Paid Clinical Trials in South Carolina

South Carolina has 1,226 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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1,109 clinical trials

At-home taVNS for Neurorehabilitation in Parkinson's Disease

for Parkinson's Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 40 - 85

Code: NCT07536022·Recruiting·Listed Apr 2026

Apply to this trial

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

for Squamous Cell Carcinoma

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07513389·Phase 2·Recruiting·Listed Apr 2026

Apply to this trial

Dietary Insights and Nutritional Education in Adults on GLP-1 Therapy

for Obesity Type 2 Diabetes Mellitus

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT07518407·Recruiting·Listed Apr 2026

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Brain Stimulation and Cognitive Training for MCI

for Mild Cognitive Impairment (MCI)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 60 - 85

Code: NCT07526740·Recruiting·Listed Apr 2026

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Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

for Opioid Use Disorder

1 location in Greenville

Sponsor: Prisma Health-Upstate

Sex: All·Age: 18+

Code: NCT07541417·Recruiting·Listed Apr 2026

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Family-Centered Implementation of Parent Training for Autistic Toddlers in Early Intervention

for Autism

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 12 Months - 36 Months·Accepts healthy volunteers

Code: NCT07471594·Recruiting·Listed Mar 2026

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Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

for Anatomic Stage II Breast Cancer AJCC v8

Drug: Ribociclib

Sites in West Columbia +71 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07391774·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

taVNS + CCT for Neurocognitive Rehab

for Psychosocial Well-being

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 45 - 80

Code: NCT07517237·Recruiting·Listed Apr 2026

Apply to this trial

Pilot of Mailing Buprenorphine

for Opioid Use Disorder

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07421102·EARLY_Phase 1·Recruiting·Listed Feb 2026

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Community Health Worker Coaching to Reduce Cardiovascular Risk Among Women After a Hypertensive Disorder of Pregnancy

for Blood Pressure Monitoring

1 location in Columbia

Sponsor: University of South Carolina

Sex: Female·Age: 18+

Code: NCT07457970·Recruiting·Listed Mar 2026

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Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

for Ampulla of Vater Carcinoma

Sites in Greenville, Greer +330 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07283939·Recruiting·Listed Dec 2025

Apply to this trial

Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder

for Nicotine Use Disoder

1 location in Greenville

Sponsor: Prisma Health-Upstate

Sex: All·Age: 21+

Code: NCT07594717·Recruiting·Listed May 2026

Apply to this trial

Add-On ZIDA Sock Therapy for Overactive Bladder

for Overactive Bladder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07432659·Recruiting·Listed Feb 2026

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Impact of Barostimulation on Hemodynamics in Adults With Heart Failure

for HFrEF - Heart Failure With Reduced Ejection Fraction

Sites in Charleston +6 more locations

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT07335510·Recruiting·Listed Jan 2026

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Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

for Open-angle Glaucoma (OAG)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07408154·Recruiting·Listed Feb 2026

Apply to this trial

Mindfulness Training During Accelerated TMS for Depression

for Depression

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 80

Code: NCT07369557·Recruiting·Listed Jan 2026

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Exoskeleton for Balance

for Stroke

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT07356011·Recruiting·Listed Jan 2026

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Accelerated TMS for Apathy in PD

for Parkinson Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 45 - 85

Code: NCT07399496·Recruiting·Listed Feb 2026

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MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

for Femoral Neck Fractures

Sites in Greenville +17 more locations

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT07244211·Recruiting·Listed Nov 2025

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Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot

for Critical Illness Recovery

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07390786·Recruiting·Listed Feb 2026

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Behavioral Health Collaborative Care Model in an ICU Recovery Clinic

for PICS

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07372586·Recruiting·Listed Jan 2026

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Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sites in Charleston +100 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07195734·Phase 2·Recruiting·Listed Sep 2025

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in Charleston, Greenville +633 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

Phentermine's Impact on Treatment in Teens

for Childhood Obesity

Sites in Columbia +1 more location

Sponsor: Russell McCulloh, MD

Sex: All·Age: 12 - 17

Code: NCT07282340·Phase 2·Recruiting·Listed Dec 2025

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Charleston, Greenville +1103 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

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Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

for Miscellaneous Neoplasm, Nos

Sites in Charleston +278 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07091617·Recruiting·Listed Jul 2025

Apply to this trial

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

Sites in Charleston, Greenville +920 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

Sites in Charleston, Greenville +774 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023

Apply to this trial

Accelerated High-Dose tDCS for Depression

for Major Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT07226011·Recruiting·Listed Nov 2025

Apply to this trial

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

for Intracranial Meningioma

Sites in Greenville, Greer +454 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT02523014·Phase 2·Recruiting·Listed Aug 2015

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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

Sites in Charleston, Spartanburg +294 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

Sites in Charleston, Greenville +296 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Charleston, Greenville +583 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

Precision Rehabilitation for Veterans With (HFpEF)

for Heart Failure

1 location in Columbia

Sponsor: Columbia VA Health Care System

Sex: All·Age: 18+

Code: NCT07493915·Recruiting·Listed Mar 2026

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mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

Sites in Charleston +642 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05677490·Phase 3·Recruiting·Listed Jan 2023

Apply to this trial

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

for Acute Lymphoblastic Leukemia

Sites in Greenville, Columbia +629 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT05334069·Recruiting·Listed Apr 2022

Apply to this trial

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

for Malignancy

Sites in Greenville +404 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: All ages

Code: NCT04242095·Recruiting·Listed Jan 2020

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Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

for Anatomic Stage II Breast Cancer AJCC v8

Drug: Durvalumab

Sites in Charleston, Greenville +525 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06058377·Phase 3·Recruiting·Listed Sep 2023

Apply to this trial

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

for Plasma Cell Myeloma

Sites in Charleston +227 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT04566328·Phase 3·Recruiting·Listed Sep 2020

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Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

Sites in Charleston, Greenville +271 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04402788·Phase 2, Phase 3·Recruiting·Listed May 2020

Apply to this trial