Clinical Trials at University of Pennsylvania

As of August 2026, 305 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

308 clinical trials at University of Pennsylvania

·Clear filters·

EXACT Study: A Blinded Study in Patients With Alport Syndrome to Evaluate Exaluren Efficacy and Safety

for Alport Syndrome, X-Linked

Sites in Philadelphia +7 more locations

Sponsor: Eloxx Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07523581·Phase 2·Recruiting·Listed Apr 2026

Apply to this trial

Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis

for Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

Sites in Philadelphia +9 more locations

Sponsor: Airiver Medical, Inc.

Sex: All·Age: 18+

Code: NCT07290140·Recruiting·Listed Dec 2025

Apply to this trial

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

for Amyotrophic Lateral Sclerosis

Sites in Philadelphia +6 more locations

Sponsor: Vector Y Therapeutics

Sex: All·Age: 18+

Code: NCT07287397·Phase 1, Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

Ultrasonic Neuromodulation of Cingulate Cortex for Fibromyalgia

for Fibromyalgia

Sites in Philadelphia +7 more locations

Sponsor: SPIRE Therapeutics Inc.

Sex: All·Age: 22+

Code: NCT07226648·Recruiting·Listed Nov 2025

Apply to this trial

A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

for Squamous Cell Carcinoma of Head and Neck

Sites in Philadelphia +9 more locations

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18 - 74

Code: NCT07219212·Phase 1·Recruiting·Listed Oct 2025

Apply to this trial

Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer

for Non Small Cell Lung Cancer (NSCLC)

Sites in Philadelphia +1 more location

Sponsor: Integro Theranostics

Sex: All·Age: 18+

Code: NCT07276789·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

A Study of SGT-501 Gene Therapy in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

for Catecholaminergic Polymorphic Ventricular Tachycardia

Sites in Philadelphia +3 more locations

Sponsor: Solid Biosciences Inc.

Sex: All·Age: 7+

Code: NCT07148089·Phase 1·Recruiting·Listed Aug 2025

Apply to this trial

Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

for Pompe Disease

Sites in Philadelphia, Pittsburgh +7 more locations

Sponsor: Shionogi

Sex: All·Age: 18+

Code: NCT07123155·Phase 2·Recruiting·Listed Aug 2025

Apply to this trial

L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

for Acute Myeloid Leukaemia (AML)

Sites in Philadelphia +7 more locations

Sponsor: Moleculin Biotech, Inc.

Sex: All·Age: 18 - 80

Code: NCT06788756·Phase 2, Phase 3·Recruiting·Listed Jan 2025

Apply to this trial

Radiation Free Study

for Aortic Aneurysm

Sites in Philadelphia +4 more locations

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT06549348·Recruiting·Listed Aug 2024

Apply to this trial

Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure

for Heart Failure With Reduced Ejection Fraction

Sites in Philadelphia +1 more location

Sponsor: VisCardia Inc.

Sex: All·Age: 18+

Code: NCT06552637·Recruiting·Listed Aug 2024

Apply to this trial

Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry

for Stress Urinary Incontinence

Sites in Philadelphia, Pittsburgh +2 more locations

Sponsor: Ethicon, Inc.

Sex: Female·Age: 21+

Code: NCT04829175·Recruiting·Listed Apr 2021

Apply to this trial

A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)

for Myotonic Dystrophy Type 1 (DM1)

Sites in Philadelphia +7 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 64

Code: NCT06185764·Phase 1, Phase 2·Recruiting·Listed Dec 2023

Apply to this trial

Abbott Structural Heart Device Registry

for Heart Diseases

Sites in Philadelphia, Pittsburgh +3 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: All ages

Code: NCT06590467·Recruiting·Listed Sep 2024

Apply to this trial

CT-95 in Advanced Cancers Associated With Mesothelin Expression

for Mesothelin-Expressing Tumors

Sites in Philadelphia +8 more locations

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06756035·Phase 1·Recruiting·Listed Jan 2025

Apply to this trial

A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

for HR+/HER2-negative Breast Cancer

Sites in Philadelphia +8 more locations

Sponsor: Totus Medicines

Sex: Female·Age: 18+

Code: NCT05683418·Phase 1·Recruiting·Listed Jan 2023

Apply to this trial

A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

for Huntington Disease

Sites in Philadelphia, Pittsburgh +3 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 65

Code: NCT06826612·Phase 1, Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma

for Ovarian Cancer

Sites in Philadelphia +3 more locations

Sponsor: Verismo Therapeutics

Sex: All·Age: 18+

Code: NCT05568680·Phase 1·Recruiting·Listed Oct 2022

Apply to this trial

Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

for Hepatocellular Carcinoma

Sites in Philadelphia +1 more location

Sponsor: Teclison Ltd.

