Paid Clinical Trials in Rochester, MN
As of July 2026, 1,196 paid clinical trials are recruiting in Rochester, Minnesota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Rochester offers studies at sites including Mayo Clinic for conditions such as Malignant Solid Neoplasm, Heart Failure, Ovarian Cancer, Breast Cancer. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Rochester
Trials by drug in Rochester
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Newly added in Rochester
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
Acute Kidney Injury In Care Transitions (ACT): Pragmatic Clinical Trial
Virtual Group Resilient Living Program For Patients Living With Advanced Cancer
COMPARE-VENT Feasibility Pilot Study
AAVrh10-PCCA Gene Therapy for Propionic Acidemia
1,014 clinical trials
A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Study of DONQ52 in Active Celiac Disease
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors
A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
A Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-antihistamines
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Top Research Study Locations in Rochester
Researchers run research studies in Rochester, MN at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Mayo Clinic | Heart Failure, Breast Cancer, Cardiovascular Diseases | 455 |
| Mayo Clinic in Rochester | Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm, Breast Carcinoma | 401 |
| Mayo Clinic Rochester | CRC, Chronic Lymphocytic Leukemia, Colorectal Cancer | 73 |
| Mayo Clinic - Rochester | Endometrial Cancer, Epilepsy, Epilepsy (Treatment Refractory) | 29 |
| Mayo Clinic Minnesota | Healthy, Advanced Melanoma, Aging | 28 |
| Mayo Clinic in Rochester, Minnesota | Multiple Myeloma, Neoplasm Metastasis, Amyloid | 13 |
| Mayo Clinic, Rochester | Interstitial Lung Diseases, Acute Kidney Failure, Acute Kidney Insufficiency | 10 |
| Mayo Clinic Cancer Center | Lung Cancer, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma | 7 |
| Mayo Clinic in Minnesota | Advanced Solid Tumor, Bladder Spasms, Colorectal Cancer (CRC) | 6 |
| Clinical Trial Site | Advanced Hepatocellular Carcinoma, End Stage Renal Disease, Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy | 5 |
| Mayo Clinic (Data Collection Only) | Adult T-cell Leukemia/Lymphoma, Aggressive NK-cell Leukemia, Anaplastic Large Cell Lymphoma, ALK-Positive | 4 |
| Mayo Clinic - PIN | Crohn's Disease (CD), Developmental and Epileptic Encephalopathy, Dravet Syndrome | 4 |
| GSK Investigational Site | Amyloidosis, Gastrointestinal Neoplasms, Neoplasms, Prostate | 3 |
| Mayo Clinic - PPDS | Alpha1-Antitrypsin Deficiency, Metastatic HER2-positive Breast Cancer, Uveal Melanoma | 3 |
| Mayo Clinic Cancer Center Outpatient Pharmacy | Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma, Cachexia | 3 |
| Mayo Clinic Comprehensive Cancer Center | Acute Myeloid Leukemia, Advanced Or Metastatic Merkel Cell Carcinoma, Clear Cell Renal Cell Carcinoma (ccRCC) | 3 |
| Mayo Clinic Hospital | ADA SCID, Glioblastoma, Glioblastoma (GBM) | 3 |
| Mayo Clinic- Rochester | Aneurysmal Subarachnoid Hemorrhage (aSAH), Cerebral Vasospasm, Crohns Disease | 3 |
| Mayo Clinic - Rochester | Multiple Myeloma, Immunoglobulin Light Chain (AL) Amyloidosis | 3 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 2 |
| Crinetics Study Site | Classic Congenital Adrenal Hyperplasia, Congenital Adrenal Hyperplasia, Neuroendocrine Neoplasm | 2 |
| Mayo Clinic - Rochester Minnesota | Intermediate Risk Non-Muscle Invasive Bladder Cancer, Low-grade Upper Tract Urothelial Carcinoma | 2 |
| Mayo Clinic Department of Ophthalmology | Amblyopia | 2 |
| Mayo Clinic Foundation | Orthostatic Hypotension, Reflex Syncope, Weight Loss | 2 |
| Mayo Clinic Saint Marys Campus | Intracerebral Hemorrhage, Stroke, Stroke, Acute | 2 |
Active & Upcoming Studies in Rochester (2026)
Recruiting trials in Rochester grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (365 active studies)
Cardiovascular (91 active studies)
- Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome · Mauro H. Schenone
- MCG In Long QT Syndrome · Mayo Clinic
Neurology & pain (69 active studies)
- The Effect of Dry Needling With Electrical Stimulation on Individuals With Restless Legs Syndrome · Mayo Clinic
- A Study Of Synthetic THC And Sleep · Phase 2, Phase 3 · Mayo Clinic
Diabetes & metabolic (34 active studies)
Mental health & behavior (13 active studies)
- A Study Of Senyo Health With Comorbid Alcohol Use Disorder Treatment In Bipolar Patients · Mayo Clinic
- A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation · Phase 2, Phase 3 · Mayo Clinic
Pediatric (8 active studies)
- Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting · Mayo Clinic
- Supraglottic Airway for Resuscitation Trial · Children's Hospital of Philadelphia
Vaccines (6 active studies)
Eye & vision (5 active studies)
- 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients · Phase 4 · Mayo Clinic
- Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) · Phase 3 · AbbVie
HIV / STI (2 active studies)
- Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States · Phase 2 · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Analytic Treatment Interruption (ATI) to Assess HIV Cure · Mayo Clinic
Common conditions studied in Rochester
- Malignant Solid Neoplasm (19 active studies)
- Heart Failure (16 active studies)
- Ovarian Cancer (15 active studies)
- Breast Cancer (14 active studies)
- Healthy (14 active studies)
- Hematopoietic and Lymphatic System Neoplasm (13 active studies)
Leading research sponsors in Rochester
- Mayo Clinic
- AstraZeneca
- National Cancer Institute (NCI)
- Children's Oncology Group
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Rochester?
There are approximately 1,196 recruiting clinical trials in Rochester, Minnesota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Rochester pay participants?
Most recruiting trials in Rochester compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Rochester?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Rochester?
The most common conditions under active study in Rochester include Malignant Solid Neoplasm (19), Heart Failure (16), Ovarian Cancer (15), Breast Cancer (14), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Rochester?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Rochester on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Rochester?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Rochester?
Recruiting research sites in Rochester include Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic Rochester, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Rochester right now?
The largest active categories in Rochester are Cancer & tumors (365), Cardiovascular (91), Neurology & pain (69). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.