Clinical Trials at University of Pennsylvania

As of August 2026, 305 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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308 clinical trials at University of Pennsylvania

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Transformative Research in Diabetic Nephropathy

for Diabetic Nephropathies

Sites in Philadelphia, Allentown +11 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100

Code: NCT02986984·Recruiting·Listed Dec 2016

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Longitudinal Assessment of Traumatic Microvascular Injury-2

for Traumatic Brain Injury

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05725993·Recruiting·Listed Feb 2023

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The APS Phenotyping Study

for ARDS

Sites in Philadelphia +19 more locations

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT06521502·Recruiting·Listed Jul 2024

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Transforming Hemodialysis-Related Vascular Access Education

for Chronic Kidney Disease

Sites in Philadelphia +2 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05997875·Recruiting·Listed Aug 2023

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Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

Sites in Philadelphia +24 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting·Listed Jul 2024

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Transitional Housing and HIV Health

for HIV

2 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06829394·Recruiting·Listed Feb 2025

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Phase IB/II of CPX-351 for Relapse Prevention in AML

for Acute Myeloid Leukemia (AML) in Remission

Sites in Philadelphia +2 more locations

Sponsor: Georgetown University

Sex: All·Age: 18+

Code: NCT04990102·Phase 1, Phase 2·Recruiting·Listed Aug 2021

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Menstrual Cycle TMS Plasticity Pilot

for Cortical Activation

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 20 - 40·Accepts healthy volunteers

Code: NCT07180654·Recruiting·Listed Sep 2025

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Closed Loop and Education for Hypoglycemia Awareness Restoration

for Diabetes Mellitus, Type 1

Sites in Philadelphia +4 more locations

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18 - 75

Code: NCT06325202·Recruiting·Listed Mar 2024

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His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

Sites in Philadelphia, Wilkes-Barre +12 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting·Listed Mar 2022

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A Randomized Multicenter Study for Isolated Skin Vasculitis

for Primary Cutaneous Vasculitis

Sites in Philadelphia +4 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT02939573·Phase 2·Recruiting·Listed Oct 2016

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Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

for E-cigarette Use

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06372899·Recruiting·Listed Apr 2024

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TumorGlow Intraoperative Molecular Imaging (IMI)

for Tumor, Solid

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04723810·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

for Aphasia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85

Code: NCT06842745·Phase 2·Recruiting·Listed Feb 2025

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The Radiation Oncology Registry and Biosample Repository

for Neoplasia

Sites in Philadelphia, Lancaster +2 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT01577251·Recruiting·Listed Apr 2012

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Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

for Cryoglobulinemic Vasculitis (CV)

Sites in Philadelphia +1 more location

Sponsor: Peter Merkel

Sex: All·Age: 5+

Code: NCT03004326·Recruiting·Listed Dec 2016

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International Registry for Patients With Castleman Disease

for Castleman Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02817997·Recruiting·Listed Jun 2016

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Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome

for CRS - Cytokine Release Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05306080·EARLY_Phase 1·Recruiting·Listed Mar 2022

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Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

Sites in Philadelphia +25 more locations

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting·Listed Jan 2024

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Topical Anti-Androgens in Pilonidal Sinus Disease

for Pilonidal Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06286397·Phase 2·Recruiting·Listed Feb 2024

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FES BPET-DBT in Newly Diagnosed Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05659797·EARLY_Phase 1·Recruiting·Listed Dec 2022

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Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)

for Induction of Labor Affected Fetus / Newborn

Sites in Philadelphia +5 more locations

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 60·Accepts healthy volunteers

Code: NCT05759988·Recruiting·Listed Mar 2023

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All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

for Glioma

1 location in Philadelphia

Sponsor: Stephen Bagley, MD, MSCE

Sex: All·Age: 18+

Code: NCT05345002·Phase 2·Recruiting·Listed Apr 2022

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The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

for Smoking

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06264154·Recruiting·Listed Feb 2024

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One-Time DNA Study for Vasculitis

for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 7+

Code: NCT01241305·Recruiting·Listed Nov 2010

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VCRC Tissue Repository

for Aortitis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02967068·Recruiting·Listed Nov 2016

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The Myelin Disorders Biorepository Project

for Leukodystrophy

Sites in Philadelphia, Pittsburgh +21 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT03047369·Recruiting·Listed Feb 2017

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Localizing Epileptic Networks Using MRI and iEEG

for Epilepsy

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04649008·EARLY_Phase 1·Recruiting·Listed Dec 2020

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Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Philadelphia, Allentown +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

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Reducing Patient Memory Recall in the Burning Mouth Patient Population

for Burning Mouth Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05819697·Recruiting·Listed Apr 2023

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An Open-Label Study of Effectiveness of Immunomodulatory Medications for Patients With Relapsing Polychondritis

for Relapsing Polychondritis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06941376·Phase 2·Recruiting·Listed Apr 2025

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Sodium Glucose Co-transporter (SGLT) Inhibitors in Nonobstructive Hypertrophic Cardiomyopathy

for Hypertrophic Cardiomyopathy Without Obstruction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06433050·EARLY_Phase 1·Recruiting·Listed May 2024

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FAPI-74 PET/CT in Adults With Fibrosis

for Fibrosis (Morphologic Abnormality)

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+

Code: NCT06413355·Phase 1·Recruiting·Listed May 2024

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Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults

for Influenza, Human

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05108818·Phase 4·Recruiting·Listed Nov 2021

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A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

Sites in Philadelphia, Hershey +66 more locations

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting·Listed Jul 2024

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Prospective 4D CTA of BAV Competence

for Bicuspid

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04645862·Recruiting·Listed Nov 2020

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Hypofractionated WPPT With HDR Boost

for Prostate Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06591819·Phase 2·Recruiting·Listed Sep 2024

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Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A

for Tauopathies

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85

Code: NCT06932809·EARLY_Phase 1·Recruiting·Listed Apr 2025

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Training for Urinary Leakage Improvement After Pregnancy

for Urinary Incontinence

Sites in Philadelphia +6 more locations

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18+

Code: NCT06411158·Recruiting·Listed May 2024

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Supporting Evidence-based Responses to Emotional Needs in Emphysema

for COPD

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06600126·Recruiting·Listed Sep 2024

Apply to this trial