Sex: All·Age: 20 - 99

Code: NCT02174549·Phase 1, Phase 2·Recruiting·Listed Jun 2014

Apply to this trial

Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial (NEXT Trial)

for Cerebral Aneurysms

Sites in Philadelphia +8 more locations

Sponsor: Cerus Endovascular, Inc.

Sex: All·Age: 18 - 75

Code: NCT06693011·Recruiting·Listed Nov 2024

Apply to this trial

A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis

for Psoriatic Arthritis

Drug: Upadacitinib

Sites in Philadelphia +2 more locations

Sponsor: CARE ARTHRITIS LTD.

Sex: All·Age: 18+

Code: NCT06454188·Phase 4·Recruiting·Listed Jun 2024

Apply to this trial

A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

for Movement Disorders

Sites in Philadelphia +3 more locations

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT05539196·Recruiting·Listed Sep 2022

Apply to this trial

BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

for Advanced Malignancies

Sites in Philadelphia +2 more locations

Sponsor: BioInvent International AB

Sex: All·Age: 18+

Code: NCT04752826·Phase 1, Phase 2·Recruiting·Listed Feb 2021

Apply to this trial

A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

for Neuroendocrine Tumors

Sites in Philadelphia +3 more locations

Sponsor: Chimeric Therapeutics

Sex: All·Age: 18 - 85

Code: NCT06055439·Phase 1, Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

for Cirrhosis, Liver

Sites in Philadelphia +8 more locations

Sponsor: PharmaIN

Sex: All·Age: 18 - 75

Code: NCT05490888·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

A Study to Investigate the Safety, Tolerability, and Efficacy of BxC-I17e Single and Multiple Dose SC Injection in Patients With Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis

Sites in Philadelphia, Camp Hill +1 more location

Sponsor: Brexogen Inc.

Sex: All·Age: 18+

Code: NCT06055361·Phase 1·Recruiting·Listed Sep 2023

Apply to this trial

CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

Sites in Philadelphia +6 more locations

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting·Listed Aug 2021

Apply to this trial

TCR1188-ABC Cells in KRAS-mutated Cancers

for Cholangiocarcinoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07594067·Phase 1·Recruiting·Listed May 2026

Apply to this trial

OCD LIFU Target Engagement

for Obsessive Compulsive Disorder (OCD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT07558148·Recruiting·Listed Apr 2026

Apply to this trial

A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia

for Insomnia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT07542756·Phase 4·Recruiting·Listed Apr 2026

Apply to this trial

CD45BE-HSPC + CART-45 Cells

for B-Cell Non-Hodgkin Lymphoma (NHL)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07451054·Phase 1·Recruiting·Listed Mar 2026

Apply to this trial

Continued Pressure for Alveolar Protection (CPAP Trial)

for Bronchopulmonary Dysplasia (BPD)

Sites in Philadelphia +14 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 31 Weeks

Code: NCT07417111·Recruiting·Listed Feb 2026

Apply to this trial

Duloxetine in Inflammatory Bowel Diseases

for Inflammatory Bowel Diseases

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 24+

Code: NCT07431606·Phase 2·Recruiting·Listed Feb 2026

Apply to this trial

Click & Pick Study

for Chronic Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07422922·Recruiting·Listed Feb 2026

Apply to this trial

Study to Enable New Diagnostics for Pulmonary Microbes in People With CF

for Cystic Fibrosis (CF)

Sites in Philadelphia, Pittsburgh +7 more locations

Sponsor: Chris Goss

Sex: All·Age: 16+

Code: NCT07312734·Recruiting·Listed Dec 2025

Apply to this trial

huCART19-IL18-eDHFR Cells in Relapsed/Refractory Follicular Lymphoma

for Relapsed or Refractory Follicular Lymphoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07343934·Phase 1·Recruiting·Listed Jan 2026

Apply to this trial

Central Vein Sign in Multiple Sclerosis Extension Study

for Multiple Sclerosis

Sites in Philadelphia +2 more locations

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT07424027·Recruiting·Listed Feb 2026

Apply to this trial

Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

Sites in Philadelphia, Hershey +59 more locations

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting·Listed Jan 2022

Apply to this trial

Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

Sites in Philadelphia, Pittsburgh +40 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting·Listed Jul 2021

Apply to this trial

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

Sites in Philadelphia +34 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting·Listed Aug 2019

Apply to this trial