Clinical Trials at University of Pennsylvania

As of July 2026, 317 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 1, 2026.

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317 clinical trials at University of Pennsylvania

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Click & Pick Study

for Chronic Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07422922·Recruiting

Apply to this trial

Sense4Safety Intervention

for Mild Cognitive Impairment

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT07220668·Phase 1, Phase 2·Recruiting

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Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

for Sickle Cell Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07316478·Recruiting

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Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

for Cigarette Smoking

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT07199517·Recruiting

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Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

for Perinatal Opioid Use Disorder

2 locations incl. Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: All ages

Code: NCT06969261·Recruiting

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Psilocybin on Brain Mechanisms of Motivation in OUD

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT06810310·Phase 2·Recruiting

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Ruxolitinib in Previously Treated Idiopathic Multicentric Castleman Disease

for Castleman's Disease (CD)

Drug: Ruxolitinib

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT07085039·Phase 2·Recruiting

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Menstrual Cycle TMS Plasticity Pilot

for Cortical Activation

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 20 - 40·Accepts healthy volunteers

Code: NCT07180654·Recruiting

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Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM

for Recurrent Glioblastoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07209241·Phase 1·Recruiting

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The GRoceries Aimed at Increasing Nutrition Study

for Type 2 Diabetes

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 45 - 70

Code: NCT07167004·Recruiting

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Wellcome Leap Psilocybin for OUD

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: Anna Rose Childress, Ph.D.

Sex: All·Age: 18 - 60

Code: NCT06786325·Phase 2·Recruiting

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MOv19-BBz CAR T Cells in FRa+ Cancers

for Metastatic Non Small Cell Lung Cancer

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07116057·Phase 1·Recruiting

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Central Vein Sign in Multiple Sclerosis Extension Study

for Multiple Sclerosis

3 locations incl. Los Angeles

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT07424027·Recruiting

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Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting

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Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care

for HIV/AIDS

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06462807·Recruiting

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Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors

for Gynecologic Cancers

3 locations incl. Corvallis

Sponsor: Oregon State University

Sex: Female·Age: 18+

Code: NCT07055854·Phase 1·Recruiting

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Autobiographical Memory in Opioid Use Disorder

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06643988·Recruiting

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An Open-Label Study of Effectiveness of Immunomodulatory Medications for Patients With Relapsing Polychondritis

for Relapsing Polychondritis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06941376·Phase 2·Recruiting

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CART-EGFR-IL13Ra2 in Newly Diagnosed GBM Following Initial Radiotherapy

for Glioblastoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06973096·Phase 1·Recruiting

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Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

for Phantom Pain Following Amputation of Lower Limb

3 locations incl. Philadelphia

Sponsor: Albert Einstein Healthcare Network

Sex: All·Age: 18 - 100

Code: NCT07044323·Recruiting

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Combined Oral Contraceptive Pill and Resistance Starch

for Metabolic Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 40

Code: NCT06852365·Phase 2·Recruiting

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Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

for Diabetes Mellitus, Type 1

3 locations incl. Louisville

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18 - 65

Code: NCT06880835·Recruiting

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Inhaled Insulin vs Rapid-acting Injections for Post-meal Glucose Control in Women With Gestational Diabetes

for Diabetes, Gestational

5 locations incl. Santa Barbara

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18 - 40

Code: NCT06535789·Phase 2, Phase 3·Recruiting

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CGM for the Early Detection and Management of Hyperglycemia in Pregnancy

for Gestational Diabetes Mellitus in Pregnancy

8 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06957028·Recruiting

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Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

for Glioblastoma

2 locations incl. Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06613841·EARLY_Phase 1·Recruiting

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Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer

for Urothelial Carcinoma Bladder

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06586255·Phase 1·Recruiting

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Philly CEAL- DECIDE+ Adaptation

for Disparities

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 35 - 75·Accepts healthy volunteers

Code: NCT06732102·Recruiting

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Transitional Housing and HIV Health

for HIV

2 locations incl. Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06829394·Recruiting

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Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

for Aphasia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85

Code: NCT06842745·Phase 2·Recruiting

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Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer

for Breast Cancer Surgery

4 locations incl. New Haven

Sponsor: Sir Mortimer B. Davis - Jewish General Hospital

Sex: Female·Age: 18 - 90

Code: NCT06888388·Recruiting

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Hypofractionated WPPT With HDR Boost

for Prostate Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06591819·Phase 2·Recruiting

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Remote Sputum Collection in Cystic Fibrosis

for Cystic Fibrosis

3 locations incl. Denver

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06950892·Recruiting

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Topical Anti-Androgens in Pilonidal Sinus Disease

for Pilonidal Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06286397·Phase 2·Recruiting

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Sodium Glucose Co-transporter (SGLT) Inhibitors in Nonobstructive Hypertrophic Cardiomyopathy

for Hypertrophic Cardiomyopathy Without Obstruction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06433050·EARLY_Phase 1·Recruiting

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Diagnostic Utility of SGLT1/2 Inhibition to Facilitate Myocardial Glucose Suppression

for Cardiac Sarcoidosis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06510894·Recruiting

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Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 Variants

for Williams Beuren Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06930417·Recruiting

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Imaging Retinal Vasculature in Infant Eyes

for Retinopathy of Prematurity

2 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: Up to 2 Months

Code: NCT05558059·Recruiting

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Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

for E-cigarette Use

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06372899·Recruiting

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Supporting Evidence-based Responses to Emotional Needs in Emphysema

for COPD

2 locations incl. Detroit

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06600126·Recruiting

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Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence

for Stress Urinary Incontinence

7 locations incl. La Jolla

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 21+

Code: NCT06480227·Recruiting

Apply to this trial