Clinical Trials at University of Pennsylvania

As of August 2026, 305 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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308 clinical trials at University of Pennsylvania

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Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

for Sickle Cell Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07316478·Recruiting·Listed Jan 2026

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The GRoceries Aimed at Increasing Nutrition Study

for Type 2 Diabetes

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 45 - 70

Code: NCT07167004·Recruiting·Listed Sep 2025

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Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

Sites in Philadelphia +26 more locations

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting·Listed May 2015

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Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

Sites in Philadelphia +35 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting·Listed May 2025

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

Sites in Philadelphia +18 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting·Listed Oct 2023

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Philadelphia +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in Philadelphia, Pittsburgh +57 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

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Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

for Cigarette Smoking

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT07199517·Recruiting·Listed Sep 2025

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

Sites in Philadelphia, Pittsburgh +19 more locations

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting·Listed Jun 2024

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Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

Sites in Philadelphia +18 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting·Listed Nov 2024

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Follow-up Visit of High Risk Infants

for Infant, Newborn

Sites in Philadelphia +18 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 18 Months - 26 Months

Code: NCT00009633·Recruiting·Listed Feb 2001

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Streamlining Telehealth for Expanded PrEP Utilization Through Community Partnerships

for HIV

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07246057·Recruiting·Listed Nov 2025

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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting·Listed May 2024

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Accelerometer Measured Early Recovery After Prolapse Surgery

for Pelvic Organ Prolapse

Sites in Philadelphia +6 more locations

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18 - 99

Code: NCT07218016·Recruiting·Listed Oct 2025

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Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

for Hiv

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06263426·Recruiting·Listed Feb 2024

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Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

Sites in Philadelphia +15 more locations

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting·Listed Feb 2024

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Randomized Controlled Trial of Two Mobile Health Strategies to Manage Postpartum Hypertension

for Hypertension, Pregnancy Induced

Sites in Philadelphia +2 more locations

Sponsor: Jennifer Lewey, MD, MPH

Sex: Female·Age: 18+

Code: NCT07209254·Recruiting·Listed Oct 2025

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Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors

for Gynecologic Cancers

Sites in Philadelphia +2 more locations

Sponsor: Oregon State University

Sex: Female·Age: 18+

Code: NCT07055854·Phase 1·Recruiting·Listed Jul 2025

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Nephrotic Syndrome Study Network

for Minimal Change Disease (MCD)

Sites in Philadelphia +33 more locations

Sponsor: University of Michigan

Sex: All·Age: Up to 80

Code: NCT01209000·Recruiting·Listed Sep 2010

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Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

for Perinatal Opioid Use Disorder

2 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: All ages

Code: NCT06969261·Recruiting·Listed May 2025

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Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM

for Recurrent Glioblastoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07209241·Phase 1·Recruiting·Listed Oct 2025

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MOv19-BBz CAR T Cells in FRa+ Cancers

for Metastatic Non Small Cell Lung Cancer

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07116057·Phase 1·Recruiting·Listed Aug 2025

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CGM for Management of Type 2 Diabetes in Pregnancy

for Type 2 Diabetes Mellitus (T2DM)

Sites in Philadelphia +6 more locations

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18 - 50

Code: NCT06628453·Recruiting·Listed Oct 2024

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Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy

for Pulmonary Embolism

Sites in Philadelphia, Wynnewood +38 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05591118·Phase 3·Recruiting·Listed Oct 2022

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Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

for Barrett's Esophagus

Sites in Philadelphia +9 more locations

Sponsor: Case Western Reserve University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00288119·Recruiting·Listed Feb 2006

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Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

for Major Depressive Disorder (MDD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 25 - 65

Code: NCT06788249·EARLY_Phase 1·Recruiting·Listed Jan 2025

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MicroRNAs as Biomarkers for Obstructive Sleep Apnea

for Obstructive Sleep Apnea

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 75

Code: NCT06189755·Recruiting·Listed Jan 2024

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Philadelphia, Hershey +34 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

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Blinatumomab Consolidation in Real World

for B-Cell Acute Lymphoblastic Leukaemia

Sites in Philadelphia +2 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07117136·Recruiting·Listed Aug 2025

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Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation

for Primary Graft Dysfunction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 13 - 68

Code: NCT00552357·Recruiting·Listed Nov 2007

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How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD

for OCD

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 45

Code: NCT05359562·Recruiting·Listed May 2022

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Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

for Diabetes Mellitus, Type 1

Sites in Philadelphia +2 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18 - 65

Code: NCT06880835·Recruiting·Listed Mar 2025

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Psilocybin on Brain Mechanisms of Motivation in OUD

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT06810310·Phase 2·Recruiting·Listed Feb 2025

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Autobiographical Memory in Opioid Use Disorder

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06643988·Recruiting·Listed Oct 2024

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Virtual Reality in End Stage Kidney Disease

for End Stage Kidney Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT06356168·Recruiting·Listed Apr 2024

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CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

for Leukemia, Myeloid, Acute

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05945849·Phase 1·Recruiting·Listed Jul 2023

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PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

Sites in Philadelphia, Pittsburgh +28 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting·Listed Jul 2020

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PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

for Cervical Cancer

Sites in Philadelphia, Lancaster +1 more location

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05758688·Phase 2·Recruiting·Listed Mar 2023

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The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

for Arrythmia

Sites in Philadelphia, Pittsburgh +17 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05034432·Phase 4·Recruiting·Listed Sep 2021

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

Sites in Philadelphia +8 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting·Listed Mar 2022

Apply to this trial