Paid Clinical Trials in Portland, ME
As of September 2026, 74 paid clinical trials are recruiting in Portland, Maine. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Portland offers studies at sites including MaineHealth Maine Medical Center - Portland for conditions such as Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Portland
Trials by drug in Portland
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67 clinical trials
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
Phase 2 Study to Assess the Safety and Efficacy of ANG003
Study of DONQ52 in Active Celiac Disease
A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
Endurant Stent Graft System vs Excluder Endoprothesis: ADVANCE Trial
A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
Pompe Disease Registry Protocol
Fabry Disease Registry & Pregnancy Sub-registry
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
The THOR IDE Study
REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema
A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment
Registry on NeVa VS for CerebraL VAsospasm ManagemenT in Post SAH PatiEnts
(CIRRUS-2023-1) CLINICAL CLIN Assessment of PathFinder 1.0 on the CIRRUS 6000 and the CIRRUS 5000
Safety and Efficacy of Adjunct Therapies in Adults With Type 1 Diabetes: Multicenter, Registry Study
Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL
A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer
Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
Top Research Study Locations in Portland
Researchers run research studies in Portland, ME at 24 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| MaineHealth Maine Medical Center - Portland | Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm | 22 |
| Maine Medical Center | Atrial Fibrillation, Heart Failure, ADHD | 20 |
| MaineHealth | Aging, Alzheimer Disease, Aneurysmal Subarachnoid Hemorrhage (aSAH) | 4 |
| Maine Medical Partners Pediatric Specialty Care | Cerebroside Lipidosis Syndrome, Fabry Disease, Gaucher Disease | 3 |
| Maine Health | Cancer, Irritable Bowel Syndrome With Constipation (IBS-C), Myocarditis Acute | 2 |
| MaineHealth Maine Medical Center | Burn (Disorder), Burn Degree Second, Burns Degree Third | 2 |
| Portland Gastroenterology Center | Celiac Disease, Crohn's Disease, Ulcerative Colitis | 2 |
| Maine Eye Center | Geographic Atrophy, Macular Degeneration, Age-Related Macular Degeneration | 2 |
| Maine Eye Center - Marginal Way Campus | Neovascular Age-related Macular Degeneration, Diabetic Retinopathy | 2 |
| Eyecare Medical Group | Dry Age Related Macular Degeneration, Epiretinal Membrane, IS/OS (Ellipsoid Zone) Disruption | 1 |
| GSK Investigational Site | Multiple Myeloma, Newly Diagnosed Multiple Myeloma | 1 |
| Maine Health - Maine Medical Center | Homocystinuria | 1 |
| Maine Health Pediatric Specialty Care | Homocystinuria | 1 |
| Maine Health Research Institute | Type 1 Diabetes | 1 |
| Maine Medical Center - Bramhall Campus | Hepatitis | 1 |
| Maine Medical Center - Division of Pulmonary and Critical Care Medicine | Cystic Fibrosis (CF), Exocrine Pancreatic Insufficiency (EPI), Pancreatic Diseases | 1 |
| Maine Medical Center-Bramhall Campus | Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma, Stage IV Prostate Cancer AJCC v8 | 1 |
| Maine Medical Centre | Community-acquired Pneumonia | 1 |
| Maine Medical Partners | Colitis, Ulcerative | 1 |
| MaineHealth Maine Medical Center Portland | Interprofessional Education, Neonatal Resuscitation, Rural Health | 1 |
| MaineHealth Pediatric Specialty Care | Cystic Fibrosis (CF), Exocrine Pancreatic Insufficiency (EPI) | 1 |
| Northern Light Breast Care | Breast Cancer | 1 |
| Ovation.io | Cancer, Other Disease | 1 |
| The Vascular Care Group | PAD, Peripheral Artery Calcification, Peripheral Artery Disease | 1 |
Active & Upcoming Studies in Portland (2026)
Recruiting trials in Portland grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (24 active studies)
- A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment · Phase 2 · Alliance for Clinical Trials in Oncology
- Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL · Phase 3 · Alliance for Clinical Trials in Oncology
Cardiovascular (8 active studies)
- Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure · Abbott Medical Devices
- CTSN Embolic Protection Trial · Icahn School of Medicine at Mount Sinai
Eye & vision (4 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) · Phase 3 · AbbVie
Neurology & pain (3 active studies)
- Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders · University of Michigan
- CTSN Embolic Protection Trial · Icahn School of Medicine at Mount Sinai
Diabetes & metabolic (2 active studies)
Pediatric (2 active studies)
- Comparative Study of Simulation Technologies for Use in Neonatal Resuscitation Training for Rural Hospitals · MaineHealth
- Supraglottic Airway for Resuscitation Trial · Children's Hospital of Philadelphia
Common conditions studied in Portland
- Acute Myeloid Leukemia (6 active studies)
- Chronic Lymphocytic Leukemia (3 active studies)
- Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm (2 active studies)
- Acute Myeloid Leukemia Post Cytotoxic Therapy (2 active studies)
- Acute Myeloid Leukemia, Myelodysplasia-Related (2 active studies)
- Atrial Fibrillation (2 active studies)
Leading research sponsors in Portland
- National Cancer Institute (NCI)
- Alliance for Clinical Trials in Oncology
- NRG Oncology
- Genzyme, a Sanofi Company
- MaineHealth
Frequently asked questions
How many paid clinical trials are currently recruiting in Portland?
There are approximately 74 recruiting clinical trials in Portland, Maine listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Portland pay participants?
Most recruiting trials in Portland compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Portland?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Portland?
The most common conditions under active study in Portland include Acute Myeloid Leukemia (6), Chronic Lymphocytic Leukemia (3), Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm (2), Acute Myeloid Leukemia Post Cytotoxic Therapy (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Portland?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Portland on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Portland?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Portland?
Recruiting research sites in Portland include MaineHealth Maine Medical Center - Portland, Maine Medical Center, MaineHealth, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Portland right now?
The largest active categories in Portland are Cancer & tumors (24), Cardiovascular (8), Eye & vision (4). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.