Clinical Trials at Mayo Clinic

As of August 2026, 387 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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391 clinical trials at Mayo Clinic

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A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy

for Multiple System Atrophy

Sites in Rochester +5 more locations

Sponsor: Dasher Neuroscience Inc.

Sex: All·Age: 30+

Code: NCT06848231·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Safety and Feasibility Study of the CELLSPAN Esophageal Implant (CEI) in Patients Requiring Short Segment Esophageal Replacement

for Esophageal Diseases

Sites in Rochester +2 more locations

Sponsor: Harvard Apparatus Regenerative Technology, Inc.

Sex: All·Age: 18+

Code: NCT05877300·Phase 1·Recruiting·Listed May 2023

Apply to this trial

Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation Therapy, in Patients With Resistant Hypertension

for Resistant Hypertension

Sites in Rochester +4 more locations

Sponsor: DeepQure Inc.

Sex: All·Age: 22 - 80

Code: NCT06526858·Recruiting·Listed Jul 2024

Apply to this trial

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

for Cirrhosis, Liver

Sites in Rochester +8 more locations

Sponsor: PharmaIN

Sex: All·Age: 18 - 75

Code: NCT05490888·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

A Prospective Research Investigation of Ischemia Using MCG

for Acute Coronary Syndrome

Sites in Rochester +1 more location

Sponsor: SB Technology, Inc.

Sex: All·Age: 18+

Code: NCT06481943·Recruiting·Listed Jul 2024

Apply to this trial

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

for Advanced Cancer

Sites in Rochester +6 more locations

Sponsor: Qurient Co., Ltd.

Sex: All·Age: 18+

Code: NCT05394103·Phase 1, Phase 2·Recruiting·Listed May 2022

Apply to this trial

The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF)

for Heart Failure With Preserved Ejection Fraction

1 location in Rochester

Sponsor: Heart Failure Solutions, Inc.

Sex: All·Age: 30+

Code: NCT06702501·Recruiting·Listed Nov 2024

Apply to this trial

Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

for Arrhythmogenic Right Ventricular Cardiomyopathy

Sites in Rochester +6 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06228924·Phase 1·Recruiting·Listed Jan 2024

Apply to this trial

Voice Analysis for Monitoring Patients With Heart Failure

for Heart Failure

1 location in Rochester

Sponsor: Noah Labs

Sex: All·Age: 18+

Code: NCT06566911·Recruiting·Listed Aug 2024

Apply to this trial

An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

for Hepatocellular Carcinoma

Drug: Nivolumab

Sites in Rochester +2 more locations

Sponsor: Virogin Biotech Canada Ltd

Sex: All·Age: 18+

Code: NCT05223816·Phase 2·Recruiting·Listed Feb 2022

Apply to this trial

Erector Spinae Plane Block Versus Trigger Point Injection for Chronic Thoracic Myofascial Pain

for Back Pain

Sites in Rochester +4 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT07632820·Phase 4·Recruiting·Listed Jun 2026

Apply to this trial

A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS

for Encephalomyelitis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07551999·Recruiting·Listed Apr 2026

Apply to this trial

SLIT ABS: Study on Patients With Autoimmune Podocytopathy

for Nephrotic Syndrome With Edema (Diagnosis)

1 location in Rochester

Sponsor: Meyer Children's Hospital IRCCS

Sex: All·Age: 0 - 99

Code: NCT07516964·Recruiting·Listed Apr 2026

Apply to this trial

PrP-targeting siRNA Safety & Mechanism Study

for Prion Disease

Sites in Rochester +4 more locations

Sponsor: Broad Institute of MIT and Harvard

Sex: All·Age: 18+

Code: NCT07444580·Phase 1·Recruiting·Listed Mar 2026

Apply to this trial

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

for Breast Cancer

Sites in Rochester +3 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07340541·Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

ECD-Score: a Study on Erdheim-Chester Disease

for Erdheim-Chester Disease (ECD)

