Clinical Trials at University of Pennsylvania

As of September 2026, 301 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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305 clinical trials at University of Pennsylvania

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How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD

for OCD

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 45

Code: NCT05359562·Recruiting·Listed May 2022

Apply to this trial

Nephrotic Syndrome Study Network

for Minimal Change Disease (MCD)

Sites in Philadelphia +33 more locations

Sponsor: University of Michigan

Sex: All·Age: Up to 80

Code: NCT01209000·Recruiting·Listed Sep 2010

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Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

for Diabetes Mellitus, Type 1

Sites in Philadelphia +2 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18 - 65

Code: NCT06880835·Recruiting·Listed Mar 2025

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CGM for Management of Type 2 Diabetes in Pregnancy

for Type 2 Diabetes Mellitus (T2DM)

Sites in Philadelphia +6 more locations

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18 - 50

Code: NCT06628453·Recruiting·Listed Oct 2024

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Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

for Cigarette Smoking

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT07199517·Recruiting·Listed Sep 2025

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Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy

for Pulmonary Embolism

Sites in Philadelphia, Wynnewood +38 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05591118·Phase 3·Recruiting·Listed Oct 2022

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Autobiographical Memory in Opioid Use Disorder

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06643988·Recruiting·Listed Oct 2024

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Psilocybin on Brain Mechanisms of Motivation in OUD

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT06810310·Phase 2·Recruiting·Listed Feb 2025

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PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

Sites in Philadelphia, Pittsburgh +28 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting·Listed Jul 2020

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CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

for Leukemia, Myeloid, Acute

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05945849·Phase 1·Recruiting·Listed Jul 2023

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Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

for Sickle Cell Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07316478·Recruiting·Listed Jan 2026

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Blinatumomab Consolidation in Real World

for B-Cell Acute Lymphoblastic Leukaemia

Sites in Philadelphia +2 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07117136·Recruiting·Listed Aug 2025

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MOv19-BBz CAR T Cells in FRa+ Cancers

for Metastatic Non Small Cell Lung Cancer

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07116057·Phase 1·Recruiting·Listed Aug 2025

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The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

for Arrythmia

Sites in Philadelphia, Pittsburgh +17 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05034432·Phase 4·Recruiting·Listed Sep 2021

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

Sites in Philadelphia +8 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting·Listed Mar 2022

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Accelerometer Measured Early Recovery After Prolapse Surgery

for Pelvic Organ Prolapse

Sites in Philadelphia +6 more locations

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18 - 99

Code: NCT07218016·Recruiting·Listed Oct 2025

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Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85

Code: NCT06968663·Phase 2·Recruiting·Listed May 2025

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Randomized Controlled Trial of Two Mobile Health Strategies to Manage Postpartum Hypertension

for Hypertension, Pregnancy Induced

Sites in Philadelphia +2 more locations

Sponsor: Jennifer Lewey, MD, MPH

Sex: Female·Age: 18+

Code: NCT07209254·Recruiting·Listed Oct 2025

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A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program

for Obesity

Sites in Philadelphia +2 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 25 - 59

Code: NCT05748158·Recruiting·Listed Feb 2023

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Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 Variants

for Williams Beuren Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06930417·Recruiting·Listed Apr 2025

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Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence

for Stress Urinary Incontinence

Sites in Philadelphia +6 more locations

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 21+

Code: NCT06480227·Recruiting·Listed Jun 2024

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IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

Sites in Philadelphia, Pittsburgh +50 more locations

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting·Listed Oct 2023

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CapTemY90 for Grade 2/3 NET Liver Metastases

for Neuroendocrine Tumor Grade 2

Sites in Philadelphia +3 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04339036·Phase 2·Recruiting·Listed Apr 2020

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GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

for Cystic Fibrosis

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04731272·Phase 2·Recruiting·Listed Jan 2021

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SEEG-Guided DBS for OCD

for Obsessive-Compulsive Disorder

1 location in Philadelphia

Sponsor: Casey H. Halpern, M.D.

Sex: All·Age: 22 - 75

Code: NCT05623306·Recruiting·Listed Nov 2022

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Matching Perfusion and Metabolic Activity in HFpEF

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04913805·Phase 2·Recruiting·Listed Jun 2021

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Combined Oral Contraceptive Pill and Resistance Starch

for Metabolic Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 40

Code: NCT06852365·Phase 2·Recruiting·Listed Feb 2025

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A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

for Plasmablastic Lymphoma

Drug: Daratumumab

Sites in Philadelphia +7 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT04139304·EARLY_Phase 1·Recruiting·Listed Oct 2019

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Parasitic Ulcer Treatment Trial

for Acanthamoeba Keratitis

Sites in Philadelphia, Pittsburgh +11 more locations

Sponsor: Jeremy Keenan, MD, MPH

Sex: All·Age: 8+

Code: NCT06213649·Phase 3·Recruiting·Listed Jan 2024

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Integrating Telehealth to Advance Lung Cancer Screening

for Early Detection of Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 50 - 80

Code: NCT06638554·Recruiting·Listed Oct 2024

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Osteochondritis Dissecans of Knee Prospective Cohort

for Osteochondritis Dissecans

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02771496·Recruiting·Listed May 2016

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

Sites in Philadelphia, Wynnewood +39 more locations

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting·Listed Oct 2019

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Short Course Radiotherapy

for Central Nervous System Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: Up to 21

Code: NCT07147179·Recruiting·Listed Aug 2025

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Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care

for HIV/AIDS

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06462807·Recruiting·Listed Jun 2024

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Testing a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health

for Autism

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07042347·Recruiting·Listed Jun 2025

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Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer

for Urothelial Carcinoma Bladder

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06586255·Phase 1·Recruiting·Listed Sep 2024

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SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia With FLT3/ITD Mutation

Sites in Philadelphia +3 more locations

Sponsor: Uma Borate

Sex: All·Age: 18+

Code: NCT06222580·Phase 1·Recruiting·Listed Jan 2024

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Neonatal Platelet Transfusion Threshold Trial

for Thrombocytopenia

Sites in Philadelphia +19 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteers

Code: NCT06676904·Recruiting·Listed Nov 2024

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A Global Study of the PETAL Consortium

for T-Cell and NK-Cell Neoplasm

Sites in Philadelphia +9 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06067347·Recruiting·Listed Oct 2023

Apply to this trial

Sense4Safety Intervention

for Mild Cognitive Impairment

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT07220668·Phase 1, Phase 2·Recruiting·Listed Oct 2025

Apply to this trial