Clinical Trials at Mayo Clinic

As of September 2026, 390 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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396 clinical trials at Mayo Clinic

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R-3750 in Patients With Mild to Moderate Ulcerative Colitis

for Ulcerative Colitis Chronic Mild

Sites in Rochester +4 more locations

Sponsor: Rise Therapeutics LLC

Sex: All·Age: 18 - 65

Code: NCT05666960·Phase 1·Recruiting·Listed Dec 2022

Apply to this trial

Post-Exablate Pregnancy Outcomes Registry Study: Exablate Treatment of Symptomatic Uterine Fibroids

for Uterine Fibroid

Sites in Rochester +2 more locations

Sponsor: InSightec

Sex: Female·Age: 18 - 50

Code: NCT05386615·Recruiting·Listed May 2022

Apply to this trial

Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

Sites in Rochester +7 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting·Listed Mar 2024

Apply to this trial

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

for Cirrhosis, Liver

Sites in Rochester +8 more locations

Sponsor: PharmaIN

Sex: All·Age: 18 - 75

Code: NCT05490888·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

for Advanced Cancer

Sites in Rochester +6 more locations

Sponsor: Qurient Co., Ltd.

Sex: All·Age: 18+

Code: NCT05394103·Phase 1, Phase 2·Recruiting·Listed May 2022

Apply to this trial

The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF)

for Heart Failure With Preserved Ejection Fraction

1 location in Rochester

Sponsor: Heart Failure Solutions, Inc.

Sex: All·Age: 30+

Code: NCT06702501·Recruiting·Listed Nov 2024

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Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

for Arrhythmogenic Right Ventricular Cardiomyopathy

Sites in Rochester +6 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06228924·Phase 1·Recruiting·Listed Jan 2024

Apply to this trial

Erector Spinae Plane Block Versus Trigger Point Injection for Chronic Thoracic Myofascial Pain

for Back Pain

Sites in Rochester +4 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT07632820·Phase 4·Recruiting·Listed Jun 2026

Apply to this trial

AAVrh10-PCCA Gene Therapy for Propionic Acidemia

for Propionic Acidemia

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 6 Months - 2

Code: NCT07643844·Phase 1·Recruiting·Listed Jun 2026

Apply to this trial

A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS

for Encephalomyelitis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07551999·Recruiting·Listed Apr 2026

Apply to this trial

PrP-targeting siRNA Safety & Mechanism Study

for Prion Disease

Sites in Rochester +4 more locations

Sponsor: Broad Institute of MIT and Harvard

Sex: All·Age: 18+

Code: NCT07444580·Phase 1·Recruiting·Listed Mar 2026

Apply to this trial

SLIT ABS: Study on Patients With Autoimmune Podocytopathy

for Nephrotic Syndrome With Edema (Diagnosis)

1 location in Rochester

Sponsor: Meyer Children's Hospital IRCCS

Sex: All·Age: 0 - 99

Code: NCT07516964·Recruiting·Listed Apr 2026

Apply to this trial

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

for Breast Cancer

Sites in Rochester +5 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07340541·Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

Statins to Prevent Cancer Associated Blood Clots

for Venous Thromboembolism

Sites in Rochester +7 more locations

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07303816·Phase 4·Recruiting·Listed Dec 2025

Apply to this trial

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

Sites in Rochester, Bemidji +100 more locations

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting·Listed Jul 2019

Apply to this trial

ECD-Score: a Study on Erdheim-Chester Disease

for Erdheim-Chester Disease (ECD)

Sites in Rochester +2 more locations

Sponsor: Meyer Children's Hospital IRCCS

Sex: All·Age: 7+

Code: NCT07454343·Recruiting·Listed Mar 2026

Apply to this trial

The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

Sites in Rochester +42 more locations

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting·Listed Jul 2023

Apply to this trial

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

Sites in Rochester, Duluth +90 more locations

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting·Listed Feb 2020

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Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

Sites in Rochester +26 more locations

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting·Listed May 2015

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

Sites in Rochester, Minneapolis +26 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

Apply to this trial

Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

Sites in Rochester +28 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting·Listed Apr 2022

Apply to this trial

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

Sites in Rochester +27 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting·Listed Mar 2023

Apply to this trial

Global Prospective, Observational Cohort of Adult Patients With Primary Sclerosing Cholangitis (WIND-PSC Study)

for PSC

Sites in Rochester +10 more locations

Sponsor: PSC Partners Seeking a Cure

Sex: All·Age: 18 - 75

Code: NCT06297993·Recruiting·Listed Mar 2024

Apply to this trial

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

Sites in Rochester +35 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting·Listed May 2025

Apply to this trial

Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

for Osteonecrosis of the Femoral Head

Sites in Rochester, Minneapolis +8 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 90

Code: NCT06123481·Recruiting·Listed Nov 2023

Apply to this trial

Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

for Relapsing Multiple Sclerosis

Sites in Rochester +19 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55

Code: NCT04047628·Phase 3·Recruiting·Listed Aug 2019

Apply to this trial

Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

for Breast Cancer

Sites in Rochester +1 more location

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06488378·Phase 1·Recruiting·Listed Jul 2024

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Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

for Inherited Retinal Degeneration

Sites in Rochester +18 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4+

Code: NCT05589714·Recruiting·Listed Oct 2022

Apply to this trial

Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

for Rheumatic Joint Disease

Sites in Rochester, Minneapolis +64 more locations

Sponsor: Duke University

Sex: All·Age: Up to 21

Code: NCT02418442·Recruiting·Listed Apr 2015

Apply to this trial

International CRDS Registry

for Calcium Release Deficiency Syndrome

Sites in Rochester +3 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: All ages

Code: NCT06508164·Recruiting·Listed Jul 2024

Apply to this trial

A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy

for Bone Cancer Metastatic

Sites in Rochester +7 more locations

Sponsor: Society of Interventional Oncology

Sex: All·Age: 21+

Code: NCT06859801·Recruiting·Listed Mar 2025

Apply to this trial

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

Sites in Rochester +7 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting·Listed Jun 2022

Apply to this trial

Subcortical Arousal in Perceptual Awareness

for Epilepsy

Sites in Rochester +7 more locations

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting·Listed Apr 2025

Apply to this trial

An International Observational Study of Adults With Acute Infection

for Infectious Disease

Sites in Rochester, Minneapolis +18 more locations

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07069400·Recruiting·Listed Jul 2025

Apply to this trial

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

Sites in Rochester +32 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting·Listed Oct 2023

Apply to this trial

Recovery From Cushing Syndrome and Mild Autonomous Cortisol Secretion (MACS)

for Cushing Syndrome

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04543253·Recruiting·Listed Sep 2020

Apply to this trial

Biomarkers of Resiliency In Childhood Cancer Surgery

for Pediatric Cancer

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 3 - 25

Code: NCT06674811·Recruiting·Listed Nov 2024

Apply to this trial

Clinical Trial of Concomitant Hip Arthroscopy During PAO

for Hip Dysplasia

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 15 - 55

Code: NCT03181048·Recruiting·Listed Jun 2017

Apply to this trial

Using Facebook to Support Opioid Recovery Among American Indian Women

for Opioid Use Disorder

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT05995886·Recruiting·Listed Aug 2023

Apply to this trial

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

for Osteoarthritis, Knee

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 50 - 100

Code: NCT06887829·Recruiting·Listed Mar 2025

Apply to this trial