Clinical Trials at University of Pennsylvania

As of July 2026, 317 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 1, 2026.

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317 clinical trials at University of Pennsylvania

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Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

for Cryoglobulinemic Vasculitis (CV)

8 locations incl. Los Angeles

Sponsor: Peter Merkel

Sex: All·Age: 5+

Code: NCT03004326·Recruiting

Apply to this trial

Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

18 locations incl. Sun City

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting

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Closed Loop and Education for Hypoglycemia Awareness Restoration

for Diabetes Mellitus, Type 1

5 locations incl. La Jolla

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18 - 75

Code: NCT06325202·Recruiting

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Accelerometer Measured Early Recovery After Prolapse Surgery

for Pelvic Organ Prolapse

7 locations incl. San Diego

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18 - 99

Code: NCT07218016·Recruiting

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

14 locations incl. Duarte

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting

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Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A

for Tauopathies

2 locations incl. San Francisco

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85

Code: NCT06932809·EARLY_Phase 1·Recruiting

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CGM for Management of Type 2 Diabetes in Pregnancy

for Type 2 Diabetes Mellitus (T2DM)

7 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18 - 50

Code: NCT06628453·Recruiting

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Training for Urinary Leakage Improvement After Pregnancy

for Urinary Incontinence

7 locations incl. San Diego

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18+

Code: NCT06411158·Recruiting

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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

for Heart Failure

6 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06517186·Recruiting

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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

18 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting

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Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

16 locations incl. Birmingham

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting

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PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

for Cervical Cancer

3 locations incl. Voorhees Township

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05758688·Phase 2·Recruiting

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Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

for Ewing Sarcoma

Drug: Cabozantinib

4 locations incl. San Francisco

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 - 40

Code: NCT06156410·Phase 1·Recruiting

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Excision of Lymph Node Trial (EXCILYNT) (Mel69)

for Melanoma

7 locations incl. Atlanta

Sponsor: Craig L Slingluff, Jr

Sex: All·Age: 18+

Code: NCT05839912·Recruiting

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Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

for Sickle Cell Disease

9 locations incl. Birmingham

Sponsor: RTI International

Sex: All·Age: 18+

Code: NCT06385886·Recruiting

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SEEG-Guided DBS for OCD

for Obsessive-Compulsive Disorder

2 locations incl. Stanford

Sponsor: Casey H. Halpern, M.D.

Sex: All·Age: 22 - 75

Code: NCT05623306·Recruiting

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Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)

for Induction of Labor Affected Fetus / Newborn

6 locations incl. Newark

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 60·Accepts healthy volunteers

Code: NCT05759988·Recruiting

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HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

6 locations incl. Sacramento

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting

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Descemet Endothelial Thickness Comparison Trial II

for Fuchs

8 locations incl. Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT05275972·Phase 3·Recruiting

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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

9 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting

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International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors

for Kidney Cancer

7 locations incl. Los Angeles

Sponsor: Azienda Ospedaliero-Universitaria Careggi

Sex: All·Age: 18+

Code: NCT05363657·Recruiting

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GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

for Cystic Fibrosis

2 locations incl. Aurora

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04731272·Phase 2·Recruiting

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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

7 locations incl. Washington D.C.

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting

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Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2

for Charcot-Marie-Tooth Disease, Type Ia (Disorder)

17 locations incl. Los Angeles

Sponsor: University of Iowa

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01193088·Recruiting

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One-Time DNA Study for Vasculitis

for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

11 locations incl. Los Angeles

Sponsor: University of Pennsylvania

Sex: All·Age: 7+

Code: NCT01241305·Recruiting

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Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma

for Anaplastic (Malignant) Meningioma

Drug: Bevacizumab

8 locations incl. Santa Monica

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT02847559·Phase 2·Recruiting

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VCRC Tissue Repository

for Aortitis

6 locations incl. Boston

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02967068·Recruiting

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Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst

for Cardiac Arrest

5 locations incl. San Francisco

Sponsor: Boston Medical Center

Sex: All·Age: 18 - 89

Code: NCT03261089·Recruiting

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Reward Sensitivity Digital Intervention for Suicide Risk

for Suicidal Ideation

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 13 - 17

Code: NCT07661901·Recruiting

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CD45BE-HSPC + CART-45 Cells

for B-Cell Non-Hodgkin Lymphoma (NHL)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07451054·Phase 1·Recruiting

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huCART19-IL18-eDHFR Cells in Relapsed/Refractory Follicular Lymphoma

for Relapsed or Refractory Follicular Lymphoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07343934·Phase 1·Recruiting

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A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia

for Insomnia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT07542756·Phase 4·Recruiting

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Intervention to Improve Parent Communication About Sexuality

for Sexual Health

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 14 - 100·Accepts healthy volunteers

Code: NCT07672067·Recruiting

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Testing a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health

for Autism

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07042347·Recruiting

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Short Course Radiotherapy

for Central Nervous System Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: Up to 21

Code: NCT07147179·Recruiting

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Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

for Major Depressive Disorder (MDD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 25 - 65

Code: NCT06788249·EARLY_Phase 1·Recruiting

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Virtual Reality in End Stage Kidney Disease

for End Stage Kidney Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT06356168·Recruiting

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Streamlining Telehealth for Expanded PrEP Utilization Through Community Partnerships

for HIV

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07246057·Recruiting

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OCD LIFU Target Engagement

for Obsessive Compulsive Disorder (OCD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT07558148·Recruiting

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Randomized Controlled Trial of Two Mobile Health Strategies to Manage Postpartum Hypertension

for Hypertension, Pregnancy Induced

3 locations incl. New York

Sponsor: Jennifer Lewey, MD, MPH

Sex: Female·Age: 18+

Code: NCT07209254·Recruiting

Apply to this trial