Clinical Trials at Mayo Clinic in Rochester

As of August 2026, 326 paid clinical trials are recruiting at Mayo Clinic in Rochester, located at 1216 2ND ST SW, ROCHESTER, MN 55902-1906, phone (507) 255-5123 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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328 clinical trials at Mayo Clinic in Rochester

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Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

for Metastatic Malignant Solid Neoplasm

Sites in Rochester +5 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04585958·Phase 1·Recruiting·Listed Oct 2020

Apply to this trial

MRI-guided Transurethral Urethral Ultrasound Ablation for the Treatment of Low to Intermediate Grade Prostate Cancer

for Prostate Carcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Male·Age: 45 - 80

Code: NCT05438563·Recruiting·Listed Jun 2022

Apply to this trial

A Study of TopSpin360 Training Device

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 21·Accepts healthy volunteers

Code: NCT06052553·Recruiting·Listed Sep 2023

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Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

for Recurrent Castration-Sensitive Prostate Carcinoma

Sites in Rochester +2 more locations

Sponsor: Mayo Clinic

Sex: Male·Age: 18+

Code: NCT06378866·Phase 2·Recruiting·Listed Apr 2024

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MC210808 Venetoclax in Combination With Lenalidomide and Dexamethasone (Ven-Rd), Daratumumab and Dexamethasone (Ven-Dd), or Daratumumab-Lenalidomide-Dexamethasone (Ven-DRd) for the Treatment of Multiple Myeloma

for Multiple Myeloma

Drug: Daratumumab

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06042725·Phase 1·Recruiting·Listed Sep 2023

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Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation

for Arrhythmia

1 location in Rochester

Sponsor: Malini Madhavan

Sex: All·Age: 18+

Code: NCT04685317·Recruiting·Listed Dec 2020

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A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04984473·Recruiting·Listed Jul 2021

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Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy

for Malignant Brain Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06377696·Phase 2·Recruiting·Listed Apr 2024

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Rochester, Minneapolis +209 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

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Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Trial

for Diffuse Midline Glioma, H3 K27M-Mutant

Sites in Rochester +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 1+

Code: NCT05077735·Phase 2·Recruiting·Listed Oct 2021

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Thalamus Seizure Detection With a Deep Brain Stimulator System

for Epilepsy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06700356·Recruiting·Listed Nov 2024

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Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer

for Stage III Hepatocellular Carcinoma AJCC v8

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT03942328·Phase 1, Phase 2·Recruiting·Listed May 2019

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Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women

for Menopause

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 45 - 60·Accepts healthy volunteers

Code: NCT06743269·Recruiting·Listed Dec 2024

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A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

Sites in Rochester, Minneapolis +144 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting·Listed May 2024

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Evaluation of a Novel Auto Segmentation Algorithm for Normal Structure Delineation in Radiation Treatment Planning

for Malignant Solid Neoplasm

Sites in Rochester, Mankato +5 more locations

Sponsor: Mayo Clinic

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06200116·Recruiting·Listed Jan 2024

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SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma

for Biochemically Recurrent Prostate Carcinoma

Sites in Rochester, Mankato +4 more locations

Sponsor: Mayo Clinic

Sex: Male·Age: 18+

Code: NCT06205316·Phase 3·Recruiting·Listed Jan 2024

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A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for Central Nervous System Nongerminomatous Germ Cell Tumor

Sites in Rochester, Minneapolis +132 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT04684368·Phase 2·Recruiting·Listed Dec 2020

Apply to this trial

Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma

for Peripheral T Cell Lymphoma

Sites in Rochester +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06508463·Phase 1·Recruiting·Listed Jul 2024

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Minibeam Radiation Therapy With Tungsten Slit Collimator for the Treatment of Recurrent or Metastatic Skin or Soft Tissue Tumors

for Metastatic Malignant Skin Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07062003·Recruiting·Listed Jul 2025

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Ultrasound-Guided Core Needle Biopsy to Stage Urothelial Carcinoma of the Bladder (US UCB)

for Bladder Urothelial Carcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07029256·Recruiting·Listed Jun 2025

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Elotuzumab, Daratumumab, Iberdomide, and Dexamethasone for the Treatment of Relapsed Multiple Myeloma

for Recurrent Multiple Myeloma

Drug: Daratumumab

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06785415·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Study of AI in Cardiac Transplant in Echocardiographic Analysis (ORACLE)

for Cardiac Transplant Rejection

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06178744·Recruiting·Listed Dec 2023

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Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts

for Pancreatic Carcinoma

Sites in Rochester +7 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06271291·Recruiting·Listed Feb 2024

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An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

for WHO Grade 3 Glioma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06444412·Phase 2·Recruiting·Listed Jun 2024

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Onvansertib for the Treatment of Recurrent or Refractory Chronic Myelomonocytic Leukemia and Myelodysplastic Syndrome/MPN Overlap Neoplasms

for Recurrent Chronic Myelomonocytic Leukemia

Drug: Onvansertib

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05549661·Phase 1·Recruiting·Listed Sep 2022

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Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

Sites in Rochester, Minneapolis +74 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting·Listed Oct 2024

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Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

for Clinical Stage III Cutaneous Melanoma AJCC v8

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06075524·Recruiting·Listed Oct 2023

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Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

for Malignant Solid Neoplasm

Sites in Rochester +3 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT03750227·Phase 3·Recruiting·Listed Nov 2018

Apply to this trial

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

for Breast Carcinoma

Sites in Rochester +3 more locations

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05557877·Phase 2·Recruiting·Listed Sep 2022

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Efficacy of Nerve Blocks for Episodic Migraine

for Episodic Migraine

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05734625·Phase 2·Recruiting·Listed Feb 2023

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3D Ultrasound for the Imaging of Lymph Nodes in Patients With Breast Cancer

for Breast Carcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT05704283·EARLY_Phase 1·Recruiting·Listed Jan 2023

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Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists

for Upper Endoscopy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07006142·Recruiting·Listed Jun 2025

Apply to this trial

Hot Flashes and Neurovascular Function in Women

for Hot Flashes

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 40 - 60·Accepts healthy volunteers

Code: NCT05193968·Recruiting·Listed Jan 2022

Apply to this trial

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

for Malignant Brain Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06788886·Recruiting·Listed Jan 2025

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

Sites in Rochester, Minneapolis +161 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022

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Non-Invasive Identification of Endometrial Cancer/Endometrial Atypical Hyperplasia With an AI-Based Classifier Applied to Transvaginal Ultrasound in Patients With Post-Menopausal Bleeding

for Endometrial Carcinoma

Sites in Rochester +2 more locations

Sponsor: Mayo Clinic

Sex: Female·Age: 55+

Code: NCT06365905·Recruiting·Listed Apr 2024

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A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma

for B-Cell Non-Hodgkin Lymphoma

Drug: Cemiplimab

Sites in Rochester +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT03017820·Phase 1·Recruiting·Listed Jan 2017

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CD19-Directed CAR-T Cell Therapy for the Treatment of Relapsed/Refractory B Cell Malignancies

for Recurrent B-Cell Non-Hodgkin Lymphoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04892277·Phase 1·Recruiting·Listed May 2021

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The Use of Ultrasound in Assessing Post-prostatectomy Erectile Dysfunction

for Prostate Adenocarcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Male·Age: 40+

Code: NCT05109208·Recruiting·Listed Nov 2021

Apply to this trial

Patient Derived Preclinical Models

for Cancer

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05324553·Recruiting·Listed Apr 2022

Apply to this trial