Clinical Trials at Mayo Clinic Rochester

As of August 2026, 69 paid clinical trials are recruiting at Mayo Clinic Rochester, located at 1216 2ND ST SW, ROCHESTER, MN 55902-1906, phone (507) 255-5123 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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69 clinical trials at Mayo Clinic Rochester

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A Study of JNJ-1761981 in Participants With Solid Tumors

for Neoplasms

Sites in Rochester +3 more locations

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18+

Code: NCT07525141·Phase 1·Recruiting·Listed Apr 2026

Apply to this trial

Phase 1 Study of CLR 125 in Triple Negative Breast Cancer

for Breast Cancer

Sites in Rochester +3 more locations

Sponsor: Cellectar Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07311993·Phase 1·Recruiting·Listed Dec 2025

Apply to this trial

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

for Esophageal Squamous Cell Carcinoma

Sites in Rochester +12 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06644781·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

FIBERGRAFT Aeridyan Posterolateral Fusion Study

for Degenerative Spine Disease

Sites in Rochester +7 more locations

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 18+

Code: NCT07059065·Recruiting·Listed Jul 2025

Apply to this trial

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia

for Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Drug: Mosunetuzumab

Sites in Rochester +2 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT05091424·Phase 1·Recruiting·Listed Oct 2021

Apply to this trial

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

for Pancreatic Ductal Adenocarcinoma

Sites in Rochester +8 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06562192·Phase 1·Recruiting·Listed Aug 2024

Apply to this trial

Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma

for Relapsed or Refractory Multiple Myeloma

Sites in Rochester +8 more locations

Sponsor: Jiangsu Simcere Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT06375044·Phase 1·Recruiting·Listed Apr 2024

Apply to this trial

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Rochester +7 more locations

Sponsor: Vividion Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05954312·Phase 1·Recruiting·Listed Jul 2023

Apply to this trial

To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva

for Fibrodysplasia Ossificans Progressiva (FOP)

Sites in Rochester +1 more location

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 99

Code: NCT05090891·Phase 2·Recruiting·Listed Oct 2021

Apply to this trial

Pacritinib vs. Hydroxyurea in Advanced Proliferative Chronic Myelomonocytic Leukemia

for Leukemia, Myelomonocytic, Chronic

Drug: Pacritinib

Sites in Rochester +3 more locations

Sponsor: Theradex

Sex: All·Age: 18+

Code: NCT07033598·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

A Study of Radiation Dosimetry, Safety, and Tolerability of Extended Lutetium (177Lu) Vipivotide Tetraxetan Treatment in Chemo-naïve Adults With Metastatic Castration-resistant Prostate Cancer: RADIOpharmaceutical DOSimetry Evaluation (RADIODOSE) Study

for Metastatic Castration-Resistant Prostate Cancer

Sites in Rochester +4 more locations

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18 - 100

Code: NCT06531499·Phase 1·Recruiting·Listed Aug 2024

Apply to this trial

A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer

for Advanced Solid Tumor

Sites in Rochester +7 more locations

Sponsor: TORL Biotherapeutics, LLC

Sex: All·Age: 18+

Code: NCT06005740·Phase 1·Recruiting·Listed Aug 2023

Apply to this trial

Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

for Castrate Resistant Prostate Cancer

Sites in Rochester +5 more locations

Sponsor: Epigenetix, Inc.

Sex: All·Age: 18+

Code: NCT05488548·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

Magnetic Resonance Elastography to Monitor Response to Manual Therapy in Myofascial Pain

for Myofascial Pain Syndrome - Lower Back

2 locations in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07278570·Recruiting·Listed Dec 2025

Apply to this trial

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Rochester +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

Apply to this trial

RA-PRO PRAGMATIC TRIAL

for Rheumatoid Arthritis

Sites in Rochester, Eagan +46 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT04692493·Phase 3·Recruiting·Listed Dec 2020

Apply to this trial

A Study of Mobility Outcomes in Post-Pulmonary Embolic Disease

for Pulmonary Embolism

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT06695247·Recruiting·Listed Nov 2024

Apply to this trial

The Effects of Sleep on Human Microbiota: Implications for Health and Disease

for Sleep

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT02573753·Recruiting·Listed Oct 2015

Apply to this trial

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

for Spontaneous Coronary Artery Dissection

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05699200·Recruiting·Listed Jan 2023

Apply to this trial

Evaluation of Gender-Affirming Treatments on Pulmonary Function in Transgender and Gender Diverse Patients

for Hormonal Gender-Affirming Therapy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 14+

Code: NCT05587751·Recruiting·Listed Oct 2022

Apply to this trial

A Study of Invasive Hemodynamic for MACHD Registry

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05849025·Recruiting·Listed May 2023

Apply to this trial

A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

for Lung Transplant

Sites in Rochester +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05547698·Recruiting·Listed Sep 2022

Apply to this trial

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

for Barrett Esophagus

Sites in Rochester, Austin +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT03961945·Recruiting·Listed May 2019

Apply to this trial

The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

for Autoimmune Encephalitis

Drug: Inebilizumab

Sites in Rochester +34 more locations

Sponsor: University of Utah

Sex: All·Age: 12+

Code: NCT04372615·Phase 2·Recruiting·Listed May 2020

Apply to this trial

Minnesota RETAIN Phase 3

for Injuries Related Work

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07037927·Recruiting·Listed Jun 2025

Apply to this trial

Optimizing Brain Stimulation Parameters

for Epilepsy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 6+

Code: NCT06617845·Recruiting·Listed Oct 2024

Apply to this trial

Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 21 - 50·Accepts healthy volunteers

Code: NCT05525845·Recruiting·Listed Sep 2022

Apply to this trial

A Study of SPX-303, a Bispecific Antibody Targeting LILRB2 and PD-L1 in Patients With Solid Tumors

for Solid Tumor

Sites in Rochester +3 more locations

Sponsor: SparX Biotech(Jiangsu) Co., Ltd.

Sex: All·Age: 18+

Code: NCT06259552·Phase 1·Recruiting·Listed Feb 2024

Apply to this trial

Dynamics of Organ Damage and Immune Exhaustion During Sepsis

for Sepsis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06817408·Recruiting·Listed Feb 2025

Apply to this trial