Clinical Trials at University of Pennsylvania

As of September 2026, 301 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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305 clinical trials at University of Pennsylvania

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Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

Sites in Philadelphia +35 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting·Listed May 2025

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Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

for Osteonecrosis of the Femoral Head

Sites in Philadelphia +9 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 90

Code: NCT06123481·Recruiting·Listed Nov 2023

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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

for Surgery-Complications

Sites in Philadelphia +23 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05991453·Recruiting·Listed Aug 2023

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A Randomized Multicenter Study for Isolated Skin Vasculitis

for Primary Cutaneous Vasculitis

Sites in Philadelphia +3 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT02939573·Phase 2·Recruiting·Listed Oct 2016

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

Sites in Philadelphia, Pittsburgh +40 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting·Listed Jul 2021

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

Sites in Philadelphia +18 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting·Listed Oct 2023

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PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

for Cervical Cancer

Sites in Philadelphia, Lancaster +1 more location

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05758688·Phase 2·Recruiting·Listed Mar 2023

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Central Vein Sign in Multiple Sclerosis Extension Study

for Multiple Sclerosis

Sites in Philadelphia +2 more locations

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT07424027·Recruiting·Listed Feb 2026

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Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

for Ewing Sarcoma

Drug: Cabozantinib

Sites in Philadelphia +3 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 - 40

Code: NCT06156410·Phase 1·Recruiting·Listed Dec 2023

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Philadelphia +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

Sites in Philadelphia +7 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting·Listed Jun 2022

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Descemet Endothelial Thickness Comparison Trial II

for Fuchs

Sites in Philadelphia +7 more locations

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT05275972·Phase 3·Recruiting·Listed Mar 2022

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The GRoceries Aimed at Increasing Nutrition Study

for Type 2 Diabetes

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 45 - 70

Code: NCT07167004·Recruiting·Listed Sep 2025

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Phenotyping Genetic Risk for Type 2 Diabetes

for Diabetes Mellitus, Type 2

2 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 10 - 70·Accepts healthy volunteers

Code: NCT04024631·Recruiting·Listed Jul 2019

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APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

for Pre-Eclampsia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 45

Code: NCT06408181·Phase 3·Recruiting·Listed May 2024

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Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

for Glioblastoma

2 locations in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06613841·EARLY_Phase 1·Recruiting·Listed Sep 2024

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[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects

for Bacterial Infections

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04263792·Phase 1·Recruiting·Listed Feb 2020

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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting·Listed May 2024

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Pragmatic, Open-Label Study to Pilot Evaluation for Clinical Trials in Relapsing Polychondritis

for Relapsing Polychondritis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06941376·Phase 2·Recruiting·Listed Apr 2025

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Li-Fraumeni Syndrome/TP53 Biobank

for Li-Fraumeni Syndrome

Sites in Philadelphia & Phildelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04367246·Recruiting·Listed Apr 2020

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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

for Alzheimer's Disease

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 120

Code: NCT05658913·Recruiting·Listed Dec 2022

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Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

for Lymphedema of the Head and Neck

Sites in Philadelphia +1 more location

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06125743·Recruiting·Listed Nov 2023

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Decoding and Modulating Affective Brain States

for Rumination

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65

Code: NCT05437705·Recruiting·Listed Jun 2022

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in Philadelphia, Pittsburgh +57 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

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tACS to Enhance Language Abilities

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06092814·Recruiting·Listed Oct 2023

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Remote Sputum Collection in Cystic Fibrosis

for Cystic Fibrosis

Sites in Philadelphia +3 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06950892·Recruiting·Listed Apr 2025

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Abatacept for the Treatment of Giant Cell Arteritis

for Giant Cell Arteritis

Sites in Philadelphia +4 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT04474847·Phase 3·Recruiting·Listed Jul 2020

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Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer

for Breast Cancer Surgery

Sites in Philadelphia +4 more locations

Sponsor: Sir Mortimer B. Davis - Jewish General Hospital

Sex: Female·Age: 18 - 90

Code: NCT06888388·Recruiting·Listed Mar 2025

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Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

Sites in Philadelphia +18 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting·Listed Nov 2024

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Follow-up Visit of High Risk Infants

for Infant, Newborn

Sites in Philadelphia +18 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 18 Months - 26 Months

Code: NCT00009633·Recruiting·Listed Feb 2001

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

Sites in Philadelphia, Pittsburgh +19 more locations

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting·Listed Jun 2024

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Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

for Barrett's Esophagus

Sites in Philadelphia +9 more locations

Sponsor: Case Western Reserve University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00288119·Recruiting·Listed Feb 2006

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Philadelphia, Hershey +34 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

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Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

Sites in Philadelphia +15 more locations

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting·Listed Feb 2024

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Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

Sites in Philadelphia +23 more locations

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting·Listed Jan 2024

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MicroRNAs as Biomarkers for Obstructive Sleep Apnea

for Obstructive Sleep Apnea

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 75

Code: NCT06189755·Recruiting·Listed Jan 2024

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Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

for Perinatal Opioid Use Disorder

2 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: All ages

Code: NCT06969261·Recruiting·Listed May 2025

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Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

for Hiv

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06263426·Recruiting·Listed Feb 2024

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Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors

for Gynecologic Cancers

Sites in Philadelphia +2 more locations

Sponsor: Oregon State University

Sex: Female·Age: 18+

Code: NCT07055854·Phase 1·Recruiting·Listed Jul 2025

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Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation

for Primary Graft Dysfunction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 13 - 68

Code: NCT00552357·Recruiting·Listed Nov 2007

Apply to this trial