Clinical Trials at University of Pennsylvania

As of September 2026, 301 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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305 clinical trials at University of Pennsylvania

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Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

Sites in Philadelphia, Pittsburgh +24 more locations

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting·Listed Jul 2022

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LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study

for LCAT Deficiency

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT06217588·Recruiting·Listed Jan 2024

Apply to this trial

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

Sites in Philadelphia +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting·Listed May 2023

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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

for Heart Failure

Sites in Philadelphia +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06517186·Recruiting·Listed Jul 2024

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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

Sites in Philadelphia +6 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting·Listed Apr 2021

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High Resolution Retinal Imaging

for Stargardts

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 7+·Accepts healthy volunteers

Code: NCT01866371·Recruiting·Listed May 2013

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Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

for Primary Progressive Aphasia

Sites in Philadelphia +1 more location

Sponsor: Johns Hopkins University

Sex: All·Age: 50 - 90·Accepts healthy volunteers

Code: NCT05386394·Phase 2·Recruiting·Listed May 2022

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Ruxolitinib in Previously Treated Idiopathic Multicentric Castleman Disease

for Castleman's Disease (CD)

Drug: Ruxolitinib

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT07085039·Phase 2·Recruiting·Listed Jul 2025

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Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)

for Prodromal Parkinsons Disease

Sites in Philadelphia +1 more location

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+

Code: NCT07265596·Phase 2·Recruiting·Listed Dec 2025

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Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green (ICG) Kinetic Modeling

for Necrotizing Fascitis

Sites in Philadelphia, Pittsburgh +6 more locations

Sponsor: Eric R. Henderson

Sex: All·Age: 18+

Code: NCT06877793·Recruiting·Listed Mar 2025

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Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503

for Tauopathies

Sites in Philadelphia +2 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85·Accepts healthy volunteers

Code: NCT06303921·EARLY_Phase 1·Recruiting·Listed Mar 2024

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Nerve Transfer to Improve Function in High Level Tetraplegia

for Cervical Spinal Cord Injury

Sites in Philadelphia +8 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 80

Code: NCT06288763·Recruiting·Listed Mar 2024

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Transformative Research in Diabetic Nephropathy

for Diabetic Nephropathies

Sites in Philadelphia, Allentown +11 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100

Code: NCT02986984·Recruiting·Listed Dec 2016

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

Sites in Philadelphia +13 more locations

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting·Listed Apr 2025

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The APS Phenotyping Study

for ARDS

Sites in Philadelphia +19 more locations

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT06521502·Recruiting·Listed Jul 2024

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Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

Sites in Philadelphia +24 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting·Listed Jul 2024

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His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

Sites in Philadelphia, Wilkes-Barre +12 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting·Listed Mar 2022

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Longitudinal Assessment of Traumatic Microvascular Injury-2

for Traumatic Brain Injury

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05725993·Recruiting·Listed Feb 2023

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Closed Loop and Education for Hypoglycemia Awareness Restoration

for Diabetes Mellitus, Type 1

Sites in Philadelphia +4 more locations

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18 - 75

Code: NCT06325202·Recruiting·Listed Mar 2024

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Transforming Hemodialysis-Related Vascular Access Education

for Chronic Kidney Disease

Sites in Philadelphia +2 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05997875·Recruiting·Listed Aug 2023

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Transitional Housing and HIV Health

for HIV

2 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06829394·Recruiting·Listed Feb 2025

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Phase IB/II of CPX-351 for Relapse Prevention in AML

for Acute Myeloid Leukemia (AML) in Remission

Sites in Philadelphia +2 more locations

Sponsor: Georgetown University

Sex: All·Age: 18+

Code: NCT04990102·Phase 1, Phase 2·Recruiting·Listed Aug 2021

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Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

for Cryoglobulinemic Vasculitis (CV)

Sites in Philadelphia +1 more location

Sponsor: Peter Merkel

Sex: All·Age: 5+

Code: NCT03004326·Recruiting·Listed Dec 2016

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Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Philadelphia, Allentown +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

Sites in Philadelphia +34 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting·Listed Aug 2019

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The Myelin Disorders Biorepository Project

for Leukodystrophy

Sites in Philadelphia, Pittsburgh +21 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT03047369·Recruiting·Listed Feb 2017

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Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

for E-cigarette Use

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06372899·Recruiting·Listed Apr 2024

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TumorGlow Intraoperative Molecular Imaging (IMI)

for Tumor, Solid

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04723810·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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Menstrual Cycle TMS Plasticity Pilot

for Cortical Activation

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 20 - 40·Accepts healthy volunteers

Code: NCT07180654·Recruiting·Listed Sep 2025

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A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

Sites in Philadelphia, Hershey +66 more locations

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting·Listed Jul 2024

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The Radiation Oncology Registry and Biosample Repository

for Neoplasia

Sites in Philadelphia, Lancaster +2 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT01577251·Recruiting·Listed Apr 2012

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Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)

for Induction of Labor Affected Fetus / Newborn

Sites in Philadelphia +5 more locations

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 60·Accepts healthy volunteers

Code: NCT05759988·Recruiting·Listed Mar 2023

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One-Time DNA Study for Vasculitis

for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 7+

Code: NCT01241305·Recruiting·Listed Nov 2010

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VCRC Tissue Repository

for Aortitis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02967068·Recruiting·Listed Nov 2016

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Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

for Major Depressive Disorder (MDD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 25 - 65

Code: NCT06788249·EARLY_Phase 1·Recruiting·Listed Jan 2025

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International Registry for Patients With Castleman Disease

for Castleman Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02817997·Recruiting·Listed Jun 2016

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Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome

for CRS - Cytokine Release Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05306080·EARLY_Phase 1·Recruiting·Listed Mar 2022

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FES BPET-DBT in Newly Diagnosed Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05659797·EARLY_Phase 1·Recruiting·Listed Dec 2022

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Topical Anti-Androgens in Pilonidal Sinus Disease

for Pilonidal Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06286397·Phase 2·Recruiting·Listed Feb 2024

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All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

for Glioma

1 location in Philadelphia

Sponsor: Stephen Bagley, MD, MSCE

Sex: All·Age: 18+

Code: NCT05345002·Phase 2·Recruiting·Listed Apr 2022

Apply to this trial