Clinical Trials at Mayo Clinic

As of September 2026, 390 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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396 clinical trials at Mayo Clinic

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Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR

for Proliferative Diabetic Retinopathy (PDR)

Sites in Rochester, Saint Louis Park +32 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT06790784·Phase 3·Recruiting·Listed Jan 2025

Apply to this trial

Fibrosis Lessens After Metabolic Surgery

for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

Sites in Rochester +3 more locations

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06374875·Phase 4·Recruiting·Listed Apr 2024

Apply to this trial

Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

Sites in Rochester +9 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting·Listed Aug 2012

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Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis/Acute Pancreatitis Associated Diabetes Mellitus

for Pancreatitis, Chronic

Drug: Empagliflozin

Sites in Rochester +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT06729996·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

ETHAN - ET for Male BC

for Male Breast Cancer

Sites in Rochester +8 more locations

Sponsor: Jose Pablo Leone

Sex: Male·Age: 18+

Code: NCT05501704·Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin

for Ototoxicity, Drug-Induced

Sites in Rochester +7 more locations

Sponsor: Kevin Winthrop

Sex: All·Age: 18 - 80

Code: NCT05730283·Phase 2·Recruiting·Listed Feb 2023

Apply to this trial

Abatacept for the Treatment of Giant Cell Arteritis

for Giant Cell Arteritis

Sites in Rochester +4 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT04474847·Phase 3·Recruiting·Listed Jul 2020

Apply to this trial

Integrated Therapies for Alcohol Use in Alcohol-associated Liver Disease (ITAALD) Trial

for Alcohol-associated Hepatitis

Sites in Rochester +5 more locations

Sponsor: Samer Gawrieh

Sex: All·Age: 18 - 70

Code: NCT07060638·Phase 2·Recruiting·Listed Jul 2025

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Study of Tadalafil vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology

for Fontan Palliation

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05206955·Phase 3·Recruiting·Listed Jan 2022

Apply to this trial

Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)

for Stickler Syndrome Type 1

Sites in Rochester, Minneapolis +3 more locations

Sponsor: Helen Keller Eye Research Foundation

Sex: All·Age: All ages

Code: NCT07146516·Recruiting·Listed Aug 2025

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A Study Of Deep Learning For Echo Analysis, Tracking, And Evaluation

for Cardiomyopathy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07308704·Recruiting·Listed Dec 2025

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Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

for Barrett's Esophagus

Sites in Rochester +9 more locations

Sponsor: Case Western Reserve University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00288119·Recruiting·Listed Feb 2006

Apply to this trial

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

Sites in Rochester +32 more locations

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting·Listed Sep 2023

Apply to this trial

Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

Sites in Rochester +15 more locations

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting·Listed Feb 2024

Apply to this trial

Mucosal and Microbiota Changes During Acute Campylobacteriosis

for Irritable Bowel Syndrome

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT03223077·Recruiting·Listed Jul 2017

Apply to this trial

Evaluation of A Clinical Diagnostic Test for CRDS

for Calcium Release Deficiency Syndrome (CRDS)

Sites in Rochester +3 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: All ages

Code: NCT06188689·Recruiting·Listed Jan 2024

Apply to this trial

Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

for Radiation Retinopathy

Sites in Rochester +26 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT05844982·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

Sites in Rochester +23 more locations

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting·Listed Jan 2024

Apply to this trial

Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment of Patients Receiving Neoadjuvant Chemotherapy With Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer

for Ovarian Cancer

Sites in Rochester, Minneapolis +7 more locations

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18+

Code: NCT04606914·Phase 2·Recruiting·Listed Oct 2020

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A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 60 - 85·Accepts healthy volunteers

Code: NCT06820658·Recruiting·Listed Feb 2025

Apply to this trial

Metabolic and Physiologic Responses to Hormone Therapy in Transgender and Gender Diverse People

for Effects of GAHT, on Skeletal Muscle in TGD

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06083766·Recruiting·Listed Oct 2023

Apply to this trial

Minimal Sedation During Knee Replacement Surgery

for Total Knee Arthroplasty

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07371390·Recruiting·Listed Jan 2026

Apply to this trial

Evaluation of Pirfenidone as a Novel Therapeutic Strategy Against Recurrent Acute Pancreatitis.

for Recurrent Acute Pancreatitis

Sites in Rochester +2 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 85

Code: NCT06253117·Phase 2·Recruiting·Listed Feb 2024

Apply to this trial

Tissue Destruction and Healing in Celiac Disease

for Celiac Disease

Sites in Rochester +2 more locations

Sponsor: University of Chicago

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT05680012·Recruiting·Listed Jan 2023

Apply to this trial

Rare Kidney Stone Consortium Biobank

for Primary Hyperoxaluria

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT02026388·Recruiting·Listed Jan 2014

Apply to this trial

Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

for Interstitial Lung Disease

Sites in Rochester +5 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 4+

Code: NCT04925375·Phase 2·Recruiting·Listed Jun 2021

Apply to this trial

Prescription of Letrozole for Uterine Myoma

for Leiomyoma, Uterine

Sites in Rochester +4 more locations

Sponsor: University of California, San Francisco

Sex: Female·Age: 21 - 53·Accepts healthy volunteers

Code: NCT06143631·Phase 4·Recruiting·Listed Nov 2023

Apply to this trial

Health and Wellness Coaching to Improve Thoracic Transplant Caregiver Self-Efficacy

for Wellbeing

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07361159·Recruiting·Listed Jan 2026

Apply to this trial

Imaging Studies in Corticobasal Syndrome

for Cortico Basal Degeneration

1 location in Rochester

Sponsor: Jennifer Whitwell

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07000851·Recruiting·Listed Jun 2025

Apply to this trial

CTSN Embolic Protection Trial

for Delirium

Sites in Rochester +18 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting·Listed Sep 2023

Apply to this trial

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

Sites in Rochester, Burnsville +462 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting·Listed May 2024

Apply to this trial

LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)

for Acute Kidney Injury

1 location in Rochester

Sponsor: University of Alberta

Sex: All·Age: 18+

Code: NCT06446739·Recruiting·Listed Jun 2024

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Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors

for Pituitary Adenoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT07335315·Recruiting·Listed Jan 2026

Apply to this trial

Localized Leiomyosarcoma Biomarker Protocol

for Leiomyosarcoma

Sites in Rochester +2 more locations

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: All ages

Code: NCT04925089·Recruiting·Listed Jun 2021

Apply to this trial

Autosomal Dominant Polycystic Kidney Disease (ADPKD) Study

for ADPKD

Sites in Rochester +3 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 18

Code: NCT04338048·Recruiting·Listed Apr 2020

Apply to this trial

Hairy Cell Leukemia Patient Data Registry

for Leukemia, Other

Sites in Rochester +4 more locations

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT02560883·Recruiting·Listed Sep 2015

Apply to this trial

Natural History Study of Synucleinopathies

for Patients With Synucleinopathies

Sites in Rochester +4 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT01799915·Recruiting·Listed Feb 2013

Apply to this trial

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

Sites in Rochester, Minneapolis +31 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010

Apply to this trial

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

Sites in Rochester +8 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting·Listed Mar 2022

Apply to this trial

Breastmilk in Response to a Bout of Exercise

for Infant Development

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06892483·Recruiting·Listed Mar 2025

Apply to this trial