Clinical Trials at University of Pennsylvania

As of August 2026, 305 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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308 clinical trials at University of Pennsylvania

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Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85

Code: NCT06968663·Phase 2·Recruiting·Listed May 2025

Apply to this trial

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

Sites in Philadelphia +8 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting·Listed Jun 2022

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A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program

for Obesity

Sites in Philadelphia +2 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 25 - 59

Code: NCT05748158·Recruiting·Listed Feb 2023

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Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 Variants

for Williams Beuren Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06930417·Recruiting·Listed Apr 2025

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IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

Sites in Philadelphia, Pittsburgh +50 more locations

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting·Listed Oct 2023

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Short Course Radiotherapy

for Central Nervous System Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: Up to 21

Code: NCT07147179·Recruiting·Listed Aug 2025

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Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

for Non Small Cell Lung Cancer

Drug: Osimertinib

Sites in Philadelphia, Willow Grove +144 more locations

Sponsor: PrECOG, LLC.

Sex: All·Age: 18+

Code: NCT06538038·Recruiting·Listed Aug 2024

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Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence

for Stress Urinary Incontinence

Sites in Philadelphia +6 more locations

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 21+

Code: NCT06480227·Recruiting·Listed Jun 2024

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Sense4Safety Intervention

for Mild Cognitive Impairment

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT07220668·Phase 1, Phase 2·Recruiting·Listed Oct 2025

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The Periviable GOALS Decision Support Tool

for Pregnancy Preterm

Sites in Philadelphia +11 more locations

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT05264779·Recruiting·Listed Mar 2022

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GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

for Cystic Fibrosis

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04731272·Phase 2·Recruiting·Listed Jan 2021

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CapTemY90 for Grade 2/3 NET Liver Metastases

for Neuroendocrine Tumor Grade 2

Sites in Philadelphia +3 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04339036·Phase 2·Recruiting·Listed Apr 2020

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SEEG-Guided DBS for OCD

for Obsessive-Compulsive Disorder

1 location in Philadelphia

Sponsor: Casey H. Halpern, M.D.

Sex: All·Age: 22 - 75

Code: NCT05623306·Recruiting·Listed Nov 2022

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Combined Oral Contraceptive Pill and Resistance Starch

for Metabolic Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 40

Code: NCT06852365·Phase 2·Recruiting·Listed Feb 2025

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Matching Perfusion and Metabolic Activity in HFpEF

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04913805·Phase 2·Recruiting·Listed Jun 2021

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A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

for Plasmablastic Lymphoma

Drug: Daratumumab

Sites in Philadelphia +7 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT04139304·EARLY_Phase 1·Recruiting·Listed Oct 2019

Apply to this trial

Integrating Telehealth to Advance Lung Cancer Screening

for Early Detection of Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 50 - 80

Code: NCT06638554·Recruiting·Listed Oct 2024

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Parasitic Ulcer Treatment Trial

for Acanthamoeba Keratitis

Sites in Philadelphia, Pittsburgh +11 more locations

Sponsor: Jeremy Keenan, MD, MPH

Sex: All·Age: 8+

Code: NCT06213649·Phase 3·Recruiting·Listed Jan 2024

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Descemet Endothelial Thickness Comparison Trial II

for Fuchs

Sites in Philadelphia +7 more locations

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT05275972·Phase 3·Recruiting·Listed Mar 2022

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Osteochondritis Dissecans of Knee Prospective Cohort

for Osteochondritis Dissecans

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02771496·Recruiting·Listed May 2016

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Testing a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health

for Autism

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07042347·Recruiting·Listed Jun 2025

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Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)

for Prodromal Parkinsons Disease

Sites in Philadelphia +1 more location

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+

Code: NCT07265596·Phase 2·Recruiting·Listed Dec 2025

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Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care

for HIV/AIDS

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06462807·Recruiting·Listed Jun 2024

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

Sites in Philadelphia, Wynnewood +39 more locations

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting·Listed Oct 2019

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Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

Sites in Philadelphia, Pittsburgh +24 more locations

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting·Listed Jul 2022

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Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer

for Urothelial Carcinoma Bladder

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06586255·Phase 1·Recruiting·Listed Sep 2024

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SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia With FLT3/ITD Mutation

Sites in Philadelphia +3 more locations

Sponsor: Uma Borate

Sex: All·Age: 18+

Code: NCT06222580·Phase 1·Recruiting·Listed Jan 2024

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Ruxolitinib in Previously Treated Idiopathic Multicentric Castleman Disease

for Castleman's Disease (CD)

Drug: Ruxolitinib

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT07085039·Phase 2·Recruiting·Listed Jul 2025

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A Global Study of the PETAL Consortium

for T-Cell and NK-Cell Neoplasm

Sites in Philadelphia +9 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06067347·Recruiting·Listed Oct 2023

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LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study

for LCAT Deficiency

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT06217588·Recruiting·Listed Jan 2024

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Neonatal Platelet Transfusion Threshold Trial

for Thrombocytopenia

Sites in Philadelphia +19 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteers

Code: NCT06676904·Recruiting·Listed Nov 2024

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High Resolution Retinal Imaging

for Stargardts

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 7+·Accepts healthy volunteers

Code: NCT01866371·Recruiting·Listed May 2013

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Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

for Primary Progressive Aphasia

Sites in Philadelphia +1 more location

Sponsor: Johns Hopkins University

Sex: All·Age: 50 - 90·Accepts healthy volunteers

Code: NCT05386394·Phase 2·Recruiting·Listed May 2022

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HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

Sites in Philadelphia +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting·Listed May 2023

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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

for Heart Failure

Sites in Philadelphia +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06517186·Recruiting·Listed Jul 2024

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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

Sites in Philadelphia +6 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting·Listed Apr 2021

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Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503

for Tauopathies

Sites in Philadelphia +2 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85·Accepts healthy volunteers

Code: NCT06303921·EARLY_Phase 1·Recruiting·Listed Mar 2024

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Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green (ICG) Kinetic Modeling

for Necrotizing Fascitis

Sites in Philadelphia, Pittsburgh +6 more locations

Sponsor: Eric R. Henderson

Sex: All·Age: 18+

Code: NCT06877793·Recruiting·Listed Mar 2025

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

Sites in Philadelphia +13 more locations

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting·Listed Apr 2025

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Nerve Transfer to Improve Function in High Level Tetraplegia

for Cervical Spinal Cord Injury

Sites in Philadelphia +8 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 80

Code: NCT06288763·Recruiting·Listed Mar 2024

Apply to this trial