Sites in Rochester +2 more locations

Sponsor: Meyer Children's Hospital IRCCS

Sex: All·Age: 7+

Code: NCT07454343·Recruiting·Listed Mar 2026

Apply to this trial

A Study Of Deep Learning For Echo Analysis, Tracking, And Evaluation

for Cardiomyopathy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07308704·Recruiting·Listed Dec 2025

Apply to this trial

Minimal Sedation During Knee Replacement Surgery

for Total Knee Arthroplasty

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07371390·Recruiting·Listed Jan 2026

Apply to this trial

Health and Wellness Coaching to Improve Thoracic Transplant Caregiver Self-Efficacy

for Wellbeing

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07361159·Recruiting·Listed Jan 2026

Apply to this trial

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

Sites in Rochester +34 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting·Listed Aug 2019

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Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors

for Pituitary Adenoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT07335315·Recruiting·Listed Jan 2026

Apply to this trial

Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

Sites in Rochester +26 more locations

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting·Listed May 2015

Apply to this trial

Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)

for Stickler Syndrome Type 1

Sites in Rochester, Minneapolis +3 more locations

Sponsor: Helen Keller Eye Research Foundation

Sex: All·Age: All ages

Code: NCT07146516·Recruiting·Listed Aug 2025

Apply to this trial

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

Sites in Rochester +32 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting·Listed Oct 2023

Apply to this trial

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

Sites in Rochester +35 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting·Listed May 2025

Apply to this trial

Integrated Therapies for Alcohol Use in Alcohol-associated Liver Disease (ITAALD) Trial

for Alcohol-associated Hepatitis

Sites in Rochester +5 more locations

Sponsor: Samer Gawrieh

Sex: All·Age: 18 - 70

Code: NCT07060638·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

Sites in Rochester +46 more locations

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting·Listed Jul 2023

Apply to this trial

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

Sites in Rochester, Duluth +89 more locations

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting·Listed Feb 2020

Apply to this trial

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

Sites in Rochester +32 more locations

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting·Listed Sep 2023

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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

Sites in Rochester, Bemidji +95 more locations

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting·Listed Jul 2019

Apply to this trial

Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin

for Ototoxicity, Drug-Induced

Sites in Rochester +7 more locations

Sponsor: Kevin Winthrop

Sex: All·Age: 18 - 80

Code: NCT05730283·Phase 2·Recruiting·Listed Feb 2023

Apply to this trial

Fibrosis Lessens After Metabolic Surgery

for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

Sites in Rochester +3 more locations

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06374875·Phase 4·Recruiting·Listed Apr 2024

Apply to this trial

Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

Sites in Rochester +9 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting·Listed Aug 2012

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Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis/Acute Pancreatitis Associated Diabetes Mellitus

for Pancreatitis, Chronic

Drug: Empagliflozin

Sites in Rochester +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT06729996·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

International CRDS Registry

for Calcium Release Deficiency Syndrome

Sites in Rochester +3 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: All ages

Code: NCT06508164·Recruiting·Listed Jul 2024

Apply to this trial

Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

for Spinal Cord Injuries

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 75

Code: NCT07210437·Recruiting·Listed Oct 2025

Apply to this trial

An International Observational Study of Adults With Acute Infection

for Infectious Disease

Sites in Rochester, Minneapolis +18 more locations

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07069400·Recruiting·Listed Jul 2025

Apply to this trial

Augmented Reality Real-Time Guidance for MRI-Guided Interventions

for Liver

Sites in Rochester +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT07120906·Recruiting·Listed Aug 2025

Apply to this trial

Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

Sites in Rochester +15 more locations

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting·Listed Feb 2024

Apply to this trial

Evaluation of A Clinical Diagnostic Test for CRDS

for Calcium Release Deficiency Syndrome (CRDS)

Sites in Rochester +3 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: All ages

Code: NCT06188689·Recruiting·Listed Jan 2024

Apply to this trial