Clinical Trials at University of Pennsylvania

As of July 2026, 317 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 1, 2026.

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317 clinical trials at University of Pennsylvania

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MEASuRE: Metreleptin Effectiveness And Safety Registry

for Generalised Lipodystrophy

16 locations incl. Birmingham

Sponsor: Amryt Pharma

Sex: All·Age: All ages

Code: NCT02325674·Recruiting

Apply to this trial

Adoptive Cell Therapy Long-term Follow-up (LTFU) Study

for Neoplasms

13 locations incl. Atlanta

Sponsor: USWM CT, LLC

Sex: All·Age: All ages

Code: NCT03391778·Phase 1·Recruiting

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A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

for Huntington Disease

14 locations incl. La Jolla

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 21 - 70

Code: NCT07326709·Phase 3·Recruiting

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A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

for Familial Pulmonary Fibrosis

Drug: Nerandomilast

13 locations incl. Los Angeles

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07201922·Phase 3·Recruiting

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Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

for Myelofibrosis

22 locations incl. Duarte

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT05320198·Phase 1, Phase 2·Recruiting

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A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

for HR+/HER2-negative Breast Cancer

9 locations incl. Chicago

Sponsor: Totus Medicines

Sex: Female·Age: 18+

Code: NCT05683418·Phase 1·Recruiting

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Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

for Pompe Disease

9 locations incl. Irvine

Sponsor: Shionogi

Sex: All·Age: 18+

Code: NCT07123155·Phase 2·Recruiting

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Radiation Free Study

for Aortic Aneurysm

5 locations incl. Birmingham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT06549348·Recruiting

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Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

for Cirrhosis, Liver

9 locations incl. Chandler

Sponsor: PharmaIN

Sex: All·Age: 18 - 75

Code: NCT05490888·Phase 1·Recruiting

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Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis

for Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

8 locations incl. Birmingham

Sponsor: Airiver Medical, Inc.

Sex: All·Age: 18+

Code: NCT07290140·Recruiting

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A Study of SGT-501 Gene Therapy in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

for Catecholaminergic Polymorphic Ventricular Tachycardia

4 locations incl. Boston

Sponsor: Solid Biosciences Inc.

Sex: All·Age: 7+

Code: NCT07148089·Phase 1·Recruiting

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Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

for Amyotrophic Lateral Sclerosis

7 locations incl. Phoenix

Sponsor: Vector Y Therapeutics

Sex: All·Age: 18+

Code: NCT07287397·Phase 1, Phase 2·Recruiting

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Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial (NEXT Trial)

for Cerebral Aneurysms

9 locations incl. Park Ridge

Sponsor: Cerus Endovascular, Inc.

Sex: All·Age: 18 - 75

Code: NCT06693011·Recruiting

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L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

for Acute Myeloid Leukaemia (AML)

6 locations incl. Miami

Sponsor: Moleculin Biotech, Inc.

Sex: All·Age: 18 - 80

Code: NCT06788756·Phase 2, Phase 3·Recruiting

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A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

for Huntington Disease

5 locations incl. Boston

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 65

Code: NCT06826612·Phase 1, Phase 2·Recruiting

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A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

for Neuroendocrine Tumors

4 locations incl. Atlanta

Sponsor: Chimeric Therapeutics

Sex: All·Age: 18 - 85

Code: NCT06055439·Phase 1, Phase 2·Recruiting

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A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)

for Myotonic Dystrophy Type 1 (DM1)

8 locations incl. San Carlos

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 64

Code: NCT06185764·Phase 1, Phase 2·Recruiting

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

for Movement Disorders

4 locations incl. Baltimore

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT05539196·Recruiting

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CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

9 locations incl. Indianapolis

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting

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Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

for Hepatocellular Carcinoma

2 locations incl. Palo Alto

Sponsor: Teclison Ltd.

Sex: All·Age: 20 - 99

Code: NCT02174549·Phase 1, Phase 2·Recruiting

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Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure

for Heart Failure With Reduced Ejection Fraction

1 location in Philadelphia

Sponsor: VisCardia Inc.

Sex: All·Age: 18+

Code: NCT06552637·Recruiting

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Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer

for Non Small Cell Lung Cancer (NSCLC)

2 locations incl. Philadelphia

Sponsor: Integro Theranostics

Sex: All·Age: 18+

Code: NCT07276789·Phase 2·Recruiting

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CT-95 in Advanced Cancers Associated With Mesothelin Expression

for Mesothelin-Expressing Tumors

9 locations incl. Denver

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06756035·Phase 1·Recruiting

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A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis

for Psoriatic Arthritis

Drug: Upadacitinib

3 locations incl. Cleveland

Sponsor: CARE ARTHRITIS LTD.

Sex: All·Age: 18+

Code: NCT06454188·Phase 4·Recruiting

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Abbott Structural Heart Device Registry

for Heart Diseases

5 locations incl. New Brunswick

Sponsor: Abbott Medical Devices

Sex: All·Age: All ages

Code: NCT06590467·Recruiting

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A Clinical Study of the TSX Dental Implant System (Xpresso)

for Tooth Loss

2 locations incl. Columbus

Sponsor: ZimVie

Sex: All·Age: 18+

Code: NCT06571812·Recruiting

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Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea

for Obstructive Sleep Apnea of Adult

9 locations incl. Aurora

Sponsor: Cryosa, Inc.

Sex: All·Age: 22 - 70

Code: NCT06008626·Recruiting

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A Study to Investigate the Safety, Tolerability, and Efficacy of BxC-I17e Single and Multiple Dose SC Injection in Patients With Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis

3 locations incl. North Little Rock

Sponsor: Brexogen Inc.

Sex: All·Age: 18+

Code: NCT06055361·Phase 1·Recruiting

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SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma

for Ovarian Cancer

5 locations incl. Tampa

Sponsor: Verismo Therapeutics

Sex: All·Age: 18+

Code: NCT05568680·Phase 1·Recruiting

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Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry

for Stress Urinary Incontinence

4 locations incl. New Haven

Sponsor: Ethicon, Inc.

Sex: Female·Age: 21+

Code: NCT04829175·Recruiting

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BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

for Advanced Malignancies

3 locations incl. Duarte

Sponsor: BioInvent International AB

Sex: All·Age: 18+

Code: NCT04752826·Phase 1, Phase 2·Recruiting

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Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

for Non Small Cell Lung Cancer

Drug: Osimertinib

146 locations incl. Birmingham

Sponsor: PrECOG, LLC.

Sex: All·Age: 18+

Code: NCT06538038·Recruiting

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

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Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting

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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

for Huntington's Disease

62 locations incl. Birmingham

Sponsor: CHDI Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01574053·Recruiting

Apply to this trial

Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

54 locations incl. Birmingham

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting

Apply to this trial

HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

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Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

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A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

68 locations incl. Birmingham

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

45 locations incl. Phoenix

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting

Apply to this trial