng, PhD, MPH (PRINCIPAL_INVESTIGATOR) |
| NYU Langone Health- Brooklyn | Brooklyn | New York | 11220 | Mary Pat Gallagher, MD (PRINCIPAL_INVESTIGATOR) Alan Jacobson, MD (PRINCIPAL_INVESTIGATOR) |
| NYU Langone Health- Long Island | Garden City | New York | 11530 | Alan Jacobson, MD (PRINCIPAL_INVESTIGATOR) |
| NYU Langone Health- Manhattan | New York | New York | 10016 | Mary Pat Gallagher, MD (PRINCIPAL_INVESTIGATOR) |
| Albert Einstein College of Medicine | The Bronx | New York | 10461 | Carmen R Isasi, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| Atrium Health | Charlotte | North Carolina | 28207 | Christine Turley, MD (PRINCIPAL_INVESTIGATOR) |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | Elizabeth Jensen, PhD (PRINCIPAL_INVESTIGATOR) |
| Cincinnati Children's Hospital | Cincinnati | Ohio | 45229 | Allen Riegler Amy S Shah, MD, MS (PRINCIPAL_INVESTIGATOR) |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | Robert P Hoffman, MD (PRINCIPAL_INVESTIGATOR) Ihuoma Eneli, MBBS (PRINCIPAL_INVESTIGATOR) |
| The University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Jeanie B Tryggestad, MD (PRINCIPAL_INVESTIGATOR) |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | Beth Schwartzman Lorraine E Levitt Katz, MD (PRINCIPAL_INVESTIGATOR) |
| Baylor College of Medicine / Texas Children's | Houston | Texas | 77030 | Fida Bacha, MD (PRINCIPAL_INVESTIGATOR) |