Clinical Trials at Mayo Clinic

As of August 2026, 387 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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391 clinical trials at Mayo Clinic

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Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment of Patients Receiving Neoadjuvant Chemotherapy With Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer

for Ovarian Cancer

Sites in Rochester, Minneapolis +7 more locations

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18+

Code: NCT04606914·Phase 2·Recruiting·Listed Oct 2020

Apply to this trial

CTSN Embolic Protection Trial

for Delirium

Sites in Rochester +18 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting·Listed Sep 2023

Apply to this trial

CVD/PH and Voice Characteristics

for Pulmonary Hypertension

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07311044·Recruiting·Listed Dec 2025

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Global Prospective, Observational Cohort of Adult Patients With Primary Sclerosing Cholangitis (WIND-PSC Study)

for PSC

Sites in Rochester +10 more locations

Sponsor: PSC Partners Seeking a Cure

Sex: All·Age: 18 - 75

Code: NCT06297993·Recruiting·Listed Mar 2024

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Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

for Spinal Cord Injuries

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07210411·Recruiting·Listed Oct 2025

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Imaging Studies in Corticobasal Syndrome

for Cortico Basal Degeneration

1 location in Rochester

Sponsor: Jennifer Whitwell

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07000851·Recruiting·Listed Jun 2025

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68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease

for Crohn's Disease

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07273188·EARLY_Phase 1·Recruiting·Listed Dec 2025

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Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

for Inherited Retinal Degeneration

Sites in Rochester +18 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4+

Code: NCT05589714·Recruiting·Listed Oct 2022

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A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 60 - 85·Accepts healthy volunteers

Code: NCT06820658·Recruiting·Listed Feb 2025

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Mucosal and Microbiota Changes During Acute Campylobacteriosis

for Irritable Bowel Syndrome

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT03223077·Recruiting·Listed Jul 2017

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Metabolic and Physiologic Responses to Hormone Therapy in Transgender and Gender Diverse People

for Effects of GAHT, on Skeletal Muscle in TGD

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06083766·Recruiting·Listed Oct 2023

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Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR

for Proliferative Diabetic Retinopathy (PDR)

Sites in Rochester, Saint Louis Park +28 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT06790784·Phase 3·Recruiting·Listed Jan 2025

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Evaluation of Pirfenidone as a Novel Therapeutic Strategy Against Recurrent Acute Pancreatitis.

for Recurrent Acute Pancreatitis

Sites in Rochester +2 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 85

Code: NCT06253117·Phase 2·Recruiting·Listed Feb 2024

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Tissue Destruction and Healing in Celiac Disease

for Celiac Disease

Sites in Rochester +2 more locations

Sponsor: University of Chicago

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT05680012·Recruiting·Listed Jan 2023

Apply to this trial

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

Sites in Rochester, Burnsville +462 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting·Listed May 2024

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Rare Kidney Stone Consortium Biobank

for Primary Hyperoxaluria

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT02026388·Recruiting·Listed Jan 2014

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Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

for Interstitial Lung Disease

Sites in Rochester +5 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 4+

Code: NCT04925375·Phase 2·Recruiting·Listed Jun 2021

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Prescription of Letrozole for Uterine Myoma

for Leiomyoma, Uterine

Sites in Rochester +4 more locations

Sponsor: University of California, San Francisco

Sex: Female·Age: 21 - 53·Accepts healthy volunteers

Code: NCT06143631·Phase 4·Recruiting·Listed Nov 2023

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Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

for Radiation Retinopathy

Sites in Rochester +24 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT05844982·Phase 3·Recruiting·Listed May 2023

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Autosomal Dominant Polycystic Kidney Disease (ADPKD) Study

for ADPKD

Sites in Rochester +3 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 18

Code: NCT04338048·Recruiting·Listed Apr 2020

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Subcortical Arousal in Perceptual Awareness

for Epilepsy

Sites in Rochester +7 more locations

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting·Listed Apr 2025

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LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)

for Acute Kidney Injury

1 location in Rochester

Sponsor: University of Alberta

Sex: All·Age: 18+

Code: NCT06446739·Recruiting·Listed Jun 2024

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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

Sites in Rochester, Minneapolis +31 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010

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Natural History Study of Synucleinopathies

for Patients With Synucleinopathies

Sites in Rochester +4 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT01799915·Recruiting·Listed Feb 2013

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Localized Leiomyosarcoma Biomarker Protocol

for Leiomyosarcoma

Sites in Rochester +2 more locations

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: All ages

Code: NCT04925089·Recruiting·Listed Jun 2021

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A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy

for Bone Cancer Metastatic

Sites in Rochester +6 more locations

Sponsor: Society of Interventional Oncology

Sex: All·Age: 21+

Code: NCT06859801·Recruiting·Listed Mar 2025

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Hairy Cell Leukemia Patient Data Registry

for Leukemia, Other

Sites in Rochester +4 more locations

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT02560883·Recruiting·Listed Sep 2015

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Horizon Two: HR NDMM (MMRC-100)

for High Risk Newly Diagnosed Multiple Myeloma

Sites in Rochester +6 more locations

Sponsor: Multiple Myeloma Research Consortium

Sex: All·Age: 18+

Code: NCT07053436·Phase 2·Recruiting·Listed Jul 2025

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AI Assisted Personalized Legacy Program (Reflections: My Story) for Patients With Serious Illness

for Serious Illness

Sites in Rochester +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07009210·Recruiting·Listed Jun 2025

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Breastmilk in Response to a Bout of Exercise

for Infant Development

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06892483·Recruiting·Listed Mar 2025

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

Sites in Rochester +8 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting·Listed Mar 2022

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Metastatic Leiomyosarcoma Biomarker Protocol

for Leiomyosarcoma

Sites in Rochester +8 more locations

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: All ages

Code: NCT05653388·Recruiting·Listed Dec 2022

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Integrated Molecular and Clinical Profiling to Improve Disease Characterization and Outcome Prediction in Nodal Marginal Zone Lymphoma

for Nodal Marginal Zone Lymphoma

Sites in Rochester +3 more locations

Sponsor: International Extranodal Lymphoma Study Group (IELSG)

Sex: All·Age: 18+

Code: NCT05700149·Recruiting·Listed Jan 2023

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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

Sites in Rochester +8 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting·Listed Jun 2022

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Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy

for Pediatric Patients Treated With Radiation Therapy

Sites in Rochester +22 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: Up to 21

Code: NCT01696721·Recruiting·Listed Oct 2012

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Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial

for Obesity

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 65

Code: NCT06770049·Recruiting·Listed Jan 2025

Apply to this trial

Deciphering Preserved Autonomic Function After Multiple Sclerosis

for Multiple Sclerosis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07012135·Recruiting·Listed Jun 2025

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Late Onset Alzheimer's Disease

for Alzheimer Disease

Sites in Rochester +11 more locations

Sponsor: Columbia University

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT05010603·Recruiting·Listed Aug 2021

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Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm

for Ventricular Tachycardia

1 location in Rochester

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18+

Code: NCT06281977·Phase 3·Recruiting·Listed Feb 2024

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Molecular Detection of Advanced Neoplasia in Pancreatic Cysts

for Pancreas Cyst

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 120

Code: NCT03855800·Recruiting·Listed Feb 2019

Apply to this trial